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Safrazine
Systematic (IUPAC) name
[3-(1,3-benzodioxol-5-yl)-1-methyl-propyl]hydrazine
Identifiers
CAS number 33419-68-0
ATC code  ?
PubChem 34042
ChemSpider 31375
Chemical data
Formula C11H16N2O2
Mol. mass 208.26 g/mol
Synonyms 4-benzo[1,3]dioxol-5-ylbutan-2-ylhydrazine; [3-(3,4-(methylenedioxy)phenyl)-1-butyl]hydrazine; 2-piperonylisopropylhydrazine
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral

Safrazine (Safra) is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used introduced as an antidepressant in the 1960s, and is still used in Japan today.[1][2]

See also

References

  1. ^ Yokoyama T, Karube T, Iwata N (January 1989). "Comparative studies of the effects of RS-8359 and safrazine on monoamine oxidase in-vitro and in-vivo in mouse brain". The Journal of Pharmacy and Pharmacology 41 (1): 32–6. PMID 2565961.  
  2. ^ Inoue T, Izumi T, Honma H, et al. (1996). "[Survey and treatment strategy of antidepressant-resistant depression]" (in Japanese). Seishin Shinkeigaku Zasshi = Psychiatria Et Neurologia Japonica 98 (5): 329–42. PMID 8741286.  







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