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Sertraline
Systematic (IUPAC) name
(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
Identifiers
CAS number 79617-96-2
ATC code N06AB06
PubChem 68617
DrugBank APRD00175
ChemSpider 61881
Chemical data
Formula C17H17Cl2N 
Mol. mass 306.229 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 44%
Metabolism Hepatic (N-demethylation mainly by CYP2B6)[1]
Half life Approximately 26 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat. C
Legal status Prescription only
Routes Oral
 Yes check.svgY(what is this?)  (verify)
.Sertraline hydrochloride (trade names Zoloft, Lustral) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.^ The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia .
  • The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia -- Sanders et al. 294 (5): E853 -- AJP - Endocrinology and Metabolism 28 January 2010 0:49 UTC ajpendo.physiology.org [Source type: Academic]

^ SUMMARY 2.1 Main risks and target organs Sertraline is a selective serotonin reuptake inhibitor (SSRI).
  • Sertraline (PIM 177) 28 January 2010 0:49 UTC www.inchem.org [Source type: Academic]

^ It is a member of a group of medicines referred to as SSRI’s, which stands for Selective Serotonin Reuptake Inhibitors.
  • Cheap Zoloft - blastpassemranch.com 28 January 2010 0:49 UTC www.blastpassemranch.com [Source type: FILTERED WITH BAYES]

.It was introduced to the market by Pfizer in 1991. Sertraline is primarily used to treat major depression in adult outpatients as well as obsessive–compulsive, panic, and social anxiety disorders in both adults and children.^ Treatment of major depression; obsessive-compulsive disorder (OCD); panic disorder; post-traumatic stress disorder (PTSD); premenstrual dysphoric disorder (PMDD); social anxiety disorder .
  • Sertraline - Erewhon Natural Foods 28 January 2010 0:49 UTC www.erewhonmarket.com [Source type: Academic]

^ There have been rare some a major depressive disorder in children.
  • Buy Zoloft (Sertraline) 50mg,100mg 28 January 2010 0:49 UTC bandindex.no [Source type: General]

^ Fluoxetine and fluvoxamine are indicated for obsessive-compulsive disorder in children 8 years and older, and sertraline in children 6 years and older.
  • Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]

.In 2007, it was the most prescribed antidepressant on the U.S. retail market, with 29,652,000 prescriptions.^ Selective serotonin reuptake inhibitors (SSRIs) were initially developed to relieve depression and have become the most commonly prescribed class of antidepressants.
  • Off-Label Applications for SSRIs - August 1, 2003 - American Family Physician 28 January 2010 0:49 UTC www.aafp.org [Source type: Academic]

^ Medications most commonly prescribed are tricyclic antidepressants, SSRIs, muscle relaxants, simple analgesics, and nonsteroidal anti-inflammatory drugs.
  • Off-Label Applications for SSRIs - August 1, 2003 - American Family Physician 28 January 2010 0:49 UTC www.aafp.org [Source type: Academic]

^ Selective serotonin reuptake inhibitors (SSRIs) have become the most commonly prescribed class of antidepressants, accounting for more than $3 billion of annual prescription costs in the United States and growing by approximately 25% each year.
  • JAMA -- Similar Effectiveness of Paroxetine, Fluoxetine, and Sertraline in Primary Care: A Randomized Trial, December 19, 2001, Kroenke et al. 286 (23): 2947 28 January 2010 0:49 UTC jama.ama-assn.org [Source type: Academic]

[2]
.The efficacy of sertraline for depression is similar to that of older tricyclic antidepressants, but its side effects are much less pronounced.^ Patients were contacted after discharge to determine sertraline efficacy and side effects.
  • DEPRESSION 28 January 2010 0:49 UTC www.psycom.net [Source type: Academic]

^ Much clavamox for clavamox side effects for dogs .
  • Walkabout Imagery Photo Gallery :: Skagit Eagles 01/15/2005 :: DSC0606 28 January 2010 0:49 UTC deweydrive.com [Source type: General]

^ The British Journal of Psychiatry (2003) 182: 492-497 © 2003 The Royal College of Psychiatrists Older community residents with depression: long-term treatment with sertraline .
  • Older community residents with depression: long-term treatment with sertraline: Randomised, double-blind, placebo-controlled study -- WILSON et al. 182 (6): 492 -- The British Journal of Psychiatry 28 January 2010 0:49 UTC bjp.rcpsych.org [Source type: Academic]

.Differences with newer antidepressants are subtler and also mostly confined to side effects.^ Labels were obtained from different sources and potentially contain different sets of side effects.
  • Side effect information for Sertraline (sertraline hydrochloride) 28 January 2010 0:49 UTC sideeffects.embl.de [Source type: Academic]

^ Structurally, the drugs are unrelated to SSRIs and have some clinically important differences in side effect profiles.
  • Nefazodone 28 January 2010 0:49 UTC www.psycom.net [Source type: Academic]

^ No matter how few or how many side effects you have had on these antidepressants, withdrawal is a whole new world.

.Evidence suggests that sertraline may work better than fluoxetine (Prozac) for some subtypes of depression.^ Regardless of their etiology, evidence exists to suggest that depression and chronic pain share common biologic pathways, namely, the serotonergic (5-HT) and noradrenergic systems.
  • Nefazodone 28 January 2010 0:49 UTC www.psycom.net [Source type: Academic]

^ Although meta-analyses of placebo-controlled trials suggest greater efficacy for clomipramine than for fluoxetine, fluvoxamine, and sertraline , the results of head-to-head trials comparing clomipramine and selective serotonin reuptake inhibitors (SSRIs) directly do not support this impression.

^ Stronger evidence exists, however, for greater compliance with fluoxetine than with TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

[3] .Sertraline is highly effective for the treatment of panic disorder, but cognitive behavioral therapy is a better treatment for obsessive-compulsive disorder, whether by itself or in combination with sertraline.^ Successful medication withdrawal after cognitive-behavioral therapy in a treatment-resistant preadolescent male with obsessive-compulsive disorder.
  • Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects. 22 January 2010 11:13 UTC www.prozactruth.com [Source type: Academic]

^ Treatment of Children and Adolescents > Obsessive-compulsive disorder Chapter 36.

^ Combination therapy consisted of the administration of sertraline and cognitive behavioral therapy.
  • NEJM -- Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety 28 January 2010 0:49 UTC content.nejm.org [Source type: Academic]

.Although approved for social phobia and posttraumatic stress disorder, sertraline leads to only modest improvement in these conditions.^ Buspirone in the treatment of posttraumatic stress disorder.
  • Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder 28 January 2010 0:49 UTC www.tu.edu [Source type: Academic]

^ The drug treatment of posttraumatic stress disorder.
  • Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder 28 January 2010 0:49 UTC www.tu.edu [Source type: Academic]

^ Efficacy of treatments for posttraumatic stress disorder.
  • Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder 28 January 2010 0:49 UTC www.tu.edu [Source type: Academic]

[4][5] .Sertraline also alleviates the symptoms of premenstrual dysphoric disorder and can be used in sub-therapeutic doses or intermittently for its treatment.^ Premenstrual Dysphoric Disorder (1 reviews) .
  • Zoloft - User ratings & reviews - Revolution Health 22 January 2010 11:13 UTC www.revolutionhealth.com [Source type: General]

^ Symptomatic improvement of premenstrual dysphoric disorder with sertraline treatment.
  • Arch Fam Med -- Luteal Phase Sertraline Treatment for Premenstrual Dysphoric Disorder: Results of a Double-blind, Placebo-Controlled, Crossover Study, July 1999, Jermain et al. 8 (4): 328 28 January 2010 0:49 UTC archfami.ama-assn.org [Source type: Academic]

^ Treatment of major depression; obsessive-compulsive disorder (OCD); panic disorder; post-traumatic stress disorder (PTSD); premenstrual dysphoric disorder (PMDD); social anxiety disorder Use - Unlabeled/Investigational: .
  • Sertraline 28 January 2010 0:49 UTC www.umm.edu [Source type: Academic]

.Sertraline shares the common side effects and contraindications of other SSRIs, with high rates of nausea, diarrhea, insomnia, and sexual side effects; however, it does not cause weight gain, and its effects on cognition are mild.^ I am assuming this is a common side effect.
  • The Anxiety Community - Treatment - Medication: Zoloft 22 January 2010 11:13 UTC anxietyhelp.org [Source type: Original source]

^ Sertraline , Side Effects , SSRI , syndrome , Zoloft .

^ However, I have 2 side effects.
  • The Anxiety Community - Treatment - Medication: Zoloft 22 January 2010 11:13 UTC anxietyhelp.org [Source type: Original source]

.In pregnant women taking sertraline, the drug was present in significant concentrations in fetal blood, and was also associated with a higher rate of various birth defects.^ Caution should be used when combining sertraline with CYP2D6 substrates (desipramine, nortriptyline, haloperidol, thioridazine, flecainide, codeine, propranolol, metoprolol), as sertraline can cause a significant increase in the serum concentrations of these drugs.
  • Sertraline (PIM 177) 28 January 2010 0:49 UTC www.inchem.org [Source type: Academic]

^ Another potentially fatal drug interaction could result from taking another SSRI with sertraline.
  • Sertraline (SER tra leen) Side Effects - The People's Pharmacy® 28 January 2010 0:49 UTC www.peoplespharmacy.com [Source type: FILTERED WITH BAYES]

^ However, the absence of detectable serum sertraline and nortriptyline levels in the infant suggests that if either medication is present in infant serum, its concentration would be extremely low.
  • DEPRESSION 28 January 2010 0:49 UTC www.psycom.net [Source type: Academic]

.Similarly to other antidepressants, the use of sertraline for depression may be associated with a higher rate of suicidality.^ Sertraline versus other antidepressive agents for depression.
  • Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects. 22 January 2010 11:13 UTC www.prozactruth.com [Source type: Academic]

^ Use of other antidepressants like Serzone may help.
  • Drug InfoNet - Zoloft - [depression] 22 January 2010 11:13 UTC www.druginfonet.com [Source type: Original source]
  • Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft 22 January 2010 11:13 UTC www.druginfonet.com [Source type: FILTERED WITH BAYES]

^ In such cases, sertraline offers certain advantages over other antidepressants, since it is well-tolerated, has no active metabolites and little impact on hepatic enzymes and can thus be used safely in patients with potentially impaired hepatic function.
  • SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism 28 January 2010 0:49 UTC alcalc.oxfordjournals.org [Source type: Academic]

.Due to the rarity of this side effect, statistically significant data are difficult to obtain, and suicidality continues to be a subject of controversy.^ Data on side effects are given in Table 5 .
  • St John�s wort or sertraline? 28 January 2010 0:49 UTC www.cfpc.ca [Source type: Academic]

^ As the side effects continue an erection also becomes difficult.
  • Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects. 22 January 2010 11:13 UTC www.prozactruth.com [Source type: Academic]

^ Craving Carbs is it used to the side effect statistically significant results.
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Contents

History

Skeletal formulae of chlorprothixene and tametraline, from which sertraline was derived
.The history of sertraline dates back to the early 1970s, when Pfizer chemist Reinhard Sarges invented a novel series of psychoactive compounds based on the structures of neuroleptics chlorprothixene and thiothixene.^ Diagnosis Diagnosis of sertraline poisoning is clinical and based on history of overdose and/or access to sertraline and the presence of minor neurological and/or gastroenterological symptoms.
  • Sertraline (PIM 177) 28 January 2010 0:49 UTC www.inchem.org [Source type: Academic]

[6][7] .Further work on these compounds led to tametraline, a norepinephrine and weaker dopamine reuptake inhibitor.^ Efficacious treatments for these disorders include cognitive behavioral therapy 10 , 11 and the use of selective serotonin-reuptake inhibitors (SSRIs).
  • NEJM -- Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety 28 January 2010 0:49 UTC content.nejm.org [Source type: Academic]

^ Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs)...
  • Zoloft | LIVESTRONG.COM 22 January 2010 11:13 UTC www.livestrong.com [Source type: General]

^ Antidepressant with selective inhibitory effects on presynaptic serotonin (5-HT) reuptake and only very weak effects on norepinephrine and dopamine neuronal uptake.
  • Sertraline 28 January 2010 0:49 UTC www.umm.edu [Source type: Academic]
  • Sertraline - Erewhon Natural Foods 28 January 2010 0:49 UTC www.erewhonmarket.com [Source type: Academic]

.Development of tametraline was soon stopped because of undesired stimulant effects observed in animals.^ Moreover, although SSRIs are usually well tolerated, a minority of patients stop treatment because of gastrointestinal, sexual, or other side effects (7 – 12) .
  • Efficacy of Sertraline in the Long-Term Treatment of Obsessive-Compulsive Disorder -- Koran et al. 159 (1): 88 -- Am J Psychiatry 28 January 2010 0:49 UTC ajp.psychiatryonline.org [Source type: Academic]

^ Stopping Zoloft : Do not stop taking Zoloft suddenly because you could get side effects.
  • Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft. 22 January 2010 11:13 UTC www.theroadback.org [Source type: FILTERED WITH BAYES]

.A few years later, in 1977, pharmacologist Kenneth Koe, after comparing the structural features of a variety of reuptake inhibitors, became interested in the tametraline series.^ Efficacy and tolerability of selective serotonin reuptake inhibitors compared with tricyclic antidepressants in depression treated in primary care: systematic review and meta-analysis.
  • Antidepressants - Pharmacy Clinical Policy Bulletins Aetna Non-Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]

^ The rates for individual side effects with the serotonin selective reuptake inhibitors, nefazodone, and venlafaxine are presented and compared with the adverse event experience for mirtazapine.
  • Nefazodone 28 January 2010 0:49 UTC www.psycom.net [Source type: Academic]

^ This interest has been stimulated by reports of serious toxic reactions in patients whose clearance of TCAs and terfenadine was delayed by selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and by antifungal agents such as ketoconazole respectively.
  • S. Preskorn M.D. SSRI's: prozac, paxil, zoloft, luvox, effexor, serzone, anafranil, fenfluramine, fen-phen, redux. 28 January 2010 0:49 UTC www.outlookcities.com [Source type: Academic]

He asked another Pfizer chemist, Willard Welch, to synthesize some previously unexplored tametraline derivatives. .Welch generated a number of potent norepinephrine and triple reuptake inhibitors, but to the surprise of the scientists, one representative of the generally inactive cis-analogs was a serotonin reuptake inhibitor.^ Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs)...
  • Zoloft | LIVESTRONG.COM 22 January 2010 11:13 UTC www.livestrong.com [Source type: General]

^ Sertraline) Zoloft is an orally administered antidepressant of the selective serotonin reuptake inhibitor (SSRI) type.
  • Zoloft: 13249 user reviews - DailyStrength 28 January 2010 0:49 UTC www.dailystrength.org [Source type: General]

^ There are three main types of antidepressants, which work in different ways: selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs).
  • Sertraline (Lustral) | Life and style | BMJ Group 28 January 2010 0:49 UTC www.guardian.co.uk [Source type: News]

Welch then prepared stereoisomers of this compound, which were tested in vivo by animal behavioral scientist Albert Weissman. .The most potent and selective (+)-isomer was taken into further development and eventually named sertraline.^ The 100-mg daily dose level was the target dose of sertraline, selected on the basis of previous literature indicating that most patients with panic disorder will respond to 50 to 100 mg/d of sertraline.
  • Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681 28 January 2010 0:49 UTC archpsyc.ama-assn.org [Source type: Academic]

^ Among six selective serotonin reuptake-inhibitor antidepressants, norfluoxetine was the most potent inhibitor (Ki = 2.7 and 8.0 microM) and fluoxetine itself was the weakest (Ki = 7.0 and 44.3 microM).
  • Nefazodone 28 January 2010 0:49 UTC www.psycom.net [Source type: Academic]

.Weissman and Koe recalled that the group did not set up to produce an antidepressant of the SSRI type—in that sense their inquiry was not "very goal driven", and the discovery of the sertraline molecule was serendipitous.^ Sertraline) Zoloft is an orally administered antidepressant of the selective serotonin reuptake inhibitor (SSRI) type.
  • Zoloft: 13249 user reviews - DailyStrength 28 January 2010 0:49 UTC www.dailystrength.org [Source type: General]

^ One child in the sertraline group had a worsening of behavior that was attributed to the parents' increased limit setting on avoidance behavior; the event was considered to be possibly related to sertraline.
  • NEJM -- Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety 28 January 2010 0:49 UTC content.nejm.org [Source type: Academic]

^ In contrast to the apparent risk of suicidal ideation and behavior in studies of depression in children and adolescents, 15 our study did not demonstrate any increased risk for suicidal behavior in the sertraline group.
  • NEJM -- Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety 28 January 2010 0:49 UTC content.nejm.org [Source type: Academic]

.According to Welch, they worked outside the mainstream at Pfizer, and even "did not have a formal project team". The group had to overcome initial bureaucratic reluctance to pursue sertraline development, as Pfizer was considering licensing an antidepressant candidate from another company.^ One child in the sertraline group had a worsening of behavior that was attributed to the parents' increased limit setting on avoidance behavior; the event was considered to be possibly related to sertraline.
  • NEJM -- Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety 28 January 2010 0:49 UTC content.nejm.org [Source type: Academic]

^ Mutagenicity In vitro and in vivo : sertraline did not show mutagenicity for chromosomes and genes (Pfizer lab., 1996).
  • Sertraline (PIM 177) 28 January 2010 0:49 UTC www.inchem.org [Source type: Academic]

^ Given that the risk of some adverse events was lower in the behavioral-therapy group than in the sertraline group, some parents and their children may consider choosing cognitive behavioral therapy as their initial treatment.
  • NEJM -- Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety 28 January 2010 0:49 UTC content.nejm.org [Source type: Academic]

[6][8][9]
.Sertraline was approved by the U.S. Food and Drug Administration (FDA) in 1991 based on the recommendation of the Psychopharmacological Drugs Advisory Committee; it had already become available in the United Kingdom the previous year.^ Sertraline is FDA approved for the treatment of OCD in children 6 years of age.
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^ This change, made at the request of the Food and Drug Administration, articulates a pimozide/sertraline interaction and arises from the results of the study entitled, Phase 1 Open Study Designed to Determine the Potential Interaction of Sertraline With Cisapride or Pimozide in Healthy Male and Female Subjects.
  • Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft. 22 January 2010 11:13 UTC www.theroadback.org [Source type: FILTERED WITH BAYES]

^ Choosing a Specific Pharmacological Treatment Clomipramine, fluoxetine, fluvoxamine, paroxetine, and sertraline , which are approved by the U.S. Food and Drug Administration (FDA) for treatment of OCD, are recommended pharmacological agents [I].

[10] .The FDA committee achieved a consensus that sertraline was safe and effective for the treatment of major depression.^ The British Journal of Psychiatry (2003) 182: 492-497 © 2003 The Royal College of Psychiatrists Older community residents with depression: long-term treatment with sertraline .
  • Older community residents with depression: long-term treatment with sertraline: Randomised, double-blind, placebo-controlled study -- WILSON et al. 182 (6): 492 -- The British Journal of Psychiatry 28 January 2010 0:49 UTC bjp.rcpsych.org [Source type: Academic]

^ Treatment of major depression; obsessive-compulsive disorder (OCD); panic disorder; post-traumatic stress disorder (PTSD); premenstrual dysphoric disorder (PMDD); social anxiety disorder .
  • Sertraline - Erewhon Natural Foods 28 January 2010 0:49 UTC www.erewhonmarket.com [Source type: Academic]

^ In patients with major depression (N=25) and bipolar depression (N=6) discharged on sertraline, only 13 (42%) were considered responders to sertraline therapy, and at follow-up, only 8 (26%) of 31 were considered responders to sertraline therapy.
  • DEPRESSION 28 January 2010 0:49 UTC www.psycom.net [Source type: Academic]

.During the discussion, Paul Leber, Director of the FDA Division of Neuropharmacological Drug Products, noted that granting approval was a "tough decision", since the treatment effect on outpatients with depression had been "modest to minimal". Other experts emphasized that the drug's effect on inpatients had not differed from placebo and criticized poor design of the trials by Pfizer.^ Please note that entries here are the experiences of individual users, and in no way means that you or anyone else will experience the same side effect, since the same medication affects people in different ways.
  • Zoloft and headaches : Medications.com 22 January 2010 11:13 UTC www.medications.com [Source type: FILTERED WITH BAYES]

^ Table 2 summarizes depression and other psychological outcomes by SSRI treatment group, and Table 3 summarizes work, social, and other health-related quality of life outcomes.
  • JAMA -- Similar Effectiveness of Paroxetine, Fluoxetine, and Sertraline in Primary Care: A Randomized Trial, December 19, 2001, Kroenke et al. 286 (23): 2947 28 January 2010 0:49 UTC jama.ama-assn.org [Source type: Academic]

^ PMDD symptoms appeared during depression treatment Beware of Possible induction of Bipolar .
  • Zoloft - User ratings & reviews - Revolution Health 22 January 2010 11:13 UTC www.revolutionhealth.com [Source type: General]

[11] .For example, 40% of participants dropped out of the trials, significantly decreasing their validity.^ The mean Clinician Administered PTSD Scale (CAPS) scores decreased by 53%, with four out of five participants responding positively to treatment.
  • DEPRESSION 28 January 2010 0:49 UTC www.psycom.net [Source type: Academic]

^ Serum lithium concentrations ranged between 0.2-0.4 mEq/L. Four out of the 5 participants had decreases in anger, irritability, anxiety and insomnia.
  • Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder 28 January 2010 0:49 UTC www.tu.edu [Source type: Academic]

^ Probability estimates (e.g., efficacy, tolerability, and drop-out rate) were derived from meta-analysis of clinical trials and expert opinion.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

[12]
.Sertraline entered the Australian market in 1994 and became the most often prescribed antidepressant in 1996 (2004 data).^ Like most clinically effective antidepressants, sertraline downregulates brain norepinephrine and serotonin receptors in animals.
  • Cheap Zoloft - blastpassemranch.com 28 January 2010 0:49 UTC www.blastpassemranch.com [Source type: FILTERED WITH BAYES]

^ You can also buy the original zoloft sertraline from Masters Marketing for far less than most online sources and it is certain to be the real McCoy.
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^ Co-prescribing antidepressants, such as sertraline, for patients on stable neuroleptic depot preparations is one pharmacological method of overcoming this problem.
  • DEPRESSION 28 January 2010 0:49 UTC www.psycom.net [Source type: Academic]

[13] It was measured as among the top ten drugs ranked by cost to the Australian government in 1998 and 2000–01, having cost $45 million and $87 million in subsidies respectively.[14][15] .Sertraline is less popular in the UK (2003 data) and Canada (2006 data)—in both countries it was fifth, based on the number of prescriptions.^ Based on our data, it will be very difficult if not impossible to identify a single biomarker affected by sertraline.
  • Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation 28 January 2010 0:49 UTC circ.ahajournals.org [Source type: Academic]

^ The mean number of prescriptions (for a 30-day supply) was higher for the sertraline group than for TCA recipients (7.5 vs. TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

[16][17]
.Until 2002, sertraline was only approved for use in adults ages 18 and over; that year, it was approved by the FDA for use in treating children aged 6 or older with severe obsessive-compulsive disorder (OCD).^ Sertraline should not be used in children and adolescents under the age of 18 years with Major Depressive Disorder (See section 4.8, Undesirable effects) but are used to treat obsessive compulsive disorder (OCD) in children of six years and over (See Section 4.2.
  • Sertraline 50mg and 100mg Film-Coated Tablets - Summary of Product Characteristics (SPC) - electronic Medicines Compendium (eMC) 28 January 2010 0:49 UTC emc.medicines.org.uk [Source type: Academic]

^ Treatment of Children and Adolescents > Obsessive-compulsive disorder Chapter 36.

^ Antidepressant use in children, adolescents, and adults .
  • Antidepressants - Pharmacy Clinical Policy Bulletins Aetna Non-Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]

.In 2003, the UK Medicines and Healthcare products Regulatory Agency issued a guidance that, apart from fluoxetine (Prozac), SSRIs are not suitable for the treatment of depression in patients under 18.[18][19] However, sertraline can still be used in the UK for the treatment of OCD in children and adolescents.^ In 2003, the FDA recommended that paroxetine not be used in children or adolescents for treatment of depression.
  • Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]

^ Antidepressant use in children, adolescents, and adults .
  • Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]

^ Use in children and adolescents under 18 years of age: .
  • Sertraline 50mg and 100mg Film-Coated Tablets - Summary of Product Characteristics (SPC) - electronic Medicines Compendium (eMC) 28 January 2010 0:49 UTC emc.medicines.org.uk [Source type: Academic]

[20] .In 2005, the FDA added a black box warning concerning pediatric suicidality to all antidepressants, including sertraline.^ The FDA has now instructed the manufacturers of ALL antidepressants to revise the labeling for their products to include a boxed warning and expanded warning statements that alert healthcare providers to an increased risk of suicidality (suicidal thinking and behavior) in children and adolescents being treated with these agents, and to include additional information about the results of pediatric studies.
  • Sertraline 28 January 2010 0:49 UTC www.umm.edu [Source type: Academic]
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^ Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials.
  • NEJM -- Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety 28 January 2010 0:49 UTC content.nejm.org [Source type: Academic]

^ In addition to the boxed warning and other information in professional labeling on antidepressants, MedGuides are being prepared for all of the antidepressants to provide information about the risk of suicidality in children and adolescents for patients and their families and caregivers.
  • Sertraline 28 January 2010 0:49 UTC www.umm.edu [Source type: Academic]
  • Sertraline - Erewhon Natural Foods 28 January 2010 0:49 UTC www.erewhonmarket.com [Source type: Academic]

In 2007, labeling was again changed to add a warning regarding suicidality in young adults ages 18 to 24.[21]
.The U.S. patent for Zoloft expired in 2006,[22] and sertraline is now available in generic form.^ I was now on a generic of Zoloft by Greenstone.
  • Sertraline (SER tra leen) Side Effects - The People's Pharmacy® 28 January 2010 0:49 UTC www.peoplespharmacy.com [Source type: FILTERED WITH BAYES]

^ Is Zoloft available in liquid form?
  • Drug InfoNet - Zoloft - [depression] 22 January 2010 11:13 UTC www.druginfonet.com [Source type: Original source]

^ The book How to Get Off Zoloft Safely is now available directly from Amazon.com.
  • Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft. 22 January 2010 11:13 UTC www.theroadback.org [Source type: FILTERED WITH BAYES]

Indications

.Sertraline has been approved for the following indications: major depression, obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder and social phobia (social anxiety disorder).^ If overdose is approved for social anxiety disorder is 50 mg day.
  • Buy Zoloft (Sertraline) 50mg,100mg 28 January 2010 0:49 UTC www.cemig.com.br [Source type: Academic]

^ Treatment of major depression; obsessive-compulsive disorder (OCD); panic disorder; post-traumatic stress disorder (PTSD); premenstrual dysphoric disorder (PMDD); social anxiety disorder .
  • Sertraline - Erewhon Natural Foods 28 January 2010 0:49 UTC www.erewhonmarket.com [Source type: Academic]

^ Many people have been successfully treated with Zoloft for depression, panic disorder, OCD, and PTSD. ...
  • Zoloft discussions (experiences, side effects, dosages, etc...) 22 January 2010 11:13 UTC www.drugtalk.com [Source type: Original source]

Depression

.The original pre-marketing clinical trials demonstrated only weak-to-moderate efficacy of sertraline for depression.^ The efficacy of sertraline in paediatric patients with depression or panic disorder has not been demonstrated in controlled trials.
  • Sertraline 50mg and 100mg Film-Coated Tablets - Summary of Product Characteristics (SPC) - electronic Medicines Compendium (eMC) 28 January 2010 0:49 UTC emc.medicines.org.uk [Source type: Academic]

^ Controlled clinical studies failed to demonstrate efficacy and do not support the use of sertraline in the treatment of children and adolescents with Major Depressive Disorder (See sections 4.3, Contra-Indications and 4.8, Undesirable effects).
  • Sertraline 50mg and 100mg Film-Coated Tablets - Summary of Product Characteristics (SPC) - electronic Medicines Compendium (eMC) 28 January 2010 0:49 UTC emc.medicines.org.uk [Source type: Academic]

^ In particular, controlled clinical studies failed to demonstrate efficacy and do not support the use of sertraline in the treatment of children and adolescents with Major Depressive Disorder (See sections 4.3, Contra-Indications and 4.8, Undesirable effects).
  • Sertraline 50mg and 100mg Film-Coated Tablets - Summary of Product Characteristics (SPC) - electronic Medicines Compendium (eMC) 28 January 2010 0:49 UTC emc.medicines.org.uk [Source type: Academic]

[23] .Nevertheless, a considerable body of later research established it as one of the drugs of choice for the treatment of depression in outpatients.^ A growing body of research has found cognitive impairment to be a common clinical feature of late-life depression ( 1 ).
  • Does Antidepressant Therapy Improve Cognition in Elderly Depressed Patients? -- Doraiswamy et al. 58 (12): 1137 -- Journals of Gerontology Series A: Biological Sciences and Medical Sciences 28 January 2010 0:49 UTC biomed.gerontologyjournals.org [Source type: Academic]

^ We began the tapping sequence for depression and after one treatment for psychological reversal (This is where the energy system literally reverses and creates opposite polarity.
  • infoholix.net - Is There A Cure For Depression? Third results 28 January 2010 0:49 UTC www.infoholix.net [Source type: FILTERED WITH BAYES]

^ Establishing the Appropriate Setting for Treatment The appropriate treatment setting may be the hospital, a residential treatment or partial hospitalization program, home-based treatment, or outpatient care.

.Despite the negative results of early trials, sertraline is often used to treat depressed inpatients as well.^ Results of our trial contribute to knowledge of the effectiveness and adverse effects of SJW. Despite the limitations of this investigation, we conclude that, given its favourable side effect profile and apparently similar effectiveness to an accepted antidepressant (sertraline), SJW has a role as first treatment option for mild-to-moderate depression in primary care settings.
  • St John�s wort or sertraline? 28 January 2010 0:49 UTC www.cfpc.ca [Source type: Academic]

^ In a meta-analysis of 23 randomized clinical trials, reviewers concluded that SJW was better than placebo for treating some depressive disorders.
  • St John�s wort or sertraline? 28 January 2010 0:49 UTC www.cfpc.ca [Source type: Academic]

^ DESIGN The study was a double-blind placebo-controlled trial of the efficacy of early coadministration of clonazepam with sertraline for the treatment of active panic disorder.
  • Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681 28 January 2010 0:49 UTC archpsyc.ama-assn.org [Source type: Academic]

[24] .Sertraline is effective for both severe depression[25] and dysthymia, a milder and more chronic variety of depression.^ Up to a tenth of people living in the community who are aged 65 years or more suffer from depression severe enough to warrant intervention.
  • Older community residents with depression: long-term treatment with sertraline: Randomised, double-blind, placebo-controlled study -- WILSON et al. 182 (6): 492 -- The British Journal of Psychiatry 28 January 2010 0:49 UTC bjp.rcpsych.org [Source type: Academic]

^ The Cost of Depressive Illness in the United States Any understanding of the cost-effectiveness of a medical therapy must be based on both the cost of the illness being treated as well as the effectiveness of the therapy.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

^ Extensive chronic safety evaluation studies in animals show that sertraline is generally well tolerated at doses that are appreciable multiples of those that are clinically effective.
  • Sertraline 50mg and 100mg Film-Coated Tablets - Summary of Product Characteristics (SPC) - electronic Medicines Compendium (eMC) 28 January 2010 0:49 UTC emc.medicines.org.uk [Source type: Academic]

.In several double-blind studies, sertraline was consistently more effective than placebo for dysthymia[26][27][28][29] and comparable to imipramine (Tofranil) in that respect.^ One study also asserts that sertraline is also more effective than TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

^ A double-blind, placebo-controlled trial.
  • SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism 28 January 2010 0:49 UTC alcalc.oxfordjournals.org [Source type: Academic]

^ One study also asserts that sertraline is more effective than TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

[27] .Sertraline also improved the depression of dysthymic patients to a greater degree than group cognitive behavioral therapy or interpersonal psychotherapy, and adding psychotherapy to sertraline did not seem to enhance the outcome.^ Combination therapy consisted of the administration of sertraline and cognitive behavioral therapy.
  • NEJM -- Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety 28 January 2010 0:49 UTC content.nejm.org [Source type: Academic]

^ Cognitive-Behavioral Therapies Chapter 24.

^ CBT denotes cognitive behavioral therapy.
  • NEJM -- Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety 28 January 2010 0:49 UTC content.nejm.org [Source type: Academic]

[28][29] .These results also held up in a two-year follow-up of sertraline-treated and interpersonal-therapy-treated groups.^ BUT I also am following up with therapy, which is helping a lot too.
  • Zoloft and headaches : Medications.com 22 January 2010 11:13 UTC www.medications.com [Source type: FILTERED WITH BAYES]

^ [CrossRef] [Web of Science] [Medline] Ferdinand RF, Verhulst FC. Psychopathology from adolescence into young adulthood: an 8-year follow-up study.
  • NEJM -- Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety 28 January 2010 0:49 UTC content.nejm.org [Source type: Academic]

^ Multivariate regression analysis revealed that sertraline use resulted in significantly lower direct medical costs than TCAs for one year of treatment following initiation of therapy ($168 per patient, or 21% less than TCAs).
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

[30] .In the treatment of depression accompanied by OCD, sertraline performed significantly better than desipramine (Norpramine) on the measures of both OCD and depression.^ Imipramine treatment was not significantly better than placebo for improvement in depression and anxiety ratings in this patient group.
  • Nefazodone 28 January 2010 0:49 UTC www.psycom.net [Source type: Academic]

^ Results of the two-way analysis of covariance with repeated measures indicated time had a significant effect, but treatment and treatment-time interaction effects were not significant for either Ham-D or BDI scores.The proportion of each group that reported taking at least three capsules daily was significantly higher at 2 weeks in the SJW group than the sertraline group ( Table 3 ).
  • St John�s wort or sertraline? 28 January 2010 0:49 UTC www.cfpc.ca [Source type: Academic]

^ Its acceptance is testimony to the need for better OCD treatments.
  • Efficacy of Sertraline in the Long-Term Treatment of Obsessive-Compulsive Disorder -- Koran et al. 159 (1): 88 -- Am J Psychiatry 28 January 2010 0:49 UTC ajp.psychiatryonline.org [Source type: Academic]

[31] .Sertraline was equivalent to imipramine for the treatment of depression with co-morbid panic disorder, but it was better tolerated.^ Sertraline treatment was generally well tolerated.
  • Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects. 22 January 2010 11:13 UTC www.prozactruth.com [Source type: Academic]

^ Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder.
  • Antidepressants - Pharmacy Clinical Policy Bulletins Aetna Non-Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]
  • Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]

^ Psychomotor changes in major depressive disorder during sertraline treatment.
  • Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects. 22 January 2010 11:13 UTC www.prozactruth.com [Source type: Academic]

[32] .Sertraline treatment of depressed patients with co-morbid personality disorders improved their personality traits, and this improvement was almost independent from the improvement of their depression.^ Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder.
  • Antidepressants - Pharmacy Clinical Policy Bulletins Aetna Non-Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]

^ Pharmacotherapy of depressive disorders in older patients.
  • Antidepressants - Pharmacy Clinical Policy Bulletins Aetna Non-Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]

^ These patients do not benefit from sertraline treatment.
  • SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism 28 January 2010 0:49 UTC alcalc.oxfordjournals.org [Source type: Academic]

[33]

Comparison with tricyclic antidepressants

.The effect of sertraline on the core symptoms of depression is similar to that of tricyclic antidepressants (TCAs); however, it is better tolerated and results in a better quality of life.^ Results of our trial contribute to knowledge of the effectiveness and adverse effects of SJW. Despite the limitations of this investigation, we conclude that, given its favourable side effect profile and apparently similar effectiveness to an accepted antidepressant (sertraline), SJW has a role as first treatment option for mild-to-moderate depression in primary care settings.
  • St John�s wort or sertraline? 28 January 2010 0:49 UTC www.cfpc.ca [Source type: Academic]

^ Conclusions The SSRI antidepressants paroxetine, fluoxetine, and sertraline were similar in effectiveness for depressive symptoms as well as multiple domains of health-related quality of life over the entire 9 months of this trial.
  • JAMA -- Similar Effectiveness of Paroxetine, Fluoxetine, and Sertraline in Primary Care: A Randomized Trial, December 19, 2001, Kroenke et al. 286 (23): 2947 28 January 2010 0:49 UTC jama.ama-assn.org [Source type: Academic]

^ [Medline] Lane RM, O'Hanlon JF. Cognitive and psychomotor effects of antidepressants with emphasis on selective serotonin reuptake inhibitors and the depressed elderly patient.
  • Does Antidepressant Therapy Improve Cognition in Elderly Depressed Patients? -- Doraiswamy et al. 58 (12): 1137 -- Journals of Gerontology Series A: Biological Sciences and Medical Sciences 28 January 2010 0:49 UTC biomed.gerontologyjournals.org [Source type: Academic]

.Similar improvement of depression scores was seen in studies comparing sertraline with clomipramine (Anafranil)[25] and amitriptyline (Elavil).^ A smaller pilot study in the United States 11 comparing SJW with sertraline in 30 outpatients with various diagnoses of depressive conditions found no difference in efficacy.
  • St John�s wort or sertraline? 28 January 2010 0:49 UTC www.cfpc.ca [Source type: Academic]

^ The results of our study confirm the short-term efficacy of sertraline for children with generalized anxiety disorder 25 and show that sertraline is effective for children with separation anxiety disorder and social phobia.
  • NEJM -- Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety 28 January 2010 0:49 UTC content.nejm.org [Source type: Academic]

^ The objectives of the study were to evaluate the efficacy of sertraline at achieving stable abstinence, at ameliorating depressive symptoms and at improving quality of life in these patients.
  • SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism 28 January 2010 0:49 UTC alcalc.oxfordjournals.org [Source type: Academic]

[34][35] At the same time, sertraline resulted in a much lower rate of side effects than amitriptyline (49%, vs. 72% for amitriptyline and 32% for placebo), particularly dry mouth, somnolence, constipation and increased appetite.[35] .However, there were more cases of nausea and sexual dysfunction in the sertraline group.^ Main adverse effects The most common adverse effects reported with therapeutic doses of sertraline are primarily nausea, diarrhea, dyspepsia, dry mouth, insomnia, somnolence, tremor, dizziness, headache and male sexual dysfunction (delayed ejaculation).
  • Sertraline (PIM 177) 28 January 2010 0:49 UTC www.inchem.org [Source type: Academic]

^ However, in sensitivity analyses, SSRIs were more cost-effective than was venlafaxine in an inpatient worst case scenario, although venlafaxine remained dominant in all outpatient analyses.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

^ Finally, use of oral anticoagulants was less frequent in the sertraline group; however, this difference did not reach significance.
  • Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation 28 January 2010 0:49 UTC circ.ahajournals.org [Source type: Academic]

[34][35] .Participants taking sertraline showed a greater improvement of the subjective quality of life on such measures as work satisfaction, subjective feeling, perceptions of health and cognitive function.^ Outcome measurements were psychopathology, quality of life, global functioning, work function and rehospitalization.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

^ For patients treated with sertraline, improvement in cognitive function is clearly proportional to improvement in depression severity, with the greatest improvement in cognitive function associated with a greater than 15-point endpoint improvement in HAM-D, which was the criteria for remission.
  • Does Antidepressant Therapy Improve Cognition in Elderly Depressed Patients? -- Doraiswamy et al. 58 (12): 1137 -- Journals of Gerontology Series A: Biological Sciences and Medical Sciences 28 January 2010 0:49 UTC biomed.gerontologyjournals.org [Source type: Academic]

^ Secondary outcomes included other depression and psychological measures, multiple measures of social and work functioning, and other domains of health-related quality of life, such as physical functioning, concentration and memory, vitality, bodily pain, sleep, and sexual functioning.
  • JAMA -- Similar Effectiveness of Paroxetine, Fluoxetine, and Sertraline in Primary Care: A Randomized Trial, December 19, 2001, Kroenke et al. 286 (23): 2947 28 January 2010 0:49 UTC jama.ama-assn.org [Source type: Academic]

[35]
.A large and thorough double-blind study compared sertraline—prescribed for chronic (longer than two years) depression or depression with dysthymia—to the "gold standard" of depression treatment, the TCA imipramine (Tofranil).^ That study is expected to take two years.

^ One study also asserts that sertraline is also more effective than TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

^ One study also asserts that sertraline is more effective than TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

.Sertraline was equivalent to imipramine for both of these indications during the first 12 weeks of the study[36][37][38] and the 16-week continuation phase.^ The possibility that discontinuation of sertraline after 36 weeks of treatment might have caused some mild discontinuation symptoms (the dizziness observed in patients who received placebo) needs to be considered as a factor that may have contributed to relapse during the early weeks of placebo treatment.
  • Efficacy of Sertraline in Preventing Relapse of Posttraumatic Stress Disorder: Results of a 28-Week Double-Blind, Placebo-Controlled Study -- Davidson et al. 158 (12): 1974 -- Am J Psychiatry 28 January 2010 0:49 UTC ajp.psychiatryonline.org [Source type: Academic]

^ Study design The study consisted of a treatment phase (8 weeks) and a continuation phase (16–20 weeks) during which participants were treated with open-label sertraline prior to randomisation into a double-blind, parallel, placebo-controlled maintenance trial of 100 weeks.
  • Older community residents with depression: long-term treatment with sertraline: Randomised, double-blind, placebo-controlled study -- WILSON et al. 182 (6): 492 -- The British Journal of Psychiatry 28 January 2010 0:49 UTC bjp.rcpsych.org [Source type: Academic]

^ Chronic toxicity Dogs were administered oral doses of 10, 30 and 90 mg/kg for 6 and 12 months; several adverse effects occurred during the first weeks, including hypersalivation, abnormal movements of the head, disorientation, agitation; the dosage of 90 mg/kg resulted in convulsions in 2 dogs; all of these effects where temporary and resolved spontaneously despite continuation of sertraline administration.
  • Sertraline (PIM 177) 28 January 2010 0:49 UTC www.inchem.org [Source type: Academic]

[39] Only 11% of patients on sertraline suffered from severe side effects vs. 24% on imipramine. .Constipation, dizziness, tremor, dry mouth, micturition disorder and sweating were observed more often with imipramine, and diarrhea and insomnia with sertraline.^ Main adverse effects The most common adverse effects reported with therapeutic doses of sertraline are primarily nausea, diarrhea, dyspepsia, dry mouth, insomnia, somnolence, tremor, dizziness, headache and male sexual dysfunction (delayed ejaculation).
  • Sertraline (PIM 177) 28 January 2010 0:49 UTC www.inchem.org [Source type: Academic]

^ Among the reported effects and uncommon side effects of Zoloft in the Physician's Desk Reference are agitation, nausea and/or vomiting, diarrhea, heartburn due to acid reflux, tremor, dizziness, insomnia, increased sweating, dry mouth, and sexual dysfunction.
  • Drug InfoNet - Zoloft - [depression] 22 January 2010 11:13 UTC www.druginfonet.com [Source type: Original source]
  • Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft 22 January 2010 11:13 UTC www.druginfonet.com [Source type: FILTERED WITH BAYES]

^ Among the reported effects and uncommon side effects of Zoloft in the Physician's Desk Reference are: agitation, nausea and/or vomiting, diarrhea, heartburn due to acid reflux, tremor, dizziness, insomnia, increased sweating, dry mouth, and sexual dysfunction.
  • Drug InfoNet - Zoloft - [depression] 22 January 2010 11:13 UTC www.druginfonet.com [Source type: Original source]
  • Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft 22 January 2010 11:13 UTC www.druginfonet.com [Source type: FILTERED WITH BAYES]

[37] .Patients on sertraline also reported significantly better social and physical functioning.^ Mean number of side effects reported by those in the sertraline group was significantly higher at 2 and 4 weeks than in the SJW group.
  • St John�s wort or sertraline? 28 January 2010 0:49 UTC www.cfpc.ca [Source type: Academic]

^ Bruxism causing significant physical consequences was associated with sertraline and other SSRIs in a case series reported by Fitzgerald & Healy (1995).
  • Sertraline (PIM 177) 28 January 2010 0:49 UTC www.inchem.org [Source type: Academic]

^ Patients suffering from both disorders have more psychological, physical, and social impairment than do patients suffering from either illness alone.
  • Nefazodone 28 January 2010 0:49 UTC www.psycom.net [Source type: Academic]

.The 30% of the patients treated with sertraline or imipramine who achieved a remission during the trial did not differ from the healthy population on the measures of marital, parental, physical and work functioning and were close to normal on social adjustment and other measures of interpersonal functioning.^ In such cases, sertraline offers certain advantages over other antidepressants, since it is well-tolerated, has no active metabolites and little impact on hepatic enzymes and can thus be used safely in patients with potentially impaired hepatic function.
  • SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism 28 January 2010 0:49 UTC alcalc.oxfordjournals.org [Source type: Academic]

^ Use of Sertraline Linked to Suicidality LONDON, May 30 (Reuters Health) – The use of sertraline might prompt some patients to commit suicide, a UK researcher warns based on a study of healthy volunteers.

