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From Wikipedia, the free encyclopedia

Sp4 transcription factor

PDB rendering based on 1va1.
Available structures
Symbols SP4; HF1B; MGC130008; MGC130009; SPR-1
External IDs OMIM600540 MGI107595 HomoloGene2341 GeneCards: SP4 Gene
RNA expression pattern
PBB GE SP4 206663 at tn.png
More reference expression data
Species Human Mouse
Entrez 6671 20688
Ensembl ENSG00000105866 ENSMUSG00000025323
UniProt Q02446 Q6DFV2
RefSeq (mRNA) NM_003112 NM_009239
RefSeq (protein) NP_003103 NP_033265
Location (UCSC) Chr 7:
21.43 - 21.52 Mb
Chr 12:
118.68 - 118.74 Mb
PubMed search [1] [2]

Transcription factor Sp4 is a protein that in humans is encoded by the SP4 gene.[1][2]



Sp4 transcription factor has been shown to interact with E2F1.[3]


  1. ^ Hagen G, Muller S, Beato M, Suske G (Jan 1993). "Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes". Nucleic Acids Res 20 (21): 5519–25. PMID 1454515.  
  2. ^ "Entrez Gene: SP4 Sp4 transcription factor".  
  3. ^ Rotheneder, H; Geymayer S, Haidweger E (Nov. 1999). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". J. Mol. Biol. (ENGLAND) 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. ISSN 0022-2836. PMID 10547281.  

Further reading

  • Suske G (1999). "The Sp-family of transcription factors.". Gene 238 (2): 291–300. doi:10.1016/S0378-1119(99)00357-1. PMID 10570957.  
  • Hagen G, Dennig J, Preiss A, et al. (1995). "Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3.". J. Biol. Chem. 270 (42): 24989–94. doi:10.1074/jbc.270.42.24989. PMID 7559627.  
  • Kalff-Suske M, Kunz J, Grzeschik KH, Suske G (1995). "Human Sp4 transcription factor gene (SP4) maps to chromosome 7p15.". Genomics 26 (3): 631–3. doi:10.1016/0888-7543(95)80191-N. PMID 7607696.  
  • Majello B, De Luca P, Hagen G, et al. (1995). "Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1.". Nucleic Acids Res. 22 (23): 4914–21. doi:10.1093/nar/22.23.4914. PMID 7800480.  
  • Rotheneder H, Geymayer S, Haidweger E (2000). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter.". J. Mol. Biol. 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. PMID 10547281.  
  • Nguyên-Trân VT, Kubalak SW, Minamisawa S, et al. (2000). "A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages.". Cell 102 (5): 671–82. doi:10.1016/S0092-8674(00)00089-1. PMID 11007485.  
  • Lerner LE, Gribanova YE, Ji M, et al. (2001). "Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of multiple response elements.". J. Biol. Chem. 276 (37): 34999–5007. doi:10.1074/jbc.M103301200. PMID 11438531.  
  • Lerner LE, Gribanova YE, Whitaker L, et al. (2002). "The rod cGMP-phosphodiesterase beta-subunit promoter is a specific target for Sp4 and is not activated by other Sp proteins or CRX.". J. Biol. Chem. 277 (29): 25877–83. doi:10.1074/jbc.M201407200. PMID 11943774.  
  • Lee DK, Suh D, Edenberg HJ, Hur MW (2002). "POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.". J. Biol. Chem. 277 (30): 26761–8. doi:10.1074/jbc.M202078200. PMID 12004059.  
  • Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts.". Mol. Vis. 8: 196–204. PMID 12107411.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Davis W, Chen ZJ, Ile KE, Tew KD (2003). "Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors.". Nucleic Acids Res. 31 (3): 1097–107. doi:10.1093/nar/gkg192. PMID 12560508.  
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.  
  • Hong J, Samudio I, Liu S, et al. (2004). "Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins.". Endocrinology 145 (12): 5774–85. doi:10.1210/en.2004-0686. PMID 15345676.  
  • Phillips RJ, Tyson-Capper Née Pollard AJ, Bailey J, et al. (2005). "Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases.". J. Clin. Endocrinol. Metab. 90 (6): 3479–90. doi:10.1210/jc.2004-1962. PMID 15788387.  
  • Higgins KJ, Liu S, Abdelrahim M, et al. (2006). "Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins.". Endocrinology 147 (7): 3285–95. doi:10.1210/en.2006-0081. PMID 16574784.  
  • Gao YQ, Danciger M, Ozgul RK, et al. (2007). "Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease.". Mol. Vis. 13: 287–92. PMID 17356515.  

External links



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