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Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
Identifiers
Symbols SRD5A1;
External IDs OMIM184753 MGI98400 HomoloGene37426 GeneCards: SRD5A1 Gene
EC number 1.3.99.5
RNA expression pattern
PBB GE SRD5A1 204675 at tn.png
PBB GE SRD5A1 210959 s at tn.png
PBB GE SRD5A1 211056 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6715 78925
Ensembl ENSG00000145545 ENSMUSG00000021594
UniProt P18405 n/a
RefSeq (mRNA) NM_001047 NM_175283
RefSeq (protein) NP_001038 NP_780492
Location (UCSC) Chr 5:
6.69 - 6.72 Mb
Chr 13:
70.04 - 70.08 Mb
PubMed search [1] [2]

3-oxo-5-alpha-steroid 4-dehydrogenase 1 is an enzyme that in humans is encoded by the SRD5A1 gene.[1]

Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). There are 2 isoforms of the enzyme: SRD5A1 and SRD5A2 (MIM 607306).[supplied by OMIM][2]

See also

References

  1. ^ Jenkins EP, Hsieh CL, Milatovich A, Normington K, Berman DM, Francke U, Russell DW (Mar 1992). "Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue". Genomics 11 (4): 1102-12. PMID 1686016.  
  2. ^ "Entrez Gene: SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6715.  

Further reading

  • Jenkins EP, Andersson S, Imperato-McGinley J, et al. (1992). "Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase.". J. Clin. Invest. 89 (1): 293–300. doi:10.1172/JCI115574. PMID 1345916.  
  • Andersson S, Russell DW (1990). "Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases.". Proc. Natl. Acad. Sci. U.S.A. 87 (10): 3640–4. doi:10.1073/pnas.87.10.3640. PMID 2339109.  
  • Moore RJ, Wilson JD (1972). "Localization of the reduced nicotinamide adenine dinucleotide phosphate: 4 -3-ketosteroid 5 -oxidoreductase in the nuclear membrane of the rat ventral prostate.". J. Biol. Chem. 247 (3): 958–67. PMID 4400474.  
  • Milewich L, Kaimal V, Toews GB (1983). "Androstenedione metabolism in human alveolar macrophages.". J. Clin. Endocrinol. Metab. 56 (5): 920–4. PMID 6833469.  
  • Thigpen AE, Silver RI, Guileyardo JM, et al. (1993). "Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression.". J. Clin. Invest. 92 (2): 903–10. doi:10.1172/JCI116665. PMID 7688765.  
  • Antonipillai I, Wahe M, Yamamoto J, Horton R (1995). "Activin and inhibin have opposite effects on steroid 5 alpha-reductase activity in genital skin fibroblasts.". Mol. Cell. Endocrinol. 107 (1): 99–104. doi:10.1016/0303-7207(94)03430-2. PMID 7796940.  
  • Hirsch KS, Jones CD, Audia JE, et al. (1993). "LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1.". Proc. Natl. Acad. Sci. U.S.A. 90 (11): 5277–81. doi:10.1073/pnas.90.11.5277. PMID 8389478.  
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.  
  • Bonkhoff H, Stein U, Aumüller G, Remberger K (1996). "Differential expression of 5 alpha-reductase isoenzymes in the human prostate and prostatic carcinomas.". Prostate 29 (4): 261–7. doi:10.1002/(SICI)1097-0045(199610)29:4<261::AID-PROS7>3.0.CO;2-E. PMID 8876709.  
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.  
  • Ellis JA, Stebbing M, Harrap SB (1998). "Genetic analysis of male pattern baldness and the 5alpha-reductase genes.". J. Invest. Dermatol. 110 (6): 849–53. doi:10.1046/j.1523-1747.1998.00224.x. PMID 9620288.  
  • Zhou Z, Shackleton CH, Pahwa S, et al. (1998). "Prominent sex steroid metabolism in human lymphocytes.". Mol. Cell. Endocrinol. 138 (1-2): 61–9. doi:10.1016/S0303-7207(98)00052-5. PMID 9685215.  
  • Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.  
  • Eminović I, Liović M, Prezelj J, et al. (2002). "New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8.". Pflugers Arch. 442 (6 Suppl 1): R187–9. PMID 11678334.  
  • Ellis JA, Wong ZY, Stebbing M, Harrap SB (2002). "Sex, genes and blood pressure.". Clin. Exp. Pharmacol. Physiol. 28 (12): 1053–5. doi:10.1046/j.1440-1681.2001.03579.x. PMID 11903314.  
  • Rodríguez-Dorantes M, Lizano-Soberón M, Camacho-Arroyo I, et al. (2002). "Evidence that steroid 5alpha-reductase isozyme genes are differentially methylated in human lymphocytes.". J. Steroid Biochem. Mol. Biol. 80 (3): 323–30. doi:10.1016/S0960-0760(02)00023-7. PMID 11948017.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ha SJ, Kim JS, Myung JW, et al. (2003). "Analysis of genetic polymorphisms of steroid 5alpha-reductase type 1 and 2 genes in Korean men with androgenetic alopecia.". J. Dermatol. Sci. 31 (2): 135–41. doi:10.1016/S0923-1811(02)00145-7. PMID 12670724.  
  • Habib FK, Ross M, Bayne CW, et al. (2004). "The loss of 5alpha-reductase type I and type II mRNA expression in metastatic prostate cancer to bone and lymph node metastasis.". Clin. Cancer Res. 9 (5): 1815–9. PMID 12738739.  
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