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Spi-B transcription factor (Spi-1/PU.1 related)
Symbols SPIB; SPI-B
External IDs OMIM606802 MGI892986 HomoloGene79220 GeneCards: SPIB Gene
RNA expression pattern
PBB GE SPIB 205861 at tn.png
More reference expression data
Species Human Mouse
Entrez 6689 272382
Ensembl ENSG00000142539 ENSMUSG00000008193
UniProt Q01892 O35906
RefSeq (mRNA) NM_003121 NM_019866
RefSeq (protein) NP_003112 NP_063919
Location (UCSC) Chr 19:
55.61 - 55.62 Mb
Chr 7:
44.39 - 44.4 Mb
PubMed search [1] [2]

Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.[1][2]

SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM][2]



SPIB has been shown to interact with MAPK3[3] and MAPK8.[3]


  1. ^ Ray D, Bosselut R, Ghysdael J, Mattei MG, Tavitian A, Moreau-Gachelin F (Oct 1992). "Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1". Mol Cell Biol 12 (10): 4297–304. PMID 1406622.  
  2. ^ a b "Entrez Gene: SPIB Spi-B transcription factor (Spi-1/PU.1 related)".  
  3. ^ a b Mao, C; Ray-Gallet D, Tavitian A, Moreau-Gachelin F (Feb. 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene (ENGLAND) 12 (4): 863–73. ISSN 0950-9232. PMID 8632909.  

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F (1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors.". Oncogene 12 (4): 863–73. PMID 8632909.  
  • Ray-Gallet D, Tavitian A, Moreau-Gachelin F (1996). "An alternatively spliced isoform of the Spi-B transcription factor.". Biochem. Biophys. Res. Commun. 223 (2): 257–63. doi:10.1006/bbrc.1996.0881. PMID 8670269.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Rao S, Matsumura A, Yoon J, Simon MC (1999). "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.". J. Biol. Chem. 274 (16): 11115–24. doi:10.1074/jbc.274.16.11115. PMID 10196196.  
  • Nagy M, Chapuis B, Matthes T (2002). "Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells.". Br. J. Haematol. 116 (2): 429–35. doi:10.1046/j.1365-2141.2002.03271.x. PMID 11841448.  
  • Yamamoto H, Kihara-Negishi F, Yamada T, et al. (2002). "Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb.". Cell Growth Differ. 13 (2): 69–75. PMID 11864910.  
  • Schotte R, Rissoan MC, Bendriss-Vermare N, et al. (2003). "The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development.". Blood 101 (3): 1015–23. doi:10.1182/blood-2002-02-0438. PMID 12393575.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Schotte R, Nagasawa M, Weijer K, et al. (2005). "The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development.". J. Exp. Med. 200 (11): 1503–9. doi:10.1084/jem.20041231. PMID 15583020.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Geng CD, Vedeckis WV (2006). "c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter.". J. Biol. Chem. 280 (52): 43264–71. doi:10.1074/jbc.M508245200. PMID 16263717.  
  • Dontje W, Schotte R, Cupedo T, et al. (2006). "Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B.". Blood 107 (6): 2446–52. doi:10.1182/blood-2005-05-2090. PMID 16317090.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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