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SRY (sex determining region Y)-box 13

PDB rendering based on 1i11.
Available structures
Symbols SOX13; ICA12; MGC117216; SRY-box 13; Sox-13
External IDs OMIM604748 MGI98361 HomoloGene4159 GeneCards: SOX13 Gene
Species Human Mouse
Entrez 9580 20668
Ensembl ENSG00000143842 ENSMUSG00000070643
UniProt Q9UN79 Q04891
RefSeq (mRNA) NM_005686 NM_011439
RefSeq (protein) NP_005677 NP_035569
Location (UCSC) Chr 1:
202.31 - 202.36 Mb
Chr 1:
135.21 - 135.22 Mb
PubMed search [1] [2]

Transcription factor SOX-13 is a protein that in humans is encoded by the SOX13 gene.[1][2]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12.[2]

In melanocytic cells SOX13 gene expression may be regulated by MITF[3].


See also


  1. ^ Roose J, Korver W, de Boer R, Kuipers J, Hurenkamp J, Clevers H (May 1999). "The Sox-13 gene: structure, promoter characterization, and chromosomal localization". Genomics 57 (2): 301-5. doi:10.1006/geno.1999.5779. PMID 10198172.  
  2. ^ a b "Entrez Gene: SOX13 SRY (sex determining region Y)-box 13".  
  3. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.  

Further reading

  • Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators.". Curr. Opin. Genet. Dev. 12 (4): 441–6. PMID 12100890.  
  • Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.". Dev. Cell 3 (2): 167–70. PMID 12194848.  
  • Roose J, Korver W, Oving E, et al. (1998). "High expression of the HMG box factor sox-13 in arterial walls during embryonic development.". Nucleic Acids Res. 26 (2): 469–76. PMID 9421502.  
  • Argentaro A, Olsson J, Critcher R, et al. (2000). "Genomic characterisation and fine mapping of the human SOX13 gene.". Gene 250 (1-2): 181–9. PMID 10854791.  
  • Kasimiotis H, Myers MA, Argentaro A, et al. (2000). "Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic islets.". Diabetes 49 (4): 555–61. PMID 10871192.  
  • Steinbrenner H, Lohmann T, Ostendorf B, et al. (2001). "Autoantibodies to ICA12 (SOX-13) are not specific for Type I diabetes.". Diabetologia 43 (11): 1381–4. PMID 11126406.  
  • Kasimiotis H, Fida S, Rowley MJ, et al. (2001). "Antibodies to SOX13 (ICA12) are associated with type 1 diabetes.". Autoimmunity 33 (2): 95–101. PMID 11264788.  
  • Lampasona V, Scirpoli M, Bosi E, Bonifacio E (2001). "ICA12(SOX13) autoantibodies are unlikely to be a useful marker for pre-clinical Type I diabetes.". Diabetologia 44 (2): 267. PMID 11270687.  
  • Argentaro A, Wapelhorst B, Concannon P, Harley VR (2001). "Linkage studies of SOX13, the ICA12 autoantigen gene, in families with type 1 diabetes.". Mol. Genet. Metab. 72 (4): 356–9. doi:10.1006/mgme.2000.3136. PMID 11286511.  
  • Fida S, Myers M, Mackay IR, et al. (2001). "Antibodies to diabetes-associated autoantigens in Indian patients with Type 1 diabetes: prevalence of anti-ICA512/IA2 and anti-SOX13.". Diabetes Res. Clin. Pract. 52 (3): 205–11. PMID 11323090.  
  • Tandon N, Shtauvere-Brameus A, Hagopian WA, Sanjeevi CB (2002). "Prevalence of ICA-12 and other autoantibodies in north Indian patients with early-onset diabetes.". Ann. N. Y. Acad. Sci. 958: 214–7. PMID 12021109.  
  • Törn C, Shtauvere-Brameus A, Sanjeevi CB, Landin-Olsson M (2002). "Increased autoantibodies to SOX13 in Swedish patients with type 1 diabetes.". Ann. N. Y. Acad. Sci. 958: 218–23. PMID 12021110.  
  • Shtauvere-Brameus A, Hagopian W, Rumba I, Sanjeevi CB (2002). "Antibodies to new beta cell antigen ICA12 in Latvian diabetes patients.". Ann. N. Y. Acad. Sci. 958: 297–304. PMID 12021128.  
  • Gupta M, Tandon N, Shtauvere-Brameus A, Sanjeevi CB (2002). "ICA12 autoantibodies are associated with non-DR3/non-DR4 in patients with latent autoimmune diabetes in adults from northern India.". Ann. N. Y. Acad. Sci. 958: 329–32. PMID 12021135.  
  • Fida S, Myers MA, Whittingham S, et al. (2003). "Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases.". J. Autoimmun. 19 (4): 251–7. PMID 12473246.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Park Y, Park H, Yoo E, Kim D (2004). "SOX13 autoantibodies are likely to be a supplementary marker for type 1 diabetes in Korea.". Ann. N. Y. Acad. Sci. 1005: 253–8. PMID 14679071.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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