^ The possibility that discontinuation of sertraline after 36 weeks of treatment might have caused some mild discontinuation symptoms (the dizziness observed in patients who received placebo) needs to be considered as a factor that may have contributed to relapse during the early weeks of placebo treatment.
  • Efficacy of Sertraline in Preventing Relapse of Posttraumatic Stress Disorder: Results of a 28-Week Double-Blind, Placebo-Controlled Study -- Davidson et al. 158 (12): 1974 -- Am J Psychiatry 28 January 2010 0:49 UTC ajp.psychiatryonline.org [Source type: Academic]

[38]
.TCAs as a group are considered to work better than selective serotonin reuptake inhibitors for melancholic depression[40] and in inpatients,[41] but not necessarily for simply more severe depression.^ Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs)...
  • Zoloft | LIVESTRONG.COM 22 January 2010 11:13 UTC www.livestrong.com [Source type: General]

^ It is a member of a group of medicines referred to as SSRI’s, which stands for Selective Serotonin Reuptake Inhibitors.
  • Cheap Zoloft - blastpassemranch.com 28 January 2010 0:49 UTC www.blastpassemranch.com [Source type: FILTERED WITH BAYES]

^ Selective serotonin reuptake inhibitors for premenstrual syndrome.
  • Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects. 22 January 2010 11:13 UTC www.prozactruth.com [Source type: Academic]

[42] .In line with this generalization, sertraline was no better than placebo in inpatients (see History) and as effective as the TCA clomipramine for severe depression.^ One study also asserts that sertraline is also more effective than TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

^ One study also asserts that sertraline is more effective than TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

^ In this analysis, venlafaxine was more cost-effective in terms of expected costs per success and per symptom free day (SFD) than TCAs both in the inpatient and outpatient setting.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

[25] .The comparative efficacy of sertraline and TCAs for melancholic depression has not been studied.^ A smaller pilot study in the United States 11 comparing SJW with sertraline in 30 outpatients with various diagnoses of depressive conditions found no difference in efficacy.
  • St John�s wort or sertraline? 28 January 2010 0:49 UTC www.cfpc.ca [Source type: Academic]

^ The results of our study confirm the short-term efficacy of sertraline for children with generalized anxiety disorder 25 and show that sertraline is effective for children with separation anxiety disorder and social phobia.
  • NEJM -- Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety 28 January 2010 0:49 UTC content.nejm.org [Source type: Academic]

^ The objectives of the study were to evaluate the efficacy of sertraline at achieving stable abstinence, at ameliorating depressive symptoms and at improving quality of life in these patients.
  • SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism 28 January 2010 0:49 UTC alcalc.oxfordjournals.org [Source type: Academic]

.A 1998 review suggested that, due to its pharmacology, sertraline may be more efficacious than other SSRIs and equal to TCAs for the treatment of melancholic depression.^ Treatment with sertraline may result in lower total costs than treatment with TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

^ One study also asserts that sertraline is also more effective than TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

^ Both of the studies reviewed below suggest that treatment with sertraline results in lower costs than treatment with TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

[43] A later open-label study of general practice patients, funded by Pfizer, found that sertraline had equal efficacy in melancholic vs. non-melancholic patients, as well as in previous TCA non-responders vs. all other patients.[44]

Comparison with other antidepressants

.According to a meta-analysis of 12 new-generation antidepressants, sertraline and escitalopram are the best in terms of efficacy and acceptability in the acute-phase treatment of adults with unipolar major depression.^ Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder.
  • Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]

^ Sertraline treatment of major depression in patients with acute MI or unstable angina.
  • Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]
  • Does Antidepressant Therapy Improve Cognition in Elderly Depressed Patients? -- Doraiswamy et al. 58 (12): 1137 -- Journals of Gerontology Series A: Biological Sciences and Medical Sciences 28 January 2010 0:49 UTC biomed.gerontologyjournals.org [Source type: Academic]

^ Pharmacologic treatment of acute major depression and dysthymia.
  • Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]

Reboxetine was significantly worse.[45]
.Comparative clinical trials demonstrated that sertraline's efficacy in depression is similar to that of moclobemide (Aurorix),[46] nefazodone (Serzone),[47] escitalopram (Lexapro),[48] bupropion (Wellbutrin),[49] citalopram (Celexa), fluvoxamine (Luvox), paroxetine (Paxil) and mirtazapine (Remeron).^ Zoloft Prozac Medication Paxil Zoloft Uses Zoloft Side Effects Anxiety Medication Sertraline Prozac Side Effects Celexa Sertraline Side Effects Antidepressant Drugs Paxil Side Effects Medication For Depression Lexapro Antidepressant Medications Paroxetine Celexa Side Effects Serotonin Medications Generic Zoloft Effexor Generic For Paxil Celexa Anxiety Lexapro Side Effects Paxil Anxiety Fluoxetine Side Effects Luvox Serotonin Weight Gain Zoloft Citalopram Cymbalta Antidepressants Anxiety Disorder Symptoms Paxil And Alcohol Zoloft Generic Prozac Suicidal Fluvoxamine Depression Medications Fluvoxamine Luvox Mental Illness Medication Depression Drugs Fluoxetine Prozac Citalopram Side Effects Cymbalta Side Effects Medications For Depression Medications For Panic Disorder Causes Of Anxiety Generic Paxil Side Effects Anxiety Disorders Symptoms New Antidepressants Anxiety Disorders more Members Who Dare More Members Who Dare .
  • Zoloft Medication | LIVESTRONG.COM 22 January 2010 11:13 UTC www.livestrong.com [Source type: General]

^ A smaller pilot study in the United States 11 comparing SJW with sertraline in 30 outpatients with various diagnoses of depressive conditions found no difference in efficacy.
  • St John�s wort or sertraline? 28 January 2010 0:49 UTC www.cfpc.ca [Source type: Academic]

^ Efficacy and tolerability of controlled-release and immediate-release paroxetine in the treatment of depression.
  • Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]

[50] Compared to patients on bupropion, those taking sertraline had much higher rates of sexual dysfunction (61% vs. 10% for men and 41% vs. 7% for women), nausea, diarrhea, somnolence and sweating, as well as a higher rate of discontinuation due to side effects (13% vs. 3%).[49] .Meta-analysis by the independent Cochrane Collaboration indicated that sertraline is more effective for the treatment of depression than fluoxetine (Prozac), with a 1.4 times higher probability of response, and is possibly better tolerated.^ Sertraline treatment was generally well tolerated.
  • Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects. 22 January 2010 11:13 UTC www.prozactruth.com [Source type: Academic]

^ One study also asserts that sertraline is also more effective than TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

^ One study also asserts that sertraline is more effective than TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

[51] .The greatest advantage of sertraline over fluoxetine was seen among severely depressed and melancholic patients with low anxiety.^ Only 28 patients (34%) had MADRS scores at inclusion of 26, consistent with severe depression.
  • SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism 28 January 2010 0:49 UTC alcalc.oxfordjournals.org [Source type: Academic]

^ Patients with a history of failure on sertraline or any other serotonin reuptake selective inhibitor, either alone or combined with another therapy, for treating the current depressive episode.
  • SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism 28 January 2010 0:49 UTC alcalc.oxfordjournals.org [Source type: Academic]

^ Total median healthcare costs were $3,466, $3,491 and $3,613 per patient for fluoxetine, sertraline and paroxetine, respectively.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

[3] .Comparative studies of sertraline and venlafaxine (Effexor) found marginal differences in favor of venlafaxine[52][53][54] or no differences.^ A smaller pilot study in the United States 11 comparing SJW with sertraline in 30 outpatients with various diagnoses of depressive conditions found no difference in efficacy.
  • St John�s wort or sertraline? 28 January 2010 0:49 UTC www.cfpc.ca [Source type: Academic]

^ The study found no significant differences in length of follow-up, length of stay, or hospitalization rates between the two treatment groups.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

^ Second, in comparing this study with other studies conducted on similar populations it is evident that antidepressants differ in terms of maintenance efficacy.
  • Older community residents with depression: long-term treatment with sertraline: Randomised, double-blind, placebo-controlled study -- WILSON et al. 182 (6): 492 -- The British Journal of Psychiatry 28 January 2010 0:49 UTC bjp.rcpsych.org [Source type: Academic]

[55]

Depression in the elderly

.Sertraline used for the treatment of depression in elderly (older than 60) patients was superior to placebo and comparable to another SSRI fluoxetine, and TCAs amitriptyline, nortriptyline (Pamelor) and imipramine.^ Pharmacotherapy of depressive disorders in older patients.
  • Antidepressants - Pharmacy Clinical Policy Bulletins Aetna Non-Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]
  • Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]

^ However, the concomitant use of sertraline and alcohol in depressed patients is not recommended.
  • Sertraline 50mg and 100mg Film-Coated Tablets - Summary of Product Characteristics (SPC) - electronic Medicines Compendium (eMC) 28 January 2010 0:49 UTC emc.medicines.org.uk [Source type: Academic]

^ Imipramine in the treatment of depressed Alzheimer's patients: impact on cognition.
  • Does Antidepressant Therapy Improve Cognition in Elderly Depressed Patients? -- Doraiswamy et al. 58 (12): 1137 -- Journals of Gerontology Series A: Biological Sciences and Medical Sciences 28 January 2010 0:49 UTC biomed.gerontologyjournals.org [Source type: Academic]

.Sertraline had much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurred more frequently with sertraline.^ One study also asserts that sertraline is more effective than TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

^ One study also asserts that sertraline is also more effective than TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

^ More ADRs with sertraline than PLB. .
  • Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder 28 January 2010 0:49 UTC www.tu.edu [Source type: Academic]

.In addition, sertraline appeared to be more effective than fluoxetine or nortriptyline in the older-than-70 subgroup.^ One study also asserts that sertraline is also more effective than TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

^ One study also asserts that sertraline is more effective than TCAs.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

^ More ADRs with sertraline than PLB. .
  • Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder 28 January 2010 0:49 UTC www.tu.edu [Source type: Academic]

[56] A 2003 trial of sertraline vs. placebo in elderly patients showed a statistically significant (that is, unlikely to occur by chance), but clinically very modest improvement in depression and no improvement in quality of life.[57] .The authors were sharply criticized by Bernard Carroll, a one-time chairman of the FDA Psychopharmacological Drugs Advisory Committee,[58] for presenting these results as positive: "The study has all the hallmarks of an 'experimercial,' a cost-is-no-object exercise driven by a corporate sponsor to create positive publicity for its product in a market niche.^ No further publication of these trial results was found at the time of this study.
  • Access and Utilization of New Antidepressant and Antipsychotic Medications 28 January 2010 0:49 UTC aspe.os.dhhs.gov [Source type: Academic]

^ Results from these studies have been mixed.
  • Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder 28 January 2010 0:49 UTC www.tu.edu [Source type: Academic]

^ Our findings indicate that all three of the treatment options may be recommended, taking into consideration the family's treatment preferences, treatment availability, cost, and time burden.
  • NEJM -- Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety 28 January 2010 0:49 UTC content.nejm.org [Source type: Academic]

... Thus does the corporate mandate to put lipstick on the pig prevail over the academic duty to communicate independent analyses of the data."[59]

Obsessive-compulsive disorder

.Placebo-controlled studies have demonstrated sertraline to be efficacious for the treatment of OCD in adults and children.^ Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder.
  • Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]

^ The efficacy of sertraline in the treatment of OCD was demonstrated in a 12-week, multicenter, placebo-controlled study with 187 outpatients 6-17 years of age.
  • Sertraline - Erewhon Natural Foods 28 January 2010 0:49 UTC www.erewhonmarket.com [Source type: Academic]

^ Sertraline is FDA approved for the treatment of OCD in children 6 years of age.
  • Sertraline - Erewhon Natural Foods 28 January 2010 0:49 UTC www.erewhonmarket.com [Source type: Academic]

[60][61][62][63] .It was better tolerated and, based on intention to treat analysis, performed better than the gold standard of OCD treatment clomipramine.^ In a meta-analysis of 23 randomized clinical trials, reviewers concluded that SJW was better than placebo for treating some depressive disorders.
  • St John�s wort or sertraline? 28 January 2010 0:49 UTC www.cfpc.ca [Source type: Academic]

^ Efficacy and tolerability of selective serotonin reuptake inhibitors compared with tricyclic antidepressants in depression treated in primary care: systematic review and meta-analysis.
  • Antidepressants - Pharmacy Clinical Policy Bulletins Aetna Non-Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]
  • Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan 28 January 2010 0:49 UTC www.aetna.com [Source type: Academic]

^ All patients who completed a baseline interview were included in the intent-to-treat analysis using the drug to which the patient was randomized as the treatment variable.
  • JAMA -- Similar Effectiveness of Paroxetine, Fluoxetine, and Sertraline in Primary Care: A Randomized Trial, December 19, 2001, Kroenke et al. 286 (23): 2947 28 January 2010 0:49 UTC jama.ama-assn.org [Source type: Academic]

[64] .Sertraline was also marginally more efficacious than fluoxetine (Prozac).^ More ADRs with sertraline than PLB. .
  • Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder 28 January 2010 0:49 UTC www.tu.edu [Source type: Academic]

