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Salicylhydroxamic acid: Wikis

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Salicylhydroxamic acid
Systematic (IUPAC) name
2-Hydroxybenzenecarbohydroxamic acid
Identifiers
CAS number 89-73-6
ATC code none
PubChem 66644
Chemical data
Formula C 7H7NO3  
Mol. mass 153.14 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Salicylhydroxamic acid (SHA) is a drug that is a potent and irreversible inhibitor of bacterial and plant urease usually used for urinary tract infections. The molecule is similar to urea but is not hydrolyzable by the urease enzyme (Fishbein and Carbone, 1965). It is also a trypanocidal agent.

When administered orally, it is metabolised to salicylamide which exerts analgesic, antipyretic and antiinflammatory effects.

See also

References

  • W. Fishbein and P. Carbone, J Biol Chem. 1965 Jun; 240:2407-14.

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