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Schaffer collaterals are axon collaterals given off by CA3 pyramidal cells in the hippocampus. These collaterals project to area CA1 of the hippocampus[1] and are an integral part of memory formation and the emotional network of the Papez circuit, and of the hippocampal trisynaptic loop. It is named after the Hungarian anatomist-neurologist Károly Schaffer.

In the early stage of long term potentiation Schaffer collaterals release glutamate that binds to AMPA receptors of CA1-dendrites.

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