^ Sertraline has one active metabolite and a lower potential for drug interactions involving CYP2D6 (hepatic cytochrome P-450 isoenzyme 2D6) than fluoxetine or paroxetine.
  • </c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="192"><a href="#citable__192"><strong>^</strong></a> <c_txt>Although meta-analyses of placebo-controlled trials suggest greater efficacy for clomipramine than for fluoxetine, fluvoxamine, and sertraline , the results of head-to-head trials comparing clomipramine and selective serotonin reuptake inhibitors (SSRIs) directly do not support this impression.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid11910259_64_0" class="reference"><a href="#cite_note-pmid11910259-64"><span>[</span>65<span>]</span></a></sup> <a name="citable__81" class="citable__local-anchor">.</a><span class='citationPopup' rel="81">It is generally accepted that the sertraline dosages necessary for the effective treatment of OCD are higher than the usual dosage for depression.</span><span class="citable__li" citable_id="81"><a href="#citable__81"><strong>^</strong></a> <c_txt>Sertraline treatment was generally well tolerated.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="81"><a href="#citable__81"><strong>^</strong></a> <c_txt>Results of our trial contribute to knowledge of the effectiveness and adverse effects of SJW. Despite the limitations of this investigation, we conclude that, given its favourable side effect profile and apparently similar effectiveness to an accepted antidepressant (sertraline), SJW has a role as first treatment option for mild-to-moderate depression in primary care settings.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>St John�s wort or sertraline?</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.cfpc.ca/cfp/2002/May/vol48-may-research-1.asp">www.cfpc.ca</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="81"><a href="#citable__81"><strong>^</strong></a> <c_txt>Comparisons Among Antipsychotics Newer Antipsychotics Compared to Older Antipsychotics Several economic models suggest that, despite their higher medication costs, risperidone, olanzapine, and clozapine may be more cost-effective than older antipsychotics (e.g., haloperidol) in the treatment of schizophrenia.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_medscape_65_0" class="reference"><a href="#cite_note-medscape-65"><span>[</span>66<span>]</span></a></sup> <a name="citable__111" class="citable__local-anchor">.</a><span class='citationPopup' rel="111">The onset of action is also slower for OCD than for depression.</span><span class="citable__li" citable_id="111"><a href="#citable__111"><strong>^</strong></a> <c_txt>Depression (including accompanying symptoms of anxiety), OCD and PTSD: In some patients doses higher than 50mg daily may be required.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Sertraline 50mg and 100mg Film-Coated Tablets - Summary of Product Characteristics (SPC) - electronic Medicines Compendium (eMC)</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://emc.medicines.org.uk/document.aspx?documentId=18935">emc.medicines.org.uk</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__85" class="citable__local-anchor">.</a><span class='citationPopup' rel="85">The treatment recommendation is to start treatment with a half of maximal recommended dose for at least two months.</span><span class="citable__li" citable_id="85"><a href="#citable__85"><strong>^</strong></a> <c_txt>Patients were included who had switched from an SSRI after at least two consecutive months of therapy followed by at least two consecutive months of a TCA (n=172) or venlafaxine (n=188).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="85"><a href="#citable__85"><strong>^</strong></a> <c_txt>Implementing Pharmacotherapy For most patients, the starting dose is that recommended by the manufacturer [I].</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="85"><a href="#citable__85"><strong>^</strong></a> <c_txt>Several weeks before the killings he was started on the antidepressant Zoloft and his dose was doubled just two days before the killings.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__200" class="citable__local-anchor">.</a><span class='citationPopup' rel="200">After that, the dose can be raised to the maximal recommended in the cases of unsatisfactory response.</span><span class="citable__li" citable_id="200"><a href="#citable__200"><strong>^</strong></a> <c_txt>This maximum dose may exceed the manufacturer's recommended maximum dose in some cases [III].</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="200"><a href="#citable__200"><strong>^</strong></a> <c_txt>Subsequent doses may be increased in case of lack of response in 50mg/day increments up to 200mg/day as needed.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Sertraline 50mg and 100mg Film-Coated Tablets - Summary of Product Characteristics (SPC) - electronic Medicines Compendium (eMC)</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://emc.medicines.org.uk/document.aspx?documentId=18935">emc.medicines.org.uk</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid16838823_66_0" class="reference"><a href="#cite_note-pmid16838823-66"><span>[</span>67<span>]</span></a></sup> <a name="citable__172" class="citable__local-anchor">.</a><span class='citationPopup' rel="172">If the patient was completely non-responsive to the maximal recommended dose of sertraline (200 mg), further increasing the dose did not significantly improve the response rates.</span><span class="citable__li" citable_id="172"><a href="#citable__172"><strong>^</strong></a> <c_txt>The maximum recommended daily dose for Zoloft is 50-200 mg.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="172"><a href="#citable__172"><strong>^</strong></a> <c_txt>In a controlled study of a single dose (2 mg) of pimozide, 200 mg sertraline (q.d.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="172"><a href="#citable__172"><strong>^</strong></a> <c_txt>Sertraline 50-200 mg .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__116" class="citable__local-anchor">.</a><span class='citationPopup' rel="116">However, patients with a partial but incomplete response to sertraline at 200 mg did see a clinically significant reduction in symptoms, when the dose was titrated up to a maximum of 400 mg.</span><span class="citable__li" citable_id="116"><a href="#citable__116"><strong>^</strong></a> <c_txt>The maximum recommended daily dose for Zoloft is 50-200 mg.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="116"><a href="#citable__116"><strong>^</strong></a> <c_txt>In a controlled study of a single dose (2 mg) of pimozide, 200 mg sertraline (q.d.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="116"><a href="#citable__116"><strong>^</strong></a> <c_txt>The dose was then titrated in weekly 25 mg/day or 50 mg/day increments, respectively, to a maximum dose of 200 mg/day based upon clinical response.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline - Erewhon Natural Foods</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.erewhonmarket.com/common/adam/DisplayMonograph.asp?storeID=D75C352CBF6F4DDEAC31FE4AA9F34525&DocID=41_114360">www.erewhonmarket.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__225" class="citable__local-anchor">.</a><span class='citationPopup' rel="225">Incidence of side effects at 400 mg was found to be comparable to 200 mg.</span><span class="citable__li" citable_id="225"><a href="#citable__225"><strong>^</strong></a> <c_txt>OBJECTIVE To compare the change in severity of depressive symptoms and occurrence of side effects in primary care patients treated with St Johns wort (SJW) and sertraline.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>St John�s wort or sertraline?</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.cfpc.ca/cfp/2002/May/vol48-may-research-1.asp">www.cfpc.ca</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="225"><a href="#citable__225"><strong>^</strong></a> <c_txt>Side effects: Week 2 compared with ever during trial .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>St John�s wort or sertraline?</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.cfpc.ca/cfp/2002/May/vol48-may-research-1.asp">www.cfpc.ca</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="225"><a href="#citable__225"><strong>^</strong></a> <c_txt>Zoloft Side Effects [posted 10/6/98] Question: I have been taking 50 mg.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid16426083_67_0" class="reference"><a href="#cite_note-pmid16426083-67"><span>[</span>68<span>]</span></a></sup></div> <div style="margin: 1.12em 0; display:block"><a name="citable__252" class="citable__local-anchor">.</a><span class='citationPopup' rel="252">The patients who responded to sertraline during a short-term trial sustained their improvement when the treatment continued for a year<sup id="wikipedia_cite_ref_pmid7673657_68_0" class="reference"><a href="#cite_note-pmid7673657-68"><span>[</span>69<span>]</span></a></sup> and longer.</span><span class="citable__li" citable_id="252"><a href="#citable__252"><strong>^</strong></a> <c_txt>These patients do not benefit from sertraline treatment.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://alcalc.oxfordjournals.org/cgi/content/full/38/6/619">alcalc.oxfordjournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="252"><a href="#citable__252"><strong>^</strong></a> <c_txt>Because of short-term treatment.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Buy Zoloft (Sertraline) 50mg,100mg</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.cemig.com.br/cemig2008/content/aplicativos/descricao.asp?codigo=803">www.cemig.com.br</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="252"><a href="#citable__252"><strong>^</strong></a> <c_txt>Depressive syndromes In terms of treatment response ( 50% improvement in the MADRS score), 39% of patients in the placebo group and 44% of patients in the sertraline group responded over the study period.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://alcalc.oxfordjournals.org/cgi/content/full/38/6/619">alcalc.oxfordjournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid9547132_69_0" class="reference"><a href="#cite_note-pmid9547132-69"><span>[</span>70<span>]</span></a></sup> <a name="citable__160" class="citable__local-anchor">.</a><span class='citationPopup' rel="160">At the same time, the prolonged treatment may not be necessary for everyone.</span><span class="citable__li" citable_id="160"><a href="#citable__160"><strong>^</strong></a> <c_txt>Our findings indicate that all three of the treatment options may be recommended, taking into consideration the family's treatment preferences, treatment availability, cost, and time burden.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>NEJM -- Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://content.nejm.org/cgi/content/full/NEJMoa0804633">content.nejm.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="160"><a href="#citable__160"><strong>^</strong></a> <c_txt>Therefore, increased treatment costs may reflect physician practices that could have improved since the time of the study.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="160"><a href="#citable__160"><strong>^</strong></a> <c_txt>Treatment of the serotonin syndrome may require aggressive supportive care including diazepam, mechanical ventilation, external cooling and if necessary, curarization.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (PIM 177)</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.inchem.org/documents/pims/pharm/pim177.htm">www.inchem.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__208" class="citable__local-anchor">.</a><span class='citationPopup' rel="208">In a <a href="/Randomized_controlled_trial" title="Randomized controlled trial">double-blind study</a>, half of the subjects who had been successfully treated for a year were discontinued from sertraline.</span><span class="citable__li" citable_id="208"><a href="#citable__208"><strong>^</strong></a> <c_txt>Eligible subjects were enrolled in the study and referred to a designated pharmacist who dispensed medication to them in the order they arrived using our randomization scheme.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>St John�s wort or sertraline?</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.cfpc.ca/cfp/2002/May/vol48-may-research-1.asp">www.cfpc.ca</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="208"><a href="#citable__208"><strong>^</strong></a> <c_txt>Hertzberg et al (1999) studied lamotrigine for PTSD in a 12-week double-blind, randomized (2:1) placebo-controlled trial.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="208"><a href="#citable__208"><strong>^</strong></a> <c_txt>Pohl RB, Wolkow RM, Clary CM. Sertraline in the treatment of panic disorder: a double-blind multicenter trial.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://archpsyc.ama-assn.org/cgi/content/full/58/7/681">archpsyc.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__163" class="citable__local-anchor">.</a><span class='citationPopup' rel="163">Only 48% of the patients in the discontinuation group were able to complete the study; however, these completers fared as well as the subjects who continued taking sertraline.</span><span class="citable__li" citable_id="163"><a href="#citable__163"><strong>^</strong></a> <c_txt>However, patient-rated weekly panic attack frequency did not differ between groups (F 4,192 = 0.91; group x time interaction, P = .46).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://archpsyc.ama-assn.org/cgi/content/full/58/7/681">archpsyc.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="163"><a href="#citable__163"><strong>^</strong></a> <c_txt>Finally, use of oral anticoagulants was less frequent in the sertraline group; however, this difference did not reach significance.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="163"><a href="#citable__163"><strong>^</strong></a> <c_txt>Several of these studies demonstrate that higher continuation rates (and lower dropout rates) of paroxetine contribute to its superior cost-effectiveness over TCAs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid11772695_70_0" class="reference"><a href="#cite_note-pmid11772695-70"><span>[</span>71<span>]</span></a></sup></div> <div style="margin: 1.12em 0; display:block"><a name="citable__226" class="citable__local-anchor">.</a><span class='citationPopup' rel="226"><a href="/Cognitive_behavioral_therapy" title="Cognitive behavioral therapy">CBT</a> alone was superior to sertraline in both adults and children; however, the best results were achieved using a combination of these treatments.</span><span class="citable__li" citable_id="226"><a href="#citable__226"><strong>^</strong></a> <c_txt>Antidepressant use in children, adolescents, and adults .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Antidepressants - Pharmacy Clinical Policy Bulletins Aetna Non-Medicare Prescription Drug Plan</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.aetna.com/products/rxnonmedicare/data/2007/CNS/antidepressants_2007.html">www.aetna.com</a> [Source type: Academic]</li><li> <em><c_title>Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.aetna.com/products/rxmedicare/data/Medicare2007/CNS/antidepressants_2007.html">www.aetna.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="226"><a href="#citable__226"><strong>^</strong></a> <c_txt>These patients do not benefit from sertraline treatment.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://alcalc.oxfordjournals.org/cgi/content/full/38/6/619">alcalc.oxfordjournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="226"><a href="#citable__226"><strong>^</strong></a> <c_txt>Caution should be used when combining sertraline with CYP2D6 substrates (desipramine, nortriptyline, haloperidol, thioridazine, flecainide, codeine, propranolol, metoprolol), as sertraline can cause a significant increase in the serum concentrations of these drugs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (PIM 177)</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.inchem.org/documents/pims/pharm/pim177.htm">www.inchem.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid15507582_71_0" class="reference"><a href="#cite_note-pmid15507582-71"><span>[</span>72<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid16889458_72_0" class="reference"><a href="#cite_note-pmid16889458-72"><span>[</span>73<span>]</span></a></sup> <a name="citable__218" class="citable__local-anchor">.</a><span class='citationPopup' rel="218">A review mentions that sertraline can be used for the treatment of OCD co-morbid with <a href="/Tourette_syndrome" title="Tourette syndrome">Tourette syndrome</a>;<sup id="wikipedia_cite_ref_pmid11772131_73_0" class="reference"><a href="#cite_note-pmid11772131-73"><span>[</span>74<span>]</span></a></sup> however, sertraline may cause exacerbation of tics in Tourette syndrome.</span><span class="citable__li" citable_id="218"><a href="#citable__218"><strong>^</strong></a> <c_txt>May exacerbate tics in Tourette's syndrome.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline - Erewhon Natural Foods</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.erewhonmarket.com/common/adam/DisplayMonograph.asp?storeID=D75C352CBF6F4DDEAC31FE4AA9F34525&DocID=41_114360">www.erewhonmarket.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="218"><a href="#citable__218"><strong>^</strong></a> <c_txt>May cause or exacerbate sexual dysfunction.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline - Erewhon Natural Foods</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.erewhonmarket.com/common/adam/DisplayMonograph.asp?storeID=D75C352CBF6F4DDEAC31FE4AA9F34525&DocID=41_114360">www.erewhonmarket.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="218"><a href="#citable__218"><strong>^</strong></a> <c_txt>Buspirone (15-60 mg/day) may be useful in treatment of sexual dysfunction during treatment with a selective serotonin reuptake inhibitor; may exacerbate tics in Tourette's syndrome.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline - Erewhon Natural Foods</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.erewhonmarket.com/common/adam/DisplayMonograph.asp?storeID=D75C352CBF6F4DDEAC31FE4AA9F34525&DocID=41_114360">www.erewhonmarket.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid8552129_74_0" class="reference"><a href="#cite_note-pmid8552129-74"><span>[</span>75<span>]</span></a></sup></div> <div style="display:table-cell;clear:both;"></div><h3><span class="mw-headline" id="wikipedia_Panic_disorder">Panic disorder</span></h3> <div style="margin: 1.12em 0; display:block"><a name="citable__83" class="citable__local-anchor">.</a><span class='citationPopup' rel="83">In four large <a href="/Randomized_controlled_trial" title="Randomized controlled trial">double-blind</a> studies sertraline was shown to be superior to <a href="/Placebo" title="Placebo">placebo</a> for the treatment of panic disorder.</span><span class="citable__li" citable_id="83"><a href="#citable__83"><strong>^</strong></a> <c_txt>DESIGN The study was a double-blind placebo-controlled trial of the efficacy of early coadministration of clonazepam with sertraline for the treatment of active panic disorder.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://archpsyc.ama-assn.org/cgi/content/full/58/7/681">archpsyc.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="83"><a href="#citable__83"><strong>^</strong></a> <c_txt>Multi-center, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="83"><a href="#citable__83"><strong>^</strong></a> <c_txt>A double-blind, placebo-controlled trial.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://alcalc.oxfordjournals.org/cgi/content/full/38/6/619">alcalc.oxfordjournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__148" class="citable__local-anchor">.</a><span class='citationPopup' rel="148">The response rate was independent of the dose (50–200 mg).</span><span class="citable__li" citable_id="148"><a href="#citable__148"><strong>^</strong></a> <c_txt>The maximum recommended daily dose for Zoloft is 50-200 mg.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="148"><a href="#citable__148"><strong>^</strong></a> <c_txt>Sertraline 50-200 mg .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="148"><a href="#citable__148"><strong>^</strong></a> <c_txt>Patients (N = 50) were treated with flexible-dose, open-label sertraline (target dose, 100 mg/d) for 12 weeks.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://archpsyc.ama-assn.org/cgi/content/full/58/7/681">archpsyc.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> In addition to decreasing the frequency of panic attacks by about 80% (vs. 45% for placebo) and decreasing general anxiety, sertraline resulted in improvement of quality of life on most parameters. <a name="citable__292" class="citable__local-anchor">.</a><span class='citationPopup' rel="292">The patients rated as "improved" on sertraline reported better quality of life than the ones who "improved" on placebo.</span><span class="citable__li" citable_id="292"><a href="#citable__292"><strong>^</strong></a> <c_txt>One of 4 patients in the placebo group responded.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="292"><a href="#citable__292"><strong>^</strong></a> <c_txt>INTERVENTION: Patients were randomly assigned to receive a flexible dosage (50-200 mg/d) of sertraline (n = 189) or matching placebo tablets (n = 187) for 10 weeks.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="292"><a href="#citable__292"><strong>^</strong></a> <c_txt>However, clozapine was no more effective than were typical agents in reducing symptoms, improving QOL or probability of life.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__35" class="citable__local-anchor">.</a><span class='citationPopup' rel="35">The authors of the study argued that the improvement achieved with sertraline is different and of a better quality than the improvement achieved with placebo.</span><span class="citable__li" citable_id="35"><a href="#citable__35"><strong>^</strong></a> <c_txt>The objectives of the study were to evaluate the efficacy of sertraline at achieving stable abstinence, at ameliorating depressive symptoms and at improving quality of life in these patients.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://alcalc.oxfordjournals.org/cgi/content/full/38/6/619">alcalc.oxfordjournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="35"><a href="#citable__35"><strong>^</strong></a> <c_txt>More paroxetine treated patients (n=151) responded than those receiving placebo (n=156) as defined by a CGI-improvement rating of much or very much improved.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="35"><a href="#citable__35"><strong>^</strong></a> <c_txt>Because this difference did not achieve statistical significance, the authors concluded that the cost of treating depression was identical between the two treatment groups.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid10945134_75_0" class="reference"><a href="#cite_note-pmid10945134-75"><span>[</span>76<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid16292466_76_0" class="reference"><a href="#cite_note-pmid16292466-76"><span>[</span>77<span>]</span></a></sup> <a name="citable__67" class="citable__local-anchor">.</a><span class='citationPopup' rel="67">Sertraline was equally effective for men and women<sup id="wikipedia_cite_ref_pmid16292466_76_1" class="reference"><a href="#cite_note-pmid16292466-76"><span>[</span>77<span>]</span></a></sup> and for patients with or without <a href="/Agoraphobia" title="Agoraphobia">agoraphobia</a>.</span><span class="citable__li" citable_id="67"><a href="#citable__67"><strong>^</strong></a> <c_txt>Drinking outcome was superior in the sertraline treatment set for patients without a history of depression, but not for patients with current or previous depression.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://alcalc.oxfordjournals.org/cgi/content/full/38/6/619">alcalc.oxfordjournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="67"><a href="#citable__67"><strong>^</strong></a> <c_txt>The study population (those taking at least one dose of sertraline and receiving at least one follow-up visit) consisted of 254 persons (65 men and 189 women) with a mean age of 77.6 years (s.d.=6.6).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Older community residents with depression: long-term treatment with sertraline: Randomised, double-blind, placebo-controlled study -- WILSON et al. 182 (6): 492 -- The British Journal of Psychiatry</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://bjp.rcpsych.org/cgi/content/full/182/6/492">bjp.rcpsych.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="67"><a href="#citable__67"><strong>^</strong></a> <c_txt>Although all SSRIs (including citalopram and escitalopram) appear to be equally effective, individual patients may respond well to one medication and not to another.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid11206597_77_0" class="reference"><a href="#cite_note-pmid11206597-77"><span>[</span>78<span>]</span></a></sup> Previous unsuccessful treatment with <a href="/Benzodiazepine" title="Benzodiazepine">benzodiazepines</a> did not diminish its efficacy.<sup id="wikipedia_cite_ref_pmid11199932_78_0" class="reference"><a href="#cite_note-pmid11199932-78"><span>[</span>79<span>]</span></a></sup> <a name="citable__206" class="citable__local-anchor">.</a><span class='citationPopup' rel="206">However, the response rate was lower for the patients with more severe panic.</span><span class="citable__li" citable_id="206"><a href="#citable__206"><strong>^</strong></a> <c_txt>Several of these studies demonstrate that higher continuation rates (and lower dropout rates) of paroxetine contribute to its superior cost-effectiveness over TCAs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="206"><a href="#citable__206"><strong>^</strong></a> <c_txt>More paroxetine treated patients (n=151) responded than those receiving placebo (n=156) as defined by a CGI-improvement rating of much or very much improved.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="206"><a href="#citable__206"><strong>^</strong></a> <c_txt>However, it should be noted that the criterion of abstinence was less severe in the current study (consumption of more than 50 g of alcohol) than in the acamprosate study (any alcohol consumption at all).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://alcalc.oxfordjournals.org/cgi/content/full/38/6/619">alcalc.oxfordjournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid11206597_77_1" class="reference"><a href="#cite_note-pmid11206597-77"><span>[</span>78<span>]</span></a></sup> <a name="citable__243" class="citable__local-anchor">.</a><span class='citationPopup' rel="243">Double-blind comparative studies found sertraline to have the same effect on panic disorder as <a href="/Paroxetine" title="Paroxetine">paroxetine</a> (Paxil)<sup id="wikipedia_cite_ref_pmid15096081_79_0" class="reference"><a href="#cite_note-pmid15096081-79"><span>[</span>80<span>]</span></a></sup> or the gold standard of panic disorder treatment <a href="/Alprazolam" title="Alprazolam">alprazolam</a> (Xanax).</span><span class="citable__li" citable_id="243"><a href="#citable__243"><strong>^</strong></a> <c_txt>Pohl RB, Wolkow RM, Clary CM. Sertraline in the treatment of panic disorder: a double-blind multicenter trial.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://archpsyc.ama-assn.org/cgi/content/full/58/7/681">archpsyc.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="243"><a href="#citable__243"><strong>^</strong></a> <c_txt>DESIGN The study was a double-blind placebo-controlled trial of the efficacy of early coadministration of clonazepam with sertraline for the treatment of active panic disorder.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://archpsyc.ama-assn.org/cgi/content/full/58/7/681">archpsyc.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="243"><a href="#citable__243"><strong>^</strong></a> <c_txt>A 1 year double-blind placebo controlled fixed dose study of sertraline in the treatment of obsessive-compulsive disorder.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (PIM 177)</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.inchem.org/documents/pims/pharm/pim177.htm">www.inchem.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid16053461_80_0" class="reference"><a href="#cite_note-pmid16053461-80"><span>[</span>81<span>]</span></a></sup> <a name="citable__43" class="citable__local-anchor">.</a><span class='citationPopup' rel="43">While imprecise, comparison of the results of trials of sertraline with separate trials of other anti-panic agents (<a href="/Clomipramine" title="Clomipramine">clomipramine</a> (Anafranil), <a href="/Imipramine" title="Imipramine">imipramine</a> (Tofranil), <a href="/Clonazepam" title="Clonazepam">clonazepam</a> (Klonopin), alprazolam, <a href="/Fluvoxamine" title="Fluvoxamine">fluvoxamine</a> (Luvox) and paroxetine) indicates approximate equivalence of these medications.</span><span class="citable__li" citable_id="43"><a href="#citable__43"><strong>^</strong></a> <c_txt>Although meta-analyses of placebo-controlled trials suggest greater efficacy for clomipramine than for fluoxetine, fluvoxamine, and sertraline , the results of head-to-head trials comparing clomipramine and selective serotonin reuptake inhibitors (SSRIs) directly do not support this impression.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="43"><a href="#citable__43"><strong>^</strong></a> <c_txt>SEE ALSO on PsychiatryOnline: - clomipramine - cognitive therapy - fluoxetine - fluvoxamine - obsessive-compulsive disorder - paroxetine - psychotherapy - serotonin uptake inhibitors - sertraline - therapeutic alliance more...</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="43"><a href="#citable__43"><strong>^</strong></a> <c_txt>Choosing a Specific Pharmacological Treatment Clomipramine, fluoxetine, fluvoxamine, paroxetine, and sertraline , which are approved by the U.S. Food and Drug Administration (FDA) for treatment of OCD, are recommended pharmacological agents [I].</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid10945134_75_1" class="reference"><a href="#cite_note-pmid10945134-75"><span>[</span>76<span>]</span></a></sup> <a name="citable__217" class="citable__local-anchor">.</a><span class='citationPopup' rel="217">Although panic disorder is considered to be a chronic condition, continuous treatment may not be necessary for everyone.</span><span class="citable__li" citable_id="217"><a href="#citable__217"><strong>^</strong></a> <c_txt>Obsessive-compulsive disorder panic attacks obsessive compulsive disorder OCD n 216 panic veterans the attend 12 treatment sessions.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Blagues sur l�informatique</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.humour.com/Blagues/blagues.asp?page=8366&VIDThemeBlague=24&srch=TH">www.humour.com</a> [Source type: General]</li><li> <em><c_title>Blagues sur l�informatique</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.humour.com/Blagues/blagues.asp?page=8353&VIDThemeBlague=24&srch=TH">www.humour.com</a> [Source type: General]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="217"><a href="#citable__217"><strong>^</strong></a> <c_txt>Pohl RB, Wolkow RM, Clary CM. Sertraline in the treatment of panic disorder: a double-blind multicenter trial.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://archpsyc.ama-assn.org/cgi/content/full/58/7/681">archpsyc.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="217"><a href="#citable__217"><strong>^</strong></a> <c_txt>Paroxetine in the treatment of chronic post-traumatic stress disorder: results of a placebo-controlled, flexible dosage trial.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> In a double-blind discontinuation trial, abruptly stopping sertraline after one year of successful treatment resulted in relapse of the disorder in 33% of the patients vs. 13% of those who continued taking sertraline over the following 28 weeks. <a name="citable__66" class="citable__local-anchor">.</a><span class='citationPopup' rel="66">The patients experienced distinct <a href="/Sertraline" title="Sertraline">withdrawal syndrome</a>, expressed primarily as insomnia and dizziness, and the authors noted that a significant part of the relapse rate among the discontinued patients could possibly be accounted for by the withdrawal syndrome.</span><span class="citable__li" citable_id="66"><a href="#citable__66"><strong>^</strong></a> <c_txt>There are clearly patients who feel a withdrawal syndrome, although the literature is pretty sparse about this problem.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="66"><a href="#citable__66"><strong>^</strong></a> <c_txt>In medication discontinuation trials, rates of relapse or trial discontinuation for insufficient clinical response are substantial but vary widely because of major methodological differences across studies.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="66"><a href="#citable__66"><strong>^</strong></a> <c_txt>For many, a long acting medication like fluoxetine ( Prozac ) is preferred for avoiding withdrawal symptoms (dizziness, nausea, insomnia, headache, sweating) experienced when stopping or switching from other antidepressants.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid11722304_81_0" class="reference"><a href="#cite_note-pmid11722304-81"><span>[</span>82<span>]</span></a></sup> <a name="citable__177" class="citable__local-anchor">.</a><span class='citationPopup' rel="177">Confirming these hypotheses, in another study, gradual discontinuation of sertraline after 12 weeks of treatment did not lead to the return of panic symptoms.</span><span class="citable__li" citable_id="177"><a href="#citable__177"><strong>^</strong></a> <c_txt>Obsessive-compulsive disorder panic attacks obsessive compulsive disorder OCD n 216 panic veterans the attend 12 treatment sessions.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Blagues sur l�informatique</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.humour.com/Blagues/blagues.asp?page=8366&VIDThemeBlague=24&srch=TH">www.humour.com</a> [Source type: General]</li><li> <em><c_title>Blagues sur l�informatique</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.humour.com/Blagues/blagues.asp?page=8353&VIDThemeBlague=24&srch=TH">www.humour.com</a> [Source type: General]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="177"><a href="#citable__177"><strong>^</strong></a> <c_txt>Discontinuing Active Treatment Successful medication treatment should be continued for 1–2 years before considering a gradual taper by decrements of 10%–25% every 1–2 months while observing for symptom return or exacerbation [I].</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="177"><a href="#citable__177"><strong>^</strong></a> <c_txt>After 4 weeks of treatment with the sertraline/clonazepam combination (at visit 5, end of week 4 of the trial), we tapered the doses for patients receiving the clonazepam/placebo over a 3-week period.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://archpsyc.ama-assn.org/cgi/content/full/58/7/681">archpsyc.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__229" class="citable__local-anchor">.</a><span class='citationPopup' rel="229">In the same study, discontinuation of paroxetine caused exacerbation of panic in about a fifth of the previously responding patients.</span><span class="citable__li" citable_id="229"><a href="#citable__229"><strong>^</strong></a> <c_txt>Seventeen sertraline-treated patients (9%) and 5 placebo patients (3%) prematurely discontinued the study because of adverse events.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="229"><a href="#citable__229"><strong>^</strong></a> <c_txt>More paroxetine treated patients (n=151) responded than those receiving placebo (n=156) as defined by a CGI-improvement rating of much or very much improved.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="229"><a href="#citable__229"><strong>^</strong></a> <c_txt>A previous study by our group documented the early antipanic efficacy of an imipramine/alprazolam regimen for the stabilization treatment of panic disorder.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://archpsyc.ama-assn.org/cgi/content/full/58/7/681">archpsyc.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__106" class="citable__local-anchor">.</a><span class='citationPopup' rel="106">The authors attributed this difference to the more severe withdrawal syndrome with paroxetine, which even discontinuation over three weeks could not remedy.</span><span class="citable__li" citable_id="106"><a href="#citable__106"><strong>^</strong></a> <c_txt>The withdrawal syndrome(if it occurs)may occur up to three weeks after stopping zoloft.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="106"><a href="#citable__106"><strong>^</strong></a> <c_txt>The clinician must keep these facts in mind when treating patients with drugs dependent on these hepatic isoenzymes for their clearance, even many weeks after the discontinuation of fluoxetine .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>S. Preskorn M.D. SSRI's: prozac, paxil, zoloft, luvox, effexor, serzone, anafranil, fenfluramine, fen-phen, redux.</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.outlookcities.com/psych/Dr_Preskorn.htm">www.outlookcities.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="106"><a href="#citable__106"><strong>^</strong></a> <c_txt>Several times in the last year alone, we have found ourselves wanting to build out something we hadn't even conceived of three weeks earlier, especially when there was a disruption in the marketplace that was directly related to our vision.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>802.11me: Market Approach: Goals, Not Competitors</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.burningdoor.com/dick/archives/001438.html?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+dick+%28My+Weblog%29">www.burningdoor.com</a> [Source type: General]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid15096081_79_1" class="reference"><a href="#cite_note-pmid15096081-79"><span>[</span>80<span>]</span></a></sup></div> <div style="display:table-cell;clear:both;"></div><h3><span class="mw-headline" id="wikipedia_Social_phobia">Social phobia</span></h3> <div style="margin: 1.12em 0; display:block"><a name="citable__294" class="citable__local-anchor">.</a><span class='citationPopup' rel="294">Sertraline has been successfully used for the treatment of social phobia (<a href="/Social_anxiety_disorder" title="Social anxiety disorder">social anxiety disorder</a>).</span><span class="citable__li" citable_id="294"><a href="#citable__294"><strong>^</strong></a> <c_txt>May be used in the treatment of social anxiety disorder.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Zoloft Side Effects, User Reviews and Expert Help</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://rateadrug.com/Zoloft-side-effects.aspx">rateadrug.com</a> [Source type: General]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="294"><a href="#citable__294"><strong>^</strong></a> <c_txt>Pohl RB, Wolkow RM, Clary CM. Sertraline in the treatment of panic disorder: a double-blind multicenter trial.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://archpsyc.ama-assn.org/cgi/content/full/58/7/681">archpsyc.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="294"><a href="#citable__294"><strong>^</strong></a> <c_txt>DESIGN The study was a double-blind placebo-controlled trial of the efficacy of early coadministration of clonazepam with sertraline for the treatment of active panic disorder.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://archpsyc.ama-assn.org/cgi/content/full/58/7/681">archpsyc.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid17092192_82_0" class="reference"><a href="#cite_note-pmid17092192-82"><span>[</span>83<span>]</span></a></sup> <a name="citable__8" class="citable__local-anchor">.</a><span class='citationPopup' rel="8">In a flexible dosing study, it appeared that a higher dose range was needed for adequate response.</span><span class="citable__li" citable_id="8"><a href="#citable__8"><strong>^</strong></a> <c_txt>This disputes the observation in most other PTSD trials that higher doses are needed for treatment of the disorder.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="8"><a href="#citable__8"><strong>^</strong></a> <c_txt>Finally, the study has been criticized because it uses doses for risperidone that are higher (6 mg/day) and doses of olanzapine that are lower (10 mg/day) than is customary in clinical practice.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="8"><a href="#citable__8"><strong>^</strong></a> <c_txt>Higher doses may also be appropriate for patients who have had little response to treatment and are tolerating a medication well [I].</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__17" class="citable__local-anchor">.</a><span class='citationPopup' rel="17">Furthermore, improvement was achieved slowly, separating from the placebo response only by week six, and continuing to increase until week 12.<sup id="wikipedia_cite_ref_pmid12934979_83_0" class="reference"><a href="#cite_note-pmid12934979-83"><span>[</span>84<span>]</span></a></sup> The response was higher among the patients with later onset, especially adult onset, of the disorder.</span><span class="citable__li" citable_id="17"><a href="#citable__17"><strong>^</strong></a> <c_txt>INTERVENTION: Patients were randomly assigned to receive a flexible dosage (50-200 mg/d) of sertraline (n = 189) or matching placebo tablets (n = 187) for 10 weeks.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="17"><a href="#citable__17"><strong>^</strong></a> <c_txt>RESULTS: Sertraline-treated patients experienced statistically significantly greater improvement than placebo patients on the CDRS-R total score (mean change at week 10, -30.24 vs -25.83, respectively; P =.001; overall mean change, -22.84 vs -20.19, respectively; P =.007).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="17"><a href="#citable__17"><strong>^</strong></a> <c_txt>Hertzberg et al (1999) studied lamotrigine for PTSD in a 12-week double-blind, randomized (2:1) placebo-controlled trial.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid14709946_3_1" class="reference"><a href="#cite_note-pmid14709946-3"><span>[</span>4<span>]</span></a></sup> Among the different rating scales, the clinician-rated global improvement demonstrated the highest difference vs. placebo, while the patient self-rated quality of life differed from placebo only modestly. The greatest improvement of quality of life was observed among the most impaired patients.<sup id="wikipedia_cite_ref_pmid12934979_83_1" class="reference"><a href="#cite_note-pmid12934979-83"><span>[</span>84<span>]</span></a></sup> <a name="citable__36" class="citable__local-anchor">.</a><span class='citationPopup' rel="36">In addition to psychological components of social phobia, such as fear and avoidance, sertraline also ameliorated some physiological components, such as blushing and palpitations but not sweating and trembling.</span><span class="citable__li" citable_id="36"><a href="#citable__36"><strong>^</strong></a> <c_txt>Zoloft withdrawal Anxiety Attack - Sudden and intense feelings of fear, terror, and dread physically creating shortness of breath, sweating, trembling and heart palpitations.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="36"><a href="#citable__36"><strong>^</strong></a> <c_txt>Paroxetine, fluoxetine, and sertraline were similar in the magnitude and time course of their effectiveness in ameliorating depression as well as improving other psychological outcomes, social and work functioning, and multiple other domains of health-related quality of life.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>JAMA -- Similar Effectiveness of Paroxetine, Fluoxetine, and Sertraline in Primary Care: A Randomized Trial, December 19, 2001, Kroenke et al. 286 (23): 2947</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://jama.ama-assn.org/cgi/content/full/286/23/2947">jama.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="36"><a href="#citable__36"><strong>^</strong></a> <c_txt>The selectivity of sertraline may account for the lower incidence of some adverse effects such as sedation, orthostatic hypotension and anticholinergic effects (Pfizer lab., 1996).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (PIM 177)</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.inchem.org/documents/pims/pharm/pim177.htm">www.inchem.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid16216019_84_0" class="reference"><a href="#cite_note-pmid16216019-84"><span>[</span>85<span>]</span></a></sup> <a name="citable__78" class="citable__local-anchor">.</a><span class='citationPopup' rel="78">In a four-way placebo-controlled comparison trial of sertraline and exposure therapy, sertraline performed significantly better than placebo, while the exposure therapy resulted in only marginal improvement.</span><span class="citable__li" citable_id="78"><a href="#citable__78"><strong>^</strong></a> <c_txt>A double-blind, placebo-controlled trial.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://alcalc.oxfordjournals.org/cgi/content/full/38/6/619">alcalc.oxfordjournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="78"><a href="#citable__78"><strong>^</strong></a> <c_txt>RESULTS: Sertraline-treated patients experienced statistically significantly greater improvement than placebo patients on the CDRS-R total score (mean change at week 10, -30.24 vs -25.83, respectively; P =.001; overall mean change, -22.84 vs -20.19, respectively; P =.007).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="78"><a href="#citable__78"><strong>^</strong></a> <c_txt>Although meta-analyses of placebo-controlled trials suggest greater efficacy for clomipramine than for fluoxetine, fluvoxamine, and sertraline , the results of head-to-head trials comparing clomipramine and selective serotonin reuptake inhibitors (SSRIs) directly do not support this impression.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__262" class="citable__local-anchor">.</a><span class='citationPopup' rel="262">The combination of sertraline and exposure therapy was not significantly better than sertraline alone; however, it appeared that the response was achieved faster with the combined treatment.</span><span class="citable__li" citable_id="262"><a href="#citable__262"><strong>^</strong></a> <c_txt>Multivariate regression analysis revealed that sertraline use resulted in significantly lower direct medical costs than TCAs for one year of treatment following initiation of therapy ($168 per patient, or 21% less than TCAs).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="262"><a href="#citable__262"><strong>^</strong></a> <c_txt>However, in neither of these cases, did treatment costs increase by more than 3%.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="262"><a href="#citable__262"><strong>^</strong></a> <c_txt>Combined SRI and CBT treatment may be provided when the patient has a co-occurring disorder that is SRI-responsive [I] or has a partial response to monotherapy [II].</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid11435264_85_0" class="reference"><a href="#cite_note-pmid11435264-85"><span>[</span>86<span>]</span></a></sup></div> <div style="display:table-cell;clear:both;"></div><h3><span class="mw-headline" id="wikipedia_Premenstrual_dysphoric_disorder">Premenstrual dysphoric disorder</span></h3> <div style="margin: 1.12em 0; display:block"><a name="citable__171" class="citable__local-anchor">.</a><span class='citationPopup' rel="171">According to several double-blind studies, sertraline is effective in alleviating the symptoms of <a href="/Premenstrual_dysphoric_disorder" title="Premenstrual dysphoric disorder">PMDD</a>, a severe form of <a href="/Premenstrual_syndrome" title="Premenstrual syndrome">premenstrual syndrome</a>.</span><span class="citable__li" citable_id="171"><a href="#citable__171"><strong>^</strong></a> <c_txt>Hertzberg et al (1999) studied lamotrigine for PTSD in a 12-week double-blind, randomized (2:1) placebo-controlled trial.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="171"><a href="#citable__171"><strong>^</strong></a> <c_txt>Sertraline premenstrual dysphoric, disorder PMDD. MAKE sure your reactions in the clinical need.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Blagues sur l�informatique</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.humour.com/Blagues/blagues.asp?page=8366&VIDThemeBlague=24&srch=TH">www.humour.com</a> [Source type: General]</li><li> <em><c_title>Blagues sur l�informatique</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.humour.com/Blagues/blagues.asp?page=8353&VIDThemeBlague=24&srch=TH">www.humour.com</a> [Source type: General]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="171"><a href="#citable__171"><strong>^</strong></a> <c_txt>Several of these studies demonstrate that higher continuation rates (and lower dropout rates) of paroxetine contribute to its superior cost-effectiveness over TCAs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> Significant improvement was observed in 50–60% of cases treated with sertraline vs. 20–30% of cases on placebo. <a name="citable__125" class="citable__local-anchor">.</a><span class='citationPopup' rel="125">The improvement began during the first week of treatment, and in addition to mood, irritability, and anxiety, improvement was reflected in better family functioning, social activity and general quality of life.</span><span class="citable__li" citable_id="125"><a href="#citable__125"><strong>^</strong></a> <c_txt>Second, are there any potential side effects to the baby if Zoloft is continued or during the first eight weeks the medication was taken.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="125"><a href="#citable__125"><strong>^</strong></a> <c_txt>Table 2 summarizes depression and other psychological outcomes by SSRI treatment group, and Table 3 summarizes work, social, and other health-related quality of life outcomes.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>JAMA -- Similar Effectiveness of Paroxetine, Fluoxetine, and Sertraline in Primary Care: A Randomized Trial, December 19, 2001, Kroenke et al. 286 (23): 2947</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://jama.ama-assn.org/cgi/content/full/286/23/2947">jama.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="125"><a href="#citable__125"><strong>^</strong></a> <c_txt>Thus, ongoing goals of treatment include decreasing symptom frequency and severity, improving the patient's functioning, and helping the patient to improve his or her quality of life [I].</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__90" class="citable__local-anchor">.</a><span class='citationPopup' rel="90">Work functioning and physical symptoms, such as swelling, bloating and breast tenderness, were less responsive to sertraline.</span><span class="citable__li" citable_id="90"><a href="#citable__90"><strong>^</strong></a> <c_txt>There are over 150 symptoms including eating binges, behavioral changes, moodiness, irritability, fatigue, fluid retention, breast tenderness, headaches, bloating, anxiety, and depression.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="90"><a href="#citable__90"><strong>^</strong></a> <c_txt>Reply It took less than a month on the generic Sertraline for all my physical symptoms to reappear.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="90"><a href="#citable__90"><strong>^</strong></a> <c_txt>Secondary outcomes included other depression and psychological measures, multiple measures of social and work functioning, and other domains of health-related quality of life, such as physical functioning, concentration and memory, vitality, bodily pain, sleep, and sexual functioning.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>JAMA -- Similar Effectiveness of Paroxetine, Fluoxetine, and Sertraline in Primary Care: A Randomized Trial, December 19, 2001, Kroenke et al. 286 (23): 2947</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://jama.ama-assn.org/cgi/content/full/286/23/2947">jama.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_86" class="reference"><a href="#cite_note-86"><span>[</span>87<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid12215058_87_0" class="reference"><a href="#cite_note-pmid12215058-87"><span>[</span>88<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid11972726_88_0" class="reference"><a href="#cite_note-pmid11972726-88"><span>[</span>89<span>]</span></a></sup> <a name="citable__70" class="citable__local-anchor">.</a><span class='citationPopup' rel="70">Despite the well-known sexual side effects of sertraline, significantly higher improvement of <a href="/Sexual_function" title="Sexual function">sexual functioning</a> was achieved by the sertraline group as compared to the placebo group.</span><span class="citable__li" citable_id="70"><a href="#citable__70"><strong>^</strong></a> <c_txt>Zoloft cause sexual side effects?</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft, Sertraline Forum - Topix</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.topix.net/forum/drug/zoloft">www.topix.net</a> [Source type: General]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="70"><a href="#citable__70"><strong>^</strong></a> <c_txt>The clozapine group showed improvements in PANSS scores relative to the haloperidol group, as well as significantly higher scores on QOL and EPS assessment scales.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="70"><a href="#citable__70"><strong>^</strong></a> <c_txt>A significantly higher proportion of patients in both the intent-to-treat and completer analysis were rated by GPs as "somewhat improved" or "very much improved" for sertraline than for the TCA group.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid14754784_89_0" class="reference"><a href="#cite_note-pmid14754784-89"><span>[</span>90<span>]</span></a></sup> <a name="citable__136" class="citable__local-anchor">.</a><span class='citationPopup' rel="136">A three-way comparison of sertraline, <a href="/Norepinephrine_reuptake_inhibitor" title="Norepinephrine reuptake inhibitor">norepinephrine reuptake inhibitor</a> <a href="/Tricyclic_antidepressant" title="Tricyclic antidepressant">tricyclic antidepressant</a> <a href="/Desipramine" title="Desipramine">desipramine</a>, and placebo demonstrated the superiority of sertraline, while desipramine fared no better than placebo.</span><span class="citable__li" citable_id="136"><a href="#citable__136"><strong>^</strong></a> <c_txt>WESTPORT, CT (Reuters Health) Dec 28 – Significantly more instances of deliberate self-harm occur in patients prescribed a selective serotonin reuptake inhibitor (SSRI) than in those prescribed a tricyclic antidepressant (TCA).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.drugawareness.org/tag/zoloft">www.drugawareness.org</a> [Source type: General]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="136"><a href="#citable__136"><strong>^</strong></a> <c_txt>There is also no clear data to demonstrate that these antidepressants are substantially better than placebo more than half the time.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="136"><a href="#citable__136"><strong>^</strong></a> <c_txt>Although meta-analyses of placebo-controlled trials suggest greater efficacy for clomipramine than for fluoxetine, fluvoxamine, and sertraline , the results of head-to-head trials comparing clomipramine and selective serotonin reuptake inhibitors (SSRIs) directly do not support this impression.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid10530636_90_0" class="reference"><a href="#cite_note-pmid10530636-90"><span>[</span>91<span>]</span></a></sup> <a name="citable__84" class="citable__local-anchor">.</a><span class='citationPopup' rel="84">Taking sertraline only during the <a href="/Luteal_phase" title="Luteal phase">luteal phase</a>, that is, the 12–14 days before menses, was shown to work as well as continuous treatment.</span><span class="citable__li" citable_id="84"><a href="#citable__84"><strong>^</strong></a> <c_txt>Greenstone brand sertraline worked well for me for a while.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="84"><a href="#citable__84"><strong>^</strong></a> <c_txt>Sertraline treatment was generally well tolerated.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="84"><a href="#citable__84"><strong>^</strong></a> <c_txt>It has been shown to be safe in the long-term treatment of pediatric OCD. Zoloft is the only SSRI approved for the long-term treatment of PTSD. Over the past decade, Zoloft has been used for more than 10.2 billion patient days of therapy worldwide.* .