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SRY (sex determining region Y)-box 12
Symbols SOX12; SOX22
External IDs OMIM601947 MGI98360 HomoloGene5057 GeneCards: SOX12 Gene
RNA expression pattern
PBB GE SOX12 204432 at tn.png
More reference expression data
Species Human Mouse
Entrez 6666 20667
Ensembl ENSG00000177732 ENSMUSG00000051817
UniProt O15370 Q04890
RefSeq (mRNA) NM_006943 XM_973626
RefSeq (protein) NP_008874 XP_978720
Location (UCSC) Chr 20:
0.25 - 0.26 Mb
Chr 2:
152.09 - 152.09 Mb
PubMed search [1] [2]

SOX12 is a protein that in humans is encoded by the SOX12 gene.[1][2] Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11.[3] Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.[4]

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.[2]


  1. ^ Jay P, Sahly I, Goze C, Taviaux S, Poulat F, Couly G, Abitbol M, Berta P (Aug 1997). "SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue". Hum Mol Genet 6 (7): 1069-77. PMID 9215677.  
  2. ^ a b "Entrez Gene: SOX12 SRY (sex determining region Y)-box 12".  
  3. ^ Hoser M, Potzner MR, Koch JM, Bösl MR, Wegner M, Sock E (August 2008). "Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors". Mol. Cell. Biol. 28 (15): 4675–87. doi:10.1128/MCB.00338-08. PMID 18505825.  
  4. ^ Dy P, Penzo-Méndez A, Wang H, Pedraza CE, Macklin WB, Lefebvre V (May 2008). "The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties". Nucleic Acids Res. 36 (9): 3101–17. doi:10.1093/nar/gkn162. PMID 18403418.  

Further reading

  • Bowles J, Schepers G, Koopman P (2001). "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators.". Dev. Biol. 227 (2): 239–55. doi:10.1006/dbio.2000.9883. PMID 11071752.  
  • Weiss MA (2001). "Floppy SOX: mutual induced fit in hmg (high-mobility group) box-DNA recognition.". Mol. Endocrinol. 15 (3): 353–62. doi:10.1210/me.15.3.353. PMID 11222737.  
  • Gozé C, Poulat F, Berta P (1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes.". Nucleic Acids Res. 21 (12): 2943. doi:10.1093/nar/21.12.2943. PMID 8332506.  


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