The Full Wiki

SREBF2: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Sterol regulatory element binding transcription factor 2

PDB rendering based on 1ukl.
Available structures
Symbols SREBF2; SREBP2
External IDs OMIM600481 MGI107585 HomoloGene20966 GeneCards: SREBF2 Gene
Species Human Mouse
Entrez 6721 20788
Ensembl ENSG00000198911 ENSMUSG00000022463
UniProt Q12772 n/a
RefSeq (mRNA) NM_004599 NM_033218
RefSeq (protein) NP_004590 NP_150087
Location (UCSC) Chr 22:
40.56 - 40.63 Mb
Chr 15:
81.97 - 82.03 Mb
PubMed search [1] [2]

Sterol regulatory element-binding protein 2 is a protein that in humans is encoded by the SREBF2 gene.[1]

This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.[2]



SREBF2 has been shown to interact with INSIG1[3][4] and CREB binding protein.[5]

See also


  1. ^ Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X (Jan 1994). "SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element". Proc Natl Acad Sci U S A 90 (24): 11603–7. PMID 7903453.  
  2. ^ "Entrez Gene: SREBF2 sterol regulatory element binding transcription factor 2".  
  3. ^ Dobrosotskaya, Irina Y; Goldstein Joseph L, Brown Michael S, Rawson Robert B (Sep. 2003). "Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs". J. Biol. Chem. (United States) 278 (37): 35837–43. doi:10.1074/jbc.M306476200. ISSN 0021-9258. PMID 12842885.  
  4. ^ Yang, Tong; Espenshade Peter J, Wright Michael E, Yabe Daisuke, Gong Yi, Aebersold Ruedi, Goldstein Joseph L, Brown Michael S (Aug. 2002). "Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER". Cell (United States) 110 (4): 489–500. ISSN 0092-8674. PMID 12202038.  
  5. ^ Oliner, J D; Andresen J M, Hansen S K, Zhou S, Tjian R (Nov. 1996). "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes Dev. (UNITED STATES) 10 (22): 2903–11. ISSN 0890-9369. PMID 8918891.  

Further reading

  • Osborne TF (2001). "CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin.". Genes Dev. 15 (15): 1873–8. doi:10.1101/gad.916601. PMID 11485982.  
  • Szolkiewicz M, Chmielewski M, Nogalska A, et al. (2007). "The potential role of sterol regulatory element binding protein transcription factors in renal injury.". Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 17 (1): 62–5. doi:10.1053/j.jrn.2006.10.009. PMID 17198935.  
  • Hua X, Wu J, Goldstein JL, et al. (1995). "Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13.". Genomics 25 (3): 667–73. PMID 7759101.  
  • Yokoyama C, Wang X, Briggs MR, et al. (1993). "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.". Cell 75 (1): 187–97. PMID 8402897.  
  • Wang X, Zelenski NG, Yang J, et al. (1996). "Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.". EMBO J. 15 (5): 1012–20. PMID 8605870.  
  • Hua X, Sakai J, Brown MS, Goldstein JL (1996). "Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane.". J. Biol. Chem. 271 (17): 10379–84. PMID 8626610.  
  • Pai JT, Brown MS, Goldstein JL (1996). "Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins.". Proc. Natl. Acad. Sci. U.S.A. 93 (11): 5437–42. PMID 8643593.  
  • Sato R, Inoue J, Kawabe Y, et al. (1996). "Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2.". J. Biol. Chem. 271 (43): 26461–4. PMID 8900111.  
  • Oliner JD, Andresen JM, Hansen SK, et al. (1996). "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein.". Genes Dev. 10 (22): 2903–11. PMID 8918891.  
  • Miserez AR, Cao G, Probst LC, Hobbs HH (1997). "Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2).". Genomics 40 (1): 31–40. doi:10.1006/geno.1996.4525. PMID 9070916.  
  • Duncan EA, Brown MS, Goldstein JL, Sakai J (1997). "Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.". J. Biol. Chem. 272 (19): 12778–85. PMID 9139737.  
  • Harris IR, Farrell AM, Holleran WM, et al. (1998). "Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis.". J. Lipid Res. 39 (2): 412–22. PMID 9508001.  
  • Kan HY, Pissios P, Chambaz J, Zannis VI (1999). "DNA binding specificity and transactivation properties of SREBP-2 bound to multiple sites on the human apoA-II promoter.". Nucleic Acids Res. 27 (4): 1104–17. PMID 9927745.  
  • Seidah NG, Mowla SJ, Hamelin J, et al. (1999). "Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.". Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1321–6. PMID 9990022.  
  • Nagoshi E, Imamoto N, Sato R, Yoneda Y (1999). "Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip.". Mol. Biol. Cell 10 (7): 2221–33. PMID 10397761.  
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.  
  • DeBose-Boyd RA, Brown MS, Li WP, et al. (2000). "Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi.". Cell 99 (7): 703–12. PMID 10619424.  
  • Kotzka J, Müller-Wieland D, Roth G, et al. (2000). "Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade.". J. Lipid Res. 41 (1): 99–108. PMID 10627507.  
  • Yang T, Goldstein JL, Brown MS (2000). "Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum.". J. Biol. Chem. 275 (38): 29881–6. doi:10.1074/jbc.M005439200. PMID 10896675.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Got something to say? Make a comment.
Your name
Your email address