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid14754784_89_1" class="reference"><a href="#cite_note-pmid14754784-89"><span>[</span>90<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid10418540_91_0" class="reference"><a href="#cite_note-pmid10418540-91"><span>[</span>92<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid12468166_92_0" class="reference"><a href="#cite_note-pmid12468166-92"><span>[</span>93<span>]</span></a></sup> <a name="citable__150" class="citable__local-anchor">.</a><span class='citationPopup' rel="150">Although the luteal-phase treatment may be more acceptable to patients, there have been indications that by the end of a three-month period it is less well-tolerated than the continuous treatment.</span><span class="citable__li" citable_id="150"><a href="#citable__150"><strong>^</strong></a> <c_txt>For FREE SHIPPING with purchase of $70 or more order weight must be less than 7 Lbs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Buy Top Herbal & Nutritional Supplements Brands Products on Discount</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.getnutri.com/brand.asp?name=NutriBiotic">www.getnutri.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="150"><a href="#citable__150"><strong>^</strong></a> <c_txt>After 4 weeks of treatment with the sertraline/clonazepam combination (at visit 5, end of week 4 of the trial), we tapered the doses for patients receiving the clonazepam/placebo over a 3-week period.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://archpsyc.ama-assn.org/cgi/content/full/58/7/681">archpsyc.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="150"><a href="#citable__150"><strong>^</strong></a> <c_txt>There are clearly patients who feel a withdrawal syndrome, although the literature is pretty sparse about this problem.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <a name="citable__124" class="citable__local-anchor">.</a><span class='citationPopup' rel="124">The study authors suggested that the continuous treatment may allow the tolerance to side effects of sertraline to develop faster.</span><span class="citable__li" citable_id="124"><a href="#citable__124"><strong>^</strong></a> <c_txt>Sertraline treatment was generally well tolerated.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="124"><a href="#citable__124"><strong>^</strong></a> <c_txt>That sertraline treatment rescued the impaired epinephrine response in recurrent hypoglycemic rats suggests that serotonergic mechanisms may contribute to the development of defective hypoglycemia-induced adrenomedullary secretion, a component of HAAF. Collectively, our findings from both 6- and 20-day treatment studies clearly demonstrate an enhancement of hormonal CRRs under conditions of single or recurrent hypoglycemia.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia -- Sanders et al. 294 (5): E853 -- AJP - Endocrinology and Metabolism</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://ajpendo.physiology.org/cgi/content/full/294/5/E853">ajpendo.physiology.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="124"><a href="#citable__124"><strong>^</strong></a> <c_txt>Second, are there any potential side effects to the baby if Zoloft is continued or during the first eight weeks the medication was taken.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid14754784_89_2" class="reference"><a href="#cite_note-pmid14754784-89"><span>[</span>90<span>]</span></a></sup> The most recent (2006) trial findings indicate that continuous treatment with sub-therapeutic doses of sertraline (25 mg vs. usual 50–100 mg) may both afford the highest effectiveness and minimize the side effects.<sup id="wikipedia_cite_ref_pmid17107257_93_0" class="reference"><a href="#cite_note-pmid17107257-93"><span>[</span>94<span>]</span></a></sup></div> <div style="display:table-cell;clear:both;"></div><h3><span class="mw-headline" id="wikipedia_Posttraumatic_stress_disorder">Posttraumatic stress disorder</span></h3> <div style="margin: 1.12em 0; display:block"><a name="citable__306" class="citable__local-anchor">.</a><span class='citationPopup' rel="306">Two double-blind placebo-controlled studies confirmed the efficacy of sertraline for severe chronic <a href="/PTSD" title="PTSD" class="mw-redirect">PTSD</a> in civilians, with the mean duration of the illness more than ten years.</span><span class="citable__li" citable_id="306"><a href="#citable__306"><strong>^</strong></a> <c_txt>Efficacy and safety of paroxetine treatment for chronic PTSD: a fixed-dose, placebo-controlled study.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="306"><a href="#citable__306"><strong>^</strong></a> <c_txt>Efficacy of sertraline in preventing relapse of posttraumatic stress disorder: results of a 28-week double-blind, placebo-controlled study.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="306"><a href="#citable__306"><strong>^</strong></a> <c_txt>Sertraline has been studied in two 12-week, double-blind, placebo controlled trials.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__30" class="citable__local-anchor">.</a><span class='citationPopup' rel="30">Physical or sexual assault was the traumatic event for more than 60% of the subjects, and 75% of them were women.</span><span class="citable__li" citable_id="30"><a href="#citable__30"><strong>^</strong></a> <c_txt>High doses–more than 4 milligrams a day–of this medication taken for long intervals may cause emotional and physical dependence.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Cheap Zoloft - blastpassemranch.com</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.blastpassemranch.com/">www.blastpassemranch.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="30"><a href="#citable__30"><strong>^</strong></a> <c_txt>After 3 months, fewer patients (0/8) in the propranolol group had a physiologic response upon reminder of the traumatic event than in the placebo group (6/14) (p=0.04).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="30"><a href="#citable__30"><strong>^</strong></a> <c_txt>Subjects were more improved when they were taking prazosin than when they were taking placebo on the CAPS-distressing dream item (six item scale), as well as on the overall CGI. .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> Over the 12-week period, 53–60% of the patients treated with sertraline were much or very much improved vs. 32–38% for placebo.<sup id="wikipedia_cite_ref_pmid11343529_4_1" class="reference"><a href="#cite_note-pmid11343529-4"><span>[</span>5<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid10770145_94_0" class="reference"><a href="#cite_note-pmid10770145-94"><span>[</span>95<span>]</span></a></sup> <a name="citable__300" class="citable__local-anchor">.</a><span class='citationPopup' rel="300">The treatment was continued for another year with some participants from both trials.</span><span class="citable__li" citable_id="300"><a href="#citable__300"><strong>^</strong></a> <c_txt>Thus, discontinuation of pharmacotherapy should be carefully considered, and for most patients, continued treatment of some form is recommended [II].</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="300"><a href="#citable__300"><strong>^</strong></a> <c_txt>Another historical comparator retrospective study compares clozapine (n=133) to conventionals (n=51) one year prior to and two years after therapy in treatment-resistant patients.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="300"><a href="#citable__300"><strong>^</strong></a> <c_txt>Results indicated that a dramatic decrease in the frequency and cost of rehospitalization contributed to a significant decrease in cost of treatment for patients who continued clozapine treatment for at least two years.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__103" class="citable__local-anchor">.</a><span class='citationPopup' rel="103">The condition of the responders further improved; some of the patients who did not respond to the initial 12-week trial slowly improved as well, so that about half of them were classified as responders by the end of the following 24 weeks.</span><span class="citable__li" citable_id="103"><a href="#citable__103"><strong>^</strong></a> <c_txt>We usually cut the dosage slowly for patients who experience the syndrome.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="103"><a href="#citable__103"><strong>^</strong></a> <c_txt>After 4 weeks of treatment with the sertraline/clonazepam combination (at visit 5, end of week 4 of the trial), we tapered the doses for patients receiving the clonazepam/placebo over a 3-week period.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://archpsyc.ama-assn.org/cgi/content/full/58/7/681">archpsyc.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="103"><a href="#citable__103"><strong>^</strong></a> <c_txt>Hertzberg et al (1999) studied lamotrigine for PTSD in a 12-week double-blind, randomized (2:1) placebo-controlled trial.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__46" class="citable__local-anchor">.</a><span class='citationPopup' rel="46">The authors noted that the medication worked more slowly for those with more severe symptoms.</span><span class="citable__li" citable_id="46"><a href="#citable__46"><strong>^</strong></a> <c_txt>However, it should be noted that the criterion of abstinence was less severe in the current study (consumption of more than 50 g of alcohol) than in the acamprosate study (any alcohol consumption at all).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://alcalc.oxfordjournals.org/cgi/content/full/38/6/619">alcalc.oxfordjournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="46"><a href="#citable__46"><strong>^</strong></a> <c_txt>Combined treatment or treatment with an SRI alone may also be considered in patients with severe OCD, since the medication may diminish symptom severity sufficiently to allow the patient to engage in CBT [II].</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="46"><a href="#citable__46"><strong>^</strong></a> <c_txt>Do you think that if I decreased the dosage very, very slowly (like over a month or more), that the withdrawal symptoms would be more tolerable?</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid11411812_95_0" class="reference"><a href="#cite_note-pmid11411812-95"><span>[</span>96<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid16734498_96_0" class="reference"><a href="#cite_note-pmid16734498-96"><span>[</span>97<span>]</span></a></sup> Discontinuation of the successful treatment after six months resulted in the return of the PTSD symptoms in 52% of the patients vs. 16% in those who continued taking sertraline.<sup id="wikipedia_cite_ref_pmid11729012_97_0" class="reference"><a href="#cite_note-pmid11729012-97"><span>[</span>98<span>]</span></a></sup> <a name="citable__58" class="citable__local-anchor">.</a><span class='citationPopup' rel="58">Longer-term treatment has been advocated in such cases.</span><span class="citable__li" citable_id="58"><a href="#citable__58"><strong>^</strong></a> <c_txt>In terms of poor impulse controls the use of a mood stabilizer such as valproate, carbamazepine, or lithium may be helpful as accessed by case reports.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid16734498_96_1" class="reference"><a href="#cite_note-pmid16734498-96"><span>[</span>97<span>]</span></a></sup></div> <div style="margin: 1.12em 0; display:block"><a name="citable__290" class="citable__local-anchor">.</a><span class='citationPopup' rel="290">Three-way (placebo–sertraline–third antidepressant) comparison trials of sertraline for PTSD found it to be better than placebo and equivalent to <a href="/Venlafaxine" title="Venlafaxine">venlafaxine</a> (Effexor)<sup id="wikipedia_cite_ref_pmid16702890_98_0" class="reference"><a href="#cite_note-pmid16702890-98"><span>[</span>99<span>]</span></a></sup> or <a href="/Citalopram" title="Citalopram">citalopram</a> (Celexa),<sup id="wikipedia_cite_ref_pmid14608246_99_0" class="reference"><a href="#cite_note-pmid14608246-99"><span>[</span>100<span>]</span></a></sup> and in a two-way comparison it had the same efficacy as <a href="/Nefazodone" title="Nefazodone">nefazodone</a> (Serzone).</span><span class="citable__li" citable_id="290"><a href="#citable__290"><strong>^</strong></a> <c_txt>A. Bupropion, bupropion SR, budeprion XL citalopram, fluoxetine, fluvoxamine, maprotiline, paroxetine, sertraline, venlafaxine , Celexa, Cymbalta, Effexor, Lexapro, Paxil, Pexeva, Prozac, Prozac Weekly, Rapiflux, Wellbutrin, Wellbutrin SR and Zoloft may be subject to quantity limits.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Antidepressants - Pharmacy Clinical Policy Bulletins Aetna Non-Medicare Prescription Drug Plan</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.aetna.com/products/rxnonmedicare/data/2007/CNS/antidepressants_2007.html">www.aetna.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="290"><a href="#citable__290"><strong>^</strong></a> <c_txt>Intolerance to one generic preferred alternative agent - budeprion, budeprion XL, bupropion, bupropion SR, citalopram, fluoxetine, fluvoxamine, paroxetine, mirtazapine, sertraline, trazodone or venlafaxine OR Contraindication to one generic preferred alternative agent - budeprion, budeprion XL, bupropion, bupropion SR, citalopram, fluoxetine, fluvoxamine, paroxetine, mirtazapine, sertraline, trazodone or venlafaxine OR Allergy to one generic preferred alternative agent - budeprion, budeprion XL, bupropion, bupropion SR, citalopram, fluoxetine, fluvoxamine, paroxetine, mirtazapine, sertraline, trazodone or venlafaxine OR Failure of an adequate trial of one month of one generic preferred alternative agent - budeprion, budeprion XL, bupropion, bupropion SR, citalopram, fluoxetine, fluvoxamine, paroxetine, mirtazapine, sertraline, trazodone or venlafaxine OR B. Member is documented to be currently stabilized on Effexor XR ONLY .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.aetna.com/products/rxmedicare/data/Medicare2007/CNS/antidepressants_2007.html">www.aetna.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="290"><a href="#citable__290"><strong>^</strong></a> <c_txt>Although meta-analyses of placebo-controlled trials suggest greater efficacy for clomipramine than for fluoxetine, fluvoxamine, and sertraline , the results of head-to-head trials comparing clomipramine and selective serotonin reuptake inhibitors (SSRIs) directly do not support this impression.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> PsychiatryOnline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.psychiatryonline.com/content.aspx?aID=149217&searchStr=sertraline">www.psychiatryonline.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid15129422_100_0" class="reference"><a href="#cite_note-pmid15129422-100"><span>[</span>101<span>]</span></a></sup> Sertraline was not effective for veterans with combat-related PTSD.<sup id="wikipedia_cite_ref_pmid11910265_101_0" class="reference"><a href="#cite_note-pmid11910265-101"><span>[</span>102<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid17503980_102_0" class="reference"><a href="#cite_note-pmid17503980-102"><span>[</span>103<span>]</span></a></sup></div> <div style="display:table-cell;clear:both;"></div><h3><span class="mw-headline" id="wikipedia_Other_indications">Other indications</span></h3> <div style="margin: 1.12em 0; display:block"><a name="citable__190" class="citable__local-anchor">.</a><span class='citationPopup' rel="190">Two large placebo-controlled clinical trials of sertraline for <a href="/Generalized_anxiety_disorder" title="Generalized anxiety disorder">generalized anxiety disorder</a> have been conducted.</span><span class="citable__li" citable_id="190"><a href="#citable__190"><strong>^</strong></a> <c_txt>Sertraline has been studied in two 12-week, double-blind, placebo controlled trials.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="190"><a href="#citable__190"><strong>^</strong></a> <c_txt>Two randomized controlled trials.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.aetna.com/products/rxmedicare/data/Medicare2007/CNS/antidepressants_2007.html">www.aetna.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="190"><a href="#citable__190"><strong>^</strong></a> <c_txt>OBJECTIVE : To evaluate the efficacy and safety of sertraline compared with placebo in treatment of pediatric patients with MDD. DESIGN AND SETTING: Two multicenter randomized, double-blind, placebo-controlled trials were conducted at 53 hospital, general practice, and academic centers in the United States, India, Canada, Costa Rica, and Mexico between December 1999 and May 2001 and were pooled a priori.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__63" class="citable__local-anchor">.</a><span class='citationPopup' rel="63">While one trial demonstrated highly significant improvements on all measures used, including anxiety, depression and quality of life,<sup id="wikipedia_cite_ref_103" class="reference"><a href="#cite_note-103"><span>[</span>104<span>]</span></a></sup> the other showed only marginal improvement of anxiety, and insignificant improvement of quality of life.</span><span class="citable__li" citable_id="63"><a href="#citable__63"><strong>^</strong></a> <c_txt>Other variables measured at baseline included alcohol use, recent anxiety attacks, past history of treatment for depression, and all self-reported clinic and emergency department visits in the past 3 months and hospital days in the past year.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>JAMA -- Similar Effectiveness of Paroxetine, Fluoxetine, and Sertraline in Primary Care: A Randomized Trial, December 19, 2001, Kroenke et al. 286 (23): 2947</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://jama.ama-assn.org/cgi/content/full/286/23/2947">jama.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="63"><a href="#citable__63"><strong>^</strong></a> <c_txt>Ten of the original 16 showed significant improvement although none of the subjects reported significant improvement in reexperiencing symptoms.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="63"><a href="#citable__63"><strong>^</strong></a> <c_txt>Table 2 summarizes depression and other psychological outcomes by SSRI treatment group, and Table 3 summarizes work, social, and other health-related quality of life outcomes.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>JAMA -- Similar Effectiveness of Paroxetine, Fluoxetine, and Sertraline in Primary Care: A Randomized Trial, December 19, 2001, Kroenke et al. 286 (23): 2947</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://jama.ama-assn.org/cgi/content/full/286/23/2947">jama.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid16848646_104_0" class="reference"><a href="#cite_note-pmid16848646-104"><span>[</span>105<span>]</span></a></sup> <a name="citable__196" class="citable__local-anchor">.</a><span class='citationPopup' rel="196">Small double-blind studies of sertraline for <a href="/Eating_disorder" title="Eating disorder" class="mw-redirect">eating disorders</a>, such as <a href="/Binge_eating_disorder" title="Binge eating disorder">binge eating disorder</a>,<sup id="wikipedia_cite_ref_105" class="reference"><a href="#cite_note-105"><span>[</span>106<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid18598735_106_0" class="reference"><a href="#cite_note-pmid18598735-106"><span>[</span>107<span>]</span></a></sup> <a href="/Night_eating_syndrome" title="Night eating syndrome">night eating syndrome</a><sup id="wikipedia_cite_ref_pmid16648332_107_0" class="reference"><a href="#cite_note-pmid16648332-107"><span>[</span>108<span>]</span></a></sup> and <a href="/Bulimia_nervosa" title="Bulimia nervosa">bulimia nervosa</a><sup id="wikipedia_cite_ref_pmid15605617_108_0" class="reference"><a href="#cite_note-pmid15605617-108"><span>[</span>109<span>]</span></a></sup> indicated its effectiveness.</span><span class="citable__li" citable_id="196"><a href="#citable__196"><strong>^</strong></a> <c_txt>Hertzberg et al (1999) studied lamotrigine for PTSD in a 12-week double-blind, randomized (2:1) placebo-controlled trial.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="196"><a href="#citable__196"><strong>^</strong></a> <c_txt>POSTTRAUMATIC STRESS DISORDER EFFICACY STUDIES This review is limited to 5 controlled studies that have examined the effectiveness of alprazolam, imipramine, desipramine, amitriptyline, phenelzine, and fluoxetine.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="196"><a href="#citable__196"><strong>^</strong></a> <c_txt>Methods Fifty patients with panic disorder were randomized into a double-blind clinical trial.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://archpsyc.ama-assn.org/cgi/content/full/58/7/681">archpsyc.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> </div> <div style="margin: 1.12em 0; display:block"><a name="citable__96" class="citable__local-anchor">.</a><span class='citationPopup' rel="96">Although sertraline can be used for the treatment of <a href="/Premature_ejaculation" title="Premature ejaculation">premature ejaculation</a><sup id="wikipedia_cite_ref_109" class="reference"><a href="#cite_note-109"><span>[</span>110<span>]</span></a></sup> a comparative study found it to be inferior to another SSRI, <a href="/Paroxetine" title="Paroxetine">paroxetine</a>.</span><span class="citable__li" citable_id="96"><a href="#citable__96"><strong>^</strong></a> <c_txt>Fluoxetine Compared to Sertraline and Paroxetine Both of the following studies evaluate the cost of treatment of depression with fluoxetine versus those same costs of treatment with sertraline and paroxetine.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="96"><a href="#citable__96"><strong>^</strong></a> <c_txt>Another potentially fatal drug interaction could result from taking another SSRI with sertraline.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="96"><a href="#citable__96"><strong>^</strong></a> <c_txt>Seventeen sertraline-treated patients (9%) and 5 placebo patients (3%) prematurely discontinued the study because of adverse events.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid9690692_110_0" class="reference"><a href="#cite_note-pmid9690692-110"><span>[</span>111<span>]</span></a></sup> <a name="citable__286" class="citable__local-anchor">.</a><span class='citationPopup' rel="286">A general disadvantage of SSRIs is that they require continuous daily treatment to delay ejaculation significantly.</span><span class="citable__li" citable_id="286"><a href="#citable__286"><strong>^</strong></a> <c_txt>However, SSRI-induced HPA axis activation and c- fos expression become blunted with daily SSRI treatment ( 20 ).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia -- Sanders et al. 294 (5): E853 -- AJP - Endocrinology and Metabolism</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://ajpendo.physiology.org/cgi/content/full/294/5/E853">ajpendo.physiology.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="286"><a href="#citable__286"><strong>^</strong></a> <c_txt>It is worth noting that patients covered by the Medicaid agency whose claims were used had been required to experience two treatment failures prior to initiating SSRI therapy.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="286"><a href="#citable__286"><strong>^</strong></a> <c_txt>Our findings reveal that continuous treatment with the SSRI sertraline enhances key hormonal CRRs to a single bout of hypoglycemia in normal nondiabetic rats.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia -- Sanders et al. 294 (5): E853 -- AJP - Endocrinology and Metabolism</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://ajpendo.physiology.org/cgi/content/full/294/5/E853">ajpendo.physiology.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid17983899_111_0" class="reference"><a href="#cite_note-pmid17983899-111"><span>[</span>112<span>]</span></a></sup> <a name="citable__93" class="citable__local-anchor">.</a><span class='citationPopup' rel="93">For the occasional "on-demand", a few hours before coitus, treatment, <a href="/Clomipramine" title="Clomipramine">clomipramine</a> gave better results than paroxetine in one study,<sup id="wikipedia_cite_ref_pmid15363569_112_0" class="reference"><a href="#cite_note-pmid15363569-112"><span>[</span>113<span>]</span></a></sup> while in another study both sertraline and clomipramine were indistinguishable from the pause–squeeze technique and inferior to paroxetine.</span><span class="citable__li" citable_id="93"><a href="#citable__93"><strong>^</strong></a> <c_txt>One study also asserts that sertraline is also more effective than TCAs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="93"><a href="#citable__93"><strong>^</strong></a> <c_txt>Both of the studies reviewed below suggest that treatment with sertraline results in lower costs than treatment with TCAs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="93"><a href="#citable__93"><strong>^</strong></a> <c_txt>One study also asserts that sertraline is more effective than TCAs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid11313839_113_0" class="reference"><a href="#cite_note-pmid11313839-113"><span>[</span>114<span>]</span></a></sup> <a name="citable__222" class="citable__local-anchor">.</a><span class='citationPopup' rel="222">The most recent research, conducted in 2007, suggests that on-demand treatment with <a href="/Sildenafil" title="Sildenafil">sildenafil</a> (Viagra) offers a dramatic improvement in ejaculation delay and sexual satisfaction as compared with daily paroxetine,<sup id="wikipedia_cite_ref_pmid17470165_114_0" class="reference"><a href="#cite_note-pmid17470165-114"><span>[</span>115<span>]</span></a></sup> with on-demand sertraline, paroxetine or clomipramine,<sup id="wikipedia_cite_ref_pmid11313839_113_1" class="reference"><a href="#cite_note-pmid11313839-113"><span>[</span>114<span>]</span></a></sup> and with the pause–squeeze technique.</span><span class="citable__li" citable_id="222"><a href="#citable__222"><strong>^</strong></a> <c_txt>Zoloft withdrawal - Ejaculation Delayed The man is not able to release sperm either during sexual intercourse or with manual stimulation in the presence of his sexual partner in spite of his wish to do so.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="222"><a href="#citable__222"><strong>^</strong></a> <c_txt>Both of the studies reviewed below suggest that treatment with sertraline results in lower costs than treatment with TCAs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="222"><a href="#citable__222"><strong>^</strong></a> <c_txt>This study suggested an increase in the risk of overall major congenital malformations for paroxetine as compared to other antidepressants.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.aetna.com/products/rxmedicare/data/Medicare2007/CNS/antidepressants_2007.html">www.aetna.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid11313839_113_2" class="reference"><a href="#cite_note-pmid11313839-113"><span>[</span>114<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid17470165_114_1" class="reference"><a href="#cite_note-pmid17470165-114"><span>[</span>115<span>]</span></a></sup></div> <div style="margin: 1.12em 0; display:block"><a name="citable__0" class="citable__local-anchor">.</a><span class='citationPopup' rel="0">A small study suggested that sertraline may help some children and adolescents with refractory <a href="/Vasovagal_syncope" title="Vasovagal syncope" class="mw-redirect">syncope</a>.</span><span class="citable__li" citable_id="0"><a href="#citable__0"><strong>^</strong></a> <c_txt>Clinical case studies in diabetic patients, however, suggest that SSRI therapy may exacerbate hypoglycemia.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia -- Sanders et al. 294 (5): E853 -- AJP - Endocrinology and Metabolism</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://ajpendo.physiology.org/cgi/content/full/294/5/E853">ajpendo.physiology.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="0"><a href="#citable__0"><strong>^</strong></a> <c_txt>Although there may be some characteristics of any medication that distinguish its use in a particular patient, our findings suggest that in general none of the 3 SSRIs in this study can be recommended over another in terms of effectiveness.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>JAMA -- Similar Effectiveness of Paroxetine, Fluoxetine, and Sertraline in Primary Care: A Randomized Trial, December 19, 2001, Kroenke et al. 286 (23): 2947</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://jama.ama-assn.org/cgi/content/full/286/23/2947">jama.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="0"><a href="#citable__0"><strong>^</strong></a> <c_txt>Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder: two randomized controlled trials.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Antidepressants - Pharmacy Clinical Policy Bulletins Aetna Non-Medicare Prescription Drug Plan</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.aetna.com/products/rxnonmedicare/data/2007/CNS/antidepressants_2007.html">www.aetna.com</a> [Source type: Academic]</li><li> <em><c_title>Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.aetna.com/products/rxmedicare/data/Medicare2007/CNS/antidepressants_2007.html">www.aetna.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_115" class="reference"><a href="#cite_note-115"><span>[</span>116<span>]</span></a></sup> <a name="citable__44" class="citable__local-anchor">.</a><span class='citationPopup' rel="44">Subsequent case reports indicated that sertraline may itself cause syncope in adolescents<sup id="wikipedia_cite_ref_pmid9433163_116_0" class="reference"><a href="#cite_note-pmid9433163-116"><span>[</span>117<span>]</span></a></sup> and that sertraline treatment of syncope may make it more frequent.</span><span class="citable__li" citable_id="44"><a href="#citable__44"><strong>^</strong></a> <c_txt>In terms of poor impulse controls the use of a mood stabilizer such as valproate, carbamazepine, or lithium may be helpful as accessed by case reports.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="44"><a href="#citable__44"><strong>^</strong></a> <c_txt>Treatment with sertraline may result in lower total costs than treatment with TCAs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="44"><a href="#citable__44"><strong>^</strong></a> <c_txt>This indicates that the extreme type of events causing PTSD are common and may in fact affect more people that originally thought (Solomon et al 1992).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid9365060_117_0" class="reference"><a href="#cite_note-pmid9365060-117"><span>[</span>118<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid9113018_118_0" class="reference"><a href="#cite_note-pmid9113018-118"><span>[</span>119<span>]</span></a></sup></div> <h2><span class="mw-headline" id="wikipedia_Adverse_effects">Adverse effects</span></h2> <div class="thumb tright"> <div class="thumbinner" style="width:222px;"><img alt="" src="http://images-mediawiki-sites.thefullwiki.org/05/3/2/3/2360529392492632.jpg" width="220" height="196" class="thumbimage" /> <div class="thumbcaption"> <div class="magnify"><img src="http://images-mediawiki-sites.thefullwiki.org/09/7/4/4/3695493113783710.png" width="15" height="11" alt="" /></div> Zoloft 25 & 50 mg tablets (US)</div> </div> </div> <div class="thumb tright"> <div class="thumbinner" style="width:222px;"><img alt="" src="http://images-mediawiki-sites.thefullwiki.org/09/9/4/9/2876813197311854.jpg" width="220" height="165" class="thumbimage" /> <div class="thumbcaption"> <div class="magnify"><img src="http://images-mediawiki-sites.thefullwiki.org/09/7/4/4/3695493113783710.png" width="15" height="11" alt="" /></div> Zoloft 100 mg tablets (AU)</div> </div> </div> <div style="margin: 1.12em 0; display:block"><a name="citable__291" class="citable__local-anchor">.</a><span class='citationPopup' rel="291">According to Pfizer, sertraline is <a href="/Contraindicated" title="Contraindicated" class="mw-redirect">contraindicated</a> in individuals taking <a href="/Monoamine_oxidase_inhibitor" title="Monoamine oxidase inhibitor">monoamine oxidase inhibitors</a> or the <a href="/Antipsychotic" title="Antipsychotic">antipsychotic</a> <a href="/Pimozide" title="Pimozide">pimozide</a> (Orap).</span><span class="citable__li" citable_id="291"><a href="#citable__291"><strong>^</strong></a> <c_txt>Never take Zoloft if you are taking Orap (pimozide) , a drug used to treat Tourettes disorder, because it can result in serious heart beat problems.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="291"><a href="#citable__291"><strong>^</strong></a> <c_txt>CONTRAINDICATIONS Concomitant use in patients taking monoamine oxidase inhibitors (MAOIs) is contraindicated (see WARNINGS).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="291"><a href="#citable__291"><strong>^</strong></a> <c_txt>Concomitant use in patients taking pimozide is contraindicated (see PRECAUTIONS).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <a name="citable__260" class="citable__local-anchor">.</a><span class='citationPopup' rel="260">Sertraline concentrate contains alcohol, and is therefore contraindicated with <a href="/Disulfiram" title="Disulfiram">disulfiram</a> (Antabuse).</span><span class="citable__li" citable_id="260"><a href="#citable__260"><strong>^</strong></a> <c_txt>Never take Zoloft oral concentrate if you are taking Antabuse (disulfiram), used to treat alcoholism, because Zoloft oral concentrate contains alcohol.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="260"><a href="#citable__260"><strong>^</strong></a> <c_txt>Those who are on disulfiram ( Antabuse ) should avoid liquid sertraline ( Zoloft ) due to its alcohol content.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <a name="citable__254" class="citable__local-anchor">.</a><span class='citationPopup' rel="254">The prescribing information recommends that treatment of the elderly and patients with liver impairment "must be approached with caution". Due to the slower elimination of sertraline in these groups, their exposure to sertraline may be as high as three times the average exposure for the same dose.</span><span class="citable__li" citable_id="254"><a href="#citable__254"><strong>^</strong></a> <c_txt>These patients do not benefit from sertraline treatment.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> SERTRALINE FOR THE PREVENTION OF RELAPSE IN DETOXICATED ALCOHOL DEPENDENT PATIENTS WITH A COMORBID DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL -- Gual et al. 38 (6): 619 -- Alcohol and Alcoholism</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://alcalc.oxfordjournals.org/cgi/content/full/38/6/619">alcalc.oxfordjournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="254"><a href="#citable__254"><strong>^</strong></a> <c_txt>Dosage adjustments are recommended for patients with mild, stable cirrhosis since these patients have a prolonged elimination half-life (e.g., 52 hours compared to 22 hours in patients without liver disease) and a higher peak serum concentration (e.g., 1.7 fold greater than in normal patients).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="254"><a href="#citable__254"><strong>^</strong></a> <c_txt>This study of biomarkers was conducted in a population of patients after ACSs, which explains the decrease in plasma levels over time in both treatment arms.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_zoloftpi_119_0" class="reference"><a href="#cite_note-zoloftpi-119"><span>[</span>120<span>]</span></a></sup></div> <div style="margin: 1.12em 0; display:block">Among the common adverse effects associated with sertraline and listed in the prescribing information, those with the greatest difference from <a href="/Placebo" title="Placebo">placebo</a> are nausea (25% vs. 11% for placebo), ejaculation failure (14% vs. 1% for placebo), insomnia (21% vs. 11% for placebo), diarrhea (20% vs. 10% for placebo), dry mouth (14% vs. 8% for placebo), somnolence (13% vs. 7% for placebo), dizziness (12% vs. 7% for placebo), tremor (8% vs. 2% for placebo) and decreased <a href="/Libido" title="Libido">libido</a> (6% vs. 1% for placebo).<sup id="wikipedia_cite_ref_zoloftpi_119_1" class="reference"><a href="#cite_note-zoloftpi-119"><span>[</span>120<span>]</span></a></sup> <a name="citable__118" class="citable__local-anchor">.</a><span class='citationPopup' rel="118">Those that most often resulted in interruption of the treatment were nausea (3%), diarrhea (2%) and insomnia (2%).</span><span class="citable__li" citable_id="118"><a href="#citable__118"><strong>^</strong></a> <c_txt>I had some expected side effects, such as nausea and insomnia, but those are now gone.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_zoloftpi_119_2" class="reference"><a href="#cite_note-zoloftpi-119"><span>[</span>120<span>]</span></a></sup> <a name="citable__167" class="citable__local-anchor">.</a><span class='citationPopup' rel="167">Sertraline appears to be associated with <a href="/Microscopic_colitis" title="Microscopic colitis">microscopic colitis</a>, a rare condition of unknown <a href="/Etiology" title="Etiology">etiology</a>.</span><span class="citable__li" citable_id="167"><a href="#citable__167"><strong>^</strong></a> <c_txt>In this study, treatment with fluoxetine was associated with greater treatment costs than was treatment with sertraline, while clinical outcomes appear similar.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid17100977_120_0" class="reference"><a href="#cite_note-pmid17100977-120"><span>[</span>121<span>]</span></a></sup></div> <div style="margin: 1.12em 0; display:block"><a name="citable__296" class="citable__local-anchor">.</a><span class='citationPopup' rel="296"><a href="/Akathisia" title="Akathisia">Akathisia</a>—that is, "inner tension, restlessness, and the inability to stay still"—caused by sertraline was observed in 16% of patients in a <a href="/Case_series" title="Case series">case series</a>.</span><span class="citable__li" citable_id="296"><a href="#citable__296"><strong>^</strong></a> <c_txt>Whether the favorable effects of sertraline as observed in this study are readily observable in patients with stable coronary artery disease remains to be determined.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="296"><a href="#citable__296"><strong>^</strong></a> <c_txt>Samples Platelet/endothelial biomarkers were measured serially at baseline, week 6, and week 16 after sertraline/placebo randomization.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="296"><a href="#citable__296"><strong>^</strong></a> <c_txt>The rates of clinical worsening as a cause of drop-out were similar between groups (3 sertraline/placebo vs 1 sertraline/clonazepam patients; Fisher exact test, P = .61).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Arch Gen Psychiatry -- Early Coadministration of Clonazepam With Sertraline for Panic Disorder, July 2001, Goddard et al. 58 (7): 681</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://archpsyc.ama-assn.org/cgi/content/full/58/7/681">archpsyc.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid9018398_121_0" class="reference"><a href="#cite_note-pmid9018398-121"><span>[</span>122<span>]</span></a></sup> <a name="citable__239" class="citable__local-anchor">.</a><span class='citationPopup' rel="239">This and other reports<sup id="wikipedia_cite_ref_pmid8909330_122_0" class="reference"><a href="#cite_note-pmid8909330-122"><span>[</span>123<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid9378692_123_0" class="reference"><a href="#cite_note-pmid9378692-123"><span>[</span>124<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid12407283_124_0" class="reference"><a href="#cite_note-pmid12407283-124"><span>[</span>125<span>]</span></a></sup> note that akathisia begins soon after the initiation of treatment or a dose increase; often, several hours after taking the medication.</span><span class="citable__li" citable_id="239"><a href="#citable__239"><strong>^</strong></a> <c_txt>Police noted she was taking medication for depression.” .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.drugawareness.org/tag/zoloft">www.drugawareness.org</a> [Source type: General]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="239"><a href="#citable__239"><strong>^</strong></a> <c_txt>Check with your doctor and pharmacist before taking any other supplements or over the counter medications to make sure you are aware of the risks the combination may carry.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="239"><a href="#citable__239"><strong>^</strong></a> <c_txt>The effects will take at least a week and often three before the medication begins to work.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li></ul></c_src></small></div><br></span> <a name="citable__240" class="citable__local-anchor">.</a><span class='citationPopup' rel="240">Akathisia usually disappears within several days after sertraline is stopped or its dose is decreased.</span><span class="citable__li" citable_id="240"><a href="#citable__240"><strong>^</strong></a> <c_txt>Clearly, stopping the drugs-with your physician's permission-would clear the diarrhea within 3 to 4 days if the diarrhea is drug related.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="240"><a href="#citable__240"><strong>^</strong></a> <c_txt>Carbamazepine ( Tegretol ): Decreases effectiveness of sertraline ( Zoloft ), so sertraline dose may need to be adjusted.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="240"><a href="#citable__240"><strong>^</strong></a> <c_txt>On the 3rd day of treatment, after two doses of the medication, I experienced severe nausea, so I skipped my dose for that day.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <a name="citable__89" class="citable__local-anchor">.</a><span class='citationPopup' rel="89">In some cases, clinicians confused akathisia with <a href="/Anxiety" title="Anxiety">anxiety</a> and increased the dose of sertraline, causing further worsening of the patients' symptoms.</span><span class="citable__li" citable_id="89"><a href="#citable__89"><strong>^</strong></a> <c_txt>This seems especially true given that some people have some major life-altering withdrawal symptoms that appear to worsen their depression!</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft Comments</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.join-the-fun.com/zoloft-comments.html">www.join-the-fun.com</a> [Source type: Original source]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="89"><a href="#citable__89"><strong>^</strong></a> <c_txt>Family members and other caregivers should help monitor people on sertraline for suicidal thoughts, self-destructive behaviors, panic attacks, impulsivity, aggressiveness, or other unusual changes in behavior or symptoms of worsening depression or anxiety especially in the early months of treatment and when the dose is adjusted.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="89"><a href="#citable__89"><strong>^</strong></a> <c_txt>Patients initiated treatment with the recommended starting dose of 20 mg of paroxetine, 20 mg of fluoxetine hydrochloride, or 50 mg of sertraline.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>JAMA -- Similar Effectiveness of Paroxetine, Fluoxetine, and Sertraline in Primary Care: A Randomized Trial, December 19, 2001, Kroenke et al. 286 (23): 2947</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://jama.ama-assn.org/cgi/content/full/286/23/2947">jama.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid12407283_124_1" class="reference"><a href="#cite_note-pmid12407283-124"><span>[</span>125<span>]</span></a></sup> Experts note that because of the possible link of akathisia with suicide and the distress it causes to the patient, "it is of vital importance to increase awareness amongst staff and patients of the symptoms of this relatively common condition".<sup id="wikipedia_cite_ref_pmid12404546_125_0" class="reference"><a href="#cite_note-pmid12404546-125"><span>[</span>126<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid16449715_126_0" class="reference"><a href="#cite_note-pmid16449715-126"><span>[</span>127<span>]</span></a></sup></div> <div style="margin: 1.12em 0; display:block"><a name="citable__256" class="citable__local-anchor">.</a><span class='citationPopup' rel="256">Over more than six months of sertraline therapy for depression, patients showed an insignificant weight increase of 0.1%.</span><span class="citable__li" citable_id="256"><a href="#citable__256"><strong>^</strong></a> <c_txt>More ADRs with sertraline than PLB. .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="256"><a href="#citable__256"><strong>^</strong></a> <c_txt>The principal measure of effectiveness was the proportion of patients remaining stable on the antidepressant for at least six consecutive months.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="256"><a href="#citable__256"><strong>^</strong></a> <c_txt>However, in neither of these cases, did treatment costs increase by more than 3%.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid11105740_127_0" class="reference"><a href="#cite_note-pmid11105740-127"><span>[</span>128<span>]</span></a></sup> <a name="citable__53" class="citable__local-anchor">.</a><span class='citationPopup' rel="53">Similarly, a 30-month-long treatment with sertraline for <a href="/Obsessive_compulsive_disorder" title="Obsessive compulsive disorder" class="mw-redirect">OCD</a> resulted in a mean weight gain of 1.5% (1 kg).</span><span class="citable__li" citable_id="53"><a href="#citable__53"><strong>^</strong></a> <c_txt>The mean change in the SF-36 Mental Component Summary score at 9 months was + 15.8 in the paroxetine group, + 15.1 in the fluoxetine group, and + 17.4 in the sertraline group.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>JAMA -- Similar Effectiveness of Paroxetine, Fluoxetine, and Sertraline in Primary Care: A Randomized Trial, December 19, 2001, Kroenke et al. 286 (23): 2947</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://jama.ama-assn.org/cgi/content/full/286/23/2947">jama.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="53"><a href="#citable__53"><strong>^</strong></a> <c_txt>Treatment with sertraline may result in lower total costs than treatment with TCAs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="53"><a href="#citable__53"><strong>^</strong></a> <c_txt>Both of the studies reviewed below suggest that treatment with sertraline results in lower costs than treatment with TCAs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid15491240_128_0" class="reference"><a href="#cite_note-pmid15491240-128"><span>[</span>129<span>]</span></a></sup> <a name="citable__102" class="citable__local-anchor">.</a><span class='citationPopup' rel="102">Although the difference did not reach <a href="/Statistical_significance" title="Statistical significance">statistical significance</a>, the weight gain was lower for <a href="/Fluoxetine" title="Fluoxetine">fluoxetine</a> (Prozac) (1%) but higher for <a href="/Citalopram" title="Citalopram">citalopram</a> (Celexa), <a href="/Fluvoxamine" title="Fluvoxamine">fluvoxamine</a> (Luvox) and <a href="/Paroxetine" title="Paroxetine">paroxetine</a> (Paxil) (2.5%).</span><span class="citable__li" citable_id="102"><a href="#citable__102"><strong>^</strong></a> <c_txt>Also, I have heard that other people have gained a significant amount of weight from anti depressants.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="102"><a href="#citable__102"><strong>^</strong></a> <c_txt>Thirty-three of these were from the TC and 23 the VA. Thirty four (54.8%) of these patients met criteria for MDD. The analysis of the data showed the fluoxetine patients having a statistically significant decrease in CAPS score (p < 0.0106), although this difference was not as large at the one seen between TC and VA patients at week 5.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="102"><a href="#citable__102"><strong>^</strong></a> <c_txt>Finally, use of oral anticoagulants was less frequent in the sertraline group; however, this difference did not reach significance.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__244" class="citable__local-anchor">.</a><span class='citationPopup' rel="244">Only 4.5% of the sertraline group gained a large amount of weight (defined as more than 7% gain).</span><span class="citable__li" citable_id="244"><a href="#citable__244"><strong>^</strong></a> <c_txt>More ADRs with sertraline than PLB. .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="244"><a href="#citable__244"><strong>^</strong></a> <c_txt>For FREE SHIPPING with purchase of $70 or more order weight must be less than 7 Lbs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Buy Top Herbal & Nutritional Supplements Brands Products on Discount</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.getnutri.com/brand.asp?name=NutriBiotic">www.getnutri.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="244"><a href="#citable__244"><strong>^</strong></a> <c_txt>Also, I have heard that other people have gained a significant amount of weight from anti depressants.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <a name="citable__129" class="citable__local-anchor">.</a><span class='citationPopup' rel="129">This result compares favorably with placebo, where, according to the literature, 3–6% of patients gained more than 7% of their initial weight.</span><span class="citable__li" citable_id="129"><a href="#citable__129"><strong>^</strong></a> <c_txt>The results of these studies exhibit mild evidence for venlafaxine being more cost-effective than SSRIs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="129"><a href="#citable__129"><strong>^</strong></a> <c_txt>More paroxetine treated patients (n=151) responded than those receiving placebo (n=156) as defined by a CGI-improvement rating of much or very much improved.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="129"><a href="#citable__129"><strong>^</strong></a> <c_txt>My psychiatrist has watched more of his patients crash and burn on it than any brand to generic drug, including me, and it wasn't a small crash.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <a name="citable__157" class="citable__local-anchor">.</a><span class='citationPopup' rel="157">The large weight gain was observed only among female members of the sertraline group; the significance of this finding is unclear because of the small size of the group.</span><span class="citable__li" citable_id="157"><a href="#citable__157"><strong>^</strong></a> <c_txt>Also, I have heard that other people have gained a significant amount of weight from anti depressants.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="157"><a href="#citable__157"><strong>^</strong></a> <c_txt>Finally, use of oral anticoagulants was less frequent in the sertraline group; however, this difference did not reach significance.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="157"><a href="#citable__157"><strong>^</strong></a> <c_txt>Because this difference did not achieve statistical significance, the authors concluded that the cost of treating depression was identical between the two treatment groups.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid15491240_128_1" class="reference"><a href="#cite_note-pmid15491240-128"><span>[</span>129<span>]</span></a></sup></div> <div style="margin: 1.12em 0; display:block"><a name="citable__251" class="citable__local-anchor">.</a><span class='citationPopup' rel="251">Over a two-week treatment of healthy volunteers, sertraline slightly improved verbal <a href="/Fluency" title="Fluency">fluency</a> but did not affect word learning, <a href="/Short-term_memory" title="Short-term memory">short-term memory</a>, <a href="/Alertness" title="Alertness">vigilance</a>, <a href="/Flicker_fusion_threshold" title="Flicker fusion threshold">flicker fusion time</a>, choice <a href="/Reaction_time" title="Reaction time">reaction time</a>, <a href="/Memory_span" title="Memory span">memory span</a>, or <a href="/Motor_coordination" title="Motor coordination">psychomotor coordination</a>.</span><span class="citable__li" citable_id="251"><a href="#citable__251"><strong>^</strong></a> <c_txt>Therefore, increased treatment costs may reflect physician practices that could have improved since the time of the study.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="251"><a href="#citable__251"><strong>^</strong></a> <c_txt>Treatment with the SSRI sertraline may have affected insulin sensitivity, thereby impacting our findings in the present study.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia -- Sanders et al. 294 (5): E853 -- AJP - Endocrinology and Metabolism</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://ajpendo.physiology.org/cgi/content/full/294/5/E853">ajpendo.physiology.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="251"><a href="#citable__251"><strong>^</strong></a> <c_txt>These need to be stopped at least two weeks prior to starting sertraline ( Zoloft ).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid11565624_129_0" class="reference"><a href="#cite_note-pmid11565624-129"><span>[</span>130<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid12692706_130_0" class="reference"><a href="#cite_note-pmid12692706-130"><span>[</span>131<span>]</span></a></sup> <a name="citable__54" class="citable__local-anchor">.</a><span class='citationPopup' rel="54">In spite of lower subjective rating, that is, feeling that they performed worse, no clinically relevant differences were observed in the objective cognitive performance in a group of people treated for depression with sertraline for 1.5 years as compared to healthy controls.</span><span class="citable__li" citable_id="54"><a href="#citable__54"><strong>^</strong></a> <c_txt>Zoloft Question: I have been on Zoloft for over 1 1/2 years to treat depression.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="54"><a href="#citable__54"><strong>^</strong></a> <c_txt>No difference in measures with placebo group.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="54"><a href="#citable__54"><strong>^</strong></a> <c_txt>Zoloft- Other Medications Question: I was diagnosed and treated for depression about six years ago when I was a police officer.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid16485140_131_0" class="reference"><a href="#cite_note-pmid16485140-131"><span>[</span>132<span>]</span></a></sup> <a name="citable__10" class="citable__local-anchor">.</a><span class='citationPopup' rel="10">In children and adolescents taking sertraline for six weeks for anxiety disorders, 18 out of 20 measures of memory, attention and alertness stayed unchanged.</span><span class="citable__li" citable_id="10"><a href="#citable__10"><strong>^</strong></a> <c_txt>Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Antidepressants - Pharmacy Clinical Policy Bulletins Aetna Non-Medicare Prescription Drug Plan</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.aetna.com/products/rxnonmedicare/data/2007/CNS/antidepressants_2007.html">www.aetna.com</a> [Source type: Academic]</li><li> <em><c_title>Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.aetna.com/products/rxmedicare/data/Medicare2007/CNS/antidepressants_2007.html">www.aetna.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="10"><a href="#citable__10"><strong>^</strong></a> <c_txt>Reply My husband has been taking Sertraline for about 3 months and just last week changed from the Teva Manufacture to Greenstone and he has had terrible sweats and a worsening of the depression/anxiety.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="10"><a href="#citable__10"><strong>^</strong></a> <c_txt>Sertraline can also help people with an obsessive compulsive disorder, panic attacks, post-trauma stress, or social anxiety.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <a href="/Attention" title="Attention">Divided attention</a> was improved and verbal memory under <a href="/Interference_theory" title="Interference theory">interference conditions</a> decreased marginally. <a name="citable__289" class="citable__local-anchor">.</a><span class='citationPopup' rel="289">Because of the large number of measures taken, it is possible that these changes were still due to chance.</span><span class="citable__li" citable_id="289"><a href="#citable__289"><strong>^</strong></a> <c_txt>A less likely possibility is that these symptoms are actually due to the medication itself, and not a diminishing effect of the drug.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="289"><a href="#citable__289"><strong>^</strong></a> <c_txt>These researchers also estimated that in 1985, the U.S. lost $6 billion in indirect costs, largely due to deaths related to these disorders.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid16190792_132_0" class="reference"><a href="#cite_note-pmid16190792-132"><span>[</span>133<span>]</span></a></sup></div> <div style="display:table-cell;clear:both;"></div><h3><span class="mw-headline" id="wikipedia_Overdosage">Overdosage</span></h3> <div style="margin: 1.12em 0; display:block">Acute overdosage is often manifested by emesis, lethargy, ataxia, tachycardia and seizures. <a name="citable__282" class="citable__local-anchor">.