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SRY (sex determining region Y)-box 11
Symbols SOX11;
External IDs OMIM600898 MGI98359 HomoloGene37733 GeneCards: SOX11 Gene
RNA expression pattern
PBB GE SOX11 204915 s at tn.png
PBB GE SOX11 204913 s at tn.png
PBB GE SOX11 204914 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6664 20666
Ensembl ENSG00000176887 ENSMUSG00000063632
UniProt P35716 Q6AZA6
RefSeq (mRNA) XM_001128542 NM_009234
RefSeq (protein) XP_001128542 NP_033260
Location (UCSC) Chr 2:
5.75 - 5.76 Mb
Chr 12:
27.93 - 27.93 Mb
PubMed search [1] [2]

Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.[1][2][3]

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis.[3]

See also


  1. ^ Jay P, Goze C, Marsollier C, Taviaux S, Hardelin JP, Koopman P, Berta P (Aug 1996). "The human SOX11 gene: cloning, chromosomal assignment and tissue expression". Genomics 29 (2): 541-5. doi:10.1006/geno.1995.9970. PMID 8666406.  
  2. ^ Wiebe MS, Nowling TK, Rizzino A (May 2003). "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity". J Biol Chem 278 (20): 17901-11. doi:10.1074/jbc.M212211200. PMID 12637543.  
  3. ^ a b "Entrez Gene: SOX11 SRY (sex determining region Y)-box 11".  

Further reading

  • Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators.". Curr. Opin. Genet. Dev. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.  
  • Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.". Dev. Cell 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.  
  • Gozé C, Poulat F, Berta P (1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes.". Nucleic Acids Res. 21 (12): 2943. doi:10.1093/nar/21.12.2943. PMID 8332506.  
  • Kuhlbrodt K, Herbarth B, Sock E, et al. (1998). "Cooperative function of POU proteins and SOX proteins in glial cells.". J. Biol. Chem. 273 (26): 16050–7. doi:10.1074/jbc.273.26.16050. PMID 9632656.  
  • Azuma T, Ao S, Saito Y, et al. (2000). "Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region.". DNA Res. 6 (5): 357–60. doi:10.1093/dnares/6.5.357. PMID 10574465.  
  • Lee CJ, Appleby VJ, Orme AT, et al. (2003). "Differential expression of SOX4 and SOX11 in medulloblastoma.". J. Neurooncol. 57 (3): 201–14. doi:10.1023/A:1015773818302. PMID 12125983.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.  
  • Bouma GJ, Albrecht KH, Washburn LL, et al. (2005). "Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells.". Development 132 (13): 3045–54. doi:10.1242/dev.01890. PMID 15944188.  
  • Thevenet L, Albrecht KH, Malki S, et al. (2006). "NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY.". J. Biol. Chem. 280 (46): 38625–30. doi:10.1074/jbc.M504127200. PMID 16166090.  
  • DesGroseilliers M, Fortin F, Lemyre E, Lemieux N (2006). "Complex mosaicism in sex reversed SRY+ male twins.". Cytogenet. Genome Res. 112 (1-2): 176–9. doi:10.1159/000087532. PMID 16276109.  


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