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Sertoli-Leydig cell tumour: Wikis


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Sertoli-Leydig cell tumour
Classification and external resources
ICD-9 183.0, 256.1
ICD-O: 8630-8631/0
MeSH D018310

Sertoli-Leydig cell tumour is a group of tumors composed of variable proportions of Sertoli cells, Leydig cells, and in the case of intermediate and poorly differentiated neoplasms, primitive gonadal stroma and sometimes heterologous elements. (WHO, 2003)

Sertoli-Leydig cell tumour is a member of the sex cord-stromal tumour group[1] of ovarian and testicular cancers. The tumour is rare, comprising less than 1% of testicular tumours,[citation needed]. While the tumour can occur at any age, it occurs most often in young adults.

Closely related terms include arrhenoblastoma[2] and androblastoma.[3] Both terms are classified under Sertoli-Leydig cell tumour in MeSH.



The tumour is subdivided into many different subtypes. The most typical is composed of tubules lined by Sertoli cells and interstitial clusters of Leydig cells.


Due to excess testosterone secreted by the tumour, one-third of female patients present with a recent history of progressive masculinization. Masculinization is preceded by anovulation, oligomenorrhea, amenorrhea and defeminization. Additional signs include acne and hirsutism, voice deepening, clitoromegaly, temporal hair recession, and an increase in musculature. Serum testosterone level is high.


Presence of an ovarian tumour plus hormonal disturbances suggests a Sertoli-Leydig cell tumour. However, hormonal disturbance is present in only 2/3 of cases. A conclusive diagnosis is made via histology, as part of a pathology report made during or after surgery. See also Sex cord-stromal tumour.


The usual treatment is surgery. The surgery usually is a fertility-sparing unilateral salpingo-oophorectomy. For malignant tumours, the surgery may be radical and usually is followed by adjuvant chemotherapy, sometimes by radiation therapy. In all cases, initial treatment is followed by surveillance. Because in many cases Sertoli-Leydig cell tumour does not produce elevated tumour markers,[4] the focus of surveillance is on repeated physical examination and imaging.

The prognosis is generally good as the tumour tends to grow slowly and usually is benign: 25% are malignant.[citation needed] For malignant tumours with undifferentiated histology, prognosis is poor.[4]

Additional images

See also




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