</a><span class='citationPopup' rel="282">Plasma, serum or blood concentrations of sertaline and norsertraline, its major active metabolite, may be measured to confirm a diagnosis of poisoning in hospitalized patients or to aid in the medicolegal investigation of fatalities.</span><span class="citable__li" citable_id="282"><a href="#citable__282"><strong>^</strong></a> <c_txt>Plasma concentrations of platelet-specific proteins and serum thromboxane B 2 production in response to treatment with dipyridamole: a pilot study of 27 post-myocardial infarction patients.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="282"><a href="#citable__282"><strong>^</strong></a> <c_txt>We confirmed that all patients had at least moderate symptom severity according to their mean baseline scores on all depression measures.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>JAMA -- Similar Effectiveness of Paroxetine, Fluoxetine, and Sertraline in Primary Care: A Randomized Trial, December 19, 2001, Kroenke et al. 286 (23): 2947</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://jama.ama-assn.org/cgi/content/full/286/23/2947">jama.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="282"><a href="#citable__282"><strong>^</strong></a> <c_txt>Elevated plasma concentrations of PECAM-1, VECAM-1, and E-selectin are also well established in patients with ACSs, although the changes in these markers over the long term are unclear.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_133" class="reference"><a href="#cite_note-133"><span>[</span>134<span>]</span></a></sup></div> <div style="display:table-cell;clear:both;"></div><h3><span class="mw-headline" id="wikipedia_Birth_defects_and_effects_on_breast_fed_infants">Birth defects and effects on breast-fed infants</span></h3> <div style="margin: 1.12em 0; display:block"><a name="citable__48" class="citable__local-anchor">.</a><span class='citationPopup' rel="48">The studies comparing the levels of sertraline and its principal <a href="/Metabolite" title="Metabolite">metabolite</a>, <a href="/Desmethylsertraline" title="Desmethylsertraline">desmethylsertraline</a>, in mother's blood to their concentration in umbilical cord blood at the time of delivery indicated that fetal exposure to sertraline and its metabolite is approximately a third of the maternal exposure.</span><span class="citable__li" citable_id="48"><a href="#citable__48"><strong>^</strong></a> <c_txt>This study of biomarkers was conducted in a population of patients after ACSs, which explains the decrease in plasma levels over time in both treatment arms.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="48"><a href="#citable__48"><strong>^</strong></a> <c_txt>Finally, long-term studies indicate that healthcare utilization in patients with schizophrenia declines over time due to several factors.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="48"><a href="#citable__48"><strong>^</strong></a> <c_txt>Conducted in a primary care setting in France, this six month multicenter study compared treatment with fluoxetine (n=120) and sertraline (n=122) in patients with major depression.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid11082480_134_0" class="reference"><a href="#cite_note-pmid11082480-134"><span>[</span>135<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid12727706_135_0" class="reference"><a href="#cite_note-pmid12727706-135"><span>[</span>136<span>]</span></a></sup> <a name="citable__56" class="citable__local-anchor">.</a><span class='citationPopup' rel="56">The use of sertraline during the <a href="/Trimester" title="Trimester">first trimester</a> of pregnancy was associated with increased odds of the following birth defects: <a href="/Omphalocele" title="Omphalocele">omphalocele</a> (six-fold), <a href="/Anal_atresia" title="Anal atresia" class="mw-redirect">anal atresia</a> and limb reduction defects (four-fold), and <a href="/Septal_defect" title="Septal defect" class="mw-redirect">septal defects</a> (two-fold).</span><span class="citable__li" citable_id="56"><a href="#citable__56"><strong>^</strong></a> <c_txt>In the mountains there, four weeks and a gastric ulcer in six to eight outbreaks per year, students are given during pregnancy.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>zolfot | BREAK THE MATRIX</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.breakthematrix.com/users/zolfot/">www.breakthematrix.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="56"><a href="#citable__56"><strong>^</strong></a> <c_txt>During the last decade, a number of studies, largely epidemiologic, have provided evidence that depression is associated with an increased risk of cardiovascular morbidity and mortality.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="56"><a href="#citable__56"><strong>^</strong></a> <c_txt>Earlier studies have tied SSRIs during pregnancy to heart defects, but also to even more serious birth defects.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.drugawareness.org/tag/sertraline">www.drugawareness.org</a> [Source type: FILTERED WITH BAYES]</li><li> <em><c_title>Zoloft</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.drugawareness.org/tag/zoloft">www.drugawareness.org</a> [Source type: General]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid17596601_136_0" class="reference"><a href="#cite_note-pmid17596601-136"><span>[</span>137<span>]</span></a></sup> <a name="citable__174" class="citable__local-anchor">.</a><span class='citationPopup' rel="174">Concentration of sertraline and desmethylsertraline in breast milk is highly variable and, on average, is of the same order of magnitude as their concentration in the <a href="/Blood_plasma" title="Blood plasma">blood plasma</a> of the mother.</span><span class="citable__li" citable_id="174"><a href="#citable__174"><strong>^</strong></a> <c_txt>In lactation, sertraline and paroxetine has very little concentrations present in breast milk and nursing infants.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.aetna.com/products/rxmedicare/data/Medicare2007/CNS/antidepressants_2007.html">www.aetna.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__147" class="citable__local-anchor">.</a><span class='citationPopup' rel="147">As a result, more than half of breast-fed babies receive less than 2 mg/day of sertraline and desmethylsertraline combined, and in most cases these substances are undetectable in their blood.</span><span class="citable__li" citable_id="147"><a href="#citable__147"><strong>^</strong></a> <c_txt>More ADRs with sertraline than PLB. .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="147"><a href="#citable__147"><strong>^</strong></a> <c_txt>The primary metabolite is N-desmethylsertraline, which is substantially less active than sertraline.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="147"><a href="#citable__147"><strong>^</strong></a> <c_txt>INTERVENTION: Patients were randomly assigned to receive a flexible dosage (50-200 mg/d) of sertraline (n = 189) or matching placebo tablets (n = 187) for 10 weeks.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid12590627_137_0" class="reference"><a href="#cite_note-pmid12590627-137"><span>[</span>138<span>]</span></a></sup> <a name="citable__55" class="citable__local-anchor">.</a><span class='citationPopup' rel="55">No changes in <a href="/Serotonin" title="Serotonin">serotonin</a> uptake by the <a href="/Platelets" title="Platelets" class="mw-redirect">platelets</a> of breast-fed infants were found, as measured by their blood serotonin levels before and after their mothers began sertraline treatment.</span><span class="citable__li" citable_id="55"><a href="#citable__55"><strong>^</strong></a> <c_txt>Results found no difference in clinical outcomes, measured by Global Assessment of Functioning (GAF) scores, but a trend towards higher total costs for risperidone.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="55"><a href="#citable__55"><strong>^</strong></a> <c_txt>Across the entire treatment period, there was a statistically greater reduction in ß-TG and E-selectin in patients treated with sertraline compared with placebo, and in no measure was placebo treatment superior to the SSRI. .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="55"><a href="#citable__55"><strong>^</strong></a> <c_txt>Phosphorus magnetic resonance spectroscopy study of tissue specific changes in high energy phosphates before and after sertraline treatment of geriatric depression.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid11578995_138_0" class="reference"><a href="#cite_note-pmid11578995-138"><span>[</span>139<span>]</span></a></sup></div> <div style="display:table-cell;clear:both;"></div><h3><span class="mw-headline" id="wikipedia_Sexual_side_effects">Sexual side effects</span></h3> <div style="margin: 1.12em 0; display:block"><a name="citable__175" class="citable__local-anchor">.</a><span class='citationPopup' rel="175">Like other SSRIs, sertraline is associated with sexual side effects, including arousal disorder and difficulty achieving orgasm.</span><span class="citable__li" citable_id="175"><a href="#citable__175"><strong>^</strong></a> <c_txt>Sertraline , Side Effects , SSRI , syndrome , Zoloft .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.drugawareness.org/tag/sertraline">www.drugawareness.org</a> [Source type: FILTERED WITH BAYES]</li><li> <em><c_title>Zoloft</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.drugawareness.org/tag/zoloft">www.drugawareness.org</a> [Source type: General]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="175"><a href="#citable__175"><strong>^</strong></a> <c_txt>Also, there is some published data on use of small doses of amphetamines with SRI to achieve better sexual arousal and orgasm.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="175"><a href="#citable__175"><strong>^</strong></a> <c_txt>After drug was administered, patient experienced the following side effects: obsessive-compulsive disorder   .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft Side Effects: Report, View, Discuss and Compare Zoloft side effects. FDA Zoloft reports, Zoloft on Twitter, Zoloft posts, Zoloft questions. Zoloft safety polls, Zoloft problems, Zoloft symptoms, 1</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.patientsville.com/medication/zoloft_side_effects.htm">www.patientsville.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__230" class="citable__local-anchor">.</a><span class='citationPopup' rel="230">The observed frequency of sexual side effects depends greatly on whether they are reported by patients spontaneously, as in the manufacturer's trials, or actively solicited by the physicians.</span><span class="citable__li" citable_id="230"><a href="#citable__230"><strong>^</strong></a> <c_txt>Seven drugs approved since 1993 have been withdrawn after reports of deaths and severe side effects.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.drugawareness.org/tag/sertraline">www.drugawareness.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="230"><a href="#citable__230"><strong>^</strong></a> <c_txt>Among the reported effects and uncommon side effects of Zoloft in the Physician's Desk Reference are agitation, nausea and/or vomiting, diarrhea, heartburn due to acid reflux, tremor, dizziness, insomnia, increased sweating, dry mouth, and sexual dysfunction.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="230"><a href="#citable__230"><strong>^</strong></a> <c_txt>Effects of pharmacotherapy and psychotherapy in depressed primary-care patients: a randomized, controlled trial including a patients' choice arm.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__199" class="citable__local-anchor">.</a><span class='citationPopup' rel="199">There have been several <a href="/Blind_experiment" title="Blind experiment">double-blind studies</a> of sexual side effects comparing sertraline with placebo or other antidepressants.</span><span class="citable__li" citable_id="199"><a href="#citable__199"><strong>^</strong></a> <c_txt>Antidepressant use doubles in U.S., study finds .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.drugawareness.org/tag/zoloft">www.drugawareness.org</a> [Source type: General]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="199"><a href="#citable__199"><strong>^</strong></a> <c_txt>Sertraline has been studied in two 12-week, double-blind, placebo controlled trials.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="199"><a href="#citable__199"><strong>^</strong></a> <c_txt>There may be other side effects not listed here.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid11229450_139_0" class="reference"><a href="#cite_note-pmid11229450-139"><span>[</span>140<span>]</span></a></sup> While <a href="/Nefazodone" title="Nefazodone">nefazodone</a> (Serzone) and <a href="/Bupropion" title="Bupropion">bupropion</a> did not have negative effects on sexual functioning, 67% of men on sertraline experienced ejaculation difficulties vs. 18% before the treatment<sup id="wikipedia_cite_ref_pmid11229450_139_1" class="reference"><a href="#cite_note-pmid11229450-139"><span>[</span>140<span>]</span></a></sup> (or 61% vs. 0% according to another paper<sup id="wikipedia_cite_ref_pmid9448656_48_2" class="reference"><a href="#cite_note-pmid9448656-48"><span>[</span>49<span>]</span></a></sup>). <a name="citable__253" class="citable__local-anchor">.</a><span class='citationPopup' rel="253">Similarly, in a group of women who initially did not have difficulties achieving orgasm, 41% acquired this problem during treatment with sertraline.</span><span class="citable__li" citable_id="253"><a href="#citable__253"><strong>^</strong></a> <c_txt>Sertraline has also been studied for the treatment of postpsychotic depression of schizophrenia, behavioral problems due to brain injury, and for premature ejaculation.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="253"><a href="#citable__253"><strong>^</strong></a> <c_txt>Sexual problems : You may have problems with impotence (erectile dysfunction), abnormal ejaculation, difficulty reaching orgasm, or decreased libido (sexual desire).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="253"><a href="#citable__253"><strong>^</strong></a> <c_txt>Patients initiating on fluoxetine were more likely to continue the originally prescribed antidepressant and were also more likely to refill prescriptions than were patients initiating on a TCA. Furthermore, the dropout rate during the first month of treatment was higher in the TCA groups than in the fluoxetine groups.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid9448656_48_3" class="reference"><a href="#cite_note-pmid9448656-48"><span>[</span>49<span>]</span></a></sup> A 40% rate of <a href="/Anorgasmia" title="Anorgasmia">orgasm dysfunction</a> (vs. 9% for placebo) on sertraline was observed in a mixed group in another study.<sup id="wikipedia_cite_ref_pmid10363731_140_0" class="reference"><a href="#cite_note-pmid10363731-140"><span>[</span>141<span>]</span></a></sup> <a name="citable__61" class="citable__local-anchor">.</a><span class='citationPopup' rel="61"><a href="/Sexual_arousal" title="Sexual arousal">Sexual arousal</a> disorder, defined as "inadequate lubrication and swelling for women and erectile difficulties for men," occurred in 12% of patients on sertraline as compared with 1% of patients on placebo.</span><span class="citable__li" citable_id="61"><a href="#citable__61"><strong>^</strong></a> <c_txt>INTERVENTION: Patients were randomly assigned to receive a flexible dosage (50-200 mg/d) of sertraline (n = 189) or matching placebo tablets (n = 187) for 10 weeks.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="61"><a href="#citable__61"><strong>^</strong></a> <c_txt>Seventeen sertraline-treated patients (9%) and 5 placebo patients (3%) prematurely discontinued the study because of adverse events.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="61"><a href="#citable__61"><strong>^</strong></a> <c_txt>More paroxetine treated patients (n=151) responded than those receiving placebo (n=156) as defined by a CGI-improvement rating of much or very much improved.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__140" class="citable__local-anchor">.</a><span class='citationPopup' rel="140">The mood improvement resulting from the treatment with sertraline counteracted these side effects, so that <a href="/Sexual_desire" title="Sexual desire" class="mw-redirect">sexual desire</a> and overall satisfaction with sex stayed the same as before the sertraline treatment.</span><span class="citable__li" citable_id="140"><a href="#citable__140"><strong>^</strong></a> <c_txt>Are these common side effects?</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="140"><a href="#citable__140"><strong>^</strong></a> <c_txt>The brain chemical these drugs increase, serotonin, is the same brain chemical that LSD, PCP and other psychedelic drugs mimic in order to produce their hallucinogenic effects.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.drugawareness.org/tag/zoloft">www.drugawareness.org</a> [Source type: General]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="140"><a href="#citable__140"><strong>^</strong></a> <c_txt>Sertraline , Sgt John , shootings , Side Effects , Springle , SSRI , Staff Sgt , Stress Center , SUICIDE , Traumatic Stress Disorder , veterans , violence , war , Zoloft .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.drugawareness.org/tag/zoloft">www.drugawareness.org</a> [Source type: General]</li></ul></c_src></small></div><br></span> However, under the action of placebo the desire and satisfaction slightly improved.<sup id="wikipedia_cite_ref_pmid10363731_140_1" class="reference"><a href="#cite_note-pmid10363731-140"><span>[</span>141<span>]</span></a></sup></div> <div style="display:table-cell;clear:both;"></div><h3><span class="mw-headline" id="wikipedia_Suicidality">Suicidality</span></h3> <div style="margin: 1.12em 0; display:block"><a name="citable__194" class="citable__local-anchor">.</a><span class='citationPopup' rel="194">The FDA requires all antidepressants, including sertraline, to carry a <a href="/Black_box_warning" title="Black box warning">black box warning</a> stating that antidepressants may increase the risk of suicide in persons younger than 25. This warning is based on statistical analyses conducted by two independent groups of FDA experts that found a 2-fold increase of suicidal ideation and behavior in children and adolescents, and a 1.5-fold increase of suicidality in the 18–24 age group.</span><span class="citable__li" citable_id="194"><a href="#citable__194"><strong>^</strong></a> <c_txt>Antidepressant use in children, adolescents, and adults .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Antidepressants - Pharmacy Clinical Policy Bulletins Aetna Non-Medicare Prescription Drug Plan</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.aetna.com/products/rxnonmedicare/data/2007/CNS/antidepressants_2007.html">www.aetna.com</a> [Source type: Academic]</li><li> <em><c_title>Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.aetna.com/products/rxmedicare/data/Medicare2007/CNS/antidepressants_2007.html">www.aetna.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="194"><a href="#citable__194"><strong>^</strong></a> <c_txt>British regulators have banned the use of some SSRIs in the UK. On October 15, 2004 the FDA directed manufacturers of all antidepressants to include a Black Box warning, expanded warning statements, and clinical trial results detailing the increased risk of suicidality in children and adolescents.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="194"><a href="#citable__194"><strong>^</strong></a> <c_txt>The FDA altered the warning labeling for all agents stating that newborns exposed to SSRIs in utero may experience symptoms that prolong hospitalization and require respiratory and nutritional support.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.aetna.com/products/rxmedicare/data/Medicare2007/CNS/antidepressants_2007.html">www.aetna.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_FDA_141_0" class="reference"><a href="#cite_note-FDA-141"><span>[</span>142<span>]</span></a></sup><sup id="wikipedia_cite_ref_FDA2_142_0" class="reference"><a href="#cite_note-FDA2-142"><span>[</span>143<span>]</span></a></sup><sup id="wikipedia_cite_ref_FDA3_143_0" class="reference"><a href="#cite_note-FDA3-143"><span>[</span>144<span>]</span></a></sup></div> <div style="margin: 1.12em 0; display:block"><a href="/Suicidal_ideation" title="Suicidal ideation">Suicidal ideation</a> and behavior in clinical trials are rare. <a name="citable__16" class="citable__local-anchor">.</a><span class='citationPopup' rel="16">For the above analysis, the FDA combined the results of 295 trials of 11 antidepressants for psychiatric indications in order to obtain <a href="/Statistically_significant" title="Statistically significant" class="mw-redirect">statistically significant</a> results.</span><span class="citable__li" citable_id="16"><a href="#citable__16"><strong>^</strong></a> <c_txt>Statistical Analysis Biomarker measures were obtained in blood samples taken at baseline and at weeks 6 and 16 of the double-blind treatment period.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="16"><a href="#citable__16"><strong>^</strong></a> <c_txt>Total costs for treatment with risperidone were $1,963 higher than for treatment with conventional agents, but the results were not judged to be statistically significant.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="16"><a href="#citable__16"><strong>^</strong></a> <c_txt>Results indicated that a dramatic decrease in the frequency and cost of rehospitalization contributed to a significant decrease in cost of treatment for patients who continued clozapine treatment for at least two years.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__187" class="citable__local-anchor">.</a><span class='citationPopup' rel="187">Considered separately, sertraline use in adults decreased the odds of suicidality with a marginal statistical significance by 37%<sup id="wikipedia_cite_ref_FDA3_143_1" class="reference"><a href="#cite_note-FDA3-143"><span>[</span>144<span>]</span></a></sup> or 50%<sup id="wikipedia_cite_ref_FDA2_142_1" class="reference"><a href="#cite_note-FDA2-142"><span>[</span>143<span>]</span></a></sup> depending on the statistical technique used.</span><span class="citable__li" citable_id="187"><a href="#citable__187"><strong>^</strong></a> <c_txt>Finally, use of oral anticoagulants was less frequent in the sertraline group; however, this difference did not reach significance.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="187"><a href="#citable__187"><strong>^</strong></a> <c_txt>Overall mean costs were significantly lower for the sertraline group than for the TCA group as determined using some statistical tests, but not others.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="187"><a href="#citable__187"><strong>^</strong></a> <c_txt>Indeed, at 6 weeks after randomization, patients treated with sertraline exhibited a significant decrease in ßTG, the well-defined platelet -granule constituent.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__165" class="citable__local-anchor">.</a><span class='citationPopup' rel="165">The authors of the FDA analysis note that "given the large number of comparisons made in this review, chance is a very plausible explanation for this difference".<sup id="wikipedia_cite_ref_FDA2_142_2" class="reference"><a href="#cite_note-FDA2-142"><span>[</span>143<span>]</span></a></sup> The more complete data submitted later by the sertraline manufacturer Pfizer indicated increased suicidality.</span><span class="citable__li" citable_id="165"><a href="#citable__165"><strong>^</strong></a> <c_txt>On March 22, 2004 the FDA issued a Public Health Advisory for several antidepressants, including sertraline, warning of increased risk of worsening depression or suicidal tendency in adults and children (see Contraindications).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="165"><a href="#citable__165"><strong>^</strong></a> <c_txt>Zoloft Question: I have been treated for 1+1/2 years with Zoloft to control PMS. It has worked very well and made a tremendous difference in my life.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="165"><a href="#citable__165"><strong>^</strong></a> <c_txt>Hospitalization data for these treatments will not be reviewed independently, but will be incorporated into more detailed reviews of these studies.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_144" class="reference"><a href="#cite_note-144"><span>[</span>145<span>]</span></a></sup> <a name="citable__133" class="citable__local-anchor">.</a><span class='citationPopup' rel="133">Similarly, the analysis conducted by the UK <a href="/Medicines_and_Healthcare_products_Regulatory_Agency" title="Medicines and Healthcare products Regulatory Agency">MHRA</a> found a 50% increase of odds of suicide-related events, not reaching statistical significance, in the patients on sertraline as compared to the ones on placebo.</span><span class="citable__li" citable_id="133"><a href="#citable__133"><strong>^</strong></a> <c_txt>One of 4 patients in the placebo group responded.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="133"><a href="#citable__133"><strong>^</strong></a> <c_txt>INTERVENTION: Patients were randomly assigned to receive a flexible dosage (50-200 mg/d) of sertraline (n = 189) or matching placebo tablets (n = 187) for 10 weeks.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="133"><a href="#citable__133"><strong>^</strong></a> <c_txt>Seventeen sertraline-treated patients (9%) and 5 placebo patients (3%) prematurely discontinued the study because of adverse events.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_145" class="reference"><a href="#cite_note-145"><span>[</span>146<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid15718537_146_0" class="reference"><a href="#cite_note-pmid15718537-146"><span>[</span>147<span>]</span></a></sup></div> <div style="display:table-cell;clear:both;"></div><h3><span class="mw-headline" id="wikipedia_Discontinuation_syndrome">Discontinuation syndrome</span></h3> <div class="rellink relarticle mainarticle">Main article: <a href="/SSRI_discontinuation_syndrome" title="SSRI discontinuation syndrome">SSRI discontinuation syndrome</a></div> <div style="margin: 1.12em 0; display:block"><a name="citable__72" class="citable__local-anchor">.</a><span class='citationPopup' rel="72">Abrupt interruption of sertraline treatment may result in withdrawal or discontinuation syndrome.</span><span class="citable__li" citable_id="72"><a href="#citable__72"><strong>^</strong></a> <c_txt>The withdrawal syndrome(if it occurs)may occur up to three weeks after stopping zoloft.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="72"><a href="#citable__72"><strong>^</strong></a> <c_txt>Treatment with sertraline may result in lower total costs than treatment with TCAs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="72"><a href="#citable__72"><strong>^</strong></a> <c_txt>Both of the studies reviewed below suggest that treatment with sertraline results in lower costs than treatment with TCAs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__141" class="citable__local-anchor">.</a><span class='citationPopup' rel="141">This syndrome occurred in 60% of the remitted depressed patients taking sertraline in a blind discontinuation study, as compared to 14% of patients on fluoxetine and 66% of patients on paroxetine.</span><span class="citable__li" citable_id="141"><a href="#citable__141"><strong>^</strong></a> <c_txt>Sertraline has one active metabolite and a lower potential for drug interactions involving CYP2D6 (hepatic cytochrome P-450 isoenzyme 2D6) than fluoxetine or paroxetine.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="141"><a href="#citable__141"><strong>^</strong></a> <c_txt>Outcomes may be skewed due to physician unfamiliarity with the drug and the fact that paroxetine and sertraline may have been used early on as second-line therapy for patients who discontinued fluoxetine.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="141"><a href="#citable__141"><strong>^</strong></a> <c_txt>Conducted in a primary care setting in France, this six month multicenter study compared treatment with fluoxetine (n=120) and sertraline (n=122) in patients with major depression.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid9646889_147_0" class="reference"><a href="#cite_note-pmid9646889-147"><span>[</span>148<span>]</span></a></sup> <a name="citable__151" class="citable__local-anchor">.</a><span class='citationPopup' rel="151">During the 5–8-day period when sertraline was temporarily replaced by placebo, the most frequent symptoms (reported by more than a quarter of patients) were irritability, agitation, dizziness, headache, nervousness, crying, <a href="/Labile_affect" title="Labile affect">emotional lability</a>, bad dreams and anger.</span><span class="citable__li" citable_id="151"><a href="#citable__151"><strong>^</strong></a> <c_txt>More ADRs with sertraline than PLB. .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="151"><a href="#citable__151"><strong>^</strong></a> <c_txt>If sertraline ( Zoloft ) is abruptly discontinued, withdrawal symptoms such as irritability, agitation, dizziness, electric shock sensations, anxiety, headaches, and increased manic episodes may occur.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="151"><a href="#citable__151"><strong>^</strong></a> <c_txt>In this analysis, venlafaxine was more cost-effective in terms of expected costs per success and per symptom free day (SFD) than TCAs both in the inpatient and outpatient setting.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__127" class="citable__local-anchor">.</a><span class='citationPopup' rel="127">Around a third experienced mood worsening to the level generally associated with a major depressive episode.</span><span class="citable__li" citable_id="127"><a href="#citable__127"><strong>^</strong></a> <c_txt>Because data have accumulated indicating that depression is associated with platelet activation, it also became apparent that the SSRIs in general and sertraline in particular affect platelet function.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="127"><a href="#citable__127"><strong>^</strong></a> <c_txt>Indeed, 40% of patients with AMI report experiencing symptoms of depression, 20 and 20% to 25% of these patients actually develop major depression.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="127"><a href="#citable__127"><strong>^</strong></a> <c_txt>Enhanced platelet activation has been suggested as a possible mechanism contributing to the increased cardiac risk associated with the diagnosis of major depression.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid9646889_147_1" class="reference"><a href="#cite_note-pmid9646889-147"><span>[</span>148<span>]</span></a></sup> In a double-blind study of remitted panic disorder patients, abrupt discontinuation of sertraline treatment resulted in insomnia and dizziness (both 16–17% vs. 4% for continuing treatment), although headache, depression and malaise did not increase significantly.<sup id="wikipedia_cite_ref_pmid11722304_81_1" class="reference"><a href="#cite_note-pmid11722304-81"><span>[</span>82<span>]</span></a></sup> <a name="citable__293" class="citable__local-anchor">.</a><span class='citationPopup' rel="293">In another double-blind study of recovered panic disorder patients, the withdrawal syndrome was completely avoided when sertraline was gradually discontinued over three weeks, while patients stopping <a href="/Paroxetine" title="Paroxetine">paroxetine</a> treatment still suffered from it.</span><span class="citable__li" citable_id="293"><a href="#citable__293"><strong>^</strong></a> <c_txt>The withdrawal syndrome(if it occurs)may occur up to three weeks after stopping zoloft.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="293"><a href="#citable__293"><strong>^</strong></a> <c_txt>Sertraline has been studied in two 12-week, double-blind, placebo controlled trials.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="293"><a href="#citable__293"><strong>^</strong></a> <c_txt>INTERVENTION: Patients were randomly assigned to receive a flexible dosage (50-200 mg/d) of sertraline (n = 189) or matching placebo tablets (n = 187) for 10 weeks.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid15096081_79_2" class="reference"><a href="#cite_note-pmid15096081-79"><span>[</span>80<span>]</span></a></sup></div> <h2><span class="mw-headline" id="wikipedia_Mechanism_of_action">Mechanism of action</span></h2> <div style="margin: 1.12em 0; display:block"><a name="citable__126" class="citable__local-anchor">.</a><span class='citationPopup' rel="126">Sertraline is primarily a <a href="/Serotonin_reuptake_inhibitor" title="Serotonin reuptake inhibitor">serotonin reuptake inhibitor</a> (SRI).</span><span class="citable__li" citable_id="126"><a href="#citable__126"><strong>^</strong></a> <c_txt>Meier CR, Schlienger RG, Jick H. Use of selective serotonin reuptake inhibitors and risk of developing first-time acute myocardial infarction.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="126"><a href="#citable__126"><strong>^</strong></a> <c_txt>Sproule BA, Naranjo CA, Bremner KE, Hassan PC. Selective serotonin reuptake inhibitors and CNS drug interactions.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Antidepressants - Pharmacy Clinical Policy Bulletins Aetna Non-Medicare Prescription Drug Plan</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.aetna.com/products/rxnonmedicare/data/2007/CNS/antidepressants_2007.html">www.aetna.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="126"><a href="#citable__126"><strong>^</strong></a> <c_txt>Mechanism of Action: Sertraline potentiates serotonin (5-HT) in the CNS. Sertraline does not significantly affect the reuptake of norepinephrine as do many tricyclic antidepressants.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <a name="citable__272" class="citable__local-anchor">.</a><span class='citationPopup' rel="272">Therapeutic doses of sertraline (50–200 mg/day) taken by patients for four weeks resulted in 80–90% inhibition of <a href="/Serotonin_transporter" title="Serotonin transporter">serotonin transporter</a> (SERT) in <a href="/Striatum" title="Striatum">striatum</a> as measured by <a href="/Positron_emission_tomography" title="Positron emission tomography">positron emission tomography</a>.</span><span class="citable__li" citable_id="272"><a href="#citable__272"><strong>^</strong></a> <c_txt>In a controlled study of a single dose (2 mg) of pimozide, 200 mg sertraline (q.d.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="272"><a href="#citable__272"><strong>^</strong></a> <c_txt>The maximum recommended daily dose for Zoloft is 50-200 mg.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="272"><a href="#citable__272"><strong>^</strong></a> <c_txt>Enrolled patients received sertraline (50 to 200 mg/d) or matching placebo.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy -- Serebruany et al. 108 (8): 939 -- Circulation</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://circ.ahajournals.org/cgi/content/full/108/8/939">circ.ahajournals.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__145" class="citable__local-anchor">.</a><span class='citationPopup' rel="145">A daily 9 mg dose was sufficient to inhibit 50% of SERT.<sup id="wikipedia_cite_ref_pmid15121647_148_0" class="reference"><a href="#cite_note-pmid15121647-148"><span>[</span>149<span>]</span></a></sup> Sertraline is also a <a href="/Dopamine_reuptake_inhibitor" title="Dopamine reuptake inhibitor">dopamine reuptake inhibitor</a>, with 1% of its SRI potency,<sup id="wikipedia_cite_ref_pmid11543737_149_0" class="reference"><a href="#cite_note-pmid11543737-149"><span>[</span>150<span>]</span></a></sup> a <a href="/Sigma-1_receptor" title="Sigma-1 receptor">σ<sub>1</sub> receptor</a> <a href="/Agonist" title="Agonist">agonist</a> with 5% of its SRI potency,<sup id="wikipedia_cite_ref_pmid8831113_150_0" class="reference"><a href="#cite_note-pmid8831113-150"><span>[</span>151<span>]</span></a></sup> and an <a href="/Alpha_blocker" title="Alpha blocker">α<sub>1</sub>-adrenoreceptor antagonist</a> with 1–10% of its SRI potency.</span><span class="citable__li" citable_id="145"><a href="#citable__145"><strong>^</strong></a> <c_txt>The maximum recommended daily dose for Zoloft is 50-200 mg.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="145"><a href="#citable__145"><strong>^</strong></a> <c_txt>Sertraline 50-200 mg .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="145"><a href="#citable__145"><strong>^</strong></a> <c_txt>Since taking the drug (50-100 mg daily) I have experienced gradual weight gain.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid11543737_149_1" class="reference"><a href="#cite_note-pmid11543737-149"><span>[</span>150<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid9400006_151_0" class="reference"><a href="#cite_note-pmid9400006-151"><span>[</span>152<span>]</span></a></sup></div> <h2><span class="mw-headline" id="wikipedia_Pharmacokinetics">Pharmacokinetics</span></h2> <div style="margin: 1.12em 0; display:block"><a name="citable__279" class="citable__local-anchor">.</a><span class='citationPopup' rel="279">Sertraline is absorbed slowly when taken by mouth, achieving its maximal concentration in the plasma 4–6 hours after ingestion.</span><span class="citable__li" citable_id="279"><a href="#citable__279"><strong>^</strong></a> <c_txt>Grapefruit juice alters plasma sertraline levels after single ingestion of sertraline in healthy volunteers.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="279"><a href="#citable__279"><strong>^</strong></a> <c_txt>The extent of absorption may be somewhat increased by administration with food; the peak concentration may be increased by 25%, and the time taken to attain peak concentration decreased from about 8 hours to 5.5 hours, if administered with food.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> In the blood, it is 98.5% <a href="/Plasma_protein_binding" title="Plasma protein binding">bound to plasma proteins</a>. <a name="citable__2" class="citable__local-anchor">.</a><span class='citationPopup' rel="2">Its half-life in the body is 13–45 hours and, on average, is about 1.5 times longer in women (32 hours) than in men (22 hours), leading to a 1.5-times-higher exposure in women.</span><span class="citable__li" citable_id="2"><a href="#citable__2"><strong>^</strong></a> <c_txt>Dosage adjustments are recommended for patients with mild, stable cirrhosis since these patients have a prolonged elimination half-life (e.g., 52 hours compared to 22 hours in patients without liver disease) and a higher peak serum concentration (e.g., 1.7 fold greater than in normal patients).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="2"><a href="#citable__2"><strong>^</strong></a> <c_txt>Also, the liver cannot metabolize the antidepressant and the alcohol simultaneously, thus leading to higher levels of both alcohol and the antidepressant in the human body.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.drugawareness.org/tag/zoloft">www.drugawareness.org</a> [Source type: General]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="2"><a href="#citable__2"><strong>^</strong></a> <c_txt>And it has long been known that women suffer more adverse reactions to antidepressants than men do.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.drugawareness.org/tag/zoloft">www.drugawareness.org</a> [Source type: General]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid12452737_152_0" class="reference"><a href="#cite_note-pmid12452737-152"><span>[</span>153<span>]</span></a></sup> <a name="citable__278" class="citable__local-anchor">.</a><span class='citationPopup' rel="278">According to <em><a href="/In_vitro" title="In vitro">in vitro</a></em> studies, sertraline is metabolized by multiple <a href="/Cytochrome_450" title="Cytochrome 450" class="mw-redirect">cytochrome 450</a> <a href="/Isoenzyme" title="Isoenzyme" class="mw-redirect">isoforms</a>: <a href="/CYP2D6" title="CYP2D6">CYP2D6</a>, <a href="/CYP2C9" title="CYP2C9">CYP2C9</a>, <a href="/CYP2B6" title="CYP2B6">CYP2B6</a>, <a href="/CYP2C19" title="CYP2C19">CYP2C19</a> and <a href="/CYP3A4" title="CYP3A4">CYP3A4</a>.</span><span class="citable__li" citable_id="278"><a href="#citable__278"><strong>^</strong></a> <c_txt>"The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study."</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="278"><a href="#citable__278"><strong>^</strong></a> <c_txt>Sertraline has one active metabolite and a lower potential for drug interactions involving CYP2D6 (hepatic cytochrome P-450 isoenzyme 2D6) than fluoxetine or paroxetine.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <a name="citable__261" class="citable__local-anchor">.</a><span class='citationPopup' rel="261">It appeared unlikely that inhibition of any single isoform could cause clinically significant changes in sertraline pharmacokinetics.</span><span class="citable__li" citable_id="261"><a href="#citable__261"><strong>^</strong></a> <c_txt>The clinical significance of these changes is unknown.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="261"><a href="#citable__261"><strong>^</strong></a> <c_txt>In this study, treatment with fluoxetine was associated with greater treatment costs than was treatment with sertraline, while clinical outcomes appear similar.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="261"><a href="#citable__261"><strong>^</strong></a> <c_txt>First it should be noted that a dosage of 50mg/day was used for sertraline instead of the later recommended dosage of 100mg/day, which could have impacted clinical outcomes.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid10383917_153_0" class="reference"><a href="#cite_note-pmid10383917-153"><span>[</span>154<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid15547048_154_0" class="reference"><a href="#cite_note-pmid15547048-154"><span>[</span>155<span>]</span></a></sup> <a name="citable__114" class="citable__local-anchor">.</a><span class='citationPopup' rel="114">No differences in sertraline pharmacokinetics were observed between people with high and low activity of CYP2D6;<sup id="wikipedia_cite_ref_pmid8941024_155_0" class="reference"><a href="#cite_note-pmid8941024-155"><span>[</span>156<span>]</span></a></sup> however, poor CYP2C19 metabolizers had a 1.5-times-higher level of sertraline than normal metabolizers.</span><span class="citable__li" citable_id="114"><a href="#citable__114"><strong>^</strong></a> <c_txt>Sertraline has one active metabolite and a lower potential for drug interactions involving CYP2D6 (hepatic cytochrome P-450 isoenzyme 2D6) than fluoxetine or paroxetine.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="114"><a href="#citable__114"><strong>^</strong></a> <c_txt>Also, the liver cannot metabolize the antidepressant and the alcohol simultaneously, thus leading to higher levels of both alcohol and the antidepressant in the human body.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.drugawareness.org/tag/zoloft">www.drugawareness.org</a> [Source type: General]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="114"><a href="#citable__114"><strong>^</strong></a> <c_txt>As shown in Table 2 , there were no differences between drug groups in anxiety symptom count at baseline or at follow-up.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>JAMA -- Similar Effectiveness of Paroxetine, Fluoxetine, and Sertraline in Primary Care: A Randomized Trial, December 19, 2001, Kroenke et al. 286 (23): 2947</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://jama.ama-assn.org/cgi/content/full/286/23/2947">jama.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid11452243_156_0" class="reference"><a href="#cite_note-pmid11452243-156"><span>[</span>157<span>]</span></a></sup> <a name="citable__144" class="citable__local-anchor">.</a><span class='citationPopup' rel="144"><em>In vitro</em> data also indicate that the inhibition of CYP2B6 should have even greater effect than the inhibition of CYP2C19, while the contribution of CYP2C9 and CYP3A4 to the <a href="/Metabolism" title="Metabolism">metabolism</a> of sertraline would be minor.</span><span class="citable__li" citable_id="144"><a href="#citable__144"><strong>^</strong></a> <c_txt>"The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study."</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="144"><a href="#citable__144"><strong>^</strong></a> <c_txt>In this study, treatment with fluoxetine was associated with greater treatment costs than was treatment with sertraline, while clinical outcomes appear similar.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <a name="citable__153" class="citable__local-anchor">.</a><span class='citationPopup' rel="153">These conclusions have not been verified in human studies.</span><span class="citable__li" citable_id="153"><a href="#citable__153"><strong>^</strong></a> <c_txt>Overall, these results are promising and support further study of propranolol in the secondary prevention of PTSD. Conclusions .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid15547048_154_1" class="reference"><a href="#cite_note-pmid15547048-154"><span>[</span>155<span>]</span></a></sup> <a name="citable__205" class="citable__local-anchor">.</a><span class='citationPopup' rel="205">Sertraline can be <a href="/Deamination" title="Deamination">deaminated</a> <em>in vitro</em> by <a href="/Monoamine_oxidase" title="Monoamine oxidase">monoamine oxidases</a>; however, this <a href="/Metabolic_pathway" title="Metabolic pathway">metabolic pathway</a> has never been studied <em>in vivo</em>.</span><span class="citable__li" citable_id="205"><a href="#citable__205"><strong>^</strong></a> <c_txt>An in vitro and in vivo study.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="205"><a href="#citable__205"><strong>^</strong></a> <c_txt>"The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study."</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="205"><a href="#citable__205"><strong>^</strong></a> <c_txt>Never take Zoloft if you are taking another drug used to treat depression, called a Monoamine Oxidase Inhibitor (MAOI), or if you have stopped taking an MAOI in the last 14 days.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid15547048_154_2" class="reference"><a href="#cite_note-pmid15547048-154"><span>[</span>155<span>]</span></a></sup> <a name="citable__95" class="citable__local-anchor">.</a><span class='citationPopup' rel="95">The major metabolite of sertraline, <a href="/Desmethylsertraline" title="Desmethylsertraline">desmethylsertraline</a>, is about 50 times weaker as a serotonin transporter inhibitor than sertraline and its clinical effect is negligible.</span><span class="citable__li" citable_id="95"><a href="#citable__95"><strong>^</strong></a> <c_txt>The primary metabolite is N-desmethylsertraline, which is substantially less active than sertraline.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="95"><a href="#citable__95"><strong>^</strong></a> <c_txt>Sertraline has one active metabolite and a lower potential for drug interactions involving CYP2D6 (hepatic cytochrome P-450 isoenzyme 2D6) than fluoxetine or paroxetine.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="95"><a href="#citable__95"><strong>^</strong></a> <c_txt>AUC and Cmax of about 40%, but was not associated with any changes in EKG. Since the highest recommended pimozide dose (10 mg) has not been evaluated in combination with sertraline, the effect on QT interval and PK parameters at doses higher than 2 mg at this time are not known.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid9400006_151_1" class="reference"><a href="#cite_note-pmid9400006-151"><span>[</span>152<span>]</span></a></sup></div> <h2><span class="mw-headline" id="wikipedia_Interactions">Interactions</span></h2> <div style="margin: 1.12em 0; display:block">Sertraline is a moderate <a href="/Enzyme_inhibitor" title="Enzyme inhibitor">inhibitor</a> of <a href="/CYP2D6" title="CYP2D6">CYP2D6</a> and <a href="/CYP2B6" title="CYP2B6">CYP2B6</a> <em>in vitro</em>.<sup id="wikipedia_cite_ref_pmid16192315_157_0" class="reference"><a href="#cite_note-pmid16192315-157"><span>[</span>158<span>]</span></a></sup> <a name="citable__71" class="citable__local-anchor">.</a><span class='citationPopup' rel="71">Accordingly, in human trials it caused increased blood levels of CYP2D6 <a href="/Substrate_(biochemistry)" title="Substrate (biochemistry)" class="mw-redirect">substrates</a> such as <a href="/Metoprolol" title="Metoprolol">metoprolol</a> (Lopressor, Toprol XL), <a href="/Dextromethorphan" title="Dextromethorphan">dextromethorphan</a> (Robitussin cough suppressant), <a href="/Desipramine" title="Desipramine">desipramine</a> (Norpramin), <a href="/Imipramine" title="Imipramine">imipramine</a> (Tofranil) and <a href="/Nortriptyline" title="Nortriptyline">nortriptyline</a> (Pamelor), as well as the <a href="/CYP3A4" title="CYP3A4">CYP3A4</a>/<a href="/CYP2D6" title="CYP2D6">CYP2D6</a> substrate <a href="/Haloperidol" title="Haloperidol">haloperidol</a> (Haldol).</span><span class="citable__li" citable_id="71"><a href="#citable__71"><strong>^</strong></a> <c_txt>I take toprol xl for high blood pressure, and Zoloft for depression.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft Side Effects: Report, View, Discuss and Compare Zoloft side effects. FDA Zoloft reports, Zoloft on Twitter, Zoloft posts, Zoloft questions. Zoloft safety polls, Zoloft problems, Zoloft symptoms, 1</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.patientsville.com/medication/zoloft_side_effects.htm">www.patientsville.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="71"><a href="#citable__71"><strong>^</strong></a> <c_txt>Usually, when children are well recognized, the value of treating growth hormone deficiency causes an increase in size rapidly.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>zolfot | BREAK THE MATRIX</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.breakthematrix.com/users/zolfot/">www.breakthematrix.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="71"><a href="#citable__71"><strong>^</strong></a> <c_txt>TCAs (amitriptyline/imipramine (n=104) or desipramine/nortriptyline (n=250)).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid9472843_158_0" class="reference"><a href="#cite_note-pmid9472843-158"><span>[</span>159<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid10211917_159_0" class="reference"><a href="#cite_note-pmid10211917-159"><span>[</span>160<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid10631623_160_0" class="reference"><a href="#cite_note-pmid10631623-160"><span>[</span>161<span>]</span></a></sup> <a name="citable__4" class="citable__local-anchor">.</a><span class='citationPopup' rel="4">This effect is dose-dependent; for example, co-administration with 50 mg of sertraline resulted in 20% greater exposure to desipramine, while 150 mg of sertraline led to a 70% increase.</span><span class="citable__li" citable_id="4"><a href="#citable__4"><strong>^</strong></a> <c_txt>Paroxetine 20-50 mg .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="4"><a href="#citable__4"><strong>^</strong></a> <c_txt>Sertraline 50-200 mg .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="4"><a href="#citable__4"><strong>^</strong></a> <c_txt>INTERVENTION: Patients were randomly assigned to receive a flexible dosage (50-200 mg/d) of sertraline (n = 189) or matching placebo tablets (n = 187) for 10 weeks.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid12452737_152_1" class="reference"><a href="#cite_note-pmid12452737-152"><span>[</span>153<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid17224709_161_0" class="reference"><a href="#cite_note-pmid17224709-161"><span>[</span>162<span>]</span></a></sup> In a placebo-controlled study, the concomitant administration of sertraline and <a href="/Methadone" title="Methadone">methadone</a> caused a 40% increase in blood levels of the latter, which is primarily metabolized by CYP2B6.<sup id="wikipedia_cite_ref_pmid10914294_162_0" class="reference"><a href="#cite_note-pmid10914294-162"><span>[</span>163<span>]</span></a></sup></div> <div style="margin: 1.12em 0; display:block"><a name="citable__137" class="citable__local-anchor">.</a><span class='citationPopup' rel="137">Sertraline had a slight inhibitory effect on the metabolism of <a href="/Diazepam" title="Diazepam">diazepam</a> (Valium), <a href="/Tolbutamide" title="Tolbutamide">tolbutamide</a> (Orinase) and <a href="/Warfarin" title="Warfarin">warfarin</a> (Coumadin), which are <a href="/CYP2C9" title="CYP2C9">CYP2C9</a> or <a href="/CYP2C19" title="CYP2C19">CYP2C19</a> substrates; this effect was not considered to be clinically relevant.</span><span class="citable__li" citable_id="137"><a href="#citable__137"><strong>^</strong></a> <c_txt>"The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study."</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid12452737_152_2" class="reference"><a href="#cite_note-pmid12452737-152"><span>[</span>153<span>]</span></a></sup> <a name="citable__280" class="citable__local-anchor">.</a><span class='citationPopup' rel="280">As expected from <em>in vitro</em> data, sertraline did not alter the human metabolism of the CYP3A4 substrates <a href="/Erythromycin" title="Erythromycin">erythromycin</a>, <a href="/Alprazolam" title="Alprazolam">alprazolam</a> (Xanax), <a href="/Carbamazepine" title="Carbamazepine">carbamazepine</a> (Tegretol), <a href="/Clonazepam" title="Clonazepam">clonazepam</a> (Klonopin), and <a href="/Terfenadine" title="Terfenadine">terfenadine</a> (Seldane); neither did it affect metabolism of the <a href="/CYP1A2" title="CYP1A2">CYP1A2</a> substrate <a href="/Clozapine" title="Clozapine">clozapine</a> (Clozaril).</span><span class="citable__li" citable_id="280"><a href="#citable__280"><strong>^</strong></a> <c_txt>They experimented on me with many different drugs: Effexor, Celexa, Abilify, Alprazolam, Clonazepam (Klonopin), Depakote, Lunesta, Trazodone, Xanax, Zyprexa and of course Zoloft (Sertraline).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.drugawareness.org/tag/zoloft">www.drugawareness.org</a> [Source type: General]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="280"><a href="#citable__280"><strong>^</strong></a> <c_txt>Carbamazepine ( Tegretol ): Decreases effectiveness of sertraline ( Zoloft ), so sertraline dose may need to be adjusted.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="280"><a href="#citable__280"><strong>^</strong></a> <c_txt>"The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study."</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> </div> <div style="margin: 1.12em 0; display:block"><a name="citable__117" class="citable__local-anchor">.</a><span class='citationPopup' rel="117">Sertraline had no effect on the actions of <a href="/Digoxin" title="Digoxin">digoxin</a> (Lanoxin) and <a href="/Atenolol" title="Atenolol">atenolol</a> (Tenormin), which are not metabolized in the liver.</span><span class="citable__li" citable_id="117"><a href="#citable__117"><strong>^</strong></a> <c_txt>Reply I've been on sertraline from CVS from the beginning for a year now, take it every morning with no bad effects.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="117"><a href="#citable__117"><strong>^</strong></a> <c_txt>"The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study."</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_zoloftpi_119_3" class="reference"><a href="#cite_note-zoloftpi-119"><span>[</span>120<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid12452737_152_3" class="reference"><a href="#cite_note-pmid12452737-152"><span>[</span>153<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid16192315_157_1" class="reference"><a href="#cite_note-pmid16192315-157"><span>[</span>158<span>]</span></a></sup><sup id="wikipedia_cite_ref_pmid14709940_163_0" class="reference"><a href="#cite_note-pmid14709940-163"><span>[</span>164<span>]</span></a></sup> <a name="citable__79" class="citable__local-anchor">.</a><span class='citationPopup' rel="79"><a href="/Case_report" title="Case report">Case reports</a> suggest that taking sertraline with <a href="/Phenytoin" title="Phenytoin">phenytoin</a> (Dilantin) or <a href="/Zolpidem" title="Zolpidem">zolpidem</a> (Ambien) may induce sertraline metabolism and decrease its efficacy, and taking sertraline with <a href="/Lamotrigine" title="Lamotrigine">lamotrigine</a> (Lamictal) may increase the blood level of lamotrigine via an unknown mechanism.