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arylalkylamine N-acetyltransferase
Serotonin N-acetyltransferase.png
Crystallographic structure of serotonin N-acetyltransferase.[1]
Symbol AANAT
Entrez 15
OMIM 600950
RefSeq NM_001088
UniProt Q16613
Other data
EC number
Locus Chr. 17 q25

Serotonin N-acetyl transferase also known as arylalkylamine N-acetyltransferase or AANAT is a protein which in humans is encoded by the AANAT gene.[2][3]



The protein encoded by this gene is an enzyme involved in the conversion of serotonin to melatonin in pinealocytes. It is an acetyl-CoA dependent enzyme of the GCN5-related family of N-acetyltransferases (GNATs).

Arylalkylamine N-acetyltransferase is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for seasonal reproduction, modulates the function of the circadian clock in the suprachiasmatic nucleus, and influences activity and sleep. This enzyme is rapidly inactivated when animals are exposed to light at night. This protein is 80% identical to sheep and rat AA-NAT. Arylalkylamine N-acetyltransferase may contribute a multifactorial genetic diseases such as altered behavior in sleep/wake cycle.[2]


This family shares four conserved sequence motifs designated A-D. Motif B serves as the location of the serotonin binding slot. The structure of Serotonin N-acetyl transferase was determined by X-ray diffraction(XRD).[1] A resolution of 1.80 angstroms was obtained. The structural weight is 24121.55 daltons. It is a polypeptide with a length of 207 residues. The secondary structure consists of alpha helices and beta sheets. It is 28% helical (10 helices;60 residues) and 23% beta sheet (9 strands;48 residues).

See also


  1. ^ a b PDB 1KUX; Wolf E, De Angelis J, Khalil EM, Cole PA, Burley SK (March 2002). "X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition". J. Mol. Biol. 317 (2): 215–24. doi:10.1006/jmbi.2001.5371. PMID 11902838.  
  2. ^ a b "Entrez Gene: arylalkylamine N-acetyltransferase".  
  3. ^ Coon SL, Mazuruk K, Bernard M, Roseboom PH, Klein DC, Rodriguez IR (May 1996). "The human serotonin N-acetyltransferase (EC gene (AANAT): structure, chromosomal localization, and tissue expression". Genomics 34 (1): 76–84. doi:10.1006/geno.1996.0243. PMID 8661026.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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