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Signal transducer and activator of transcription 6, interleukin-4 induced
Identifiers
Symbols STAT6; D12S1644; IL-4-STAT; STAT6B; STAT6C
External IDs OMIM601512 MGI103034 HomoloGene2373 GeneCards: STAT6 Gene
RNA expression pattern
PBB GE STAT6 201331 s at tn.png
PBB GE STAT6 201332 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6778 20852
Ensembl ENSG00000166888 ENSMUSG00000002147
UniProt P42226 P70383
RefSeq (mRNA) NM_003153 NM_009284
RefSeq (protein) NP_003144 NP_033310
Location (UCSC) Chr 12:
55.78 - 55.79 Mb
Chr 10:
127.05 - 127.06 Mb
PubMed search [1] [2]

STAT6 is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors.[1][2]

In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.[3]

Contents

Interactions

STAT6 has been shown to interact with EP300,[4] CREB binding protein,[5][4] NFKB1,[6] Nuclear receptor coactivator 1,[5][7] IRF4[8] and SND1.[9]

See also

References

  1. ^ Leek JP, Hamlin PJ, Bell SM, Lench NJ (1997). "Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization". Cytogenet. Cell Genet. 79 (3-4): 208–9. doi:10.1159/000134723. PMID 9605853.  
  2. ^ Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL (September 1994). "An interleukin-4-induced transcription factor: IL-4 Stat". Science (journal) 265 (5179): 1701–6. doi:10.1126/science.8085155. PMID 8085155. http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=8085155.  
  3. ^ "Entrez Gene: STAT6 signal transducer and activator of transcription 6, interleukin-4 induced". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6778.  
  4. ^ a b McDonald, C; Reich N C (Jul. 1999). "Cooperation of the transcriptional coactivators CBP and p300 with Stat6". J. Interferon Cytokine Res. (UNITED STATES) 19 (7): 711–22. doi:10.1089/107999099313550. ISSN 1079-9907. PMID 10454341.  
  5. ^ a b Litterst, C M; Pfitzner E (Dec. 2001). "Transcriptional activation by STAT6 requires the direct interaction with NCoA-1". J. Biol. Chem. (United States) 276 (49): 45713–21. doi:10.1074/jbc.M108132200. ISSN 0021-9258. PMID 11574547.  
  6. ^ Shen, C H; Stavnezer J (Jun. 1998). "Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription". Mol. Cell. Biol. (UNITED STATES) 18 (6): 3395–404. ISSN 0270-7306. PMID 9584180.  
  7. ^ Litterst, Claudia M; Pfitzner Edith (Sep. 2002). "An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1". J. Biol. Chem. (United States) 277 (39): 36052–60. doi:10.1074/jbc.M203556200. ISSN 0021-9258. PMID 12138096.  
  8. ^ Gupta, S; Jiang M, Anthony A, Pernis A B (Dec. 1999). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". J. Exp. Med. (UNITED STATES) 190 (12): 1837–48. ISSN 0022-1007. PMID 10601358.  
  9. ^ Yang, Jie; Aittomäki Saara, Pesu Marko, Carter Kara, Saarinen Jussi, Kalkkinen Nisse, Kieff Elliott, Silvennoinen Olli (Sep. 2002). "Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II". EMBO J. (England) 21 (18): 4950–8. ISSN 0261-4189. PMID 12234934.  

Further reading

  • Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT.". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. doi:10.1067/mai.2000.107604. PMID 10856136.  
  • Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges.". Gene 285 (1-2): 1–24. doi:10.1016/S0378-1119(02)00398-0. PMID 12039028.  
  • Hou J, Schindler U, Henzel WJ, et al. (1994). "An interleukin-4-induced transcription factor: IL-4 Stat.". Science 265 (5179): 1701–6. doi:10.1126/science.8085155. PMID 8085155.  
  • Takeda K, Tanaka T, Shi W, et al. (1996). "Essential role of Stat6 in IL-4 signalling.". Nature 380 (6575): 627–30. doi:10.1038/380627a0. PMID 8602263.  
  • Shimoda K, van Deursen J, Sangster MY, et al. (1996). "Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene.". Nature 380 (6575): 630–3. doi:10.1038/380630a0. PMID 8602264.  
  • Kotanides H, Reich NC (1996). "Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene.". J. Biol. Chem. 271 (41): 25555–61. doi:10.1074/jbc.271.41.25555. PMID 8810328.  
  • Mikita T, Campbell D, Wu P, et al. (1996). "Requirements for interleukin-4-induced gene expression and functional characterization of Stat6.". Mol. Cell. Biol. 16 (10): 5811–20. PMID 8816495.  
  • Shen CH, Stavnezer J (1998). "Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription.". Mol. Cell. Biol. 18 (6): 3395–404. PMID 9584180.  
  • Leek JP, Hamlin PJ, Bell SM, Lench NJ (1998). "Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization.". Cytogenet. Cell Genet. 79 (3-4): 208–9. doi:10.1159/000134723. PMID 9605853.  
  • Mikita T, Kurama M, Schindler U (1998). "Synergistic activation of the germline epsilon promoter mediated by Stat6 and C/EBP beta.". J. Immunol. 161 (4): 1822–8. PMID 9712049.  
  • Patel BK, Keck CL, O'Leary RS, et al. (1998). "Localization of the human stat6 gene to chromosome 12q13.3-q14.1, a region implicated in multiple solid tumors.". Genomics 52 (2): 192–200. doi:10.1006/geno.1998.5436. PMID 9782085.  
  • Zhu M, John S, Berg M, Leonard WJ (1999). "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.". Cell 96 (1): 121–30. doi:10.1016/S0092-8674(00)80965-4. PMID 9989503.  
  • McDonald C, Reich NC (1999). "Cooperation of the transcriptional coactivators CBP and p300 with Stat6.". J. Interferon Cytokine Res. 19 (7): 711–22. doi:10.1089/107999099313550. PMID 10454341.  
  • Harris MB, Chang CC, Berton MT, et al. (2000). "Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching.". Mol. Cell. Biol. 19 (10): 7264–75. PMID 10490661.  
  • Gupta S, Jiang M, Pernis AB (1999). "IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells.". J. Immunol. 163 (7): 3834–41. PMID 10490982.  
  • Gupta S, Jiang M, Anthony A, Pernis AB (2000). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4.". J. Exp. Med. 190 (12): 1837–48. doi:10.1084/jem.190.12.1837. PMID 10601358.  
  • Daniel C, Salvekar A, Schindler U (2000). "A gain-of-function mutation in STAT6.". J. Biol. Chem. 275 (19): 14255–9. doi:10.1074/jbc.C000129200. PMID 10747856.  
  • Arinobu Y, Sugimoto R, Akaiwa M, et al. (2000). "Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells.". Biochem. Biophys. Res. Commun. 277 (2): 317–24. doi:10.1006/bbrc.2000.3674. PMID 11032724.  
  • Masuda A, Matsuguchi T, Yamaki K, et al. (2001). "Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression.". J. Biol. Chem. 276 (28): 26107–13. doi:10.1074/jbc.M011475200. PMID 11369758.  

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