</span><span class="citable__li" citable_id="79"><a href="#citable__79"><strong>^</strong></a> <c_txt>In terms of poor impulse controls the use of a mood stabilizer such as valproate, carbamazepine, or lithium may be helpful as accessed by case reports.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="79"><a href="#citable__79"><strong>^</strong></a> <c_txt>Grapefruit Juice (6): Avoid taking sertraline ( Zoloft ) with grapefruit juice as this may result in elevated drug levels in the bloodstream.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="79"><a href="#citable__79"><strong>^</strong></a> <c_txt>II. TAKE with CLOSE MEDICAL MONITORING • Propafenone ( Rythmol ): Certain SSRIs, including sertraline ( Zoloft ), may increase the level of this drug, so cardiac function should be carefully monitored.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <sup class="Template-Fact" title="This claim needs references to reliable sources from March 2010" style="white-space:nowrap;">[<em>citation needed</em>]</sup></div> <div style="margin: 1.12em 0; display:block"><a name="citable__198" class="citable__local-anchor">.</a><span class='citationPopup' rel="198">Clinical reports indicate that interaction between sertraline and the <a href="/Monoamine_oxidase_inhibitor" title="Monoamine oxidase inhibitor">MAOIs</a> <a href="/Isocarboxazid" title="Isocarboxazid">isocarboxazid</a> (Marplan) and <a href="/Tranylcypromine" title="Tranylcypromine">tranylcypromine</a> (Parnate) may cause <a href="/Serotonin_syndrome" title="Serotonin syndrome">serotonin syndrome</a>.</span><span class="citable__li" citable_id="198"><a href="#citable__198"><strong>^</strong></a> <c_txt>What drug(s) may interact with sertraline?</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="198"><a href="#citable__198"><strong>^</strong></a> <c_txt>High body temperature Coma Seizures (convulsions) MAOI drugs include Nardil (phenelzine sulfate), Parnate (tranylcypromine sulfate), Marplan (isocarboxazid), and other brands.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="198"><a href="#citable__198"><strong>^</strong></a> <c_txt>Not recommended: People who have had an allergic reaction to SSRIs, sertraline ( Zoloft ), or its components or who are taking the MAOI class of antidepressants (isocarboxazid- Marplan , phenelzine- Nardil , tranylcypromine- Parnate , selegiline- EmSam ) or drugs with MAOI activity such as pimozide ( Orap ) or linezolid ( Zyvox ).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <a name="citable__12" class="citable__local-anchor">.</a><span class='citationPopup' rel="12">In a placebo-controlled study in which sertraline was co-administered with <a href="/Lithium_pharmacology" title="Lithium pharmacology">lithium</a>, 35% of the subjects experienced tremors, while none of those taking placebo did.</span><span class="citable__li" citable_id="12"><a href="#citable__12"><strong>^</strong></a> <c_txt>Seventeen sertraline-treated patients (9%) and 5 placebo patients (3%) prematurely discontinued the study because of adverse events.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="12"><a href="#citable__12"><strong>^</strong></a> <c_txt>Hertzberg et al (1999) studied lamotrigine for PTSD in a 12-week double-blind, randomized (2:1) placebo-controlled trial.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="12"><a href="#citable__12"><strong>^</strong></a> <c_txt>PLACEBO CONTROLLED TRIAL: SECONDARY PREVENTION OF PTSD Pitman et al (2002) studied propranolol in the secondary prevention of PTSD in a double-blind, placebo-controlled trial.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Virtual Hospital: Clinical Psychopharmacology Seminar : Posttraumatic Stress Disorder</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.tu.edu/user_files/10/38.html">www.tu.edu</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_pmid12452737_152_4" class="reference"><a href="#cite_note-pmid12452737-152"><span>[</span>153<span>]</span></a></sup></div> <h2><span class="mw-headline" id="wikipedia_Controversy">Controversy</span></h2> <div style="margin: 1.12em 0; display:block"><a name="citable__186" class="citable__local-anchor">.</a><span class='citationPopup' rel="186">The brand-name form of sertraline, Zoloft, was <a href="/Direct-to-consumer_advertising" title="Direct-to-consumer advertising">advertised to consumers</a> by Pfizer using the following wording: "While the cause is unknown, depression may be related to an imbalance of natural chemicals between nerve cells in the brain.</span><span class="citable__li" citable_id="186"><a href="#citable__186"><strong>^</strong></a> <c_txt>Answer: Zoloft (sertraline hydrochloride) is a drug normally used in depression.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="186"><a href="#citable__186"><strong>^</strong></a> <c_txt>Using an ointment can cause temporary swelling of the brain messenger chemicals that have been affected.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>zolfot | BREAK THE MATRIX</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.breakthematrix.com/users/zolfot/">www.breakthematrix.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="186"><a href="#citable__186"><strong>^</strong></a> <c_txt>In 1997 and 1998, Pfizer, the pharmaceutical company that manufactures Zoloft, wrote two reports on Zoloft that made it to the FDA and were used by the FDA for the approval of Zoloft for additional applications.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> Prescription Zoloft works to correct this imbalance. <a name="citable__302" class="citable__local-anchor">.</a><span class='citationPopup' rel="302">You just shouldn't have to feel this way anymore."</span><span class="citable__li" citable_id="302"><a href="#citable__302"><strong>^</strong></a> <c_txt>You shouldn't mess with the brain in this way.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <a name="citable__5" class="citable__local-anchor">.</a><span class='citationPopup' rel="5">An essay published in the journal <em><a href="/PLoS_Medicine" title="PLoS Medicine">PLoS Medicine</a></em> noted that there is no scientific support for the "serotonin imbalance" theory of depression, and criticized Pfizer and manufacturers of other SSRIs for using it.</span><span class="citable__li" citable_id="5"><a href="#citable__5"><strong>^</strong></a> <c_txt>In 1997 and 1998, Pfizer, the pharmaceutical company that manufactures Zoloft, wrote two reports on Zoloft that made it to the FDA and were used by the FDA for the approval of Zoloft for additional applications.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="5"><a href="#citable__5"><strong>^</strong></a> <c_txt>There also does not appear to be an increased risk of major congenital malformations with the other SSRIs at this time; however, information on sertraline, fluvoxamine, escitalopram, and citalopram is limited.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Antidepressants, SSRIs/SNRIs/other - Pharmacy Clinical Policy Bulletins Aetna Medicare Prescription Drug Plan</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.aetna.com/products/rxmedicare/data/Medicare2007/CNS/antidepressants_2007.html">www.aetna.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="5"><a href="#citable__5"><strong>^</strong></a> <c_txt>There is no clear evidence that any one drug (including duloxetine- Cymbalta or venlafaxine- Effexor ) is better than others.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <a name="citable__134" class="citable__local-anchor">.</a><span class='citationPopup' rel="134">When asked to comment on this apparent breach of federal regulations, the FDA answered that such "reductionist statements" are acceptable to explain the neurochemistry of depression "to the fraction of the public that functions at no higher than a 6th-grade reading level."</span><span class="citable__li" citable_id="134"><a href="#citable__134"><strong>^</strong></a> <c_txt>Results found no difference in clinical outcomes, measured by Global Assessment of Functioning (GAF) scores, but a trend towards higher total costs for risperidone.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="134"><a href="#citable__134"><strong>^</strong></a> <c_txt>The authors stated that any such increase was no more than $130 per patient (1.8%) for each percentage increase in the proportion of patients remaining stable on initial pharmacotherapy for at least 6 months.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="134"><a href="#citable__134"><strong>^</strong></a> <c_txt>These differences are explained by differences in model parameters such as hospitalization, compliance rates and depression recurrence rates.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_PLoS_164_0" class="reference"><a href="#cite_note-PLoS-164"><span>[</span>165<span>]</span></a></sup> <a name="citable__201" class="citable__local-anchor">.</a><span class='citationPopup' rel="201">However, the FDA reacted promptly with a warning letter when a Zoloft advertisement omitted information about the risk of suicidality.</span><span class="citable__li" citable_id="201"><a href="#citable__201"><strong>^</strong></a> <c_txt>On March 22, 2004 the FDA issued a Public Health Advisory for several antidepressants, including sertraline, warning of increased risk of worsening depression or suicidal tendency in adults and children (see Contraindications).</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="201"><a href="#citable__201"><strong>^</strong></a> <c_txt>Sertraline , Side Effects , Sikora , SSRI , Suicidal Thoughts , SUICIDE , teen , violence , warning , Withdrawal , Youth Suicide Rate , Zoloft .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.drugawareness.org/tag/zoloft">www.drugawareness.org</a> [Source type: General]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="201"><a href="#citable__201"><strong>^</strong></a> <c_txt>We hope you found our information about Zoloft Side Effects helpful.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft Side Effects: Report, View, Discuss and Compare Zoloft side effects. FDA Zoloft reports, Zoloft on Twitter, Zoloft posts, Zoloft questions. Zoloft safety polls, Zoloft problems, Zoloft symptoms, 1</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.patientsville.com/medication/zoloft_side_effects.htm">www.patientsville.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_165" class="reference"><a href="#cite_note-165"><span>[</span>166<span>]</span></a></sup></div> <div style="margin: 1.12em 0; display:block">In the case of <em>Regina v Hawkins,</em> an Australian criminal case from the state of New South Wales, Zoloft was described as an important factor in David Hawkins's killing in 1999 (through strangling) of his wife. <a name="citable__179" class="citable__local-anchor">.</a><span class='citationPopup' rel="179">Hawkins had been depressed, was prescribed 50 mg of Zoloft a day and on his first day of treatment took 250 mg.</span><span class="citable__li" citable_id="179"><a href="#citable__179"><strong>^</strong></a> <c_txt>Zoloft Question: Today is my second day on 50 mg of Zoloft.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="179"><a href="#citable__179"><strong>^</strong></a> <c_txt>Zoloft Dosing Levels Question: I have been prescribed 50 mg.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="179"><a href="#citable__179"><strong>^</strong></a> <c_txt>Zoloft Concerns [posted 11/11/98] Question: I'm taking zoloft for the first time and never taken anything else for depression.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <a name="citable__219" class="citable__local-anchor">.</a><span class='citationPopup' rel="219">He claimed that on the night of the murder he could not sleep and was agitated, and that he had hallucinations during the attack on his wife.</span><span class="citable__li" citable_id="219"><a href="#citable__219"><strong>^</strong></a> <c_txt>I was finally able to get a good night's sleep and best of all my doctor said Zoloft was not addictive so I could stop taking it eventually with no withdrawal symptoms.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Sertraline (SER tra leen) Side Effects - The People's Pharmacy®</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://www.peoplespharmacy.com/2008/03/31/sertraline/">www.peoplespharmacy.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="219"><a href="#citable__219"><strong>^</strong></a> <c_txt>I also could not sleep and take Restoril 30 mg at night to be able to sleep through the pain.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li></ul></c_src></small></div><br></span> <a name="citable__266" class="citable__local-anchor">.</a><span class='citationPopup' rel="266">Several experts agreed that "Zoloft can cause agitation and a certain amount of disinhibition so that some individuals engage in aggressive or dangerous behaviours without due regard for the consequences and in a manner that is out of character for them" and that the prisoner's behavior was consistent with <a href="/Mixed_state_(psychiatry)" title="Mixed state (psychiatry)">agitated depression</a> further exacerbated by <a href="/Akathisia" title="Akathisia">akathisia</a> and toxic delirium that developed as a result of Zoloft overdose.</span><span class="citable__li" citable_id="266"><a href="#citable__266"><strong>^</strong></a> <c_txt>Did Zoloft cause the behavior of Christopher?</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft withdrawal. Zoloft withdrawal side effects, Zoloft withdrawal warnings, Zoloft withdrawal precautions, Zoloft withdrawal adverse effects.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.prozactruth.com/zoloft.htm">www.prozactruth.com</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="266"><a href="#citable__266"><strong>^</strong></a> <c_txt>Zoloft side effects Bruise - Damage to the skin resulting in a purple-green-yellow skin coloration thats caused by breaking the blood vessels in the area without breaking the surface of the skin.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="266"><a href="#citable__266"><strong>^</strong></a> <c_txt>Sertraline has also been studied for the treatment of postpsychotic depression of schizophrenia, behavioral problems due to brain injury, and for premature ejaculation.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title></c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://frames.healthinkonline.com/modules/goldstandard/monograph.asp?cpnum=562&name=Sertraline">frames.healthinkonline.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <a name="citable__104" class="citable__local-anchor">.</a><span class='citationPopup' rel="104">The court concluded that "it can be seen that the medical evidence strongly supports a conclusion that, but for the effects of the 250 milligrams of Zoloft he had taken, it is wholly unlikely that the prisoner would have committed the crime to which he has pleaded guilty.</span><span class="citable__li" citable_id="104"><a href="#citable__104"><strong>^</strong></a> <c_txt>Second, are there any potential side effects to the baby if Zoloft is continued or during the first eight weeks the medication was taken.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="104"><a href="#citable__104"><strong>^</strong></a> <c_txt>Zoloft side effects Sweating Increased - A large quantity of perspiration that is medically caused.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="104"><a href="#citable__104"><strong>^</strong></a> <c_txt>Zoloft side effects Vision Abnormal - Normal images are seen differently by the viewer.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> Furthermore, it is common ground that his having done such an act is quite foreign to his former life history, his personality and psychological makeup. It was also wholly inconsistent with his love for his marriage partner of nearly 50 years."<sup id="wikipedia_cite_ref_166" class="reference"><a href="#cite_note-166"><span>[</span>167<span>]</span></a></sup></div> <div style="margin: 1.12em 0; display:block"><a name="citable__170" class="citable__local-anchor">.</a><span class='citationPopup' rel="170">In 2004, a Los Angeles nurse sued Pfizer as a <a href="/Private_attorney_general" title="Private attorney general">private attorney general</a> "on behalf of all California residents who have been misled about Zoloft," claiming the company covered up side effects.</span><span class="citable__li" citable_id="170"><a href="#citable__170"><strong>^</strong></a> <c_txt>Zoloft negative side effects.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>zolfot | BREAK THE MATRIX</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.breakthematrix.com/users/zolfot/">www.breakthematrix.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="170"><a href="#citable__170"><strong>^</strong></a> <c_txt>Zoloft side effects Dyspepsia - Indigestion.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="170"><a href="#citable__170"><strong>^</strong></a> <c_txt>Zoloft side effects Gagging - Involuntary choking and/or involuntary throwing up.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft. Zoloft side effects, Zoloft withdrawal side effects, Zoloft stories and Zoloft solutions. Zoloft.</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.theroadback.org/zoloft-withdrawal.htm">www.theroadback.org</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_167" class="reference"><a href="#cite_note-167"><span>[</span>168<span>]</span></a></sup> <a name="citable__267" class="citable__local-anchor">.</a><span class='citationPopup' rel="267">In 2005, the Los Angeles Superior Court dismissed the case and ordered the plaintiff to pay Pfizer's cost of the suit.</span><span class="citable__li" citable_id="267"><a href="#citable__267"><strong>^</strong></a> <c_txt>In the worst case inpatient scenario, TCAs were superior to venlafaxine; in the worst case outpatient scenario, venlafaxine remained more cost-effective than TCAs.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Access and Utilization of New Antidepressant and Antipsychotic Medications</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://aspe.os.dhhs.gov/health/reports/Psychmedaccess/chap07.htm">aspe.os.dhhs.gov</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="267"><a href="#citable__267"><strong>^</strong></a> <c_txt>PLAINTIFFS WILLING TO HAVE SCIENTIFIC EVIDENCE IN WRONGFUL DEATH/SUICIDE CASE AGAINST MANUFACTURER OF ZOLOFT MEASURED BY NEUTRAL, COURT-APPOINTED EXPERTS. PFIZER IS NOT. .</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Zoloft</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.drugawareness.org/tag/zoloft">www.drugawareness.org</a> [Source type: General]</li></ul></c_src></small></div><br></span> <sup id="wikipedia_cite_ref_lasc_168_0" class="reference"><a href="#cite_note-lasc-168"><span>[</span>169<span>]</span></a></sup></div> <h2><span class="mw-headline" id="wikipedia_Notes">Notes</span></h2> <div class="references-small"> <dl> <dd><span id="wikipedia_endnote_TradeNameA"><a href="#ref_TradeNameA"><strong><sup>A</sup></strong></a></span>  Medication trade names may differ among countries. <a name="citable__265" class="citable__local-anchor">.</a><span class='citationPopup' rel="265">In general, this article uses North American trade names.</span><span class="citable__li" citable_id="265"><a href="#citable__265"><strong>^</strong></a> <c_txt>Answer: Zoloft, generic name sertraline, is a commonly used and effective antidepressant medication.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>Drug InfoNet - Zoloft - [depression]</c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/index.php?pageID=faq/new/DRUG_FAQ/Zoloft.htm">www.druginfonet.com</a> [Source type: Original source]</li><li> <em><c_title> Drug InfoNet Doctors' Answers to Frequently Asked Questions - Zoloft </c_title></em> <c_date>22 January 2010 11:13 UTC</c_date> <a href="http://www.druginfonet.com/faq/faqzolof.htm">www.druginfonet.com</a> [Source type: FILTERED WITH BAYES]</li></ul></c_src></small></div><br></span> <span class="citable__li" citable_id="265"><a href="#citable__265"><strong>^</strong></a> <c_txt>FULL TEXT Using Second-Generation Antidepressants to Treat Depressive Disorders: A Clinical Practice Guideline from the American College of Physicians Qaseem et al.</c_txt><div style="padding-left: 10px"><small><c_src><ul><li> <em><c_title>JAMA -- Similar Effectiveness of Paroxetine, Fluoxetine, and Sertraline in Primary Care: A Randomized Trial, December 19, 2001, Kroenke et al. 286 (23): 2947</c_title></em> <c_date>28 January 2010 0:49 UTC</c_date> <a href="http://jama.ama-assn.org/cgi/content/full/286/23/2947">jama.ama-assn.org</a> [Source type: Academic]</li></ul></c_src></small></div><br></span> </dd> </dl> </div> <h2><span class="mw-headline" id="wikipedia_References">References</span></h2> <div class="references-small references-column-count references-column-count-2" style="-moz-column-count:2; column-count:2;"> <ol class="references"> <li id="wikipedia_cite_note_0"><strong><a href="#cite_ref-0">^</a></strong> <span class="citation Journal">Obach RS, Cox LM, Tremaine LM (2005). <a href="http://dmd.aspetjournals.org/content/33/2/262.full" class="external text" rel="nofollow">"Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study"</a> (free access). <em>Drug Metabolism & Disposition</em> <strong>33</strong>: 262. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1124%2Fdmd.104.002428" class="external text" rel="nofollow">10.1124/dmd.104.002428</a><span class="printonly">. <a href="http://dmd.aspetjournals.org/content/33/2/262.full" class="external free" rel="nofollow">http://dmd.aspetjournals.org/content/33/2/262.full</a></span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sertraline+is+metabolized+by+multiple+cytochrome+P450+enzymes%2C+monoamine+oxidases%2C+and+glucuronyl+transferases+in+human%3A+an+in+vitro+study&rft.jtitle=Drug+Metabolism+%26+Disposition&rft.aulast=Obach+RS%2C+Cox+LM%2C+Tremaine+LM&rft.au=Obach+RS%2C+Cox+LM%2C+Tremaine+LM&rft.date=2005&rft.volume=33&rft.pages=262&rft_id=info:doi/10.1124%2Fdmd.104.002428&rft_id=http%3A%2F%2Fdmd.aspetjournals.org%2Fcontent%2F33%2F2%2F262.full&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_1"><strong><a href="#cite_ref-1">^</a></strong> The sertraline prescriptions were calculated as a total of prescriptions for Zoloft and generic Sertraline using data from the charts for generic and <a href="/Brand" title="Brand">brand name</a> drugs, see: <span class="citation web">Verispan (2008-02-18). <a href="http://www.drugtopics.com/drugtopics/article/articleDetail.jsp?id=491181" class="external text" rel="nofollow">"Top 200 Generic Drugs by Units in 2007"</a> (PDF). Drug Topics<span class="printonly">. <a href="http://www.drugtopics.com/drugtopics/article/articleDetail.jsp?id=491181" class="external free" rel="nofollow">http://www.drugtopics.com/drugtopics/article/articleDetail.jsp?id=491181</a></span><span class="reference-accessdate">. Retrieved 2008-03-30</span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=Top+200+Generic+Drugs+by+Units+in+2007&rft.atitle=&rft.aulast=Verispan&rft.au=Verispan&rft.date=2008-02-18&rft.pub=Drug+Topics&rft_id=http%3A%2F%2Fwww.drugtopics.com%2Fdrugtopics%2Farticle%2FarticleDetail.jsp%3Fid%3D491181&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span> and <span class="citation web">Verispan (2008-02-18). <a href="http://www.drugtopics.com/drugtopics/article/articleDetail.jsp?id=491207" class="external text" rel="nofollow">"Top 200 Brand Drugs by Units in 2007"</a> (PDF). Drug Topics<span class="printonly">. <a href="http://www.drugtopics.com/drugtopics/article/articleDetail.jsp?id=491207" class="external free" rel="nofollow">http://www.drugtopics.com/drugtopics/article/articleDetail.jsp?id=491207</a></span><span class="reference-accessdate">. Retrieved 2008-03-30</span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=Top+200+Brand+Drugs+by+Units+in+2007&rft.atitle=&rft.aulast=Verispan&rft.au=Verispan&rft.date=2008-02-18&rft.pub=Drug+Topics&rft_id=http%3A%2F%2Fwww.drugtopics.com%2Fdrugtopics%2Farticle%2FarticleDetail.jsp%3Fid%3D491207&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid10529069_2">^ <a href="#cite_ref-pmid10529069_2-0"><sup><em><strong>a</strong></em></sup></a> <a href="#cite_ref-pmid10529069_2-1"><sup><em><strong>b</strong></em></sup></a> <span class="citation Journal">Flament MF, Lane RM, Zhu R, Ying Z (1999). "Predictors of an acute antidepressant response to fluoxetine and sertraline". <em>Int Clin Psychopharmacol</em> <strong>14</strong> (5): 259–75. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1097%2F00004850-199914050-00001" class="external text" rel="nofollow">10.1097/00004850-199914050-00001</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/10529069" class="external text" rel="nofollow">10529069</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Predictors+of+an+acute+antidepressant+response+to+fluoxetine+and+sertraline&rft.jtitle=Int+Clin+Psychopharmacol&rft.aulast=Flament+MF%2C+Lane+RM%2C+Zhu+R%2C+Ying+Z&rft.au=Flament+MF%2C+Lane+RM%2C+Zhu+R%2C+Ying+Z&rft.date=1999&rft.volume=14&rft.issue=5&rft.pages=259%E2%80%9375&rft_id=info:doi/10.1097%2F00004850-199914050-00001&rft_id=info:pmid/10529069&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid14709946_3">^ <a href="#cite_ref-pmid14709946_3-0"><sup><em><strong>a</strong></em></sup></a> <a href="#cite_ref-pmid14709946_3-1"><sup><em><strong>b</strong></em></sup></a> The BSPS15 criterion identified 28 (21%) of sertraline-treated patients and 4 (6%) of placebo-treated patients as responders. The 50% reduction in BSPS criterion identified 47 (35%) of sertraline-treated patients and 9 (13%) of placebo-treated patients as responders. Finally, the 50% reduction in MFQ-SP criterion identified 53 (39%) of sertraline-treated patients and 9 (13%) of placebo-treated patients as responders. <span class="citation Journal">Van Ameringen M, Oakman J, Mancini C, Pipe B, Chung H (February 2004). "Predictors of response in generalized social phobia: effect of age of onset". <em>J Clin Psychopharmacol</em> <strong>24</strong> (1): 42–8. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1097%2F01.jcp.0000104909.75206.6f" class="external text" rel="nofollow">10.1097/01.jcp.0000104909.75206.6f</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/14709946" class="external text" rel="nofollow">14709946</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Predictors+of+response+in+generalized+social+phobia%3A+effect+of+age+of+onset&rft.jtitle=J+Clin+Psychopharmacol&rft.aulast=Van+Ameringen+M%2C+Oakman+J%2C+Mancini+C%2C+Pipe+B%2C+Chung+H&rft.au=Van+Ameringen+M%2C+Oakman+J%2C+Mancini+C%2C+Pipe+B%2C+Chung+H&rft.date=February+2004&rft.volume=24&rft.issue=1&rft.pages=42%E2%80%938&rft_id=info:doi/10.1097%2F01.jcp.0000104909.75206.6f&rft_id=info:pmid/14709946&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid11343529_4">^ <a href="#cite_ref-pmid11343529_4-0"><sup><em><strong>a</strong></em></sup></a> <a href="#cite_ref-pmid11343529_4-1"><sup><em><strong>b</strong></em></sup></a> CGI-Improvement, mean ± SD: Sertraline = 2.3 ± 0.1 Placebo = 2.8 ± 0.1. CGI-Severity, mean ± SD: Change Sertraline = −1.3 ± 0.1; placebo = −1.0 ± 0.1 <span class="citation Journal">Davidson JR, Rothbaum BO, van der Kolk BA, Sikes CR, Farfel GM (2001). "Multicenter, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder". <em>Arch. Gen. Psychiatry</em> <strong>58</strong> (5): 485–92. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1001%2Farchpsyc.58.5.485" class="external text" rel="nofollow">10.1001/archpsyc.58.5.485</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/11343529" class="external text" rel="nofollow">11343529</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Multicenter%2C+double-blind+comparison+of+sertraline+and+placebo+in+the+treatment+of+posttraumatic+stress+disorder&rft.jtitle=Arch.+Gen.+Psychiatry&rft.aulast=Davidson+JR%2C+Rothbaum+BO%2C+van+der+Kolk+BA%2C+Sikes+CR%2C+Farfel+GM&rft.au=Davidson+JR%2C+Rothbaum+BO%2C+van+der+Kolk+BA%2C+Sikes+CR%2C+Farfel+GM&rft.date=2001&rft.volume=58&rft.issue=5&rft.pages=485%E2%80%9392&rft_id=info:doi/10.1001%2Farchpsyc.58.5.485&rft_id=info:pmid/11343529&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_Welch_5">^ <a href="#cite_ref-Welch_5-0"><sup><em><strong>a</strong></em></sup></a> <a href="#cite_ref-Welch_5-1"><sup><em><strong>b</strong></em></sup></a> The most complete account of sertraline discovery, targeted at chemists, see: <span class="citation Journal">Welch WM (1995). "Discovery and Development of Sertraline". <em>Advances in Medicinal Chemistry</em> <strong>3</strong>: 113–148. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1016%2FS1067-5698%2806%2980005-2" class="external text" rel="nofollow">10.1016/S1067-5698(06)80005-2</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Discovery+and+Development+of+Sertraline&rft.jtitle=Advances+in+Medicinal+Chemistry&rft.aulast=Welch+WM&rft.au=Welch+WM&rft.date=1995&rft.volume=3&rft.pages=113%E2%80%93148&rft_id=info:doi/10.1016%2FS1067-5698%2806%2980005-2&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_6"><strong><a href="#cite_ref-6">^</a></strong> <span class="citation Journal">Sarges R, Tretter JR, Tenen SS, Weissman A (1973). "5,8-Disubstituted 1-Aminotetralins. A Class of Compounds with a Novel Profile of Central Nervous System Activity". <em>Journal of Medicinal Chemistry</em> <strong>16</strong> (9): 1003–1011. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1021%2Fjm00267a010" class="external text" rel="nofollow">10.1021/jm00267a010</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=5%2C8-Disubstituted+1-Aminotetralins.+A+Class+of+Compounds+with+a+Novel+Profile+of+Central+Nervous+System+Activity&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.aulast=Sarges+R%2C+Tretter+JR%2C+Tenen+SS%2C+Weissman+A&rft.au=Sarges+R%2C+Tretter+JR%2C+Tenen+SS%2C+Weissman+A&rft.date=1973&rft.volume=16&rft.issue=9&rft.pages=1003%E2%80%931011&rft_id=info:doi/10.1021%2Fjm00267a010&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_7"><strong><a href="#cite_ref-7">^</a></strong> See also: <span class="citation Journal">Mullin R (2006). "ACS Award for Team Innovation". <em>Chemical & Engineering News</em> <strong>84</strong> (5): 45–52.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=ACS+Award+for+Team+Innovation&rft.jtitle=Chemical+%26+Engineering+News&rft.aulast=Mullin+R&rft.au=Mullin+R&rft.date=2006&rft.volume=84&rft.issue=5&rft.pages=45%E2%80%9352&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_8"><strong><a href="#cite_ref-8">^</a></strong> A short blurb on the history of sertraline, see: <span class="citation Journal">Couzin J (2005). "The brains behind blockbusters". <em><a href="/Science_(journal)" title="Science (journal)">Science</a></em> <strong>309</strong> (5735): 728. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1126%2Fscience.309.5735.728" class="external text" rel="nofollow">10.1126/science.309.5735.728</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/16051786" class="external text" rel="nofollow">16051786</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+brains+behind+blockbusters&rft.jtitle=%5B%5BScience+%28journal%29%7CScience%5D%5D&rft.aulast=Couzin+J&rft.au=Couzin+J&rft.date=2005&rft.volume=309&rft.issue=5735&rft.pages=728&rft_id=info:doi/10.1126%2Fscience.309.5735.728&rft_id=info:pmid/16051786&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_He168_9"><strong><a href="#cite_ref-He168_9-0">^</a></strong> <span class="citation book"><a href="/David_Healy_(psychiatrist)" title="David Healy (psychiatrist)">Healy, David</a> (1999). <em>The Antidepressant Era</em>. Cambridge, Massachusetts: Harvard University Press. pp. 168. <a href="/International_Standard_Book_Number" title="International Standard Book Number">ISBN</a> 0-674-03958-0.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=The+Antidepressant+Era&rft.aulast=Healy&rft.aufirst=David&rft.au=Healy%2C%26%2332%3BDavid&rft.date=1999&rft.pages=pp.%26nbsp%3B168&rft.place=Cambridge%2C+Massachusetts&rft.pub=Harvard+University+Press&rft.isbn=0-674-03958-0&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pdac_10"><strong><a href="#cite_ref-pdac_10-0">^</a></strong> <span class="citation web"><a href="http://www.healyprozac.com/PDAC/PDAC-Zoloft%20Nov%2090.pdf" class="external text" rel="nofollow">"Minutes of the 33rd Meeting of Psychopharmacological Drugs Advisory Committee on November 19, 1990"</a> (PDF). FDA. 1990<span class="printonly">. <a href="http://www.healyprozac.com/PDAC/PDAC-Zoloft%20Nov%2090.pdf" class="external free" rel="nofollow">http://www.healyprozac.com/PDAC/PDAC-Zoloft%20Nov%2090.pdf</a></span><span class="reference-accessdate">. Retrieved 2008-07-11</span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=Minutes+of+the+33rd+Meeting+of+Psychopharmacological+Drugs+Advisory+Committee+on+November+19%2C+1990&rft.atitle=&rft.date=1990&rft.pub=FDA&rft_id=http%3A%2F%2Fwww.healyprozac.com%2FPDAC%2FPDAC-Zoloft%2520Nov%252090.pdf&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid8573661_11"><strong><a href="#cite_ref-pmid8573661_11-0">^</a></strong> See also:<span class="citation Journal">Fabre LF, Abuzzahab FS, Amin M, Claghorn JL, Mendels J, Petrie WM, Dubé S, Small JG (1995). "Sertraline safety and efficacy in major depression: a double-blind fixed-dose comparison with placebo". <em>Biol. Psychiatry</em> <strong>38</strong> (9): 592–602. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1016%2F0006-3223%2895%2900178-8" class="external text" rel="nofollow">10.1016/0006-3223(95)00178-8</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/8573661" class="external text" rel="nofollow">8573661</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sertraline+safety+and+efficacy+in+major+depression%3A+a+double-blind+fixed-dose+comparison+with+placebo&rft.jtitle=Biol.+Psychiatry&rft.aulast=Fabre+LF%2C+Abuzzahab+FS%2C+Amin+M%2C+Claghorn+JL%2C+Mendels+J%2C+Petrie+WM%2C+Dub%C3%A9+S%2C+Small+JG&rft.au=Fabre+LF%2C+Abuzzahab+FS%2C+Amin+M%2C+Claghorn+JL%2C+Mendels+J%2C+Petrie+WM%2C+Dub%C3%A9+S%2C+Small+JG&rft.date=1995&rft.volume=38&rft.issue=9&rft.pages=592%E2%80%93602&rft_id=info:doi/10.1016%2F0006-3223%2895%2900178-8&rft_id=info:pmid/8573661&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid15462638_12"><strong><a href="#cite_ref-pmid15462638_12-0">^</a></strong> <span class="citation Journal">Mant A, Rendle VA, Hall WD, <em>et al.</em> (October 2004). "Making new choices about antidepressants in Australia: the long view 1975-2002". <em>Med. J. Aust.</em> <strong>181</strong> (7 Suppl): S21–4. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/15462638" class="external text" rel="nofollow">15462638</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Making+new+choices+about+antidepressants+in+Australia%3A+the+long+view+1975-2002&rft.jtitle=Med.+J.+Aust.&rft.aulast=Mant+A%2C+Rendle+VA%2C+Hall+WD%2C+%27%27et+al.%27%27&rft.au=Mant+A%2C+Rendle+VA%2C+Hall+WD%2C+%27%27et+al.%27%27&rft.date=October+2004&rft.volume=181&rft.issue=7+Suppl&rft.pages=S21%E2%80%934&rft_id=info:pmid/15462638&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_13"><strong><a href="#cite_ref-13">^</a></strong> <span class="citation Journal"><a href="http://www.australianprescriber.com/magazine/22/5/artid/328/" class="external text" rel="nofollow">"Top 10 drugs - 1998"</a>. <em>Australian Prescriber</em> <strong>22</strong>: 119. 1999<span class="printonly">. <a href="http://www.australianprescriber.com/magazine/22/5/artid/328/" class="external free" rel="nofollow">http://www.australianprescriber.com/magazine/22/5/artid/328/</a></span><span class="reference-accessdate">. Retrieved 2008-04-30</span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Top+10+drugs+-+1998&rft.jtitle=Australian+Prescriber&rft.date=1999&rft.volume=22&rft.pages=119&rft_id=http%3A%2F%2Fwww.australianprescriber.com%2Fmagazine%2F22%2F5%2Fartid%2F328%2F&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_14"><strong><a href="#cite_ref-14">^</a></strong> <span class="citation Journal"><a href="http://www.australianprescriber.com/magazine/24/6/artid/549/" class="external text" rel="nofollow">"Top 10 drugs - 2000-01"</a>. <em>Australian Prescriber</em> <strong>24</strong>: 136. 2001<span class="printonly">. <a href="http://www.australianprescriber.com/magazine/24/6/artid/549/" class="external free" rel="nofollow">http://www.australianprescriber.com/magazine/24/6/artid/549/</a></span><span class="reference-accessdate">. Retrieved 2008-04-30</span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Top+10+drugs+-+2000-01&rft.jtitle=Australian+Prescriber&rft.date=2001&rft.volume=24&rft.pages=136&rft_id=http%3A%2F%2Fwww.australianprescriber.com%2Fmagazine%2F24%2F6%2Fartid%2F549%2F&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_url_15"><strong><a href="#cite_ref-url_15-0">^</a></strong> <span class="citation web"><a href="http://www.mhra.gov.uk/home/groups/pl-p/documents/websiteresources/con019473.pdf" class="external text" rel="nofollow">"Prescribing trends for SSRIs and related antidepressants"</a> (PDF). UK MHRA. 2004<span class="printonly">. <a href="http://www.mhra.gov.uk/home/groups/pl-p/documents/websiteresources/con019473.pdf" class="external free" rel="nofollow">http://www.mhra.gov.uk/home/groups/pl-p/documents/websiteresources/con019473.pdf</a></span><span class="reference-accessdate">. Retrieved 2008-04-30</span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=Prescribing+trends+for+SSRIs+and+related+antidepressants&rft.atitle=&rft.date=2004&rft.pub=UK+MHRA&rft_id=http%3A%2F%2Fwww.mhra.gov.uk%2Fhome%2Fgroups%2Fpl-p%2Fdocuments%2Fwebsiteresources%2Fcon019473.pdf&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_16"><strong><a href="#cite_ref-16">^</a></strong> <span class="citation web">Skinner BJ, Rovere M (2007-07-31). <a href="http://www.fraserinstitute.org/COMMERCE.WEB/publication_details.aspx?pubID=4542" class="external text" rel="nofollow">"Canada's Drug Price Paradox 2007"</a> (PDF). 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Disord.</em> <strong>10</strong> (5): 682–4. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1002%2Fmds.870100529" class="external text" rel="nofollow">10.1002/mds.870100529</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/8552129" class="external text" rel="nofollow">8552129</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sertraline-induced+exacerbation+of+tics+in+Tourette%27s+syndrome&rft.jtitle=Mov.+Disord.&rft.aulast=Hauser+RA%2C+Zesiewicz+TA&rft.au=Hauser+RA%2C+Zesiewicz+TA&rft.date=September+1995&rft.volume=10&rft.issue=5&rft.pages=682%E2%80%934&rft_id=info:doi/10.1002%2Fmds.870100529&rft_id=info:pmid/8552129&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid10945134_75">^ <a href="#cite_ref-pmid10945134_75-0"><sup><em><strong>a</strong></em></sup></a> <a href="#cite_ref-pmid10945134_75-1"><sup><em><strong>b</strong></em></sup></a> Review: <span class="citation Journal">Hirschfeld RM (2000). "Sertraline in the treatment of anxiety disorders". <em>Depress Anxiety</em> <strong>11</strong> (4): 139–57. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1002%2F1520-6394%282000%2911%3A4%3C139%3A%3AAID-DA1%3E3.0.CO%3B2-C" class="external text" rel="nofollow">10.1002/1520-6394(2000)11:4<139::AID-DA1>3.0.CO;2-C</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/10945134" class="external text" rel="nofollow">10945134</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sertraline+in+the+treatment+of+anxiety+disorders&rft.jtitle=Depress+Anxiety&rft.aulast=Hirschfeld+RM&rft.au=Hirschfeld+RM&rft.date=2000&rft.volume=11&rft.issue=4&rft.pages=139%E2%80%9357&rft_id=info:doi/10.1002%2F1520-6394%282000%2911%3A4%3C139%3A%3AAID-DA1%3E3.0.CO%3B2-C&rft_id=info:pmid/10945134&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid16292466_76">^ <a href="#cite_ref-pmid16292466_76-0"><sup><em><strong>a</strong></em></sup></a> <a href="#cite_ref-pmid16292466_76-1"><sup><em><strong>b</strong></em></sup></a> Meta-analysis: <span class="citation Journal">Clayton AH, Stewart RS, Fayyad R, Clary CM (2006). "Sex differences in clinical presentation and response in panic disorder: pooled data from sertraline treatment studies". <em>Arch Womens Ment Health</em> <strong>9</strong> (3): 151–7. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1007%2Fs00737-005-0111-y" class="external text" rel="nofollow">10.1007/s00737-005-0111-y</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/16292466" class="external text" rel="nofollow">16292466</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sex+differences+in+clinical+presentation+and+response+in+panic+disorder%3A+pooled+data+from+sertraline+treatment+studies&rft.jtitle=Arch+Womens+Ment+Health&rft.aulast=Clayton+AH%2C+Stewart+RS%2C+Fayyad+R%2C+Clary+CM&rft.au=Clayton+AH%2C+Stewart+RS%2C+Fayyad+R%2C+Clary+CM&rft.date=2006&rft.volume=9&rft.issue=3&rft.pages=151%E2%80%937&rft_id=info:doi/10.1007%2Fs00737-005-0111-y&rft_id=info:pmid/16292466&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid11206597_77">^ <a href="#cite_ref-pmid11206597_77-0"><sup><em><strong>a</strong></em></sup></a> <a href="#cite_ref-pmid11206597_77-1"><sup><em><strong>b</strong></em></sup></a> <span class="citation Journal">Pollack MH, Rapaport MH, Clary CM, Mardekian J, Wolkow R (2000). "Sertraline treatment of panic disorder: response in patients at risk for poor outcome". <em>J Clin Psychiatry</em> <strong>61</strong> (12): 922–7. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/11206597" class="external text" rel="nofollow">11206597</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sertraline+treatment+of+panic+disorder%3A+response+in+patients+at+risk+for+poor+outcome&rft.jtitle=J+Clin+Psychiatry&rft.aulast=Pollack+MH%2C+Rapaport+MH%2C+Clary+CM%2C+Mardekian+J%2C+Wolkow+R&rft.au=Pollack+MH%2C+Rapaport+MH%2C+Clary+CM%2C+Mardekian+J%2C+Wolkow+R&rft.date=2000&rft.volume=61&rft.issue=12&rft.pages=922%E2%80%937&rft_id=info:pmid/11206597&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid11199932_78"><strong><a href="#cite_ref-pmid11199932_78-0">^</a></strong> <span class="citation Journal">Rapaport MH, Pollack MH, Clary CM, Mardekian J, Wolkow R (2001). "Panic disorder and response to sertraline: the effect of previous treatment with benzodiazepines". <em>J Clin Psychopharmacol</em> <strong>21</strong> (1): 104–7. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1097%2F00004714-200102000-00019" class="external text" rel="nofollow">10.1097/00004714-200102000-00019</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/11199932" class="external text" rel="nofollow">11199932</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Panic+disorder+and+response+to+sertraline%3A+the+effect+of+previous+treatment+with+benzodiazepines&rft.jtitle=J+Clin+Psychopharmacol&rft.aulast=Rapaport+MH%2C+Pollack+MH%2C+Clary+CM%2C+Mardekian+J%2C+Wolkow+R&rft.au=Rapaport+MH%2C+Pollack+MH%2C+Clary+CM%2C+Mardekian+J%2C+Wolkow+R&rft.date=2001&rft.volume=21&rft.issue=1&rft.pages=104%E2%80%937&rft_id=info:doi/10.1097%2F00004714-200102000-00019&rft_id=info:pmid/11199932&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid15096081_79">^ <a href="#cite_ref-pmid15096081_79-0"><sup><em><strong>a</strong></em></sup></a> <a href="#cite_ref-pmid15096081_79-1"><sup><em><strong>b</strong></em></sup></a> <a href="#cite_ref-pmid15096081_79-2"><sup><em><strong>c</strong></em></sup></a> <span class="citation Journal">Bandelow B, Behnke K, Lenoir S, Hendriks GJ, Alkin T, Goebel C, Clary CM (2004). "Sertraline versus paroxetine in the treatment of panic disorder: an acute, double-blind noninferiority comparison". <em>J Clin Psychiatry</em> <strong>65</strong> (3): 405–13. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/15096081" class="external text" rel="nofollow">15096081</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sertraline+versus+paroxetine+in+the+treatment+of+panic+disorder%3A+an+acute%2C+double-blind+noninferiority+comparison&rft.jtitle=J+Clin+Psychiatry&rft.aulast=Bandelow+B%2C+Behnke+K%2C+Lenoir+S%2C+Hendriks+GJ%2C+Alkin+T%2C+Goebel+C%2C+Clary+CM&rft.au=Bandelow+B%2C+Behnke+K%2C+Lenoir+S%2C+Hendriks+GJ%2C+Alkin+T%2C+Goebel+C%2C+Clary+CM&rft.date=2004&rft.volume=65&rft.issue=3&rft.pages=405%E2%80%9313&rft_id=info:pmid/15096081&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid16053461_80"><strong><a href="#cite_ref-pmid16053461_80-0">^</a></strong> <span class="citation Journal">Fiseković S, Loga-Zec S (2005). "Sertraline and alprazolam in the treatment of panic desorder [<em><a href="/Sic" title="Sic">sic</a></em>]". <em>Bosn J Basic Med Sci</em> <strong>5</strong> (2): 78–81. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/16053461" class="external text" rel="nofollow">16053461</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sertraline+and+alprazolam+in+the+treatment+of+panic+desorder%26%2332%3B%26%2391%3B%27%27%5B%5Bsic%5D%5D%27%27%26%2393%3B&rft.jtitle=Bosn+J+Basic+Med+Sci&rft.aulast=Fisekovi%C4%87+S%2C+Loga-Zec+S&rft.au=Fisekovi%C4%87+S%2C+Loga-Zec+S&rft.date=2005&rft.volume=5&rft.issue=2&rft.pages=78%E2%80%9381&rft_id=info:pmid/16053461&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid11722304_81">^ <a href="#cite_ref-pmid11722304_81-0"><sup><em><strong>a</strong></em></sup></a> <a href="#cite_ref-pmid11722304_81-1"><sup><em><strong>b</strong></em></sup></a> <span class="citation Journal">Rapaport MH, Wolkow R, Rubin A, Hackett E, Pollack M, Ota KY (2001). "Sertraline treatment of panic disorder: results of a long-term study". <em>Acta Psychiatr Scand</em> <strong>104</strong> (4): 289–98. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1034%2Fj.1600-0447.2001.00263.x" class="external text" rel="nofollow">10.1034/j.1600-0447.2001.00263.x</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/11722304" class="external text" rel="nofollow">11722304</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sertraline+treatment+of+panic+disorder%3A+results+of+a+long-term+study&rft.jtitle=Acta+Psychiatr+Scand&rft.aulast=Rapaport+MH%2C+Wolkow+R%2C+Rubin+A%2C+Hackett+E%2C+Pollack+M%2C+Ota+KY&rft.au=Rapaport+MH%2C+Wolkow+R%2C+Rubin+A%2C+Hackett+E%2C+Pollack+M%2C+Ota+KY&rft.date=2001&rft.volume=104&rft.issue=4&rft.pages=289%E2%80%9398&rft_id=info:doi/10.1034%2Fj.1600-0447.2001.00263.x&rft_id=info:pmid/11722304&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid17092192_82"><strong><a href="#cite_ref-pmid17092192_82-0">^</a></strong> Review: <span class="citation Journal">Davidson JR (2006). "Pharmacotherapy of social anxiety disorder: what does the evidence tell us?". <em>J Clin Psychiatry</em> <strong>67 Suppl 12</strong>: 20–6. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/17092192" class="external text" rel="nofollow">17092192</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pharmacotherapy+of+social+anxiety+disorder%3A+what+does+the+evidence+tell+us%3F&rft.jtitle=J+Clin+Psychiatry&rft.aulast=Davidson+JR&rft.au=Davidson+JR&rft.date=2006&rft.volume=67+Suppl+12&rft.pages=20%E2%80%936&rft_id=info:pmid/17092192&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid12934979_83">^ <a href="#cite_ref-pmid12934979_83-0"><sup><em><strong>a</strong></em></sup></a> <a href="#cite_ref-pmid12934979_83-1"><sup><em><strong>b</strong></em></sup></a> <span class="citation Journal">Liebowitz MR, DeMartinis NA, Weihs K, Londborg PD, Smith WT, Chung H, Fayyad R, Clary CM (2003). "Efficacy of sertraline in severe generalized social anxiety disorder: results of a double-blind, placebo-controlled study". <em>J Clin Psychiatry</em> <strong>64</strong> (7): 785–92. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/12934979" class="external text" rel="nofollow">12934979</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Efficacy+of+sertraline+in+severe+generalized+social+anxiety+disorder%3A+results+of+a+double-blind%2C+placebo-controlled+study&rft.jtitle=J+Clin+Psychiatry&rft.aulast=Liebowitz+MR%2C+DeMartinis+NA%2C+Weihs+K%2C+Londborg+PD%2C+Smith+WT%2C+Chung+H%2C+Fayyad+R%2C+Clary+CM&rft.au=Liebowitz+MR%2C+DeMartinis+NA%2C+Weihs+K%2C+Londborg+PD%2C+Smith+WT%2C+Chung+H%2C+Fayyad+R%2C+Clary+CM&rft.date=2003&rft.volume=64&rft.issue=7&rft.pages=785%E2%80%9392&rft_id=info:pmid/12934979&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid16216019_84"><strong><a href="#cite_ref-pmid16216019_84-0">^</a></strong> <span class="citation Journal">Connor KM, Davidson JR, Chung H, Yang R, Clary CM (2006). "Multidimensional effects of sertraline in social anxiety disorder". <em>Depress Anxiety</em> <strong>23</strong> (1): 6–10. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1002%2Fda.20086" class="external text" rel="nofollow">10.1002/da.20086</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/16216019" class="external text" rel="nofollow">16216019</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Multidimensional+effects+of+sertraline+in+social+anxiety+disorder&rft.jtitle=Depress+Anxiety&rft.aulast=Connor+KM%2C+Davidson+JR%2C+Chung+H%2C+Yang+R%2C+Clary+CM&rft.au=Connor+KM%2C+Davidson+JR%2C+Chung+H%2C+Yang+R%2C+Clary+CM&rft.date=2006&rft.volume=23&rft.issue=1&rft.pages=6%E2%80%9310&rft_id=info:doi/10.1002%2Fda.20086&rft_id=info:pmid/16216019&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid11435264_85"><strong><a href="#cite_ref-pmid11435264_85-0">^</a></strong> <span class="citation Journal">Blomhoff S, Haug TT, Hellström K, Holme I, Humble M, Madsbu HP, Wold JE (2001). "Randomised controlled general practice trial of sertraline, exposure therapy and combined treatment in generalised social phobia". <em>Br J Psychiatry</em> <strong>179</strong>: 23–30. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1192%2Fbjp.179.1.23" class="external text" rel="nofollow">10.1192/bjp.179.1.23</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/11435264" class="external text" rel="nofollow">11435264</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Randomised+controlled+general+practice+trial+of+sertraline%2C+exposure+therapy+and+combined+treatment+in+generalised+social+phobia&rft.jtitle=Br+J+Psychiatry&rft.aulast=Blomhoff+S%2C+Haug+TT%2C+Hellstr%C3%B6m+K%2C+Holme+I%2C+Humble+M%2C+Madsbu+HP%2C+Wold+JE&rft.au=Blomhoff+S%2C+Haug+TT%2C+Hellstr%C3%B6m+K%2C+Holme+I%2C+Humble+M%2C+Madsbu+HP%2C+Wold+JE&rft.date=2001&rft.volume=179&rft.pages=23%E2%80%9330&rft_id=info:doi/10.1192%2Fbjp.179.1.23&rft_id=info:pmid/11435264&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_86"><strong><a href="#cite_ref-86">^</a></strong> <span class="citation Journal">Yonkers KA, Halbreich U, Freeman E, Brown C, Endicott J, Frank E, Parry B, Pearlstein T, Severino S, Stout A, Stone A, Harrison W. (1997). "Symptomatic improvement of premenstrual dysphoric disorder with sertraline treatment. A randomized controlled trial. Sertraline Premenstrual Dysphoric Collaborative Study Group". <em>The Journal of the American Medical Association</em> <strong>278</strong> (12): 983–988. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1001%2Fjama.278.12.983" class="external text" rel="nofollow">10.1001/jama.278.12.983</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/9307345" class="external text" rel="nofollow">9307345</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Symptomatic+improvement+of+premenstrual+dysphoric+disorder+with+sertraline+treatment.+A+randomized+controlled+trial.+Sertraline+Premenstrual+Dysphoric+Collaborative+Study+Group&rft.jtitle=The+Journal+of+the+American+Medical+Association&rft.aulast=Yonkers+KA%2C+Halbreich+U%2C+Freeman+E%2C+Brown+C%2C+Endicott+J%2C+Frank+E%2C+Parry+B%2C+Pearlstein+T%2C+Severino+S%2C+Stout+A%2C+Stone+A%2C+Harrison+W.&rft.au=Yonkers+KA%2C+Halbreich+U%2C+Freeman+E%2C+Brown+C%2C+Endicott+J%2C+Frank+E%2C+Parry+B%2C+Pearlstein+T%2C+Severino+S%2C+Stout+A%2C+Stone+A%2C+Harrison+W.&rft.date=1997&rft.volume=278&rft.issue=12&rft.pages=983%E2%80%93988&rft_id=info:doi/10.1001%2Fjama.278.12.983&rft_id=info:pmid/9307345&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid12215058_87"><strong><a href="#cite_ref-pmid12215058_87-0">^</a></strong> Review: <span class="citation Journal">Pearlstein T (2002). "Selective serotonin reuptake inhibitors for premenstrual dysphoric disorder: the emerging gold standard?". <em>Drugs</em> <strong>62</strong> (13): 1869–85. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.2165%2F00003495-200262130-00004" class="external text" rel="nofollow">10.2165/00003495-200262130-00004</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/12215058" class="external text" rel="nofollow">12215058</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Selective+serotonin+reuptake+inhibitors+for+premenstrual+dysphoric+disorder%3A+the+emerging+gold+standard%3F&rft.jtitle=Drugs&rft.aulast=Pearlstein+T&rft.au=Pearlstein+T&rft.date=2002&rft.volume=62&rft.issue=13&rft.pages=1869%E2%80%9385&rft_id=info:doi/10.2165%2F00003495-200262130-00004&rft_id=info:pmid/12215058&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid11972726_88"><strong><a href="#cite_ref-pmid11972726_88-0">^</a></strong> Review: <span class="citation Journal">Ackermann RT, Williams JW (2002). "Rational treatment choices for non-major depressions in primary care: an evidence-based review". <em>J Gen Intern Med</em> <strong>17</strong> (4): 293–301. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1046%2Fj.1525-1497.2002.10350.x" class="external text" rel="nofollow">10.1046/j.1525-1497.2002.10350.x</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/11972726" class="external text" rel="nofollow">11972726</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Rational+treatment+choices+for+non-major+depressions+in+primary+care%3A+an+evidence-based+review&rft.jtitle=J+Gen+Intern+Med&rft.aulast=Ackermann+RT%2C+Williams+JW&rft.au=Ackermann+RT%2C+Williams+JW&rft.date=2002&rft.volume=17&rft.issue=4&rft.pages=293%E2%80%93301&rft_id=info:doi/10.1046%2Fj.1525-1497.2002.10350.x&rft_id=info:pmid/11972726&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid14754784_89">^ <a href="#cite_ref-pmid14754784_89-0"><sup><em><strong>a</strong></em></sup></a> <a href="#cite_ref-pmid14754784_89-1"><sup><em><strong>b</strong></em></sup></a> <a href="#cite_ref-pmid14754784_89-2"><sup><em><strong>c</strong></em></sup></a> <span class="citation Journal">Freeman EW, Rickels K, Sondheimer SJ, Polansky M, Xiao S (2004). "Continuous or intermittent dosing with sertraline for patients with severe premenstrual syndrome or premenstrual dysphoric disorder". <em>Am J Psychiatry</em> <strong>161</strong> (2): 343–51. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1176%2Fappi.ajp.161.2.343" class="external text" rel="nofollow">10.1176/appi.ajp.161.2.343</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/14754784" class="external text" rel="nofollow">14754784</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Continuous+or+intermittent+dosing+with+sertraline+for+patients+with+severe+premenstrual+syndrome+or+premenstrual+dysphoric+disorder&rft.jtitle=Am+J+Psychiatry&rft.aulast=Freeman+EW%2C+Rickels+K%2C+Sondheimer+SJ%2C+Polansky+M%2C+Xiao+S&rft.au=Freeman+EW%2C+Rickels+K%2C+Sondheimer+SJ%2C+Polansky+M%2C+Xiao+S&rft.date=2004&rft.volume=161&rft.issue=2&rft.pages=343%E2%80%9351&rft_id=info:doi/10.1176%2Fappi.ajp.161.2.343&rft_id=info:pmid/14754784&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid10530636_90"><strong><a href="#cite_ref-pmid10530636_90-0">^</a></strong> <span class="citation Journal">Freeman EW, Rickels K, Sondheimer SJ, Polansky M (1999). "Differential response to antidepressants in women with premenstrual syndrome/premenstrual dysphoric disorder: a randomized controlled trial". <em>Arch. Gen. Psychiatry</em> <strong>56</strong> (10): 932–9. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1001%2Farchpsyc.56.10.932" class="external text" rel="nofollow">10.1001/archpsyc.56.10.932</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/10530636" class="external text" rel="nofollow">10530636</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Differential+response+to+antidepressants+in+women+with+premenstrual+syndrome%2Fpremenstrual+dysphoric+disorder%3A+a+randomized+controlled+trial&rft.jtitle=Arch.+Gen.+Psychiatry&rft.aulast=Freeman+EW%2C+Rickels+K%2C+Sondheimer+SJ%2C+Polansky+M&rft.au=Freeman+EW%2C+Rickels+K%2C+Sondheimer+SJ%2C+Polansky+M&rft.date=1999&rft.volume=56&rft.issue=10&rft.pages=932%E2%80%939&rft_id=info:doi/10.1001%2Farchpsyc.56.10.932&rft_id=info:pmid/10530636&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid10418540_91"><strong><a href="#cite_ref-pmid10418540_91-0">^</a></strong> <span class="citation Journal">Jermain DM, Preece CK, Sykes RL, Kuehl TJ, Sulak PJ (1999). "Luteal phase sertraline treatment for premenstrual dysphoric disorder. Results of a double-blind, placebo-controlled, crossover study". <em>Arch Fam Med</em> <strong>8</strong> (4): 328–32. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1001%2Farchfami.8.4.328" class="external text" rel="nofollow">10.1001/archfami.8.4.328</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/10418540" class="external text" rel="nofollow">10418540</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Luteal+phase+sertraline+treatment+for+premenstrual+dysphoric+disorder.