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Serotonergic or serotoninergic means "related to the neurotransmitter serotonin". A synapse is serotonergic if it uses serotonin as its neurotransmitter. A substance is serotonergic if it is capable of producing, altering, or releasing serotonin.

A serotonergic, or serotonergic agent, is any chemical which functions to enhance the effects mediated by serotonin in the central nervous system, and they include the following classes of chemicals:

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