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Signal transducer and activator of transcription 5A

PDB rendering based on 1y1u.
Available structures
1y1u
Identifiers
Symbols STAT5A; MGF; STAT5
External IDs OMIM601511 MGI103036 HomoloGene20680 GeneCards: STAT5A Gene
RNA expression pattern
PBB GE STAT5A 203010 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6776 20850
Ensembl ENSG00000126561 ENSMUSG00000004043
UniProt P42229 Q3UZ79
RefSeq (mRNA) NM_003152 NM_011488
RefSeq (protein) NP_003143 NP_035618
Location (UCSC) Chr 17:
37.69 - 37.72 Mb
Chr 11:
100.68 - 100.7 Mb
PubMed search [1] [2]

Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene.[1][2]

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.[3]

Contents

Interactions

STAT5A has been shown to interact with Epidermal growth factor receptor,[4][5] NMI,[6] ERBB4,[7][4] PTPN11,[8][9] Erythropoietin receptor,[10] Janus kinase 2,[11][12] CRKL,[13] MAPK1[14][15] and Janus kinase 1.[12]

See also

References

  1. ^ Hou J, Schindler U, Henzel WJ, Wong SC, McKnight SL (May 1995). "Identification and purification of human Stat proteins activated in response to interleukin-2". Immunity 2 (4): 321–9. PMID 7719937.  
  2. ^ Lin JX, Mietz J, Modi WS, John S, Leonard WJ (Jul 1996). "Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells". J Biol Chem 271 (18): 10738–44. PMID 8631883.  
  3. ^ "Entrez Gene: STAT5A signal transducer and activator of transcription 5A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6776.  
  4. ^ a b Schulze, Waltraud X; Deng Lei, Mann Matthias (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. (England) 1: 2005.0008. doi:10.1038/msb4100012. PMID 16729043.  
  5. ^ Olayioye, M A; Beuvink I, Horsch K, Daly J M, Hynes N E (Jun. 1999). "ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". J. Biol. Chem. (UNITED STATES) 274 (24): 17209–18. ISSN 0021-9258. PMID 10358079.  
  6. ^ Zhu, M; John S, Berg M, Leonard W J (Jan. 1999). "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling". Cell (UNITED STATES) 96 (1): 121–30. ISSN 0092-8674. PMID 9989503.  
  7. ^ Williams, Christopher C; Allison June G, Vidal Gregory A, Burow Matthew E, Beckman Barbara S, Marrero Luis, Jones Frank E (Nov. 2004). "The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone". J. Cell Biol. (United States) 167 (3): 469–78. doi:10.1083/jcb.200403155. ISSN 0021-9525. PMID 15534001.  
  8. ^ Yu, C L; Jin Y J, Burakoff S J (Jan. 2000). "Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation". J. Biol. Chem. (UNITED STATES) 275 (1): 599–604. ISSN 0021-9258. PMID 10617656.  
  9. ^ Chughtai, Naila; Schimchowitsch Sarah, Lebrun Jean-Jacques, Ali Suhad (Aug. 2002). "Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells". J. Biol. Chem. (United States) 277 (34): 31107–14. doi:10.1074/jbc.M200156200. ISSN 0021-9258. PMID 12060651.  
  10. ^ Chin, H; Nakamura N, Kamiyama R, Miyasaka N, Ihle J N, Miura O (Dec. 1996). "Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3". Blood (UNITED STATES) 88 (12): 4415–25. ISSN 0006-4971. PMID 8977232.  
  11. ^ Barahmand-Pour, F; Meinke A, Groner B, Decker T (May. 1998). "Jak2-Stat5 interactions analyzed in yeast". J. Biol. Chem. (UNITED STATES) 273 (20): 12567–75. ISSN 0021-9258. PMID 9575217.  
  12. ^ a b Fujitani, Y; Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T (Feb. 1997). "An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT". Oncogene (ENGLAND) 14 (7): 751–61. doi:10.1038/sj.onc.1200907. ISSN 0950-9232. PMID 9047382.  
  13. ^ Ota, J; Kimura F, Sato K, Wakimoto N, Nakamura Y, Nagata N, Suzu S, Yamada M, Shimamura S, Motoyoshi K (Nov. 1998). "Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating factor or erythropoietin". Biochem. Biophys. Res. Commun. (UNITED STATES) 252 (3): 779–86. doi:10.1006/bbrc.1998.9445. ISSN 0006-291X. PMID 9837784.  
  14. ^ Pircher, T J; Petersen H, Gustafsson J A, Haldosén L A (Apr. 1999). "Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a". Mol. Endocrinol. (UNITED STATES) 13 (4): 555–65. ISSN 0888-8809. PMID 10194762.  
  15. ^ Dinerstein-Cali, H; Ferrag F, Kayser C, Kelly P A, Postel-Vinay M (Aug. 2000). "Growth hormone (GH) induces the formation of protein complexes involving Stat5, Erk2, Shc and serine phosphorylated proteins". Mol. Cell. Endocrinol. (IRELAND) 166 (2): 89–99. ISSN 0303-7207. PMID 10996427.  

Further reading

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