+Results+of+a+double-blind%2C+placebo-controlled%2C+crossover+study&rft.jtitle=Arch+Fam+Med&rft.aulast=Jermain+DM%2C+Preece+CK%2C+Sykes+RL%2C+Kuehl+TJ%2C+Sulak+PJ&rft.au=Jermain+DM%2C+Preece+CK%2C+Sykes+RL%2C+Kuehl+TJ%2C+Sulak+PJ&rft.date=1999&rft.volume=8&rft.issue=4&rft.pages=328%E2%80%9332&rft_id=info:doi/10.1001%2Farchfami.8.4.328&rft_id=info:pmid/10418540&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid12468166_92"><strong><a href="#cite_ref-pmid12468166_92-0">^</a></strong> <span class="citation Journal">Halbreich U, Bergeron R, Yonkers KA, Freeman E, Stout AL, Cohen L (2002). "Efficacy of intermittent, luteal phase sertraline treatment of premenstrual dysphoric disorder". <em>Obstet Gynecol</em> <strong>100</strong> (6): 1219–29. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1016%2FS0029-7844%2802%2902326-8" class="external text" rel="nofollow">10.1016/S0029-7844(02)02326-8</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/12468166" class="external text" rel="nofollow">12468166</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Efficacy+of+intermittent%2C+luteal+phase+sertraline+treatment+of+premenstrual+dysphoric+disorder&rft.jtitle=Obstet+Gynecol&rft.aulast=Halbreich+U%2C+Bergeron+R%2C+Yonkers+KA%2C+Freeman+E%2C+Stout+AL%2C+Cohen+L&rft.au=Halbreich+U%2C+Bergeron+R%2C+Yonkers+KA%2C+Freeman+E%2C+Stout+AL%2C+Cohen+L&rft.date=2002&rft.volume=100&rft.issue=6&rft.pages=1219%E2%80%9329&rft_id=info:doi/10.1016%2FS0029-7844%2802%2902326-8&rft_id=info:pmid/12468166&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid17107257_93"><strong><a href="#cite_ref-pmid17107257_93-0">^</a></strong> <span class="citation Journal">Kornstein SG, Pearlstein TB, Fayyad R, Farfel GM, Gillespie JA (2006). "Low-dose sertraline in the treatment of moderate-to-severe premenstrual syndrome: efficacy of 3 dosing strategies". <em>J Clin Psychiatry</em> <strong>67</strong> (10): 1624–32. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/17107257" class="external text" rel="nofollow">17107257</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Low-dose+sertraline+in+the+treatment+of+moderate-to-severe+premenstrual+syndrome%3A+efficacy+of+3+dosing+strategies&rft.jtitle=J+Clin+Psychiatry&rft.aulast=Kornstein+SG%2C+Pearlstein+TB%2C+Fayyad+R%2C+Farfel+GM%2C+Gillespie+JA&rft.au=Kornstein+SG%2C+Pearlstein+TB%2C+Fayyad+R%2C+Farfel+GM%2C+Gillespie+JA&rft.date=2006&rft.volume=67&rft.issue=10&rft.pages=1624%E2%80%9332&rft_id=info:pmid/17107257&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid10770145_94"><strong><a href="#cite_ref-pmid10770145_94-0">^</a></strong> <span class="citation Journal">Brady K, Pearlstein T, Asnis GM, Baker D, Rothbaum B, Sikes CR, Farfel GM (2000). "Efficacy and safety of sertraline treatment of posttraumatic stress disorder: a randomized controlled trial". <em>JAMA</em> <strong>283</strong> (14): 1837–44. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1001%2Fjama.283.14.1837" class="external text" rel="nofollow">10.1001/jama.283.14.1837</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/10770145" class="external text" rel="nofollow">10770145</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Efficacy+and+safety+of+sertraline+treatment+of+posttraumatic+stress+disorder%3A+a+randomized+controlled+trial&rft.jtitle=JAMA&rft.aulast=Brady+K%2C+Pearlstein+T%2C+Asnis+GM%2C+Baker+D%2C+Rothbaum+B%2C+Sikes+CR%2C+Farfel+GM&rft.au=Brady+K%2C+Pearlstein+T%2C+Asnis+GM%2C+Baker+D%2C+Rothbaum+B%2C+Sikes+CR%2C+Farfel+GM&rft.date=2000&rft.volume=283&rft.issue=14&rft.pages=1837%E2%80%9344&rft_id=info:doi/10.1001%2Fjama.283.14.1837&rft_id=info:pmid/10770145&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid11411812_95"><strong><a href="#cite_ref-pmid11411812_95-0">^</a></strong> <span class="citation Journal">Londborg PD, Hegel MT, Goldstein S, Goldstein D, Himmelhoch JM, Maddock R, Patterson WM, Rausch J, Farfel GM (2001). "Sertraline treatment of posttraumatic stress disorder: results of 24 weeks of open-label continuation treatment". <em>The Journal of Clinical Psychiatry</em> <strong>62</strong> (5): 325–31. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/11411812" class="external text" rel="nofollow">11411812</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sertraline+treatment+of+posttraumatic+stress+disorder%3A+results+of+24+weeks+of+open-label+continuation+treatment&rft.jtitle=The+Journal+of+Clinical+Psychiatry&rft.aulast=Londborg+PD%2C+Hegel+MT%2C+Goldstein+S%2C+Goldstein+D%2C+Himmelhoch+JM%2C+Maddock+R%2C+Patterson+WM%2C+Rausch+J%2C+Farfel+GM&rft.au=Londborg+PD%2C+Hegel+MT%2C+Goldstein+S%2C+Goldstein+D%2C+Himmelhoch+JM%2C+Maddock+R%2C+Patterson+WM%2C+Rausch+J%2C+Farfel+GM&rft.date=2001&rft.volume=62&rft.issue=5&rft.pages=325%E2%80%9331&rft_id=info:pmid/11411812&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid16734498_96">^ <a href="#cite_ref-pmid16734498_96-0"><sup><em><strong>a</strong></em></sup></a> <a href="#cite_ref-pmid16734498_96-1"><sup><em><strong>b</strong></em></sup></a> <span class="citation Journal">Davis LL, Frazier EC, Williford RB, Newell JM (2006). 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"Efficacy of sertraline in preventing relapse of posttraumatic stress disorder: results of a 28-week double-blind, placebo-controlled study". <em>The American Journal of Psychiatry</em> <strong>158</strong> (12): 1974–81. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1176%2Fappi.ajp.158.12.1974" class="external text" rel="nofollow">10.1176/appi.ajp.158.12.1974</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/11729012" class="external text" rel="nofollow">11729012</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Efficacy+of+sertraline+in+preventing+relapse+of+posttraumatic+stress+disorder%3A+results+of+a+28-week+double-blind%2C+placebo-controlled+study&rft.jtitle=The+American+Journal+of+Psychiatry&rft.aulast=Davidson+J%2C+Pearlstein+T%2C+Londborg+P%2C+Brady+KT%2C+Rothbaum+B%2C+Bell+J%2C+Maddock+R%2C+Hegel+MT%2C+Farfel+G&rft.au=Davidson+J%2C+Pearlstein+T%2C+Londborg+P%2C+Brady+KT%2C+Rothbaum+B%2C+Bell+J%2C+Maddock+R%2C+Hegel+MT%2C+Farfel+G&rft.date=2001&rft.volume=158&rft.issue=12&rft.pages=1974%E2%80%9381&rft_id=info:doi/10.1176%2Fappi.ajp.158.12.1974&rft_id=info:pmid/11729012&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid16702890_98"><strong><a href="#cite_ref-pmid16702890_98-0">^</a></strong> <span class="citation Journal">Davidson J, Rothbaum BO, Tucker P, Asnis G, Benattia I, Musgnung JJ (2006). 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"Comparison of duloxetine, escitalopram, and sertraline effects on cytochrome P450 2D6 function in healthy volunteers". <em>Journal of Clinical Psychopharmacology</em> <strong>27</strong> (1): 28–34. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1097%2F00004714-200702000-00005" class="external text" rel="nofollow">10.1097/00004714-200702000-00005</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/17224709" class="external text" rel="nofollow">17224709</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparison+of+duloxetine%2C+escitalopram%2C+and+sertraline+effects+on+cytochrome+P450+2D6+function+in+healthy+volunteers&rft.jtitle=Journal+of+Clinical+Psychopharmacology&rft.aulast=Preskorn+SH%2C+Greenblatt+DJ%2C+Flockhart+D%2C+Luo+Y%2C+Perloff+ES%2C+Harmatz+JS%2C+Baker+B%2C+Klick-Davis+A%2C+Desta+Z%2C+Burt+T&rft.au=Preskorn+SH%2C+Greenblatt+DJ%2C+Flockhart+D%2C+Luo+Y%2C+Perloff+ES%2C+Harmatz+JS%2C+Baker+B%2C+Klick-Davis+A%2C+Desta+Z%2C+Burt+T&rft.date=2007&rft.volume=27&rft.issue=1&rft.pages=28%E2%80%9334&rft_id=info:doi/10.1097%2F00004714-200702000-00005&rft_id=info:pmid/17224709&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid10914294_162"><strong><a href="#cite_ref-pmid10914294_162-0">^</a></strong> <span class="citation Journal">Hamilton SP, Nunes EV, Janal M, Weber L (2000). "The effect of sertraline on methadone plasma levels in methadone-maintenance patients". <em>The American Journal on Addictions / American Academy of Psychiatrists in Alcoholism and Addictions</em> <strong>9</strong> (1): 63–9. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/10914294" class="external text" rel="nofollow">10914294</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+effect+of+sertraline+on+methadone+plasma+levels+in+methadone-maintenance+patients&rft.jtitle=The+American+Journal+on+Addictions+%2F+American+Academy+of+Psychiatrists+in+Alcoholism+and+Addictions&rft.aulast=Hamilton+SP%2C+Nunes+EV%2C+Janal+M%2C+Weber+L&rft.au=Hamilton+SP%2C+Nunes+EV%2C+Janal+M%2C+Weber+L&rft.date=2000&rft.volume=9&rft.issue=1&rft.pages=63%E2%80%939&rft_id=info:pmid/10914294&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_pmid14709940_163"><strong><a href="#cite_ref-pmid14709940_163-0">^</a></strong> <span class="citation Journal">DeVane CL, Donovan JL, Liston HL, Markowitz JS, Cheng KT, Risch SC, Willard L (2004). "Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers". <em>Journal of Clinical Psychopharmacology</em> <strong>24</strong> (1): 4–10. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1097%2F01.jcp.0000104908.75206.26" class="external text" rel="nofollow">10.1097/01.jcp.0000104908.75206.26</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/14709940" class="external text" rel="nofollow">14709940</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparative+CYP3A4+inhibitory+effects+of+venlafaxine%2C+fluoxetine%2C+sertraline%2C+and+nefazodone+in+healthy+volunteers&rft.jtitle=Journal+of+Clinical+Psychopharmacology&rft.aulast=DeVane+CL%2C+Donovan+JL%2C+Liston+HL%2C+Markowitz+JS%2C+Cheng+KT%2C+Risch+SC%2C+Willard+L&rft.au=DeVane+CL%2C+Donovan+JL%2C+Liston+HL%2C+Markowitz+JS%2C+Cheng+KT%2C+Risch+SC%2C+Willard+L&rft.date=2004&rft.volume=24&rft.issue=1&rft.pages=4%E2%80%9310&rft_id=info:doi/10.1097%2F01.jcp.0000104908.75206.26&rft_id=info:pmid/14709940&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_PLoS_164"><strong><a href="#cite_ref-PLoS_164-0">^</a></strong> <span class="citation Journal">Lacasse J, Leo J (2005). "Serotonin and depression: a disconnect between the advertisements and the scientific literature". <em><a href="/PLoS_Medicine" title="PLoS Medicine">PLoS Med</a></em> <strong>2</strong> (12): e392. <a href="/Digital_object_identifier" title="Digital object identifier">doi</a>:<a href="http://dx.doi.org/10.1371%2Fjournal.pmed.0020392.g001" class="external text" rel="nofollow">10.1371/journal.pmed.0020392.g001</a>. <a href="/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect">PMID</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/16268734" class="external text" rel="nofollow">16268734</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Serotonin+and+depression%3A+a+disconnect+between+the+advertisements+and+the+scientific+literature&rft.jtitle=%5B%5BPLoS+Medicine%7CPLoS+Med%5D%5D&rft.aulast=Lacasse+J%2C+Leo+J&rft.au=Lacasse+J%2C+Leo+J&rft.date=2005&rft.volume=2&rft.issue=12&rft.pages=e392&rft_id=info:doi/10.1371%2Fjournal.pmed.0020392.g001&rft_id=info:pmid/16268734&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span> <a href="http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0020392" class="external text" rel="nofollow">Free full text, open-access source</a></li> <li id="wikipedia_cite_note_165"><strong><a href="#cite_ref-165">^</a></strong> <span class="citation web"><a href="http://www.fda.gov/cder/warn/2005/zoloft_letter.pdf" class="external text" rel="nofollow">"Food and Drug Administration Division of Drug Marketing Advertising and Communications. (2005) Zoloft warning letter."</a> (PDF). FDA<span class="printonly">. <a href="http://www.fda.gov/cder/warn/2005/zoloft_letter.pdf" class="external free" rel="nofollow">http://www.fda.gov/cder/warn/2005/zoloft_letter.pdf</a></span><span class="reference-accessdate">. Retrieved 2008-07-11</span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=Food+and+Drug+Administration+Division+of+Drug+Marketing+Advertising+and+Communications.+%282005%29+Zoloft+warning+letter.&rft.atitle=&rft.pub=FDA&rft_id=http%3A%2F%2Fwww.fda.gov%2Fcder%2Fwarn%2F2005%2Fzoloft_letter.pdf&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_166"><strong><a href="#cite_ref-166">^</a></strong> <span class="citation web"><a href="http://www.lawlink.nsw.gov.au/scjudgments/2001nswsc.nsf/27602436db586906ca256983001e137a/bd5c743050325110ca256a54007de04f?opendocument" class="external text" rel="nofollow">"Regina v Hawkins [2001] NSWSC 420"</a>. New South Wales Supreme Court. 2001-05-24<span class="printonly">. <a href="http://www.lawlink.nsw.gov.au/scjudgments/2001nswsc.nsf/27602436db586906ca256983001e137a/bd5c743050325110ca256a54007de04f?opendocument" class="external free" rel="nofollow">http://www.lawlink.nsw.gov.au/scjudgments/2001nswsc.nsf/27602436db586906ca256983001e137a/bd5c743050325110ca256a54007de04f?opendocument</a></span><span class="reference-accessdate">. Retrieved 2008-07-11</span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=Regina+v+Hawkins+%7FUNIQ2630bbb34aa31f60-nowiki-0000057C-QINU%7F+NSWSC+420&rft.atitle=&rft.date=2001-05-24&rft.pub=New+South+Wales+Supreme+Court&rft_id=http%3A%2F%2Fwww.lawlink.nsw.gov.au%2Fscjudgments%2F2001nswsc.nsf%2F27602436db586906ca256983001e137a%2Fbd5c743050325110ca256a54007de04f%3Fopendocument&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_167"><strong><a href="#cite_ref-167">^</a></strong> <span class="citation press release">Business Wire/Findarticles.com (2004-07-23). <a href="http://findarticles.com/p/articles/mi_m0EIN/is_2004_July_23/ai_n6122283" class="external text" rel="nofollow">"Suit Claims Pfizer Conceals Evidence and Misleads Doctors and Patients About Safety and Effectiveness of Zoloft"</a>. Press release<span class="printonly">. <a href="http://findarticles.com/p/articles/mi_m0EIN/is_2004_July_23/ai_n6122283" class="external free" rel="nofollow">http://findarticles.com/p/articles/mi_m0EIN/is_2004_July_23/ai_n6122283</a></span><span class="reference-accessdate">. Retrieved 2008-07-11</span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=Suit+Claims+Pfizer+Conceals+Evidence+and+Misleads+Doctors+and+Patients+About+Safety+and+Effectiveness+of+Zoloft&rft.atitle=&rft.aulast=Business+Wire%2FFindarticles.com&rft.au=Business+Wire%2FFindarticles.com&rft.date=2004-07-23&rft.series=Press+release&rft_id=http%3A%2F%2Ffindarticles.com%2Fp%2Farticles%2Fmi_m0EIN%2Fis_2004_July_23%2Fai_n6122283&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> <li id="wikipedia_cite_note_lasc_168"><strong><a href="#cite_ref-lasc_168-0">^</a></strong> Enter the case number "BC 318871" into the form to see the summary of the case stating that the suit was dismissed. The images of the case documents are available for a nominal price. <span class="citation web"><a href="http://www.lasuperiorcourt.org/civilCaseSummary/index.asp?CaseType=Civil" class="external text" rel="nofollow">"Los Angeles Superior Court — Civil Case Summary"</a>. Los Angeles Superior Court. 2005-05-31<span class="printonly">. <a href="http://www.lasuperiorcourt.org/civilCaseSummary/index.asp?CaseType=Civil" class="external free" rel="nofollow">http://www.lasuperiorcourt.org/civilCaseSummary/index.asp?CaseType=Civil</a></span><span class="reference-accessdate">. Retrieved 2007-11-04</span>. "It is thereby ordered, adjudged and decreed that this action is dismissed and that Defendant Pfizer Inc is awarded its costs of suit incurred therein."</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=Los+Angeles+Superior+Court%26nbsp%3B%E2%80%94+Civil+Case+Summary&rft.atitle=&rft.date=2005-05-31&rft.pub=Los+Angeles+Superior+Court&rft_id=http%3A%2F%2Fwww.lasuperiorcourt.org%2FcivilCaseSummary%2Findex.asp%3FCaseType%3DCivil&rfr_id=info:sid/en.wikipedia.org:Sertraline"><span style="display: none;"> </span></span></li> </ol> </div> <h2><span class="mw-headline" id="wikipedia_External_links">External links</span></h2> <div class="noprint tright portal" style="border:solid #aaa 1px;margin:0.5em 0 0.5em 0.5em;"> <table style="background:#f9f9f9; font-size:85%; line-height:110%;"> <tr> <td><img alt="" src="http://images-mediawiki-sites.thefullwiki.org/07/2/0/6/276847150862808.jpg" width="32" height="26" /></td> <td style="padding:0 0.2em;"><em><strong><a href="/Portal:Pharmacy_and_Pharmacology" title="Portal:Pharmacy and Pharmacology">Pharmacy and Pharmacology portal</a></strong></em></td> </tr> </table> </div> <ul> <li><a href="http://www.merck.com/mmpe/lexicomp/sertraline.html" class="external text" rel="nofollow">List of international brand names for sertraline</a></li> <li>Prescribing information from <a href="http://www.zoloft.com/" class="external text" rel="nofollow">Zoloft</a> manufacturer</li> <li><a href="http://druginfo.nlm.nih.gov/drugportal/dpdirect.jsp?name=Sertraline" class="external text" rel="nofollow">U.S. National Library of Medicine: Drug Information Portal - Sertraline</a></li> </ul> <table class="navbox" cellspacing="0" style=";"> <tr> <td style="padding:2px;"> <table cellspacing="0" class="nowraplinks collapsible collapsed" style="width:100%;background:transparent;color:inherit;;"> <tr> <th style=";" colspan="2" class="navbox-title"><span class="" style="font-size:110%;"><a href="/Antidepressant" title="Antidepressant">Antidepressants</a> (<a href="/ATC_code_N06" title="ATC code N06">N06A</a>)</span></th> </tr> <tr style="height:2px;"> <td></td> </tr> <tr> <td colspan="2" style="width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <table cellspacing="0" class="nowraplinks collapsible collapsed navbox-subgroup" style="width:100%;;;;"> <tr> <th style=";;" colspan="2" class="navbox-title"> <div style="float:left; width:6em;text-align:left;"> </div> <span class="" style="font-size:100%;">Specific <a href="/Reuptake" title="Reuptake">Reuptake</a> <a href="/Reuptake_inhibitor" title="Reuptake inhibitor">Inhibitors</a> (RIs), <a href="/Reuptake_enhancer" title="Reuptake enhancer">Enhancers</a> (REs), and <a href="/Releasing_agent" title="Releasing agent">Releasing Agents</a> (RAs)</span></th> </tr> <tr style="height:2px;"> <td></td> </tr> <tr> <td colspan="2" style="width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <table cellspacing="0" class="nowraplinks navbox-subgroup" style="width:100%;;;;"> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Selective_serotonin_reuptake_inhibitor" title="Selective serotonin reuptake inhibitor">Selective Serotonin Reuptake Inhibitors</a> (SSRIs)</small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Alaproclate" title="Alaproclate">Alaproclate</a> • <a href="/Citalopram" title="Citalopram">Citalopram</a> • <a href="/Escitalopram" title="Escitalopram">Escitalopram</a> • <a href="/Femoxetine" title="Femoxetine">Femoxetine</a> • <a href="/Fluvoxamine" title="Fluvoxamine">Fluvoxamine</a> • <a href="/Indalpine" title="Indalpine">Indalpine</a> • <a href="/Litoxetine" title="Litoxetine">Litoxetine</a> • <a href="/Lubazodone" title="Lubazodone">Lubazodone</a> • <a href="/Paroxetine" title="Paroxetine">Paroxetine</a> • <a href="/Pirandamine" title="Pirandamine">Pirandamine</a> • <a href="/Seproxetine" title="Seproxetine">Seproxetine</a> • <strong class="selflink">Sertraline</strong> • <a href="/Vilazodone" title="Vilazodone">Vilazodone</a> • <a href="/Zimelidine" title="Zimelidine">Zimelidine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Serotonin-norepinephrine_reuptake_inhibitor" title="Serotonin-norepinephrine reuptake inhibitor" class="mw-redirect">Serotonin-Norepinephrine Reuptake Inhibitors</a> (SNRIs)</small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Bicifadine" title="Bicifadine">Bicifadine</a> • <a href="/Clovoxamine" title="Clovoxamine">Clovoxamine</a> • <a href="/Desvenlafaxine" title="Desvenlafaxine">Desvenlafaxine</a> • <a href="/Duloxetine" title="Duloxetine">Duloxetine</a> • <a href="/Levomilnacipran" title="Levomilnacipran">Levomilnacipran</a> • <a href="/Milnacipran" title="Milnacipran">Milnacipran</a> • <a href="/Sibutramine" title="Sibutramine">Sibutramine</a> • <a href="/Venlafaxine" title="Venlafaxine">Venlafaxine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Serotonin-norepinephrine-dopamine_reuptake_inhibitor" title="Serotonin-norepinephrine-dopamine reuptake inhibitor" class="mw-redirect">Serotonin-Norepinephrine-Dopamine Reuptake Inhibitors</a> (SNDRIs)</small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Brasofensine" title="Brasofensine">Brasofensine</a> • <a href="/BTS-74,398" title="BTS-74,398" class="mw-redirect">BTS-74,398</a> • <a href="/Cocaine" title="Cocaine">Cocaine</a> • <a href="/Diclofensine" title="Diclofensine">Diclofensine</a> • <a href="/DOV-21,947" title="DOV-21,947">DOV-21,947</a> • <a href="/DOV-102,677" title="DOV-102,677">DOV-102,677</a> • <a href="/DOV-216,303" title="DOV-216,303">DOV-216,303</a> • <a href="/JNJ-7,925,476" title="JNJ-7,925,476">JNJ-7,925,476</a> • <a href="/NS-2359" title="NS-2359">NS-2359</a> • <a href="/PRC200-SS" title="PRC200-SS" class="mw-redirect">PRC200-SS</a> • <a href="/SEP-225,289" title="SEP-225,289" class="mw-redirect">SEP-225,289</a> • <a href="/SEP-227,162" title="SEP-227,162">SEP-227,162</a> • <a href="/Tesofensine" title="Tesofensine">Tesofensine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Norepinephrine_reuptake_inhibitor" title="Norepinephrine reuptake inhibitor">Norepinephrine Reuptake Inhibitors</a> (NRIs)</small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Atomoxetine" title="Atomoxetine">Atomoxetine/Tomoxetine</a> • <a href="/Binedaline" title="Binedaline">Binedaline</a> • <a href="/Ciclazindol" title="Ciclazindol">Ciclazindol</a> • <a href="/Esreboxetine" title="Esreboxetine">Esreboxetine</a> • <a href="/Mazindol" title="Mazindol">Mazindol</a> • <a href="/Nisoxetine" title="Nisoxetine">Nisoxetine</a> • <a href="/Reboxetine" title="Reboxetine">Reboxetine</a> • <a href="/Talopram" title="Talopram">Talopram</a> • <a href="/Talsupram" title="Talsupram">Talsupram</a> • <a href="/Tandamine" title="Tandamine">Tandamine</a> • <a href="/Viloxazine" title="Viloxazine">Viloxazine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Dopamine_reuptake_inhibitor" title="Dopamine reuptake inhibitor">Dopamine Reuptake Inhibitors</a> (DRIs)</small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Medifoxamine" title="Medifoxamine">Medifoxamine</a> • <a href="/Vanoxerine" title="Vanoxerine">Vanoxerine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Norepinephrine-dopamine_reuptake_inhibitor" title="Norepinephrine-dopamine reuptake inhibitor">Norepinephrine-Dopamine Reuptake Inhibitors</a> (NDRIs)</small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Amineptine" title="Amineptine">Amineptine</a> • <a href="/Bupropion" title="Bupropion">Bupropion/Amfebutamone</a> • <a href="/Cilobamine" title="Cilobamine">Cilobamine</a> • <a href="/Manifaxine" title="Manifaxine">Manifaxine</a> • <a href="/Methylphenidate" title="Methylphenidate">Methylphenidate</a> • <a href="/Nomifensine" title="Nomifensine">Nomifensine</a> • <a href="/Radafaxine" title="Radafaxine">Radafaxine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Norepinephrine-dopamine_releasing_agent" title="Norepinephrine-dopamine releasing agent" class="mw-redirect">Norepinephrine-Dopamine Releasing Agents</a> (NDRAs)</small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Amphetamine" title="Amphetamine">Amphetamine</a> • <a href="/Befuraline" title="Befuraline">Befuraline</a> • <a href="/Lisdexamfetamine" title="Lisdexamfetamine">Lisdexamfetamine</a> • <a href="/Methamphetamine" title="Methamphetamine">Methamphetamine</a> • <a href="/Phenethylamine" title="Phenethylamine">Phenethylamine</a> • <a href="/Piberaline" title="Piberaline">Piberaline</a> • <a href="/Tranylcypromine" title="Tranylcypromine">Tranylcypromine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Serotonin-norepinephrine-dopamine_releasing_agent" title="Serotonin-norepinephrine-dopamine releasing agent" class="mw-redirect">Serotonin-Norepinephrine-Dopamine Releasing Agents</a> (SNDRAs)</small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/4-Methyl-%CE%B1MT" title="4-Methyl-αMT" class="mw-redirect">4-Methyl-αMT</a> • <a href="/Alpha-Ethyltryptamine" title="Alpha-Ethyltryptamine">αET/Etryptamine</a> • <a href="/Alpha-Methyltryptamine" title="Alpha-Methyltryptamine">αMT/Metryptamine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Selective_serotonin_reuptake_enhancer" title="Selective serotonin reuptake enhancer">Selective Serotonin Reuptake Enhancers</a> (SSREs)</small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Tianeptine" title="Tianeptine">Tianeptine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small>Others</small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Indeloxazine" title="Indeloxazine">Indeloxazine</a> • <a href="/Tramadol" title="Tramadol">Tramadol</a> • <a href="/Viqualine" title="Viqualine">Viqualine</a></div> </td> </tr> </table> </td> </tr> </table> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td colspan="2" style="width:100%;padding:0px;;;" class="navbox-list navbox-even"> <table cellspacing="0" class="nowraplinks collapsible collapsed navbox-subgroup" style="width:100%;;;;"> <tr> <th style=";;" colspan="2" class="navbox-title"> <div style="float:left; width:6em;text-align:left;"> </div> <span class="" style="font-size:100%;"><a href="/Receptor_antagonist" title="Receptor antagonist">Receptor Antagonists</a> and/or <a href="/Reuptake_inhibitor" title="Reuptake inhibitor">Reuptake Inhibitors</a></span></th> </tr> <tr style="height:2px;"> <td></td> </tr> <tr> <td colspan="2" style="width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <table cellspacing="0" class="nowraplinks navbox-subgroup" style="width:100%;;;;"> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Serotonin_antagonist_and_reuptake_inhibitor" title="Serotonin antagonist and reuptake inhibitor">Serotonin Antagonists and Reuptake Inhibitors</a> (SARIs)</small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Etoperidone" title="Etoperidone">Etoperidone</a> • <a href="/Nefazodone" title="Nefazodone">Nefazodone</a> • <a href="/Trazodone" title="Trazodone">Trazodone</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Noradrenergic_and_specific_serotonergic_antidepressant" title="Noradrenergic and specific serotonergic antidepressant">Noradrenergic and Specific Serotonergic Antidepressants</a> (NaSSAs)</small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Esmirtazapine" title="Esmirtazapine">Esmirtazapine</a> • <a href="/Mianserin" title="Mianserin">Mianserin</a> • <a href="/Mirtazapine" title="Mirtazapine">Mirtazapine</a> • <a href="/Setiptiline" title="Setiptiline">Setiptiline/Teciptiline</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Norepinephrine-dopamine_disinhibitor" title="Norepinephrine-dopamine disinhibitor">Norepinephrine-Dopamine Disinhibitors</a> (NDDIs)</small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Agomelatine" title="Agomelatine">Agomelatine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small>Serotonin Modulators and Stimulators (SMSs)</small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Lu_AA21004" title="Lu AA21004">Lu AA21004</a></div> </td> </tr> </table> </td> </tr> </table> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td colspan="2" style="width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <table cellspacing="0" class="nowraplinks collapsible collapsed navbox-subgroup" style="width:100%;;;;"> <tr> <th style=";;" colspan="2" class="navbox-title"> <div style="float:left; width:6em;text-align:left;"> </div> <span class="" style="font-size:100%;"><a href="/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic</a> and <a href="/Tetracyclic_antidepressant" title="Tetracyclic antidepressant">Tetracyclic Antidepressants</a> (TCAs/TeCAs)</span></th> </tr> <tr style="height:2px;"> <td></td> </tr> <tr> <td colspan="2" style="width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><strong>Tricyclics</strong>: <a href="/Amineptine" title="Amineptine">Amineptine</a> • <a href="/Amitriptyline" title="Amitriptyline">Amitriptyline</a> • <a href="/Amitriptylinoxide" title="Amitriptylinoxide">Amitriptylinoxide</a> • <a href="/Azepindole" title="Azepindole">Azepindole</a> • <a href="/Butriptyline" title="Butriptyline">Butriptyline</a> • <a href="/Cianopramine" title="Cianopramine">Cianopramine</a> • <a href="/Clomipramine" title="Clomipramine">Clomipramine</a> • Cyanodothiepin • <a href="/Demexiptiline" title="Demexiptiline">Demexiptiline</a> • <a href="/Desipramine" title="Desipramine">Desipramine</a> • <a href="/Dibenzepine" title="Dibenzepine" class="mw-redirect">Dibenzepine</a> • <a href="/Dimetacrine" title="Dimetacrine">Dimetacrine</a> • <a href="/Dosulepin" title="Dosulepin">Dosulepin/Dothiepin</a> • <a href="/Doxepin" title="Doxepin">Doxepin</a> • Fluotracen • Hepzidine • Homopipramol • <a href="/Imipramine" title="Imipramine">Imipramine</a> • <a href="/Imipraminoxide" title="Imipraminoxide">Imipraminoxide</a> • <a href="/Intriptyline" title="Intriptyline">Intriptyline</a> • <a href="/Iprindole" title="Iprindole">Iprindole</a> • Ketipramine • Litracen • <a href="/Lofepramine" title="Lofepramine">Lofepramine</a> • Lortalamine • Losindole • Mariptiline • <a href="/Melitracen" title="Melitracen">Melitracen</a> • <a href="/Metapramine" title="Metapramine">Metapramine</a> • Mezepine • Naranol • <a href="/Nitroxazepine" title="Nitroxazepine">Nitroxazepine</a> • <a href="/Nortriptyline" title="Nortriptyline">Nortriptyline</a> • <a href="/Noxiptiline" title="Noxiptiline">Noxiptiline</a> • <a href="/Octriptyline" title="Octriptyline">Octriptyline</a> • <a href="/Opipramol" title="Opipramol">Opipramol</a> • <a href="/Pipofezine" title="Pipofezine">Pipofezine</a> • <a href="/Propizepine" title="Propizepine">Propizepine</a> • <a href="/Protriptyline" title="Protriptyline">Protriptyline</a> • <a href="/Quinupramine" title="Quinupramine">Quinupramine</a> • <a href="/Tianeptine" title="Tianeptine">Tianeptine</a> • Tienopramine • <a href="/Trimipramine" title="Trimipramine">Trimipramine</a>; <strong>Tetracyclics</strong>: <a href="/Amoxapine" title="Amoxapine">Amoxapine</a> • <a href="/Ciclazindol" title="Ciclazindol">Ciclazindol</a> • <a href="/Esmirtazapine" title="Esmirtazapine">Esmirtazapine</a> • <a href="/Loxapine" title="Loxapine">Loxapine</a> • <a href="/Maprotiline" title="Maprotiline">Maprotiline</a> • <a href="/Mazindol" title="Mazindol">Mazindol</a> • <a href="/Mianserin" title="Mianserin">Mianserin</a> • <a href="/Mirtazapine" title="Mirtazapine">Mirtazapine</a> • <a href="/Oxaprotiline" title="Oxaprotiline">Oxaprotiline</a> • <a href="/Setiptiline" title="Setiptiline">Setiptiline/Teciptiline</a></div> </td> </tr> </table> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td colspan="2" style="width:100%;padding:0px;;;" class="navbox-list navbox-even"> <table cellspacing="0" class="nowraplinks collapsible collapsed navbox-subgroup" style="width:100%;;;;"> <tr> <th style=";;" colspan="2" class="navbox-title"> <div style="float:left; width:6em;text-align:left;"> </div> <span class="" style="font-size:100%;"><a href="/Monoamine_oxidase_inhibitor" title="Monoamine oxidase inhibitor">Monoamine Oxidase Inhibitors</a> (MAOIs)</span></th> </tr> <tr style="height:2px;"> <td></td> </tr> <tr> <td colspan="2" style="width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><strong>Nonselective:</strong> <em>Irreversible:</em> <a href="/Benmoxin" title="Benmoxin">Benmoxin</a> • <a href="/Echinopsidine" title="Echinopsidine">Echinopsidine</a> • <a href="/Iproclozide" title="Iproclozide">Iproclozide</a> • <a href="/Iproniazid" title="Iproniazid">Iproniazid</a> • <a href="/Isocarboxazid" title="Isocarboxazid">Isocarboxazid</a> • <a href="/Mebanazine" title="Mebanazine">Mebanazine</a> • <a href="/Metfendrazine" title="Metfendrazine">Metfendrazine</a> • <a href="/Nialamide" title="Nialamide">Nialamide</a> • <a href="/Octamoxin" title="Octamoxin">Octamoxin</a> • <a href="/Phenelzine" title="Phenelzine">Phenelzine</a> • <a href="/Pheniprazine" title="Pheniprazine">Pheniprazine</a> • <a href="/Phenoxypropazine" title="Phenoxypropazine">Phenoxypropazine</a> • <a href="/Pivalylbenzhydrazine" title="Pivalylbenzhydrazine">Pivalylbenzhydrazine</a> • <a href="/Safrazine" title="Safrazine">Safrazine</a> • <a href="/Tranylcypromine" title="Tranylcypromine">Tranylcypromine</a>; <em>Reversible:</em> <a href="/Caroxazone" title="Caroxazone">Caroxazone</a>; <strong>MAO<sub>A</sub>-Selective:</strong> <em>Irreversible:</em> <a href="/Clorgyline" title="Clorgyline" class="mw-redirect">Clorgyline</a>; <em>Reversible:</em> <a href="/Amiflamine" title="Amiflamine">Amiflamine</a> • Bazinaprine • <a href="/Befloxatone" title="Befloxatone">Befloxatone</a> • Befol • <a href="/Brofaromine" title="Brofaromine">Brofaromine</a> • <a href="/Cimoxatone" title="Cimoxatone">Cimoxatone</a> • Esuperone • <a href="/Harmala_alkaloid" title="Harmala alkaloid">Harmala Alkaloids</a> (<a href="/Harmine" title="Harmine">Harmine</a>, <a href="/Harmaline" title="Harmaline">Harmaline</a>, <a href="/Tetrahydroharmine" title="Tetrahydroharmine" class="mw-redirect">Tetrahydroharmine</a>, <a href="/Harmala_alkaloid" title="Harmala alkaloid">Harman</a>, <a href="/Norharman" title="Norharman" class="mw-redirect">Norharman</a>, etc) • <a href="/Methylene_blue" title="Methylene blue">Methylene Blue</a> • <a href="/Metralindole" title="Metralindole">Metralindole</a> • <a href="/Minaprine" title="Minaprine">Minaprine</a> • <a href="/Moclobemide" title="Moclobemide">Moclobemide</a> • <a href="/Pirlindole" title="Pirlindole">Pirlindole</a> • Sercloremine • Tetrindole • <a href="/Toloxatone" title="Toloxatone">Toloxatone</a> • <a href="/Tyrima" title="Tyrima">Tyrima</a>; <strong>MAO<sub>B</sub>-Selective:</strong> <em>Irreversible:</em> <a href="/Ladostigil" title="Ladostigil">Ladostigil</a> • Mofegiline • <a href="/Pargyline" title="Pargyline">Pargyline</a> • <a href="/Rasagiline" title="Rasagiline">Rasagiline</a> • <a href="/Selegiline" title="Selegiline">Selegiline</a>; <em>Reversible:</em> <a href="/Lazabemide" title="Lazabemide">Lazabemide</a> • Milacemide</div> </td> </tr> </table> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td colspan="2" style="width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <table cellspacing="0" class="nowraplinks collapsible collapsed navbox-subgroup" style="width:100%;;;;"> <tr> <th style=";;" colspan="2" class="navbox-title"> <div style="float:left; width:6em;text-align:left;"> </div> <span class="" style="font-size:100%;"><a href="/Azapirone" title="Azapirone">Azapirones</a> and Other <a href="/5-HT1A_receptor" title="5-HT1A receptor">5-HT<sub>1A</sub> Receptor</a> <a href="/Serotonin_receptor_agonist" title="Serotonin receptor agonist">Agonists</a></span></th> </tr> <tr style="height:2px;"> <td></td> </tr> <tr> <td colspan="2" style="width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Alnespirone" title="Alnespirone">Alnespirone</a> • <a href="/Aripiprazole" title="Aripiprazole">Aripiprazole</a> • <a href="/Befiradol" title="Befiradol">Befiradol</a> • <a href="/Buspirone" title="Buspirone">Buspirone</a> • <a href="/Eptapirone" title="Eptapirone">Eptapirone</a> • <a href="/Flesinoxan" title="Flesinoxan">Flesinoxan</a> • <a href="/Flibanserin" title="Flibanserin">Flibanserin</a> • <a href="/Gepirone" title="Gepirone">Gepirone</a> • <a href="/Ipsapirone" title="Ipsapirone">Ipsapirone</a> • <a href="/Oxaflozane" title="Oxaflozane">Oxaflozane</a> • <a href="/Tandospirone" title="Tandospirone">Tandospirone</a> • <a href="/Vilazodone" title="Vilazodone">Vilazodone</a> • <a href="/Zalospirone" title="Zalospirone">Zalospirone</a></div> </td> </tr> </table> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td colspan="2" style="width:100%;padding:0px;;;" class="navbox-list navbox-even"> <table cellspacing="0" class="nowraplinks collapsible collapsed navbox-subgroup" style="width:100%;;;;"> <tr> <th style=";;" colspan="2" class="navbox-title"> <div style="float:left; width:6em;text-align:left;"> </div> <span class="" style="font-size:100%;"><a href="/Dietary_supplement" title="Dietary supplement">Dietary Supplements</a> (<a href="/Vitamin" title="Vitamin">Vitamins</a>, <a href="/Mineral" title="Mineral">Minerals</a>, <a href="/Amino_acid" title="Amino acid">Amino Acids</a>, etc)</span></th> </tr> <tr style="height:2px;"> <td></td> </tr> <tr> <td colspan="2" style="width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Ascorbic_acid" title="Ascorbic acid">Ascorbic Acid</a> (Vitamin C) • <a href="/Fish_oil" title="Fish oil">Fish Oil</a> • <a href="/Folic_acid" title="Folic acid">Folic Acid</a> (Vitamin B<sub>9</sub>) • <a href="/L-5-Hydroxytryptophan" title="L-5-Hydroxytryptophan" class="mw-redirect">L-5-HTP</a> (Oxitriptan) • <a href="/L-DOPA" title="L-DOPA">L-DOPA</a> (Levodopa) • <a href="/L-Methionine" title="L-Methionine" class="mw-redirect">L-Methionine</a> • <a href="/L-Phenylalanine" title="L-Phenylalanine" class="mw-redirect">L-Phenylalanine</a> • <a href="/L-Tryptophan" title="L-Tryptophan" class="mw-redirect">L-Tryptophan</a> • <a href="/L-Tyrosine" title="L-Tyrosine" class="mw-redirect">L-Tyrosine</a> • <a href="/Lithium" title="Lithium">Lithium</a> • <a href="/Magnesium" title="Magnesium">Magnesium</a> • <a href="/Melatonin" title="Melatonin">Melatonin</a> • <a href="/Niacin" title="Niacin">Niacin</a>/<a href="/Niacinamide" title="Niacinamide" class="mw-redirect">Niacinamide</a> (Vitamin B<sub>3</sub>) • <a href="/Omega-3_fatty_acid" title="Omega-3 fatty acid">Omega-3 Fatty Acids</a> • <a href="/Pyridoxine" title="Pyridoxine">Pyridoxine</a> (Vitamin B<sub>6</sub>) • <a href="/Rubidium" title="Rubidium">Rubidium</a> • <a href="/S-Adenosyl-L-methionine" title="S-Adenosyl-L-methionine" class="mw-redirect">SAMe</a> • <a href="/Zinc" title="Zinc">Zinc</a></div> </td> </tr> </table> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td colspan="2" style="width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <table cellspacing="0" class="nowraplinks collapsible collapsed navbox-subgroup" style="width:100%;;;;"> <tr> <th style=";;" colspan="2" class="navbox-title"> <div style="float:left; width:6em;text-align:left;"> </div> <span class="" style="font-size:100%;"><a href="/Research_chemical" title="Research chemical" class="mw-redirect">Research Compounds</a> and Miscellaneous Agents</span></th> </tr> <tr style="height:2px;"> <td></td> </tr> <tr> <td colspan="2" style="width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <table cellspacing="0" class="nowraplinks navbox-subgroup" style="width:100%;;;;"> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/5-HT4_receptor" title="5-HT4 receptor">5-HT<sub>4</sub>R</a> <a href="/Serotonin_receptor_agonist" title="Serotonin receptor agonist">Agonists</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/RS-67,333" title="RS-67,333">RS-67,333</a> • <a href="/SL65.0155" title="SL65.0155">SL65.0155</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/5-HT7_receptor" title="5-HT7 receptor">5-HT<sub>7</sub>R</a> <a href="/Serotonin_receptor_antagonist" title="Serotonin receptor antagonist" class="mw-redirect">Antagonists</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Amisulpride" title="Amisulpride">Amisulpride</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Voltage-dependent_calcium_channel" title="Voltage-dependent calcium channel">α2δ-VDCC</a> <a href="/Calcium_channel_blocker" title="Calcium channel blocker">Blockers</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Gabapentin" title="Gabapentin">Gabapentin</a> • <a href="/Pregabalin" title="Pregabalin">Pregabalin</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Beta-3_adrenergic_receptor" title="Beta-3 adrenergic receptor">β<sub>3</sub>-Adrenoceptor</a> <a href="/Adrenergic_agonist" title="Adrenergic agonist">Agonists</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Amibegron" title="Amibegron">Amibegron</a> • <a href="/Solabegron" title="Solabegron">Solabegron</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Sigma_receptor" title="Sigma receptor">σ<sub>1</sub>R</a> <a href="/Agonist" title="Agonist">Agonists</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Opipramol" title="Opipramol">Opipramol</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/CB1_receptor" title="CB1 receptor" class="mw-redirect">CB<sub>1</sub>R</a> <a href="/Cannabinoid" title="Cannabinoid">Agonists</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Nabilone" title="Nabilone">Nabilone</a> • <a href="/Tetrahydrocannabinol" title="Tetrahydrocannabinol">Tetrahydrocannabinol</a>/<a href="/Dronabinol" title="Dronabinol" class="mw-redirect">Dronabinol</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Catechol_O-methyltransferase" title="Catechol O-methyltransferase" class="mw-redirect">COMT</a> <a href="/COMT_inhibitor" title="COMT inhibitor">Inhibitors</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Entacapone" title="Entacapone">Entacapone</a> • <a href="/Tolcapone" title="Tolcapone">Tolcapone</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Corticotropin_releasing_hormone_receptor_1" title="Corticotropin releasing hormone receptor 1">CRF<sub>1</sub>R</a> <a href="/Corticotropin_releasing_hormone_antagonist" title="Corticotropin releasing hormone antagonist">Antagonists</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Antalarmin" title="Antalarmin">Antalarmin</a> • <a href="/CP-154,526" title="CP-154,526">CP-154,526</a> • <a href="/Pexacerfont" title="Pexacerfont">Pexacerfont</a> • <a href="/Pivagabine" title="Pivagabine">Pivagabine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/D2_receptor" title="D2 receptor" class="mw-redirect">D<sub>2</sub></a>/<a href="/D3_receptor" title="D3 receptor" class="mw-redirect">D<sub>3</sub></a><a href="/Autoreceptor" title="Autoreceptor">AR</a> <a href="/Dopamine_receptor_antagonist" title="Dopamine receptor antagonist" class="mw-redirect">Antagonists</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Amisulpride" title="Amisulpride">Amisulpride</a> • <a href="/Sulpiride" title="Sulpiride">Sulpiride</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/D2_receptor" title="D2 receptor" class="mw-redirect">D<sub>2</sub></a>/<a href="/D3_receptor" title="D3 receptor" class="mw-redirect">D<sub>3</sub></a>/<a href="/D4_receptor" title="D4 receptor" class="mw-redirect">D<sub>4</sub></a><a href="/Dopamine_receptor_agonist" title="Dopamine receptor agonist" class="mw-redirect">R Agonists</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Piribedil" title="Piribedil">Piribedil</a> • <a href="/Pramipexole" title="Pramipexole">Pramipexole</a> • <a href="/Ropinirole" title="Ropinirole">Ropinirole</a> • <a href="/Rotigotine" title="Rotigotine">Rotigotine</a> • <a href="/Roxindole" title="Roxindole">Roxindole</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Delta-opioid_receptor" title="Delta-opioid receptor" class="mw-redirect">DOR</a> <a href="/Opioid" title="Opioid">Agonists</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/BU-48" title="BU-48">BU-48</a> • <a href="/Buprenorphine" title="Buprenorphine">Buprenorphine</a> • <a href="/BW373U86" title="BW373U86">BW373U86</a> • <a href="/DPI-287" title="DPI-287">DPI-287</a> • <a href="/Heroin" title="Heroin">Heroin</a> • <a href="/Kratom" title="Kratom">Kratom</a> • <a href="/SNC-80" title="SNC-80">SNC-80</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Enkephalinase" title="Enkephalinase">Enkephalinase</a> <a href="/Enzyme_inhibitor" title="Enzyme inhibitor">Inhibitors</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Phenylalanine" title="Phenylalanine">D-Phenylalanine</a> • <a href="/RB-101" title="RB-101">RB-101</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Fatty_acid_amide_hydrolase" title="Fatty acid amide hydrolase" class="mw-redirect">FAAH</a> <a href="/Enzyme_inhibitor" title="Enzyme inhibitor">Inhibitors</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Acetaminophen" title="Acetaminophen" class="mw-redirect">Acetaminophen</a>/<a href="/Paracetamol" title="Paracetamol">Paracetamol</a> • <a href="/AM404" title="AM404">AM-404</a> • <a href="/URB597" title="URB597">URB-597</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Kappa-opioid_receptor" title="Kappa-opioid receptor" class="mw-redirect">KOR</a> <a href="/Opioid" title="Opioid">Antagonists</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/5%27-Guanidinonaltrindole" title="5'-Guanidinonaltrindole">5-GNTI</a> • <a href="/Buprenorphine" title="Buprenorphine">Buprenorphine</a> • <a href="/JDTic" title="JDTic">JDTic</a> • <a href="/Norbinaltorphimine" title="Norbinaltorphimine">Norbinaltorphimine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/Mu-opioid_receptor" title="Mu-opioid receptor" class="mw-redirect">MOR</a> <a href="/Opioid" title="Opioid">Agonists</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Buprenorphine" title="Buprenorphine">Buprenorphine</a> • <a href="/Codeine" title="Codeine">Codeine</a> • <a href="/Dextropropoxyphene" title="Dextropropoxyphene">Dextropropoxyphene</a> • <a href="/Dihydrocodeine" title="Dihydrocodeine">Dihydrocodeine</a> • <a href="/Fentanyl" title="Fentanyl">Fentanyl</a> • <a href="/Heroin" title="Heroin">Heroin</a> • <a href="/Hydrocodone" title="Hydrocodone">Hydrocodone</a> • <a href="/Hydromorphone" title="Hydromorphone">Hydromorphone</a> • <a href="/Kratom" title="Kratom">Kratom</a> • <a href="/Methadone" title="Methadone">Methadone</a> • <a href="/Morphine" title="Morphine">Morphine</a> • <a href="/Opium" title="Opium">Opium</a> • <a href="/Oxycodone" title="Oxycodone">Oxycodone</a> • <a href="/Oxymorphone" title="Oxymorphone">Oxymorphone</a> • <a href="/Pethidine" title="Pethidine">Pethidine/Meperidine</a> • <a href="/Tapentadol" title="Tapentadol">Tapentadol</a> • <a href="/Tramadol" title="Tramadol">Tramadol</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/MT1_receptor" title="MT1 receptor" class="mw-redirect">MT<sub>1</sub></a>/<a href="/MT2_receptor" title="MT2 receptor" class="mw-redirect">MT<sub>2</sub>R</a> <a href="/Agonist" title="Agonist">Agonists</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Agomelatine" title="Agomelatine">Agomelatine</a> • <a href="/Melatonin" title="Melatonin">Melatonin</a> • <a href="/Ramelteon" title="Ramelteon">Ramelteon</a> • <a href="/Tasimelteon" title="Tasimelteon">Tasimelteon</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/NK1_receptor" title="NK1 receptor" class="mw-redirect">NK<sub>1</sub>R</a> <a href="/NK1_receptor_antagonist" title="NK1 receptor antagonist">Antagonists</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Aprepitant" title="Aprepitant">Aprepitant</a> • <a href="/Casopitant" title="Casopitant">Casopitant</a> • <a href="/Fosaprepitant" title="Fosaprepitant">Fosaprepitant</a> • <a href="/L-733,060" title="L-733,060">L-733,060</a> • <a href="/Maropitant" title="Maropitant">Maropitant</a> • <a href="/Vestipitant" title="Vestipitant">Vestipitant</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/NMDA_receptor" title="NMDA receptor">NMDAR</a> <a href="/NMDA_receptor_antagonist" title="NMDA receptor antagonist">Antagonists</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Dextromethorphan" title="Dextromethorphan">Dextromethorphan</a> • <a href="/Ketamine" title="Ketamine">Ketamine</a> • <a href="/Magnesium" title="Magnesium">Magnesium</a> • <a href="/Memantine" title="Memantine">Memantine</a> • <a href="/Zinc" title="Zinc">Zinc</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/PDE4" title="PDE4" class="mw-redirect">PDE4</a> <a href="/Phosphodiesterase_inhibitor" title="Phosphodiesterase inhibitor">Inhibitors</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Mesembrine" title="Mesembrine">Mesembrine</a> (<a href="/Sceletium_tortuosum" title="Sceletium tortuosum">Kanna</a>) • <a href="/Rolipram" title="Rolipram">Rolipram</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;;"> <div style="padding:0em 0.75em;"><small><a href="/TRPC6" title="TRPC6">TRPC6</a> <a href="/Agonist" title="Agonist">Activators</a></small></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Adhyperforin" title="Adhyperforin">Adhyperforin</a> (<a href="/Hypericum_perforatum" title="Hypericum perforatum" class="mw-redirect">St. John's Wort</a>) • <a href="/Hyperforin" title="Hyperforin">Hyperforin</a> (<a href="/Hypericum_perforatum" title="Hypericum perforatum" class="mw-redirect">St. John's Wort</a>)</div> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> <table class="navbox" cellspacing="0" style=";"> <tr> <td style="padding:2px;"> <table cellspacing="0" class="nowraplinks collapsible autocollapse" style="width:100%;background:transparent;color:inherit;;"> <tr> <th style=";" colspan="2" class="navbox-title"><span class="" style="font-size:110%;"><a href="/Anxiolytic" title="Anxiolytic">Anxiolytics</a> (<a href="/ATC_code_N05" title="ATC code N05">N05B</a>)</span></th> </tr> <tr style="height:2px;"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LemonChiffon;"><a href="/GABAA_receptor" title="GABAA receptor">GABA<sub>A</sub></a> <a href="/Positive_allosteric_modulator" title="Positive allosteric modulator">PAMs</a></td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <table cellspacing="0" class="nowraplinks navbox-subgroup" style="width:100%;;;;"> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LemonChiffon;"> <div style="padding:0em 0.75em;"><a href="/Benzodiazepine" title="Benzodiazepine">Benzodiazepine</a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Adinazolam" title="Adinazolam">Adinazolam</a> • <a href="/Alprazolam" title="Alprazolam">Alprazolam</a> • <a href="/Bretazenil" title="Bretazenil">Bretazenil</a> • <a href="/Bromazepam" title="Bromazepam">Bromazepam</a> • <a href="/Camazepam" title="Camazepam">Camazepam</a> • <a href="/Chlordiazepoxide" title="Chlordiazepoxide">Chlordiazepoxide</a> • <a href="/Clobazam" title="Clobazam">Clobazam</a> • <a href="/Clonazepam" title="Clonazepam">Clonazepam</a> • <a href="/Clorazepate" title="Clorazepate">Clorazepate</a> • <a href="/Clotiazepam" title="Clotiazepam">Clotiazepam</a> • <a href="/Cloxazolam" title="Cloxazolam">Cloxazolam</a> • <a href="/Diazepam" title="Diazepam">Diazepam</a> • <a href="/Ethyl_loflazepate" title="Ethyl loflazepate">Ethyl Loflazepate</a> • <a href="/Etizolam" title="Etizolam">Etizolam</a> • <a href="/Fludiazepam" title="Fludiazepam">Fludiazepam</a> • <a href="/Halazepam" title="Halazepam">Halazepam</a> • <a href="/Imidazenil" title="Imidazenil">Imidazenil</a> • <a href="/Ketazolam" title="Ketazolam">Ketazolam</a> • <a href="/Lorazepam" title="Lorazepam">Lorazepam</a> • <a href="/Medazepam" title="Medazepam">Medazepam</a> • <a href="/Nordazepam" title="Nordazepam">Nordazepam</a> • <a href="/Oxazepam" title="Oxazepam">Oxazepam</a> • <a href="/Pinazepam" title="Pinazepam">Pinazepam</a> • <a href="/Prazepam" title="Prazepam">Prazepam</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LemonChiffon;"> <div style="padding:0em 0.75em;"><a href="/Carbamate" title="Carbamate">Carbamates</a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Emylcamate" title="Emylcamate">Emylcamate</a> • <a href="/Mebutamate" title="Mebutamate">Mebutamate</a> • <a href="/Meprobamate" title="Meprobamate">Meprobamate</a> (<a href="/Carisoprodol" title="Carisoprodol">Carisoprodol</a>, <a href="/Tybamate" title="Tybamate">Tybamate</a>) • <a href="/Phenprobamate" title="Phenprobamate">Phenprobamate</a> • <a href="/Procymate" title="Procymate">Procymate</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LemonChiffon;"> <div style="padding:0em 0.75em;"><a href="/Nonbenzodiazepine" title="Nonbenzodiazepine">Nonbenzodiazepines</a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Abecarnil" title="Abecarnil">Abecarnil</a> • <a href="/Adipiplon" title="Adipiplon">Adipiplon</a> • <a href="/Alpidem" title="Alpidem">Alpidem</a> • <a href="/CGS-9896" title="CGS-9896">CGS-9896</a> • <a href="/CGS-20625" title="CGS-20625">CGS-20625</a> • <a href="/Divaplon" title="Divaplon">Divaplon</a> • <a href="/ELB-139" title="ELB-139">ELB-139</a> • <a href="/Etifoxine" title="Etifoxine">Etifoxine</a> • <a href="/GBLD-345" title="GBLD-345">GBLD-345</a> • <a href="/Gedocarnil" title="Gedocarnil">Gedocarnil</a> • <a href="/ICI-190,622" title="ICI-190,622">ICI-190,622</a> • <a href="/L-838,417" title="L-838,417">L-838,417</a> • <a href="/NS-2664" title="NS-2664">NS-2664</a> • <a href="/NS-2710" title="NS-2710">NS-2710</a> • <a href="/Ocinaplon" title="Ocinaplon">Ocinaplon</a> • <a href="/Pagoclone" title="Pagoclone">Pagoclone</a> • <a href="/Panadiplon" title="Panadiplon">Panadiplon</a> • <a href="/Pipequaline" title="Pipequaline">Pipequaline</a> • <a href="/RWJ-51204" title="RWJ-51204">RWJ-51204</a> • <a href="/SB-205,384" title="SB-205,384">SB-205,384</a> • <a href="/SL-651,498" title="SL-651,498">SL-651,498</a> • <a href="/TP-003" title="TP-003">TP-003</a> • <a href="/TP-13" title="TP-13">TP-13</a> • <a href="/TPA-023" title="TPA-023">TPA-023</a> • <a href="/Tracazolate" title="Tracazolate">Tracazolate</a> • <a href="/Y-23684" title="Y-23684">Y-23684</a> • <a href="/ZK-93423" title="ZK-93423">ZK-93423</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LemonChiffon;"> <div style="padding:0em 0.75em;">Others</div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Chlormezanone" title="Chlormezanone">Chlormezanone</a> • <a href="/Etazolate" title="Etazolate">Etazolate</a> • <a href="/Ethanol" title="Ethanol">Ethanol</a> (Alcohol) • <a href="/Kavalactone" title="Kavalactone">Kavalactones</a> (<a href="/Kava_Kava" title="Kava Kava" class="mw-redirect">Kava Kava</a>) • <a href="/Scutellaria" title="Scutellaria">Skullcap</a> • <a href="/Valerenic_acid" title="Valerenic acid">Valerenic Acid</a> (<a href="/Valerian_(herb)" title="Valerian (herb)">Valerian</a>)</div> </td> </tr> </table> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LemonChiffon;"><a href="/Voltage-dependent_calcium_channel" title="Voltage-dependent calcium channel">α<sub>2</sub>δ VDCC</a> <a href="/Channel_blocker" title="Channel blocker">Blockers</a></td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Gabapentin" title="Gabapentin">Gabapentin</a> • <a href="/Pregabalin" title="Pregabalin">Pregabalin</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LemonChiffon;"><a href="/5-HT1A_receptor" title="5-HT1A receptor">5-HT<sub>1A</sub></a> <a href="/Serotonin_receptor_agonist" title="Serotonin receptor agonist">Agonists</a></td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><em>Azapirones:</em> <a href="/Buspirone" title="Buspirone">Buspirone</a> • <a href="/Gepirone" title="Gepirone">Gepirone</a> • <a href="/Tandospirone" title="Tandospirone">Tandospirone</a>; <em>Others:</em> <a href="/Flesinoxan" title="Flesinoxan">Flesinoxan</a> • <a href="/Oxaflozane" title="Oxaflozane">Oxaflozane</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LemonChiffon;"><a href="/Antihistamine" title="Antihistamine" class="mw-redirect">H<sub>1</sub> Antagonists</a></td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><em>Diphenylmethanes:</em> <a href="/Captodiame" title="Captodiame">Captodiame</a> • <a href="/Hydroxyzine" title="Hydroxyzine">Hydroxyzine</a>; <em>Others:</em> <a href="/Brompheniramine" title="Brompheniramine">Brompheniramine</a> • <a href="/Chlorpheniramine" title="Chlorpheniramine" class="mw-redirect">Chlorpheniramine</a> • <a href="/Pheniramine" title="Pheniramine">Pheniramine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LemonChiffon;"><a href="/Corticotropin_releasing_hormone_antagonist" title="Corticotropin releasing hormone antagonist">CRF<sub>1</sub> Antagonists</a></td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Antalarmin" title="Antalarmin">Antalarmin</a> • <a href="/CP-154,526" title="CP-154,526">CP-154,526</a> • <a href="/Pexacerfont" title="Pexacerfont">Pexacerfont</a> • <a href="/Pivagabine" title="Pivagabine">Pivagabine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LemonChiffon;"><a href="/Tachykinin_receptor_2" title="Tachykinin receptor 2">NK<sub>2</sub></a> <a href="/Receptor_antagonist" title="Receptor antagonist">Antagonists</a></td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/GR-159,897" title="GR-159,897">GR-159,897</a> • <a href="/Saredutant" title="Saredutant">Saredutant</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LemonChiffon;"><a href="/Melanin-concentrating_hormone_receptor_1" title="Melanin-concentrating hormone receptor 1">MCH<sub>1</sub> antagonists</a></td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/ATC-0175" title="ATC-0175">ATC-0175</a> • <a href="/SNAP-94847" title="SNAP-94847">SNAP-94847</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LemonChiffon;"><a href="/Metabotropic_glutamate_receptor_2" title="Metabotropic glutamate receptor 2">mGluR<sub>2</sub></a><sub>/</sub><a href="/Metabotropic_glutamate_receptor_3" title="Metabotropic glutamate receptor 3"><sub>3</sub></a> <a href="/Agonist" title="Agonist">Agonists</a></td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Eglumegad" title="Eglumegad">Eglumegad</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LemonChiffon;"><a href="/Metabotropic_glutamate_receptor_5" title="Metabotropic glutamate receptor 5">mGluR5</a> <a href="/Negative_allosteric_modulator" title="Negative allosteric