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Sertaconazole: Wikis

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Sertaconazole
Systematic (IUPAC) name
1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
Identifiers
CAS number 99592-32-2
ATC code D01AC14
PubChem 65863
DrugBank APRD00305
Chemical data
Formula C20H15Cl3N2OS 
Mol. mass 437.77 g/mol
Pharmacokinetic data
Bioavailability Negligible
Protein binding >99% to plasma
Therapeutic considerations
Licence data

US FDA:link

Pregnancy cat. C(US)
Legal status Prescription only
Routes Topical
 Yes check.svgY(what is this?)  (verify)

Sertaconazole nitrate (Ertaczo) is an antifungal medication of the imidazole class. It is available as a cream to treat skin infections such as athlete's foot.

Contents

Mechanism of action

Sertaconazole has different mechanisms of action: Fungistatic, fungicidal, antibacterial, antiinflammatory, antitrichomonal, antipruritic actions.

It inhibits, like other imidazole antifungals, the synthesis of ergosterol by inhibiting the 14α-demethylase enzyme. Ergosterol is a component of the fungal cell membrane. By this way, the fungal cell can not grow larger and multiply. The hyphae formation of the Candida will be impeded. This is the fungistatic action of sertaconazole.

Uniquely, sertaconazole owns a benzothiophene ring in its structure. It resembles an amino acid, tryptophan, which can be found on the fungal membrane. The benzothiophene ring takes the place of tryptophan, that is it mimics tryptophan. So pores, holes and craters are formed on the fungal cell membrane. These pores open at the 10th minute after application. When the pore forms the fungal cell loses its intracellular content. Mainly, ATP is lost. The fungus lacks energy and dies. After 1 hour of application, 90% of the fungi die. This is the fungicidal action of sertaconazole. Sertaconazole is the sole antifungal, which owns this mechanism of action.

Sertaconazole has also antiinflammatory and antipruritic action. It reduces the release of cytokines from activated lymphocytes. It is shown that sertaconazole activatates of the p38-COX-2-PGE2 pathway which is related to sertaconazole's fungicidal action.

Sertaconazole has antibacterial action. It is hypothysed that it happens like its fungicidal mechanism of action: By means of benzothiophene ring's similarity to tryptophan.

It is shown that sertaconazole can kill Trichomonas vaginalis on in vitro experiments. This mechanism of action is unknown.

Sertaconazole also inhibits the dimorfic transformation of Candida albicans into pathogenic fungi.

Microbiology

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Susceptible organisms

Therapeutic efficacy

In randomized, double-blind, multicentre trials of 3–6 weeks' duration (n=127-383), a significantly greater number of patients with tinea of the glabrous skin and tinea pedis receiving a topical 2% sertaconazole cream once or twice daily achieved a successful mycological cure copmared with recipients of a placebo cream.[1]

Side effects

Side effects were rarely reported with sertaconazole therapy, but may include contact dermatitis, burning on application site and skin dryness.

References

  1. ^ Croxtall JD, Plosker GL.[1].Drugs 2009; 69(3):339-359.doi: 10.2165/00003495-200969030-00009.

External links


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