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Serine/threonine kinase 10

PDB rendering based on 2j7t.
Available structures
2j7t
Identifiers
Symbols STK10; LOK; PRO2729
External IDs OMIM603919 MGI1099439 HomoloGene38122 GeneCards: STK10 Gene
RNA expression pattern
PBB GE STK10 40420 at tn.png
PBB GE STK10 203047 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6793 20868
Ensembl ENSG00000072786 ENSMUSG00000020272
UniProt O94804 Q5SS74
RefSeq (mRNA) XM_001129121 NM_009288
RefSeq (protein) XP_001129121 NP_033314
Location (UCSC) Chr 5:
171.4 - 171.55 Mb
Chr 11:
32.43 - 32.52 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.[1][2]

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.[2]

References

  1. ^ Kuramochi S, Matsuda Y, Okamoto M, Kitamura F, Yonekawa H, Karasuyama H (Jun 1999). "Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues". Immunogenetics 49 (5): 369-75. PMID 10199912.  
  2. ^ a b "Entrez Gene: STK10 serine/threonine kinase 10". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6793.  

Further reading

  • Kuramochi S, Moriguchi T, Kuida K, et al. (1997). "LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes.". J. Biol. Chem. 272 (36): 22679–84. doi:10.1074/jbc.272.36.22679. PMID 9278426.  
  • Tao L, Wadsworth S, Mercer J, et al. (2002). "Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells.". Biochem. J. 363 (Pt 1): 175–82. doi:10.1042/0264-6021:3630175. PMID 11903060.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Walter SA, Cutler RE, Martinez R, et al. (2003). "Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue.". J. Biol. Chem. 278 (20): 18221–8. doi:10.1074/jbc.M212556200. PMID 12639966.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Bignell G, Smith R, Hunter C, et al. (2006). "Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults.". Genes Chromosomes Cancer 45 (1): 42–6. doi:10.1002/gcc.20265. PMID 16175573.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.  
  • Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.  
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