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SRY (sex determining region Y)-box 5

PDB rendering based on 1i11.
Available structures
1i11
Identifiers
Symbols SOX5; L-SOX5; MGC35153
External IDs OMIM604975 MGI98367 HomoloGene21378 GeneCards: SOX5 Gene
RNA expression pattern
PBB GE SOX5 207336 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6660 20678
Ensembl ENSG00000134532 ENSMUSG00000041540
UniProt P35711 Q3TVF9
RefSeq (mRNA) NM_006940 NM_011444
RefSeq (protein) NP_008871 NP_035574
Location (UCSC) Chr 12:
23.58 - 23.99 Mb
Chr 6:
143.79 - 144.16 Mb
PubMed search [1] [2]

Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.[1][2]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[2]

See also

References

  1. ^ Wunderle VM, Critcher R, Ashworth A, Goodfellow PN (Jan 1997). "Cloning and characterization of SOX5, a new member of the human SOX gene family". Genomics 36 (2): 354-8. doi:10.1006/geno.1996.0474. PMID 8812465.  
  2. ^ a b "Entrez Gene: SOX5 SRY (sex determining region Y)-box 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6660.  

Further reading

  • Kamachi Y, Uchikawa M, Kondoh H (2000). "Pairing SOX off: with partners in the regulation of embryonic development.". Trends Genet. 16 (4): 182–7. doi:10.1016/S0168-9525(99)01955-1. PMID 10729834.  
  • Bowles J, Schepers G, Koopman P (2001). "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators.". Dev. Biol. 227 (2): 239–55. doi:10.1006/dbio.2000.9883. PMID 11071752.  
  • Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators.". Curr. Opin. Genet. Dev. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.  
  • Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.". Dev. Cell 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.  
  • Denny P, Swift S, Brand N, et al. (1992). "A conserved family of genes related to the testis determining gene, SRY.". Nucleic Acids Res. 20 (11): 2887. doi:10.1093/nar/20.11.2887. PMID 1614875.  
  • Connor F, Cary PD, Read CM, et al. (1994). "DNA binding and bending properties of the post-meiotically expressed Sry-related protein Sox-5.". Nucleic Acids Res. 22 (16): 3339–46. doi:10.1093/nar/22.16.3339. PMID 8078769.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Lefebvre V, Li P, de Crombrugghe B (1998). "A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene.". Embo J. 17 (19): 5718–33. doi:10.1093/emboj/17.19.5718. PMID 9755172.  
  • Uusitalo H, Hiltunen A, Ahonen M, et al. (2002). "Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing.". J. Bone Miner. Res. 16 (10): 1837–45. doi:10.1359/jbmr.2001.16.10.1837. PMID 11585348.  
  • Zafarana G, Gillis AJ, van Gurp RJ, et al. (2002). "Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation.". Cancer Res. 62 (6): 1822–31. PMID 11912161.  
  • Ikeda T, Zhang J, Chano T, et al. (2003). "Identification and characterization of the human long form of Sox5 (L-SOX5) gene.". Gene 298 (1): 59–68. doi:10.1016/S0378-1119(02)00927-7. PMID 12406576.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
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