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SRY (sex determining region Y)-box 15
Identifiers
Symbols SOX15; SOX20; SOX26; SOX27
External IDs OMIM601297 MGI98363 HomoloGene74586 GeneCards: SOX15 Gene
RNA expression pattern
PBB GE SOX15 206122 at tn.png
PBB GE SOX15 217040 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6665 20670
Ensembl ENSG00000129194 ENSMUSG00000041287
UniProt O60248 Q5F2B2
RefSeq (mRNA) NM_006942 NM_009235
RefSeq (protein) NP_008873 NP_033261
Location (UCSC) Chr 17:
7.43 - 7.43 Mb
Chr 11:
69.47 - 69.47 Mb
PubMed search [1] [2]

Protein SOX-15 is a protein that in humans is encoded by the SOX15 gene.[1][2][3]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.[3]

See also

References

  1. ^ Meyer J, Wirth J, Held M, Schempp W, Scherer G (Jan 1997). "SOX20, a new member of the SOX gene family, is located on chromosome 17p13". Cytogenet Cell Genet 72 (2-3): 246-9. PMID 8978787.  
  2. ^ Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (Oct 1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenet Cell Genet 81 (3-4): 294-5. PMID 9730625.  
  3. ^ a b "Entrez Gene: SOX15 SRY (sex determining region Y)-box 15". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6665.  

Further reading

  • Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators.". Curr. Opin. Genet. Dev. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.  
  • Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.". Dev. Cell 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.  
  • Gozé C, Poulat F, Berta P (1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes.". Nucleic Acids Res. 21 (12): 2943. doi:10.1093/nar/21.12.2943. PMID 8332506.  
  • Hiraoka Y, Ogawa M, Sakai Y, et al. (1998). "Isolation and expression of a human SRY-related cDNA hSOX20.". Biochim. Biophys. Acta 1396 (2): 132–7. PMID 9540826.  
  • Cremazy F, Soullier S, Berta P, Jay P (1998). "Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR.". FEBS Lett. 438 (3): 311–4. doi:10.1016/S0014-5793(98)01294-0. PMID 9827568.  
  • Vujić M, Rajić T, Goodfellow PN, Stevanović M (1999). "cDNA characterization and high resolution mapping of the human SOX20 gene.". Mamm. Genome 9 (12): 1059–61. doi:10.1007/s003359900925. PMID 9880678.  
  • Miyashita A, Shimizu N, Endo N, et al. (1999). "Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11.". Gene 237 (1): 53–60. doi:10.1016/S0378-1119(99)00301-7. PMID 10524236.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
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