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SRY (sex determining region Y)-box 4
Symbols SOX4; EVI16
External IDs OMIM184430 MGI98366 HomoloGene2338 GeneCards: SOX4 Gene
RNA expression pattern
PBB GE SOX4 201417 at tn.png
PBB GE SOX4 201416 at tn.png
PBB GE SOX4 201418 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6659 20677
Ensembl ENSG00000124766 ENSMUSG00000076431
UniProt Q06945 Q5SW95
RefSeq (mRNA) NM_003107 NM_009238
RefSeq (protein) NP_003098 NP_033264
Location (UCSC) Chr 6:
21.7 - 21.71 Mb
Chr 13:
28.96 - 28.96 Mb
PubMed search [1] [2]

Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.[1][2][3]

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.[3]

Sox4 is expressed in lymphocytes (B and T) and is required for B lymphocyte development.[4]



SOX4 has been shown to interact with SDCBP.[5]

See also


  1. ^ Farr CJ, Easty DJ, Ragoussis J, Collignon J, Lovell-Badge R, Goodfellow PN (Jan 1994). "Characterization and mapping of the human SOX4 gene". Mamm Genome 4 (10): 577–84. PMID 8268656.  
  2. ^ Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (Oct 1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenet Cell Genet 81 (3-4): 294–5. PMID 9730625.  
  3. ^ a b "Entrez Gene: SOX4 SRY (sex determining region Y)-box 4".  
  4. ^ Smith E, Sigvardsson M (2004). "The roles of transcription factors in B lymphocyte commitment, development, and transformation". J. Leukoc. Biol. 75 (6): 973–81. doi:10.1189/jlb.1103554. PMID 14982952.  
  5. ^ Geijsen, N; Uings I J, Pals C, Armstrong J, McKinnon M, Raaijmakers J A, Lammers J W, Koenderman L, Coffer P J (Aug. 2001). "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein". Science (United States) 293 (5532): 1136–8. doi:10.1126/science.1059157. ISSN 0036-8075. PMID 11498591.  

Further reading

  • Kamachi Y, Uchikawa M, Kondoh H (2000). "Pairing SOX off: with partners in the regulation of embryonic development.". Trends Genet. 16 (4): 182–7. doi:10.1016/S0168-9525(99)01955-1. PMID 10729834.  
  • Bowles J, Schepers G, Koopman P (2001). "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators.". Dev. Biol. 227 (2): 239–55. doi:10.1006/dbio.2000.9883. PMID 11071752.  
  • Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators.". Curr. Opin. Genet. Dev. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.  
  • Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.". Dev. Cell 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.  
  • Denny P, Swift S, Brand N, et al. (1992). "A conserved family of genes related to the testis determining gene, SRY.". Nucleic Acids Res. 20 (11): 2887. doi:10.1093/nar/20.11.2887. PMID 1614875.  
  • Wotton D, Lake RA, Farr CJ, Owen MJ (1995). "The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer.". J. Biol. Chem. 270 (13): 7515–22. doi:10.1074/jbc.270.13.7515. PMID 7706298.  
  • van de Wetering M, Oosterwegel M, van Norren K, Clevers H (1993). "Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes.". EMBO J. 12 (10): 3847–54. PMID 8404853.  
  • van Houte LP, Chuprina VP, van der Wetering M, et al. (1996). "Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator Sox-4.". J. Biol. Chem. 270 (51): 30516–24. doi:10.1074/jbc.270.51.30516. PMID 8530483.  
  • Ahn SG, Cho GH, Jeong SY, et al. (1999). "Identification of cDNAs for Sox-4, an HMG-Box protein, and a novel human homolog of yeast splicing factor SSF-1 differentially regulated during apoptosis induced by prostaglandin A2/delta12-PGJ2 in Hep3B cells.". Biochem. Biophys. Res. Commun. 260 (1): 216–21. doi:10.1006/bbrc.1999.0856. PMID 10381369.  
  • van Beest M, Dooijes D, van De Wetering M, et al. (2000). "Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs.". J. Biol. Chem. 275 (35): 27266–73. doi:10.1074/jbc.M004102200. PMID 10867006.  
  • Reppe S, Rian E, Jemtland R, et al. (2001). "Sox-4 messenger RNA is expressed in the embryonic growth plate and regulated via the parathyroid hormone/parathyroid hormone-related protein receptor in osteoblast-like cells.". J. Bone Miner. Res. 15 (12): 2402–12. doi:10.1359/jbmr.2000.15.12.2402. PMID 11127205.  
  • Geijsen N, Uings IJ, Pals C, et al. (2001). "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein.". Science 293 (5532): 1136–8. doi:10.1126/science.1059157. PMID 11498591.  
  • Lee CJ, Appleby VJ, Orme AT, et al. (2003). "Differential expression of SOX4 and SOX11 in medulloblastoma.". J. Neurooncol. 57 (3): 201–14. doi:10.1023/A:1015773818302. PMID 12125983.  
  • Ahn SG, Kim HS, Jeong SW, et al. (2003). "Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A(2) and delta(12)-PGJ(2).". Exp. Mol. Med. 34 (3): 243–9. PMID 12216117.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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