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SRY (sex determining region Y)-box 6

PDB rendering based on 1i11.
Available structures
Symbols SOX6; HSSOX6
External IDs OMIM607257 MGI98368 HomoloGene22631 GeneCards: SOX6 Gene
Species Human Mouse
Entrez 55553 20679
Ensembl ENSG00000110693 ENSMUSG00000051910
UniProt P35712 Q3V1J7
RefSeq (mRNA) NM_017508 NM_001025560
RefSeq (protein) NP_059978 NP_001020731
Location (UCSC) Chr 11:
15.95 - 16.45 Mb
Chr 7:
115.26 - 115.79 Mb
PubMed search [1] [2]

Transcription factor SOX-6 is a protein that in humans is encoded by the SOX6 gene.[1][2]

The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor groove of DNA, causing a 70- to 85-degree bend and introducing local conformational changes.[supplied by OMIM][2]



SOX6 has been shown to interact with CTBP2[3] and CENPK.[4]

See also


  1. ^ Cohen-Barak O, Hagiwara N, Arlt MF, Horton JP, Brilliant MH (Mar 2001). "Cloning, characterization and chromosome mapping of the human SOX6 gene". Gene 265 (1-2): 157–64. PMID 11255018.  
  2. ^ a b "Entrez Gene: SOX6 SRY (sex determining region Y)-box 6".  
  3. ^ Murakami, A; Ishida S, Thurlow J, Revest J M, Dickson C (Aug. 2001). "SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter". Nucleic Acids Res. (England) 29 (16): 3347–55. PMID 11504872.  
  4. ^ Yamashita, A; Ito M, Takamatsu N, Shiba T (Sep. 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Lett. (NETHERLANDS) 481 (2): 147–51. ISSN 0014-5793. PMID 10996314.  

Further reading

  • Denny P, Swift S, Brand N, et al. (1992). "A conserved family of genes related to the testis determining gene, SRY.". Nucleic Acids Res. 20 (11): 2887. doi:10.1093/nar/20.11.2887. PMID 1614875.  
  • Lefebvre V, Li P, de Crombrugghe B (1998). "A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene.". Embo J. 17 (19): 5718–33. doi:10.1093/emboj/17.19.5718. PMID 9755172.  
  • Hagiwara N, Klewer SE, Samson RA, et al. (2000). "Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death.". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4180–5. doi:10.1073/pnas.97.8.4180. PMID 10760285.  
  • Yamashita A, Ito M, Takamatsu N, Shiba T (2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis.". FEBS Lett. 481 (2): 147–51. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314.  
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.  
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.  
  • Murakami A, Ishida S, Thurlow J, et al. (2001). "SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter.". Nucleic Acids Res. 29 (16): 3347–55. doi:10.1093/nar/29.16.3347. PMID 11504872.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Cohen-Barak O, Yi Z, Hagiwara N, et al. (2004). "Sox6 regulation of cardiac myocyte development.". Nucleic Acids Res. 31 (20): 5941–8. doi:10.1093/nar/gkg807. PMID 14530442.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.  
  • Ueda R, Yoshida K, Kawakami Y, et al. (2005). "Expression of a transcriptional factor, SOX6, in human gliomas.". Brain tumor pathology 21 (1): 35–8. doi:10.1007/BF02482175. PMID 15696967.  
  • Ueda R, Yoshida K, Kawakami Y, et al. (2005). "Immunohistochemical analysis of SOX6 expression in human brain tumors.". Brain tumor pathology 21 (3): 117–20. doi:10.1007/BF02482186. PMID 15696972.  
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.  
  • Fernández-Lloris R, Osses N, Jaffray E, et al. (2006). "Repression of SOX6 transcriptional activity by SUMO modification.". FEBS Lett. 580 (5): 1215–21. doi:10.1016/j.febslet.2006.01.031. PMID 16442531.  
  • Ikeda T, Saito T, Ushita M, et al. (2007). "Identification and characterization of the human SOX6 promoter.". Biochem. Biophys. Res. Commun. 357 (2): 383–90. doi:10.1016/j.bbrc.2007.03.133. PMID 17433257.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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