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Butabarbital
Systematic (IUPAC) name
5-butan-2-yl-5-ethyl-1,3-diazinane-2,4,6-trione
Identifiers
CAS number 143-81-7
ATC code none
PubChem 2479
ChemSpider 2385
Chemical data
Formula C10H16N2O3 
Mol. mass 212.246 g/mol
SMILES eMolecules & PubChem
Synonyms Butabarbital, Butisol
Pharmacokinetic data
Half life 100 hours [1]
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule III (CA) Schedule III (US)

Butabarbital (trade name Butisol) is a prescription barbiturate sleep aid. Butabarbital has a particularly fast onset of effects and short duration of action compared to other barbiturates, which makes it useful for certain applications such as treating severe insomnia and relieving anxiety before surgical procedures; however it is also relatively dangerous particularly when combined with alcohol, and so is now rarely used, although it is still prescribed in some Eastern European and South American countries. Its intermediate duration of action gives butabarbital an abuse potential slightly lower than secobarbital.

Butabarbital is also sold in combination with belladonna alkaloids under the brand name Butibel. This product contains a low dose of butabarbital combined with a standardised mix of belladonna alkaloids and is used as an antispasmodic taken to relieve cramping and spasms of the stomach and intestines. They are used also to decrease the amount of acid formed in the stomach. Another similar product is Donnatal, which contains belladonna alkaloids combined with phenobarbital.


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