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SSR-180,711
Systematic (IUPAC) name
(4-bromophenyl) 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate
Identifiers
ATC code  ?
PubChem 9928899
Chemical data
Formula C14H21BrN2O2 
Mol. mass 329.232
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status

SSR-180,711 is a drug which acts as a potent and selective partial agonist for the α7 subtype of neural nicotinic acetylcholine receptors.[1][2] In animal studies it shows nootropic effects and may be useful in the treatment of schizophrenia.[3][4]

References

  1. ^ Pichat, P.; Bergis, O.; Terranova, J.; Urani, A.; Duarte, C.; Santucci, V.; Gueudet, C.; Voltz, C. et al. (2007). "SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia". Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 32 (1): 17–34. doi:10.1038/sj.npp.1301188. PMID 16936709.  edit
  2. ^ Biton, B.; Bergis, O.; Galli, F.; Nedelec, A.; Lochead, A.; Jegham, S.; Godet, D.; Lanneau, C. et al. (2007). "SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (1) binding and functional profile". Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 32 (1): 1–16. doi:10.1038/sj.npp.1301189. PMID 17019409.  edit
  3. ^ Hashimoto, K.; Ishima, T.; Fujita, Y.; Matsuo, M.; Kobashi, T.; Takahagi, M.; Tsukada, H.; Iyo, M. (2008). "Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective alpha7 nicotinic receptor agonist SSR180711". Biological psychiatry 63 (1): 92–97. doi:10.1016/j.biopsych.2007.04.034. PMID 17601496.  edit
  4. ^ Barak, S.; Arad, M.; De Levie, A.; Black, M.; Griebel, G.; Weiner, I. (2009). "Pro-cognitive and antipsychotic efficacy of the alpha7 nicotinic partial agonist SSR180711 in pharmacological and neurodevelopmental latent inhibition models of schizophrenia". Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 34 (7): 1753–1763. doi:10.1038/npp.2008.232. PMID 19158670.  edit
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