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SRY (sex determining region Y)-box 5

PDB rendering based on 1i11.
Available structures
Symbols SOX5; L-SOX5; MGC35153
External IDs OMIM604975 MGI98367 HomoloGene21378 GeneCards: SOX5 Gene
RNA expression pattern
PBB GE SOX5 207336 at tn.png
More reference expression data
Species Human Mouse
Entrez 6660 20678
Ensembl ENSG00000134532 ENSMUSG00000041540
UniProt P35711 Q3TVF9
RefSeq (mRNA) NM_006940 NM_011444
RefSeq (protein) NP_008871 NP_035574
Location (UCSC) Chr 12:
23.58 - 23.99 Mb
Chr 6:
143.79 - 144.16 Mb
PubMed search [1] [2]

Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.[1][2]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[2]

See also


  1. ^ Wunderle VM, Critcher R, Ashworth A, Goodfellow PN (Jan 1997). "Cloning and characterization of SOX5, a new member of the human SOX gene family". Genomics 36 (2): 354-8. doi:10.1006/geno.1996.0474. PMID 8812465.  
  2. ^ a b "Entrez Gene: SOX5 SRY (sex determining region Y)-box 5".  

Further reading

  • Kamachi Y, Uchikawa M, Kondoh H (2000). "Pairing SOX off: with partners in the regulation of embryonic development.". Trends Genet. 16 (4): 182–7. doi:10.1016/S0168-9525(99)01955-1. PMID 10729834.  
  • Bowles J, Schepers G, Koopman P (2001). "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators.". Dev. Biol. 227 (2): 239–55. doi:10.1006/dbio.2000.9883. PMID 11071752.  
  • Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators.". Curr. Opin. Genet. Dev. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.  
  • Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.". Dev. Cell 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.  
  • Denny P, Swift S, Brand N, et al. (1992). "A conserved family of genes related to the testis determining gene, SRY.". Nucleic Acids Res. 20 (11): 2887. doi:10.1093/nar/20.11.2887. PMID 1614875.  
  • Connor F, Cary PD, Read CM, et al. (1994). "DNA binding and bending properties of the post-meiotically expressed Sry-related protein Sox-5.". Nucleic Acids Res. 22 (16): 3339–46. doi:10.1093/nar/22.16.3339. PMID 8078769.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Lefebvre V, Li P, de Crombrugghe B (1998). "A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene.". Embo J. 17 (19): 5718–33. doi:10.1093/emboj/17.19.5718. PMID 9755172.  
  • Uusitalo H, Hiltunen A, Ahonen M, et al. (2002). "Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing.". J. Bone Miner. Res. 16 (10): 1837–45. doi:10.1359/jbmr.2001.16.10.1837. PMID 11585348.  
  • Zafarana G, Gillis AJ, van Gurp RJ, et al. (2002). "Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation.". Cancer Res. 62 (6): 1822–31. PMID 11912161.  
  • Ikeda T, Zhang J, Chano T, et al. (2003). "Identification and characterization of the human long form of Sox5 (L-SOX5) gene.". Gene 298 (1): 59–68. doi:10.1016/S0378-1119(02)00927-7. PMID 12406576.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  


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