modulator">NAMs</a></td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Fenobam" title="Fenobam">Fenobam</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LemonChiffon;"><a href="/Translocator_protein" title="Translocator protein">TSPO agonists</a></td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/DAA-1097" title="DAA-1097">DAA-1097</a> • <a href="/DAA-1106" title="DAA-1106">DAA-1106</a> • <a href="/Emapunil" title="Emapunil">Emapunil</a> • <a href="/FGIN-127" title="FGIN-127">FGIN-127</a> • <a href="/FGIN-143" title="FGIN-143">FGIN-143</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LemonChiffon;"><a href="/Sigma-1_receptor" title="Sigma-1 receptor">σ<sub>1</sub> agonists</a></td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/Afobazole" title="Afobazole">Afobazole</a> • <a href="/Opipramol" title="Opipramol">Opipramol</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LemonChiffon;">Others</td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Benzoctamine" title="Benzoctamine">Benzoctamine</a> • <a href="/Carbetocin" title="Carbetocin">Carbetocin</a> • <a href="/Demoxytocin" title="Demoxytocin">Demoxytocin</a> • <a href="/Mephenoxalone" title="Mephenoxalone">Mephenoxalone</a> • <a href="/Oxanamide" title="Oxanamide">Oxanamide</a> • <a href="/Oxytocin" title="Oxytocin">Oxytocin</a> • <a href="/Promoxolane" title="Promoxolane">Promoxolane</a> • <a href="/Tofisopam" title="Tofisopam">Tofisopam</a> • <a href="/Trimetozine" title="Trimetozine">Trimetozine</a> • <a href="/WAY-267,464" title="WAY-267,464">WAY-267,464</a></div> </td> </tr> </table> </td> </tr> </table> <table class="navbox" cellspacing="0" style=";"> <tr> <td style="padding:2px;"> <table cellspacing="0" class="nowraplinks collapsible collapsed" style="width:100%;background:transparent;color:inherit;;"> <tr> <th style=";" colspan="2" class="navbox-title"><span class="" style="font-size:110%;"><a href="/Serotonergic" title="Serotonergic">Serotonergics</a></span></th> </tr> <tr style="height:2px;"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LightYellow;"><a href="/Receptor_(biochemistry)" title="Receptor (biochemistry)">Receptor</a><br /> <a href="/Ligand" title="Ligand">ligands</a></td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <table cellspacing="0" class="nowraplinks navbox-subgroup" style="width:100%;;;;"> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT1" title="5-HT1" class="mw-redirect">5-HT<sub>1</sub></a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <table cellspacing="0" class="nowraplinks navbox-subgroup" style="width:100%;;;;"> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT1A" title="5-HT1A" class="mw-redirect">5-HT<sub>1A</sub></a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><strong>Agonists</strong>: <em>Azapirones</em>: <a href="/Alnespirone" title="Alnespirone">Alnespirone</a> • <a href="/Binospirone" title="Binospirone">Binospirone</a> • <a href="/Buspirone" title="Buspirone">Buspirone</a> • <a href="/Enilospirone" title="Enilospirone">Enilospirone</a> • <a href="/Eptapirone" title="Eptapirone">Eptapirone</a> • <a href="/Gepirone" title="Gepirone">Gepirone</a> • <a href="/Ipsapirone" title="Ipsapirone">Ipsapirone</a> • <a href="/Perospirone" title="Perospirone">Perospirone</a> • <a href="/Revospirone" title="Revospirone">Revospirone</a> • <a href="/Tandospirone" title="Tandospirone">Tandospirone</a> • <a href="/Tiospirone" title="Tiospirone">Tiospirone</a> • <a href="/Umespirone" title="Umespirone">Umespirone</a> • <a href="/Zalospirone" title="Zalospirone">Zalospirone</a>; <em>Antidepressants</em>: <a href="/Etoperidone" title="Etoperidone">Etoperidone</a> • <a href="/Nefazodone" title="Nefazodone">Nefazodone</a> • <a href="/Trazodone" title="Trazodone">Trazodone</a>; <em>Antipsychotics</em>: <a href="/Aripiprazole" title="Aripiprazole">Aripiprazole</a> • <a href="/Asenapine" title="Asenapine">Asenapine</a> • <a href="/Clozapine" title="Clozapine">Clozapine</a> • <a href="/Quetiapine" title="Quetiapine">Quetiapine</a> • <a href="/Ziprasidone" title="Ziprasidone">Ziprasidone</a>; <em>Ergolines</em>: <a href="/Dihydroergotamine" title="Dihydroergotamine">Dihydroergotamine</a> • <a href="/Ergotamine" title="Ergotamine">Ergotamine</a> • <a href="/Lisuride" title="Lisuride">Lisuride</a> • <a href="/Methysergide" title="Methysergide">Methysergide</a> • <a href="/Lysergic_acid_diethylamide" title="Lysergic acid diethylamide">LSD</a>; <em>Tryptamines</em>: <a href="/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a> • <a href="/5-MeO-DMT" title="5-MeO-DMT">5-MeO-DMT</a> • <a href="/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a> • <a href="/Bufotenin" title="Bufotenin">Bufotenin</a> • <a href="/Dimethyltryptamine" title="Dimethyltryptamine">DMT</a> • <a href="/Psilocin" title="Psilocin">Psilocin</a> • <a href="/Psilocybin" title="Psilocybin">Psilocybin</a>; <em>Others</em>: <a href="/8-OH-DPAT" title="8-OH-DPAT">8-OH-DPAT</a> • <a href="/Adatanserin" title="Adatanserin">Adatanserin</a> • <a href="/Befiradol" title="Befiradol">Befiradol</a> • <a href="/Dimemebfe" title="Dimemebfe">Dimemebfe</a> • <a href="/Eltoprazine" title="Eltoprazine">Eltoprazine</a> • <a href="/F-11440" title="F-11440" class="mw-redirect">F-11440</a> • <a href="/Flesinoxan" title="Flesinoxan">Flesinoxan</a> • <a href="/Flibanserin" title="Flibanserin">Flibanserin</a> • Lesopitron • <a href="/Lu_AA21004" title="Lu AA21004">Lu AA21004</a> • LY-293,284 • LY-301,317 • MKC-242 • <a href="/NBUMP" title="NBUMP">NBUMP</a> • Osemozotan • <a href="/Oxaflozane" title="Oxaflozane">Oxaflozane</a> • <a href="/Pardoprunox" title="Pardoprunox">Pardoprunox</a> • Piclozotan • <a href="/Rauwolscine" title="Rauwolscine">Rauwolscine</a> • Repinotan • <a href="/Roxindole" title="Roxindole">Roxindole</a> • <a href="/RU-24969" title="RU-24969" class="mw-redirect">RU-24969</a> • <a href="/S-15535" title="S-15535">S-15535</a> • Sarizotan • SSR-181,507 • Sunepitron • <a href="/U-92016A" title="U-92016A" class="mw-redirect">U-92016A</a> • <a href="/Urapidil" title="Urapidil">Urapidil</a> • <a href="/Vilazodone" title="Vilazodone">Vilazodone</a> • <a href="/Xaliproden" title="Xaliproden">Xaliproden</a> • <a href="/Yohimbine" title="Yohimbine">Yohimbine</a><br /> <strong>Antagonists</strong>: <em>Antipsychotics</em>: <a href="/Iloperidone" title="Iloperidone">Iloperidone</a> • <a href="/Risperidone" title="Risperidone">Risperidone</a> • <a href="/Sertindole" title="Sertindole">Sertindole</a>; <em>Beta Blockers</em>: <a href="/Alprenolol" title="Alprenolol">Alprenolol</a> • <a href="/Cyanopindolol" title="Cyanopindolol">Cyanopindolol</a> • <a href="/Iodocyanopindolol" title="Iodocyanopindolol">Iodocyanopindolol</a> • <a href="/Oxprenolol" title="Oxprenolol">Oxprenolol</a> • Pindobind • <a href="/Pindolol" title="Pindolol">Pindolol</a> • <a href="/Propranolol" title="Propranolol">Propranolol</a>; <em>Others</em>: AV965 • <a href="/BMY-7378" title="BMY-7378" class="mw-redirect">BMY-7378</a> • <a href="/Dotarizine" title="Dotarizine">Dotarizine</a> • <a href="/Flopropione" title="Flopropione">Flopropione</a> • GR-46611 • <a href="/Isamoltane" title="Isamoltane">Isamoltane</a> • <a href="/Lecozotan" title="Lecozotan">Lecozotan</a> • <a href="/Metitepine" title="Metitepine">Metitepine/Methiothepin</a> • <a href="/MPPF" title="MPPF">MPPF</a> • <a href="/NAN-190" title="NAN-190">NAN-190</a> • <a href="/PRX-00023" title="PRX-00023">PRX-00023</a> • <a href="/Robalzotan" title="Robalzotan">Robalzotan</a> • <a href="/S-15535" title="S-15535">S-15535</a> • <a href="/SB-649915" title="SB-649915" class="mw-redirect">SB-649915</a> • SDZ 216-525 • <a href="/Spiperone" title="Spiperone">Spiperone</a> • <a href="/Spiramide" title="Spiramide">Spiramide</a> • <a href="/Spiroxatrine" title="Spiroxatrine">Spiroxatrine</a> • <a href="/UH-301" title="UH-301">UH-301</a> • <a href="/WAY-100,135" title="WAY-100,135">WAY-100,135</a> • <a href="/WAY-100,635" title="WAY-100,635">WAY-100,635</a> • <a href="/Xylamidine" title="Xylamidine">Xylamidine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT1B" title="5-HT1B" class="mw-redirect">5-HT<sub>1B</sub></a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><strong>Agonists</strong>: <em>Lysergamides</em>: <a href="/Dihydroergotamine" title="Dihydroergotamine">Dihydroergotamine</a> • <a href="/Ergotamine" title="Ergotamine">Ergotamine</a> • <a href="/Methysergide" title="Methysergide">Methysergide</a>; <em>Piperazines</em>: <a href="/Eltoprazine" title="Eltoprazine">Eltoprazine</a> • <a href="/TFMPP" title="TFMPP" class="mw-redirect">TFMPP</a>; <em>Triptans</em>: <a href="/Avitriptan" title="Avitriptan">Avitriptan</a> • <a href="/Eletriptan" title="Eletriptan">Eletriptan</a> • <a href="/Sumatriptan" title="Sumatriptan">Sumatriptan</a> • <a href="/Zolmitriptan" title="Zolmitriptan">Zolmitriptan</a>; <em>Tryptamines</em>: <a href="/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a> • <a href="/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>; <em>Others</em>: <a href="/CGS-12066A" title="CGS-12066A">CGS-12066A</a> • CP-93,129 • <a href="/CP-94,253" title="CP-94,253">CP-94,253</a> • CP-135,807 • <a href="/RU-24969" title="RU-24969" class="mw-redirect">RU-24969</a><br /> <strong>Antagonists</strong>: <em>Lysergamides</em>: <a href="/Metergoline" title="Metergoline">Metergoline</a>; <em>Others</em>: <a href="/AR-A000002" title="AR-A000002">AR-A000002</a> • <a href="/GR-127,935" title="GR-127,935">GR-127,935</a> • <a href="/Isamoltane" title="Isamoltane">Isamoltane</a> • <a href="/Metitepine" title="Metitepine">Metitepine/Methiothepin</a> • <a href="/SB-216,641" title="SB-216,641">SB-216,641</a> • SB-224,289 • SB-236,057 • <a href="/Yohimbine" title="Yohimbine">Yohimbine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT1D" title="5-HT1D" class="mw-redirect">5-HT<sub>1D</sub></a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><strong>Agonists</strong>: <em>Lysergamides</em>: <a href="/Dihydroergotamine" title="Dihydroergotamine">Dihydroergotamine</a> • <a href="/Methysergide" title="Methysergide">Methysergide</a>; <em>Triptans</em>: <a href="/Almotriptan" title="Almotriptan">Almotriptan</a> • <a href="/Avitriptan" title="Avitriptan">Avitriptan</a> • <a href="/Eletriptan" title="Eletriptan">Eletriptan</a> • <a href="/Frovatriptan" title="Frovatriptan">Frovatriptan</a> • <a href="/Naratriptan" title="Naratriptan">Naratriptan</a> • <a href="/Rizatriptan" title="Rizatriptan">Rizatriptan</a> • <a href="/Sumatriptan" title="Sumatriptan">Sumatriptan</a> • <a href="/Zolmitriptan" title="Zolmitriptan">Zolmitriptan</a>; <em>Tryptamines</em>: <a href="/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a> • <a href="/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>; <em>Others</em>: CP-135,807 • CP-286,601 • GR-46611 • L-694,247 • L-772,405 • PNU-109,291 • PNU-142,633<br /> <strong>Antagonists</strong>: <em>Lysergamides</em>: <a href="/Metergoline" title="Metergoline">Metergoline</a>; <em>Others</em>: <a href="/Alniditan" title="Alniditan">Alniditan</a> <a href="/BRL-15572" title="BRL-15572">BRL-15572</a> • <a href="/GR-127,935" title="GR-127,935">GR-127,935</a> • <a href="/Ketanserin" title="Ketanserin">Ketanserin</a> • LY-310,762 • LY-367,642 • LY-456,219 • LY-456,220 • <a href="/Metitepine" title="Metitepine">Metitepine/Methiothepin</a> • <a href="/Ritanserin" title="Ritanserin">Ritanserin</a> • <a href="/Yohimbine" title="Yohimbine">Yohimbine</a> • <a href="/Ziprasidone" title="Ziprasidone">Ziprasidone</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT1E" title="5-HT1E" class="mw-redirect">5-HT<sub>1E</sub></a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><strong>Agonists</strong>: <em>Lysergamides</em>: <a href="/Methysergide" title="Methysergide">Methysergide</a>; <em>Triptans</em>: <a href="/Eletriptan" title="Eletriptan">Eletriptan</a>; <em>Tryptamines</em>: <a href="/Tryptamine" title="Tryptamine">Tryptamine</a><br /> <strong>Antagonists</strong>: <a href="/Metitepine" title="Metitepine">Metitepine/Methiothepin</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT1F" title="5-HT1F" class="mw-redirect">5-HT<sub>1F</sub></a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><strong>Agonists</strong>: <em>Triptans</em>: <a href="/Eletriptan" title="Eletriptan">Eletriptan</a> • <a href="/Naratriptan" title="Naratriptan">Naratriptan</a> • <a href="/Sumatriptan" title="Sumatriptan">Sumatriptan</a>; <em>Tryptamines</em>: <a href="/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>; <em>Others</em>: <a href="/LY-334,370" title="LY-334,370">LY-334,370</a><br /> <strong>Antagonists</strong>: <a href="/Metitepine" title="Metitepine">Metitepine/Methiothepin</a></div> </td> </tr> </table> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT2" title="5-HT2" class="mw-redirect">5-HT<sub>2</sub></a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <table cellspacing="0" class="nowraplinks navbox-subgroup" style="width:100%;;;;"> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT2A" title="5-HT2A" class="mw-redirect">5-HT<sub>2A</sub></a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><strong>Agonists</strong>: <em>Lysergamides</em>: <a href="/ALD-52" title="ALD-52">ALD-52</a> • <a href="/Ergonovine" title="Ergonovine" class="mw-redirect">Ergonovine</a> • <a href="/Lisuride" title="Lisuride">Lisuride</a> • <a href="/Lysergic_acid_2,4-dimethylazetidide" title="Lysergic acid 2,4-dimethylazetidide">LA-SS-Az</a> • <a href="/LSD" title="LSD" class="mw-redirect">LSD</a> • <a href="/Lysergic_acid_2-butyl_amide" title="Lysergic acid 2-butyl amide">Lysergic acid 2-butyl amide</a> • <a href="/Methysergide" title="Methysergide">Methysergide</a>; <em>Phenethylamines</em>: <a href="/25I-NBMD" title="25I-NBMD">25I-NBMD</a> • <a href="/25I-NBOH" title="25I-NBOH">25I-NBOH</a> • <a href="/25I-NBOMe" title="25I-NBOMe">25I-NBOMe</a> • <a href="/2C-B" title="2C-B">2C-B</a> • <a href="/2C-B-FLY" title="2C-B-FLY">2C-B-FLY</a> • <a href="/2C-E" title="2C-E">2C-E</a> • <a href="/2C-I" title="2C-I">2C-I</a> • <a href="/2C-T-2" title="2C-T-2">2C-T-2</a> • <a href="/2C-T-7" title="2C-T-7">2C-T-7</a> • <a href="/2C-T-21" title="2C-T-21">2C-T-21</a> • <a href="/2CBCB-NBOMe" title="2CBCB-NBOMe">2CBCB-NBOMe</a> • <a href="/2CBFly-NBOMe" title="2CBFly-NBOMe">2CBFly-NBOMe</a> • <a href="/Bromo-DragonFLY" title="Bromo-DragonFLY">Bromo-DragonFLY</a> • <a href="/2,5-Dimethoxy-4-bromoamphetamine" title="2,5-Dimethoxy-4-bromoamphetamine">DOB</a> • <a href="/4-chloro-2,5-dimethoxyamphetamine" title="4-chloro-2,5-dimethoxyamphetamine" class="mw-redirect">DOC</a> • <a href="/2,5-Dimethoxy-4-iodoamphetamine" title="2,5-Dimethoxy-4-iodoamphetamine">DOI</a> • <a href="/2,5-Dimethoxy-4-methylamphetamine" title="2,5-Dimethoxy-4-methylamphetamine">DOM</a> • <a href="/3,4-Methylenedioxyamphetamine" title="3,4-Methylenedioxyamphetamine">MDA</a> • <a href="/MDMA" title="MDMA">MDMA</a> • <a href="/Mescaline" title="Mescaline">Mescaline</a> • <a href="/TCB-2" title="TCB-2">TCB-2</a> • <a href="/TFMFly" title="TFMFly">TFMFly</a>; <em>Piperazines</em>: <a href="/Benzylpiperazine" title="Benzylpiperazine">BZP</a> • <a href="/Quipazine" title="Quipazine">Quipazine</a> • <a href="/TFMPP" title="TFMPP" class="mw-redirect">TFMPP</a>; <em>Tryptamines</em>: <a href="/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a> • <a href="/5-MeO-AET" title="5-MeO-AET">5-MeO-α-ET</a> • <a href="/5-MeO-AMT" title="5-MeO-AMT">5-MeO-α-MT</a> • <a href="/5-MeO-DET" title="5-MeO-DET">5-MeO-DET</a> • <a href="/5-Methoxy-diisopropyltryptamine" title="5-Methoxy-diisopropyltryptamine">5-MeO-DiPT</a> • <a href="/5-MeO-DMT" title="5-MeO-DMT">5-MeO-DMT</a> • <a href="/5-MeO-DPT" title="5-MeO-DPT">5-MeO-DPT</a> • <a href="/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a> • <a href="/Alpha-Ethyltryptamine" title="Alpha-Ethyltryptamine">α-ET</a> • <a href="/%CE%91-Methyl-5-HT" title="Α-Methyl-5-HT" class="mw-redirect">α-Methyl-5-HT</a> • <a href="/Alpha-Methyltryptamine" title="Alpha-Methyltryptamine">α-MT</a> • <a href="/Bufotenin" title="Bufotenin">Bufotenin</a> • <a href="/Diethyltryptamine" title="Diethyltryptamine">DET</a> • <a href="/Diisopropyltryptamine" title="Diisopropyltryptamine">DiPT</a> • <a href="/Dimethyltryptamine" title="Dimethyltryptamine">DMT</a> • <a href="/Dipropyltryptamine" title="Dipropyltryptamine">DPT</a> • <a href="/Psilocin" title="Psilocin">Psilocin</a> • <a href="/Psilocybin" title="Psilocybin">Psilocybin</a>; <em>Others</em>: <a href="/AL-34662" title="AL-34662">AL-34662</a> • <a href="/AL-37350A" title="AL-37350A">AL-37350A</a> • <a href="/Dimemebfe" title="Dimemebfe">Dimemebfe</a> • <a href="/Medifoxamine" title="Medifoxamine">Medifoxamine</a> • <a href="/Oxaflozane" title="Oxaflozane">Oxaflozane</a> • <a href="/PNU-22394" title="PNU-22394">PNU-22394</a><br /> <strong>Antagonists</strong>: <em>Atypical Antipsychotics</em>: <a href="/Amperozide" title="Amperozide">Amperozide</a> • <a href="/Aripiprazole" title="Aripiprazole">Aripiprazole</a> • <a href="/Clozapine" title="Clozapine">Clozapine</a> • <a href="/Iloperidone" title="Iloperidone">Iloperidone</a> • <a href="/Melperone" title="Melperone">Melperone</a> • <a href="/Olanzapine" title="Olanzapine">Olanzapine</a> • <a href="/Paliperidone" title="Paliperidone">Paliperidone</a> • <a href="/Pimozide" title="Pimozide">Pimozide</a> • <a href="/Quetiapine" title="Quetiapine">Quetiapine</a> • <a href="/Risperidone" title="Risperidone">Risperidone</a> • <a href="/Sertindole" title="Sertindole">Sertindole</a> • <a href="/Ziprasidone" title="Ziprasidone">Ziprasidone</a> • <a href="/Zotepine" title="Zotepine">Zotepine</a>; <em>Typical Antipsychotics</em>: <a href="/Loxapine" title="Loxapine">Loxapine</a> • <a href="/Pipamperone" title="Pipamperone">Pipamperone</a>; <em>Antidepressants</em>: <a href="/Amitriptyline" title="Amitriptyline">Amitriptyline</a> • <a href="/Amoxapine" title="Amoxapine">Amoxapine</a> • <a href="/Etoperidone" title="Etoperidone">Etoperidone</a> • <a href="/Mianserin" title="Mianserin">Mianserin</a> • <a href="/Mirtazapine" title="Mirtazapine">Mirtazapine</a> • <a href="/Nefazodone" title="Nefazodone">Nefazodone</a> • <a href="/Trazodone" title="Trazodone">Trazodone</a>; <em>Others</em>: <a href="/5-I-R91150" title="5-I-R91150">5-I-R91150</a> • AC-90179 • <a href="/Adatanserin" title="Adatanserin">Adatanserin</a> • <a href="/Altanserin" title="Altanserin">Altanserin</a> • <a href="/9-Aminomethyl-9,10-dihydroanthracene" title="9-Aminomethyl-9,10-dihydroanthracene">AMDA</a> • APD-215 • <a href="/Blonanserin" title="Blonanserin">Blonanserin</a> • <a href="/Cinanserin" title="Cinanserin">Cinanserin</a> • <a href="/Cyproheptadine" title="Cyproheptadine">Cyproheptadine</a> • <a href="/Deramciclane" title="Deramciclane">Deramciclane</a> • <a href="/Dotarizine" title="Dotarizine">Dotarizine</a> • <a href="/Eplivanserin" title="Eplivanserin">Eplivanserin</a> • <a href="/Esmirtazapine" title="Esmirtazapine">Esmirtazapine</a> • <a href="/Fananserin" title="Fananserin">Fananserin</a> • <a href="/Flibanserin" title="Flibanserin">Flibanserin</a> • <a href="/Ketanserin" title="Ketanserin">Ketanserin</a> • <a href="/KML-010" title="KML-010">KML-010</a> • <a href="/Lubazodone" title="Lubazodone">Lubazodone</a> • <a href="/Metitepine" title="Metitepine">Metitepine/Methiothepin</a> • <a href="/Nantenine" title="Nantenine">Nantenine</a> • <a href="/Pimavanserin" title="Pimavanserin">Pimavanserin</a> • <a href="/Pizotifen" title="Pizotifen">Pizotifen</a> • Pruvanserin • <a href="/Rauwolscine" title="Rauwolscine">Rauwolscine</a> • <a href="/Ritanserin" title="Ritanserin">Ritanserin</a> • <a href="/Sarpogrelate" title="Sarpogrelate">Sarpogrelate</a> • <a href="/Setoperone" title="Setoperone">Setoperone</a> • <a href="/Spiperone" title="Spiperone">Spiperone</a> • <a href="/Spiramide" title="Spiramide">Spiramide</a> • SR-46349B • <a href="/Volinanserin" title="Volinanserin">Volinanserin</a> • <a href="/Xylamidine" title="Xylamidine">Xylamidine</a> • <a href="/Yohimbine" title="Yohimbine">Yohimbine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT2B" title="5-HT2B" class="mw-redirect">5-HT<sub>2B</sub></a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><strong>Agonists</strong>: <em>Oxazolines</em>: <a href="/4-Methylaminorex" title="4-Methylaminorex">4-Methylaminorex</a> • <a href="/Aminorex" title="Aminorex">Aminorex</a>; <em>Phenethylamines</em>: <a href="/Chlorphentermine" title="Chlorphentermine">Chlorphentermine</a> • <a href="/2,5-Dimethoxy-4-bromoamphetamine" title="2,5-Dimethoxy-4-bromoamphetamine">DOB</a> • <a href="/4-chloro-2,5-dimethoxyamphetamine" title="4-chloro-2,5-dimethoxyamphetamine" class="mw-redirect">DOC</a> • <a href="/2,5-Dimethoxy-4-iodoamphetamine" title="2,5-Dimethoxy-4-iodoamphetamine">DOI</a> • <a href="/2,5-Dimethoxy-4-methylamphetamine" title="2,5-Dimethoxy-4-methylamphetamine">DOM</a> • <a href="/Fenfluramine" title="Fenfluramine">Fenfluramine</a> • <a href="/3,4-Methylenedioxyamphetamine" title="3,4-Methylenedioxyamphetamine">MDA</a> • <a href="/MDMA" title="MDMA">MDMA</a> • <a href="/Norfenfluramine" title="Norfenfluramine">Norfenfluramine</a>; <em>Tryptamines</em>: <a href="/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a> • <a href="/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a> • <a href="/%CE%91-Methyl-5-HT" title="Α-Methyl-5-HT" class="mw-redirect">α-Methyl-5-HT</a>; <em>Others</em>: <a href="/BW-723C86" title="BW-723C86">BW-723C86</a> • <a href="/Cabergoline" title="Cabergoline">Cabergoline</a> • <a href="/1-(3-Chlorophenyl)piperazine" title="1-(3-Chlorophenyl)piperazine" class="mw-redirect">mCPP</a> • <a href="/Pergolide" title="Pergolide">Pergolide</a> • <a href="/PNU-22394" title="PNU-22394">PNU-22394</a> • <a href="/Ro60-0175" title="Ro60-0175">Ro60-0175</a><br /> <strong>Antagonists</strong>: <a href="/Agomelatine" title="Agomelatine">Agomelatine</a> • <a href="/Asenapine" title="Asenapine">Asenapine</a> • EGIS-7625 • <a href="/Ketanserin" title="Ketanserin">Ketanserin</a> • <a href="/Lisuride" title="Lisuride">Lisuride</a> • <a href="/LY-272,015" title="LY-272,015">LY-272,015</a> • <a href="/Metitepine" title="Metitepine">Metitepine/Methiothepin</a> • <a href="/Rauwolscine" title="Rauwolscine">Rauwolscine</a> • <a href="/Ritanserin" title="Ritanserin">Ritanserin</a> • <a href="/RS-127,445" title="RS-127,445">RS-127,445</a> • <a href="/Sarpogrelate" title="Sarpogrelate">Sarpogrelate</a> • SB-200,646 • <a href="/SB-204,741" title="SB-204,741">SB-204,741</a> • SB-206,553 • <a href="/SB-215,505" title="SB-215,505">SB-215,505</a> • SB-221,284 • SB-228,357 • <a href="/SDZ_SER-082" title="SDZ SER-082">SDZ SER-082</a> • <a href="/Tegaserod" title="Tegaserod">Tegaserod</a> • <a href="/Yohimbine" title="Yohimbine">Yohimbine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT2C" title="5-HT2C" class="mw-redirect">5-HT<sub>2C</sub></a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><strong>Agonists</strong>: <em>Phenethylamines</em>: <a href="/2C-B" title="2C-B">2C-B</a> • <a href="/2C-E" title="2C-E">2C-E</a> • <a href="/2C-I" title="2C-I">2C-I</a> • <a href="/2C-T-2" title="2C-T-2">2C-T-2</a> • <a href="/2C-T-7" title="2C-T-7">2C-T-7</a> • <a href="/2C-T-21" title="2C-T-21">2C-T-21</a> • <a href="/2,5-Dimethoxy-4-bromoamphetamine" title="2,5-Dimethoxy-4-bromoamphetamine">DOB</a> • <a href="/4-chloro-2,5-dimethoxyamphetamine" title="4-chloro-2,5-dimethoxyamphetamine" class="mw-redirect">DOC</a> • <a href="/2,5-Dimethoxy-4-iodoamphetamine" title="2,5-Dimethoxy-4-iodoamphetamine">DOI</a> • <a href="/2,5-Dimethoxy-4-methylamphetamine" title="2,5-Dimethoxy-4-methylamphetamine">DOM</a> • <a href="/3,4-Methylenedioxyamphetamine" title="3,4-Methylenedioxyamphetamine">MDA</a> • <a href="/MDMA" title="MDMA">MDMA</a> • <a href="/Mescaline" title="Mescaline">Mescaline</a>; <em>Piperazines</em>: <a href="/Aripiprazole" title="Aripiprazole">Aripiprazole</a> • <a href="/1-(3-Chlorophenyl)piperazine" title="1-(3-Chlorophenyl)piperazine" class="mw-redirect">mCPP</a> • <a href="/TFMPP" title="TFMPP" class="mw-redirect">TFMPP</a>; <em>Tryptamines</em>: <a href="/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a> • <a href="/5-MeO-AET" title="5-MeO-AET">5-MeO-α-ET</a> • <a href="/5-MeO-AMT" title="5-MeO-AMT">5-MeO-α-MT</a> • <a href="/5-MeO-DET" title="5-MeO-DET">5-MeO-DET</a> • <a href="/5-Methoxy-diisopropyltryptamine" title="5-Methoxy-diisopropyltryptamine">5-MeO-DiPT</a> • <a href="/5-MeO-DMT" title="5-MeO-DMT">5-MeO-DMT</a> • <a href="/5-MeO-DPT" title="5-MeO-DPT">5-MeO-DPT</a> • <a href="/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a> • <a href="/Alpha-Ethyltryptamine" title="Alpha-Ethyltryptamine">α-ET</a> • <a href="/%CE%91-Methyl-5-HT" title="Α-Methyl-5-HT" class="mw-redirect">α-Methyl-5-HT</a> • <a href="/Alpha-Methyltryptamine" title="Alpha-Methyltryptamine">α-MT</a> • <a href="/Bufotenin" title="Bufotenin">Bufotenin</a> • <a href="/Diethyltryptamine" title="Diethyltryptamine">DET</a> • <a href="/Diisopropyltryptamine" title="Diisopropyltryptamine">DiPT</a> • <a href="/Dimethyltryptamine" title="Dimethyltryptamine">DMT</a> • <a href="/Dipropyltryptamine" title="Dipropyltryptamine">DPT</a> • <a href="/Psilocin" title="Psilocin">Psilocin</a> • <a href="/Psilocybin" title="Psilocybin">Psilocybin</a>; <em>Others</em>: <a href="/A-372,159" title="A-372,159">A-372,159</a> • <a href="/AL-38022A" title="AL-38022A">AL-38022A</a> • <a href="/CP-809,101" title="CP-809,101">CP-809,101</a> • <a href="/Dimemebfe" title="Dimemebfe">Dimemebfe</a> • <a href="/Lorcaserin" title="Lorcaserin">Lorcaserin</a>• <a href="/Medifoxamine" title="Medifoxamine">Medifoxamine</a> • MK-212 • <a href="/ORG-37,684" title="ORG-37,684">ORG-37,684</a> • <a href="/Oxaflozane" title="Oxaflozane">Oxaflozane</a> • <a href="/PNU-22394" title="PNU-22394">PNU-22394</a> • <a href="/Ro60-0175" title="Ro60-0175">Ro60-0175</a> • <a href="/Vabicaserin" title="Vabicaserin">Vabicaserin</a> • WAY-629 • WAY-161,503 • <a href="/YM-348" title="YM-348">YM-348</a><br /> <strong>Antagonists</strong>: <em>Atypical Antipsychotics</em>: <a href="/Clozapine" title="Clozapine">Clozapine</a> • <a href="/Iloperidone" title="Iloperidone">Iloperidone</a> • <a href="/Melperone" title="Melperone">Melperone</a> • <a href="/Olanzapine" title="Olanzapine">Olanzapine</a> • <a href="/Paliperidone" title="Paliperidone">Paliperidone</a> • <a href="/Pimozide" title="Pimozide">Pimozide</a> • <a href="/Quetiapine" title="Quetiapine">Quetiapine</a> • <a href="/Risperidone" title="Risperidone">Risperidone</a> • <a href="/Sertindole" title="Sertindole">Sertindole</a> • <a href="/Ziprasidone" title="Ziprasidone">Ziprasidone</a> • <a href="/Zotepine" title="Zotepine">Zotepine</a>; <em>Typical Antipsychotics</em>: <a href="/Chlorpromazine" title="Chlorpromazine">Chlorpromazine</a> • <a href="/Loxapine" title="Loxapine">Loxapine</a> • <a href="/Pipamperone" title="Pipamperone">Pipamperone</a>; <em>Antidepressants</em>: <a href="/Agomelatine" title="Agomelatine">Agomelatine</a> • <a href="/Amitriptyline" title="Amitriptyline">Amitriptyline</a> • <a href="/Amoxapine" title="Amoxapine">Amoxapine</a> • <a href="/Etoperidone" title="Etoperidone">Etoperidone</a> • <a href="/Fluoxetine" title="Fluoxetine">Fluoxetine</a> • <a href="/Mianserin" title="Mianserin">Mianserin</a> • <a href="/Mirtazapine" title="Mirtazapine">Mirtazapine</a> • <a href="/Nefazodone" title="Nefazodone">Nefazodone</a> • <a href="/Nortriptyline" title="Nortriptyline">Nortriptyline</a> • <a href="/Trazodone" title="Trazodone">Trazodone</a>; <em>Others</em>: <a href="/Adatanserin" title="Adatanserin">Adatanserin</a> • <a href="/Cinanserin" title="Cinanserin">Cinanserin</a> • <a href="/Cyproheptadine" title="Cyproheptadine">Cyproheptadine</a> • <a href="/Deramciclane" title="Deramciclane">Deramciclane</a> • <a href="/Dimebolin" title="Dimebolin">Dimebolin</a> • <a href="/Dotarizine" title="Dotarizine">Dotarizine</a> • <a href="/Eltoprazine" title="Eltoprazine">Eltoprazine</a> • <a href="/Esmirtazapine" title="Esmirtazapine">Esmirtazapine</a> • FR-260,010 • <a href="/Ketanserin" title="Ketanserin">Ketanserin</a> • <a href="/Ketotifen" title="Ketotifen">Ketotifen</a> • <a href="/Lu_AA24530" title="Lu AA24530">Lu AA24530</a> • <a href="/Metitepine" title="Metitepine">Metitepine/Methiothepin</a> • <a href="/Methysergide" title="Methysergide">Methysergide</a> • <a href="/Pizotifen" title="Pizotifen">Pizotifen</a> • <a href="/Ritanserin" title="Ritanserin">Ritanserin</a> • <a href="/RS-102,221" title="RS-102,221">RS-102,221</a> • SB-200,646 • SB-206,553 • SB-221,284 • SB-228,357 • <a href="/SB-242,084" title="SB-242,084">SB-242,084</a> • SB-243,213 • <a href="/SDZ_SER-082" title="SDZ SER-082">SDZ SER-082</a> • <a href="/Xylamidine" title="Xylamidine">Xylamidine</a></div> </td> </tr> </table> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT3" title="5-HT3" class="mw-redirect">5-HT<sub>3</sub></a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><strong>Agonists</strong>: <em>Piperazines</em>: <a href="/Benzylpiperazine" title="Benzylpiperazine">BZP</a> • <a href="/Quipazine" title="Quipazine">Quipazine</a>; <em>Tryptamines</em>: <a href="/2-Methyl-5-hydroxytryptamine" title="2-Methyl-5-hydroxytryptamine">2-Methyl-5-HT</a> • <a href="/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>; <em>Others</em>: Chlorophenylbiguanide • <a href="/RS-56812" title="RS-56812">RS-56812</a> • SR-57,227 • SR-57,227-A • YM-31636<br /> <strong>Antagonists</strong>: <em>Antiemetics</em>: <a href="/AS-8112" title="AS-8112">AS-8112</a> • <a href="/Alosetron" title="Alosetron">Alosetron</a> • <a href="/Azasetron" title="Azasetron">Azasetron</a> • <a href="/Batanopride" title="Batanopride">Batanopride</a> • <a href="/Bemesetron" title="Bemesetron">Bemesetron</a> • <a href="/Cilansetron" title="Cilansetron">Cilansetron</a> • <a href="/Dazopride" title="Dazopride">Dazopride</a> • <a href="/Dolasetron" title="Dolasetron">Dolasetron</a> • <a href="/Granisetron" title="Granisetron">Granisetron</a> • <a href="/Lerisetron" title="Lerisetron">Lerisetron</a> • <a href="/Ondansetron" title="Ondansetron">Ondansetron</a> • <a href="/Palonosetron" title="Palonosetron">Palonosetron</a> • <a href="/Ramosetron" title="Ramosetron">Ramosetron</a> • <a href="/Renzapride" title="Renzapride">Renzapride</a> • <a href="/Tropisetron" title="Tropisetron">Tropisetron</a> • <a href="/Zacopride" title="Zacopride">Zacopride</a> • <a href="/Zatosetron" title="Zatosetron">Zatosetron</a>; <em>Atypical Antipsychotics</em>: <a href="/Clozapine" title="Clozapine">Clozapine</a> • <a href="/Olanzapine" title="Olanzapine">Olanzapine</a> • <a href="/Quetiapine" title="Quetiapine">Quetiapine</a>; <em>Tetracyclic Antidepressants</em>: <a href="/Amoxapine" title="Amoxapine">Amoxapine</a> • <a href="/Mianserin" title="Mianserin">Mianserin</a> • <a href="/Mirtazapine" title="Mirtazapine">Mirtazapine</a>; <em>Others</em>: ICS-205,930 • <a href="/Lu_AA21004" title="Lu AA21004">Lu AA21004</a> • <a href="/Lu_AA24530" title="Lu AA24530">Lu AA24530</a> • MDL-72,222 • <a href="/Memantine" title="Memantine">Memantine</a> • <a href="/Ricasetron" title="Ricasetron">Ricasetron</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT4" title="5-HT4" class="mw-redirect">5-HT<sub>4</sub></a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><strong>Agonists</strong>: <em>Gastroprokinetic Agents</em>: <a href="/Cinitapride" title="Cinitapride">Cinitapride</a> • <a href="/Cisapride" title="Cisapride">Cisapride</a> • <a href="/Dazopride" title="Dazopride">Dazopride</a> • <a href="/Metoclopramide" title="Metoclopramide">Metoclopramide</a> • <a href="/Mosapride" title="Mosapride">Mosapride</a> • <a href="/Prucalopride" title="Prucalopride">Prucalopride</a> • <a href="/Renzapride" title="Renzapride">Renzapride</a> • <a href="/Tegaserod" title="Tegaserod">Tegaserod</a> • <a href="/Zacopride" title="Zacopride">Zacopride</a>; <em>Others</em>: <a href="/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a> • <a href="/BIMU-8" title="BIMU-8" class="mw-redirect">BIMU-8</a> • CJ-033,466 • PRX-03140 • <a href="/RS-67333" title="RS-67333" class="mw-redirect">RS-67333</a> • RS-67506 • <a href="/SL65.0155" title="SL65.0155">SL65.0155</a> • TD-5108<br /> <strong>Antagonists</strong>: GR-113,808 • GR-125,487 • <a href="/Lysine" title="Lysine">L-Lysine</a> • <a href="/Piboserod" title="Piboserod">Piboserod</a> • RS-39604 • RS-67532 • SB-203,186</div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT5" title="5-HT5" class="mw-redirect">5-HT<sub>5</sub></a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <table cellspacing="0" class="nowraplinks navbox-subgroup" style="width:100%;;;;"> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT5A" title="5-HT5A" class="mw-redirect">5-HT<sub>5A</sub></a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><strong>Agonists</strong>: <em>Lysergamides</em>: <a href="/Ergotamine" title="Ergotamine">Ergotamine</a> • <a href="/LSD" title="LSD" class="mw-redirect">LSD</a>; <em>Tryptamines</em>: <a href="/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>; <em>Others</em>: <a href="/Valerenic_acid" title="Valerenic acid">Valerenic Acid</a><br /> <strong>Antagonists</strong>: <a href="/Asenapine" title="Asenapine">Asenapine</a> • <a href="/Dimebolin" title="Dimebolin">Dimebolin</a> • <a href="/Metitepine" title="Metitepine">Metitepine/Methiothepin</a> • <a href="/Ritanserin" title="Ritanserin">Ritanserin</a> • <a href="/SB-699,551" title="SB-699,551">SB-699,551</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT5B_receptor" title="5-HT5B receptor">5-HT<sub>5B</sub></a><strong>*</strong></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><strong>Agonists</strong>: <em>Lysergamides</em>: <a href="/Ergotamine" title="Ergotamine">Ergotamine</a> • <a href="/LSD" title="LSD" class="mw-redirect">LSD</a><br /> <strong>Antagonists</strong>: <a href="/Metitepine" title="Metitepine">Metitepine/Methiothepin</a><br /> <strong>*</strong> <small><em>Note that the 5-HT<sub>5B</sub> receptor is not functional in humans.</em></small></div> </td> </tr> </table> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT6" title="5-HT6" class="mw-redirect">5-HT<sub>6</sub></a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><strong>Agonists</strong>: <em>Lysergamides</em>: <a href="/Lisuride" title="Lisuride">Lisuride</a> • <a href="/LSD" title="LSD" class="mw-redirect">LSD</a> • <a href="/Metergoline" title="Metergoline">Metergoline</a>; <em>Tryptamines</em>: <a href="/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a> • <a href="/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a> • E-6801 • E-6837 • <a href="/EMD-386,088" title="EMD-386,088">EMD-386,088</a> • <a href="/EMDT" title="EMDT">EMDT</a> • LY-586,713 • WAY-181,187 • WAY-208,466<br /> <strong>Antagonists</strong>: <em>Antidepressants</em>: <a href="/Amitriptyline" title="Amitriptyline">Amitriptyline</a> • <a href="/Amoxapine" title="Amoxapine">Amoxapine</a> • <a href="/Clomipramine" title="Clomipramine">Clomipramine</a> • <a href="/Doxepin" title="Doxepin">Doxepin</a> • <a href="/Mianserin" title="Mianserin">Mianserin</a> • <a href="/Nortriptyline" title="Nortriptyline">Nortriptyline</a>; <em>Atypical Antipsychotics</em>: <a href="/Aripiprazole" title="Aripiprazole">Aripiprazole</a> • <a href="/Asenapine" title="Asenapine">Asenapine</a> • <a href="/Clozapine" title="Clozapine">Clozapine</a> • Fluperlapine • <a href="/Iloperidone" title="Iloperidone">Iloperidone</a> • <a href="/Olanzapine" title="Olanzapine">Olanzapine</a> • <a href="/Tiospirone" title="Tiospirone">Tiospirone</a>; <em>Typical Antipsychotics</em>: <a href="/Chlorpromazine" title="Chlorpromazine">Chlorpromazine</a> • <a href="/Loxapine" title="Loxapine">Loxapine</a>; <em>Others</em>: BGC20-760 • BVT-5182 • BVT-74316 • <a href="/Dimebolin" title="Dimebolin">Dimebolin</a> • <a href="/EGIS-12233" title="EGIS-12233" class="mw-redirect">EGIS-12233</a> • GW-742,457 • <a href="/Ketanserin" title="Ketanserin">Ketanserin</a> • <a href="/Lu_AE58054" title="Lu AE58054">Lu AE58054</a> • <a href="/Metitepine" title="Metitepine">Metitepine/Methiothepin</a> • <a href="/MS-245" title="MS-245">MS-245</a> • <a href="/PRX-07034" title="PRX-07034">PRX-07034</a> • <a href="/Ritanserin" title="Ritanserin">Ritanserin</a> • <a href="/Ro_04-6790" title="Ro 04-6790" class="mw-redirect">Ro 04-6790</a> • Ro 63-0563 • <a href="/SB-258,585" title="SB-258,585">SB-258,585</a> • <a href="/SB-271,046" title="SB-271,046">SB-271,046</a> • <a href="/SB-357,134" title="SB-357,134">SB-357,134</a> • <a href="/SB-399,885" title="SB-399,885">SB-399,885</a> • <a href="/SB-742,457" title="SB-742,457">SB-742,457</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/5-HT7" title="5-HT7" class="mw-redirect">5-HT<sub>7</sub></a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><strong>Agonists</strong>: <em>Lysergamides</em>: <a href="/LSD" title="LSD" class="mw-redirect">LSD</a>; <em>Tryptamines</em>: <a href="/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a> • <a href="/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>; <em>Others</em>: <a href="/8-OH-DPAT" title="8-OH-DPAT">8-OH-DPAT</a> • <a href="/AS-19_(drug)" title="AS-19 (drug)">AS-19</a> • <a href="/Bifeprunox" title="Bifeprunox">Bifeprunox</a> • LP-12 • LP-44 • Sarizotan<br /> <strong>Antagonists</strong>: <em>Antidepressants</em>: <a href="/Amitriptyline" title="Amitriptyline">Amitriptyline</a> • <a href="/Amoxapine" title="Amoxapine">Amoxapine</a> • <a href="/Clomipramine" title="Clomipramine">Clomipramine</a> • <a href="/Imipramine" title="Imipramine">Imipramine</a> • <a href="/Maprotiline" title="Maprotiline">Maprotiline</a> • <a href="/Mianserin" title="Mianserin">Mianserin</a>; <em>Atypical Antipsychotics</em>: <a href="/Amisulpride" title="Amisulpride">Amisulpride</a> • <a href="/Aripiprazole" title="Aripiprazole">Aripiprazole</a> • <a href="/Clozapine" title="Clozapine">Clozapine</a> • <a href="/Olanzapine" title="Olanzapine">Olanzapine</a> • <a href="/Risperidone" title="Risperidone">Risperidone</a> • <a href="/Sertindole" title="Sertindole">Sertindole</a> • <a href="/Tiospirone" title="Tiospirone">Tiospirone</a> • <a href="/Ziprasidone" title="Ziprasidone">Ziprasidone</a> • <a href="/Zotepine" title="Zotepine">Zotepine</a>; <em>Typical Antipsychotics</em>: <a href="/Chlorpromazine" title="Chlorpromazine">Chlorpromazine</a> • <a href="/Loxapine" title="Loxapine">Loxapine</a>; <em>Others</em>: <a href="/EGIS-12233" title="EGIS-12233" class="mw-redirect">EGIS-12233</a> • LY-215,840 • <a href="/Mesulergine" title="Mesulergine">Mesulergine</a> • <a href="/Metergoline" title="Metergoline">Metergoline</a> • <a href="/Metitepine" title="Metitepine">Metitepine/Methiothepin</a> • <a href="/Pimozide" title="Pimozide">Pimozide</a> • <a href="/Ritanserin" title="Ritanserin">Ritanserin</a> • SB-258,719 • SB-258,741 • <a href="/SB-269,970" title="SB-269,970">SB-269,970</a> • SB-656,104 • SB-656,104-A • SB-691,673 • SLV-313 • SLV-314 • <a href="/Spiperone" title="Spiperone">Spiperone</a> • SSR-181,507</div> </td> </tr> </table> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LightYellow;"><a href="/Reuptake_inhibitor" title="Reuptake inhibitor">Reuptake<br /> inhibitors</a></td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <table cellspacing="0" class="nowraplinks navbox-subgroup" style="width:100%;;;;"> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/Serotonin_transporter" title="Serotonin transporter">SERT</a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><em>Selective Serotonin Reuptake Inhibitors (SSRIs)</em>: <a href="/Alaproclate" title="Alaproclate">Alaproclate</a> • <a href="/Citalopram" title="Citalopram">Citalopram</a> • <a href="/Dapoxetine" title="Dapoxetine">Dapoxetine</a> • <a href="/Desmethylcitalopram" title="Desmethylcitalopram">Desmethylcitalopram</a> • <a href="/Desmethylsertraline" title="Desmethylsertraline">Desmethylsertraline</a> • Elzasonan • <a href="/Escitalopram" title="Escitalopram">Escitalopram</a> • <a href="/Femoxetine" title="Femoxetine">Femoxetine</a> • <a href="/Fluoxetine" title="Fluoxetine">Fluoxetine</a> • <a href="/Fluvoxamine" title="Fluvoxamine">Fluvoxamine</a> • <a href="/Indalpine" title="Indalpine">Indalpine</a> • <a href="/Litoxetine" title="Litoxetine">Litoxetine</a> • <a href="/Lu_AA21004" title="Lu AA21004">Lu AA21004</a> • <a href="/Lubazodone" title="Lubazodone">Lubazodone</a> • <a href="/Paroxetine" title="Paroxetine">Paroxetine</a> • <a href="/Pirandamine" title="Pirandamine">Pirandamine</a> • <a href="/RTI-353" title="RTI-353">RTI-353</a> • <a href="/Seproxetine" title="Seproxetine">Seproxetine</a> • <strong class="selflink">Sertraline</strong> • <a href="/Vilazodone" title="Vilazodone">Vilazodone</a> • <a href="/Zimelidine" title="Zimelidine">Zimelidine</a>; <em>Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)</em>: <a href="/Bicifadine" title="Bicifadine">Bicifadine</a> • <a href="/Desvenlafaxine" title="Desvenlafaxine">Desvenlafaxine</a> • <a href="/Duloxetine" title="Duloxetine">Duloxetine</a> • <a href="/Levomilnacipran" title="Levomilnacipran">Levomilnacipran</a> • <a href="/Milnacipran" title="Milnacipran">Milnacipran</a> • <a href="/Sibutramine" title="Sibutramine">Sibutramine</a> • <a href="/Venlafaxine" title="Venlafaxine">Venlafaxine</a>; <em>Serotonin-Norepinephrine-Dopamine Reuptake Inhibitors (SNDRIs)</em>: <a href="/Brasofensine" title="Brasofensine">Brasofensine</a> • <a href="/Diclofensine" title="Diclofensine">Diclofensine</a> • <a href="/DOV-102,677" title="DOV-102,677">DOV-102,677</a> • <a href="/DOV-21,947" title="DOV-21,947">DOV-21,947</a> • <a href="/DOV-216,303" title="DOV-216,303">DOV-216,303</a> • <a href="/NS-2359" title="NS-2359">NS-2359</a> • <a href="/SEP-225,289" title="SEP-225,289" class="mw-redirect">SEP-225,289</a> • <a href="/SEP-227,162" title="SEP-227,162">SEP-227,162</a> • <a href="/Tesofensine" title="Tesofensine">Tesofensine</a>; <em>Tricyclic Antidepressants (TCAs)</em>: <a href="/Amitriptyline" title="Amitriptyline">Amitriptyline</a> • <a href="/Butriptyline" title="Butriptyline">Butriptyline</a> • <a href="/Cianopramine" title="Cianopramine">Cianopramine</a> • <a href="/Clomipramine" title="Clomipramine">Clomipramine</a> • <a href="/Desipramine" title="Desipramine">Desipramine</a> • <a href="/Dosulepin" title="Dosulepin">Dosulepin</a> • <a href="/Doxepin" title="Doxepin">Doxepin</a> • <a href="/Imipramine" title="Imipramine">Imipramine</a> • <a href="/Lofepramine" title="Lofepramine">Lofepramine</a> • <a href="/Nortriptyline" title="Nortriptyline">Nortriptyline</a> • <a href="/Pipofezine" title="Pipofezine">Pipofezine</a> • <a href="/Protriptyline" title="Protriptyline">Protriptyline</a> • <a href="/Trimipramine" title="Trimipramine">Trimipramine</a>; <em>Tetracyclic Antidepressants (TeCAs)</em>: <a href="/Amoxapine" title="Amoxapine">Amoxapine</a>; <em>Piperazines</em>: <a href="/Nefazodone" title="Nefazodone">Nefazodone</a> • <a href="/Trazodone" title="Trazodone">Trazodone</a>; <em>Antihistamines</em>: <a href="/Brompheniramine" title="Brompheniramine">Brompheniramine</a> • <a href="/Chlorpheniramine" title="Chlorpheniramine" class="mw-redirect">Chlorpheniramine</a> • <a href="/Diphenhydramine" title="Diphenhydramine">Diphenhydramine</a> • <a href="/Mepyramine" title="Mepyramine">Mepyramine/Pyrilamine</a> • <a href="/Pheniramine" title="Pheniramine">Pheniramine</a> • <a href="/Tripelennamine" title="Tripelennamine">Tripelennamine</a>; <em>Opioids</em>: <a href="/Meperidine" title="Meperidine" class="mw-redirect">Meperidine</a> (Pethidine) • <a href="/Methadone" title="Methadone">Methadone</a> • <a href="/Propoxyphene" title="Propoxyphene" class="mw-redirect">Propoxyphene</a>; <em>Others</em>: <a href="/Cocaine" title="Cocaine">Cocaine</a> • <a href="/Cyclobenzaprine" title="Cyclobenzaprine">Cyclobenzaprine</a> • <a href="/Dextromethorphan" title="Dextromethorphan">Dextromethorphan</a> • <a href="/Dextrorphan" title="Dextrorphan">Dextrorphan</a> • <a href="/Mesembrine" title="Mesembrine">Mesembrine</a> • <a href="/Nefopam" title="Nefopam">Nefopam</a> • <a href="/Roxindole" title="Roxindole">Roxindole</a> • <a href="/SB-649,915" title="SB-649,915">SB-649,915</a> • <a href="/Ziprasidone" title="Ziprasidone">Ziprasidone</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/VMAT" title="VMAT" class="mw-redirect">VMAT</a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Ibogaine" title="Ibogaine">Ibogaine</a> • <a href="/Reserpine" title="Reserpine">Reserpine</a> • <a href="/Tetrabenazine" title="Tetrabenazine">Tetrabenazine</a></div> </td> </tr> </table> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LightYellow;"><a href="/Releasing_agent" title="Releasing agent">Releasing<br /> agents</a></td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><em>Aminoindanes</em>: <a href="/5-Iodoaminoindane" title="5-Iodoaminoindane" class="mw-redirect">5-IAI</a> • <a href="/Ethyltrifluoromethylaminoindane" title="Ethyltrifluoromethylaminoindane">ETAI</a> • <a href="/Methylenedioxyaminoindane" title="Methylenedioxyaminoindane" class="mw-redirect">MDAI</a> • <a href="/Methylenedioxymethylaminoindane" title="Methylenedioxymethylaminoindane" class="mw-redirect">MDMAI</a> • <a href="/Methoxymethylaminoindane" title="Methoxymethylaminoindane" class="mw-redirect">MMAI</a> • <a href="/Trifluoromethylaminoindane" title="Trifluoromethylaminoindane">TAI</a>; <em>Aminotetralins</em>: <a href="/6-Chloroaminotetralin" title="6-Chloroaminotetralin" class="mw-redirect">6-CAT</a> • <a href="/8-OH-DPAT" title="8-OH-DPAT">8-OH-DPAT</a> • <a href="/Methylenedioxyaminotetralin" title="Methylenedioxyaminotetralin" class="mw-redirect">MDAT</a>; <em>Oxazolines</em>: <a href="/4-Methylaminorex" title="4-Methylaminorex">4-Methylaminorex</a> • <a href="/Aminorex" title="Aminorex">Aminorex</a> • <a href="/Clominorex" title="Clominorex">Clominorex</a> • <a href="/Fluminorex" title="Fluminorex">Fluminorex</a>; <em>Phenethylamines</em> (also <em>Amphetamines</em>, <em>Cathinones</em>, <em>Phentermines</em>, etc): <a href="/4-Fluoroamphetamine" title="4-Fluoroamphetamine">4-FA</a> • <a href="/4-Fluoromethamphetamine" title="4-Fluoromethamphetamine">4-FMA</a> • <a href="/4-Hydroxyamphetamine" title="4-Hydroxyamphetamine" class="mw-redirect">4-HA</a> • <a href="/4-Methylthioamphetamine" title="4-Methylthioamphetamine">4-MTA</a> • <a href="/5-(2-Aminopropyl)-2,3-dihydrobenzofuran" title="5-(2-Aminopropyl)-2,3-dihydrobenzofuran">5-APDB</a> • <a href="/Amiflamine" title="Amiflamine">Amiflamine</a> • <a href="/Benzodioxolylbutanamine" title="Benzodioxolylbutanamine">BDB</a> • <a href="/Benzodioxolylhydroxybutanamine" title="Benzodioxolylhydroxybutanamine">BOH</a> • <a href="/Brephedrone" title="Brephedrone" class="mw-redirect">Brephedrone</a> • <a href="/Butylone" title="Butylone">Butylone</a> • <a href="/Chlorphentermine" title="Chlorphentermine">Chlorphentermine</a> • <a href="/Diethylcathinone" title="Diethylcathinone" class="mw-redirect">Diethylcathinone</a> • <a href="/Dimethylcathinone" title="Dimethylcathinone">Dimethylcathinone</a> • <a href="/Dimethoxyamphetamine" title="Dimethoxyamphetamine">DMA</a> • <a href="/Dimethoxymethamphetamine" title="Dimethoxymethamphetamine">DMMA</a> • <a href="/Ethylbenzodioxolylbutanamine" title="Ethylbenzodioxolylbutanamine">EBDB</a> • <a href="/Ethylone" title="Ethylone">Ethylone</a> • <a href="/Fenfluramine" title="Fenfluramine">Fenfluramine</a> (also <a href="/Dexfenfluramine" title="Dexfenfluramine">dexfenfluramine</a>) • <a href="/Flephedrone" title="Flephedrone">Flephedrone</a> • <a href="/Indanylaminopropane" title="Indanylaminopropane">IAP</a> • <a href="/Indanylmethylaminopropane" title="Indanylmethylaminopropane">IMP</a> • <a href="/Lophophine" title="Lophophine" class="mw-redirect">Lophophine</a> • <a href="/Methylbenzodioxolylbutanamine" title="Methylbenzodioxolylbutanamine">MBDB</a> • <a href="/Methylenedioxyamphetamine" title="Methylenedioxyamphetamine" class="mw-redirect">MDA</a> • <a href="/Methylenedioxyethylamphetamine" title="Methylenedioxyethylamphetamine">MDEA</a> • <a href="/Methylenedioxyhydroxymethamphetamine" title="Methylenedioxyhydroxymethamphetamine">MDHMA</a> • <a href="/Methylenedioxymethamphetamine" title="Methylenedioxymethamphetamine" class="mw-redirect">MDMA</a> • <a href="/Methylenedioxymethylphenethylamine" title="Methylenedioxymethylphenethylamine">MDMPEA</a> • <a href="/Methylenedioxyhydroxyamphetamine" title="Methylenedioxyhydroxyamphetamine">MDOH</a> • <a href="/Methylenedioxyphenethylamine" title="Methylenedioxyphenethylamine">MDPEA</a> • <a href="/Mephedrone" title="Mephedrone">Mephedrone</a> • <a href="/Methedrone" title="Methedrone" class="mw-redirect">Methedrone</a> • <a href="/Methylone" title="Methylone">Methylone</a> • <a href="/Methoxymethylamphetamine" title="Methoxymethylamphetamine" class="mw-redirect">MMA</a> • <a href="/Methoxymethylenedioxyamphetamine" title="Methoxymethylenedioxyamphetamine">MMDA</a> • <a href="/Methoxymethylenedioxymethamphetamine" title="Methoxymethylenedioxymethamphetamine">MMDMA</a> • <a href="/Naphthylisopropylamine" title="Naphthylisopropylamine" class="mw-redirect">NAP</a> • <a href="/Norfenfluramine" title="Norfenfluramine">Norfenfluramine</a> • <a href="/Parabromoamphetamine" title="Parabromoamphetamine" class="mw-redirect">pBA</a> • <a href="/Parachloroamphetamine" title="Parachloroamphetamine" class="mw-redirect">pCA</a> • <a href="/Paraiodoamphetamine" title="Paraiodoamphetamine" class="mw-redirect">pIA</a> • <a href="/Paramethoxyamphetamine" title="Paramethoxyamphetamine" class="mw-redirect">PMA</a> • <a href="/Paramethoxyethylamphetamine" title="Paramethoxyethylamphetamine">PMEA</a> • <a href="/Paramethoxymethamphetamine" title="Paramethoxymethamphetamine">PMMA</a>; <em>Piperazines</em>: <a href="/2,5-Dimethoxy-4-bromobenzylpiperazine" title="2,5-Dimethoxy-4-bromobenzylpiperazine" class="mw-redirect">2C-B-BZP</a> • <a href="/Benzylpiperazine" title="Benzylpiperazine">BZP</a> • <a href="/Methylbenzylpiperazine" title="Methylbenzylpiperazine">MBZP</a> • <a href="/Metachlorophenylpiperazine" title="Metachlorophenylpiperazine" class="mw-redirect">mCPP</a> • <a href="/Methylenedioxybenzylpiperazine" title="Methylenedioxybenzylpiperazine">MDBZP</a> • <a href="/Methoxyphenylpiperazine" title="Methoxyphenylpiperazine" class="mw-redirect">MeOPP</a> • <a href="/Parafluorophenylpiperazine" title="Parafluorophenylpiperazine" class="mw-redirect">pFPP</a> • <a href="/Trifluoromethylphenylpiperazine" title="Trifluoromethylphenylpiperazine">TFMPP</a>; <em>Tryptamines</em>: <a href="/4-Methyl-AMT" title="4-Methyl-AMT">4-Methyl-αMT</a> • <a href="/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a> • <a href="/5-MeO-AET" title="5-MeO-AET">5-MeO-αET</a> • <a href="/5-MeO-AMT" title="5-MeO-AMT">5-MeO-αMT</a> • <a href="/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a> • <a href="/Alphaethyltryptamine" title="Alphaethyltryptamine" class="mw-redirect">αET</a> • <a href="/Alphamethyltryptamine" title="Alphamethyltryptamine" class="mw-redirect">αMT</a> • <a href="/Tryptamine" title="Tryptamine">Tryptamine</a> (itself); <em>Others</em>: <a href="/Indeloxazine" title="Indeloxazine">Indeloxazine</a> • <a href="/Tramadol" title="Tramadol">Tramadol</a> • <a href="/Viqualine" title="Viqualine">Viqualine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LightYellow;"><a href="/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme<br /> inhibitors</a></td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <table cellspacing="0" class="nowraplinks navbox-subgroup" style="width:100%;;;;"> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/Anabolism" title="Anabolism">Anabolism</a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <table cellspacing="0" class="nowraplinks navbox-subgroup" style="width:100%;;;;"> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/Tryptophan_hydroxylase" title="Tryptophan hydroxylase">TPH</a> inhibitors</div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/AGN-2979" title="AGN-2979">AGN-2979</a> • <a href="/Fenclonine" title="Fenclonine">Fenclonine</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/Aromatic_L-amino_acid_decarboxylase" title="Aromatic L-amino acid decarboxylase">AAAD inhibitors</a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Benserazide" title="Benserazide">Benserazide</a> • <a href="/Carbidopa" title="Carbidopa">Carbidopa</a></div> </td> </tr> </table> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/Catabolism" title="Catabolism">Catabolism</a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <table cellspacing="0" class="nowraplinks navbox-subgroup" style="width:100%;;;;"> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/Monoamine_oxidase_inhibitor" title="Monoamine oxidase inhibitor">MAO Inhibitors</a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><em>Nonselective</em>: <a href="/Benmoxin" title="Benmoxin">Benmoxin</a> • <a href="/Caroxazone" title="Caroxazone">Caroxazone</a> • <a href="/Echinopsidine" title="Echinopsidine">Echinopsidine</a> • <a href="/Furazolidone" title="Furazolidone">Furazolidone</a> • <a href="/Hydralazine" title="Hydralazine">Hydralazine</a> • <a href="/Iproclozide" title="Iproclozide">Iproclozide</a> • <a href="/Iproniazid" title="Iproniazid">Iproniazid</a> • <a href="/Isocarboxazid" title="Isocarboxazid">Isocarboxazid</a> • <a href="/Isoniazid" title="Isoniazid">Isoniazid</a> • <a href="/Linezolid" title="Linezolid">Linezolid</a> • <a href="/Mebanazine" title="Mebanazine">Mebanazine</a> • <a href="/Metfendrazine" title="Metfendrazine">Metfendrazine</a> • <a href="/Nialamide" title="Nialamide">Nialamide</a> • <a href="/Octamoxin" title="Octamoxin">Octamoxin</a> • <a href="/Phenelzine" title="Phenelzine">Phenelzine</a> • <a href="/Pheniprazine" title="Pheniprazine">Pheniprazine</a> • <a href="/Phenoxypropazine" title="Phenoxypropazine">Phenoxypropazine</a> • <a href="/Pivalylbenzhydrazine" title="Pivalylbenzhydrazine">Pivalylbenzhydrazine</a> • <a href="/Procarbazine" title="Procarbazine">Procarbazine</a> • <a href="/Safrazine" title="Safrazine">Safrazine</a> • <a href="/Tranylcypromine" title="Tranylcypromine">Tranylcypromine</a>; <em>MAO-A Selective</em>: <a href="/Amiflamine" title="Amiflamine">Amiflamine</a> • Bazinaprine • <a href="/Befloxatone" title="Befloxatone">Befloxatone</a> • Befol • <a href="/Brofaromine" title="Brofaromine">Brofaromine</a> • <a href="/Cimoxatone" title="Cimoxatone">Cimoxatone</a> • <a href="/Clorgiline" title="Clorgiline">Clorgiline</a> • Esuprone • <a href="/Harmala_alkaloid" title="Harmala alkaloid">Harmala alkaloids</a> (<a href="/Harmine" title="Harmine">Harmine</a>, <a href="/Harmaline" title="Harmaline">Harmaline</a>, <a href="/Tetrahydroharmine" title="Tetrahydroharmine" class="mw-redirect">Tetrahydroharmine</a>, <a href="/Harmala_alkaloid" title="Harmala alkaloid">Harman</a>, <a href="/Norharman" title="Norharman" class="mw-redirect">Norharman</a>, etc) • <a href="/Methylene_blue" title="Methylene blue">Methylene Blue</a> • <a href="/Metralindole" title="Metralindole">Metralindole</a> • <a href="/Minaprine" title="Minaprine">Minaprine</a> • <a href="/Moclobemide" title="Moclobemide">Moclobemide</a> • <a href="/Pirlindole" title="Pirlindole">Pirlindole</a> • Sercloremine • Tetrindole • <a href="/Toloxatone" title="Toloxatone">Toloxatone</a> • <a href="/Tyrima" title="Tyrima">Tyrima</a></div> </td> </tr> </table> </td> </tr> </table> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";background-color: LightYellow;">Others</td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <table cellspacing="0" class="nowraplinks navbox-subgroup" style="width:100%;;;;"> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/Precursor_(chemistry)" title="Precursor (chemistry)">Precursors</a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><a href="/L-Tryptophan" title="L-Tryptophan" class="mw-redirect">L-Tryptophan</a> → <a href="/5-HTP" title="5-HTP" class="mw-redirect">5-HTP</a></div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;"><a href="/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactors</a></div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-even"> <div style="padding:0em 0.25em"><a href="/Ferrous" title="Ferrous">Ferrous</a> <a href="/Iron" title="Iron">iron</a> (Fe<sup>2+</sup>) • <a href="/Magnesium" title="Magnesium">Magnesium</a> (Mg<sup>2+</sup>) • <a href="/Tetrahydrobiopterin" title="Tetrahydrobiopterin">Tetrahydrobiopterin</a> • <a href="/Vitamin_B3" title="Vitamin B3" class="mw-redirect">Vitamin B3</a> (<a href="/Niacin" title="Niacin">Niacin</a>, <a href="/Nicotinamide" title="Nicotinamide">Nicotinamide</a> → <a href="/NADPH" title="NADPH" class="mw-redirect">NADPH</a>) • <a href="/Vitamin_B6" title="Vitamin B6">Vitamin B6</a> (<a href="/Pyridoxine" title="Pyridoxine">Pyridoxine</a>, <a href="/Pyridoxamine" title="Pyridoxamine">Pyridoxamine</a>, <a href="/Pyridoxal" title="Pyridoxal">Pyridoxal</a> → <a href="/Pyridoxal_phosphate" title="Pyridoxal phosphate">Pyridoxal phosphate</a>) • <a href="/Vitamin_B9" title="Vitamin B9" class="mw-redirect">Vitamin B9</a> (<a href="/Folic_acid" title="Folic acid">Folic Acid</a> → <a href="/Tetrahydrofolic_acid" title="Tetrahydrofolic acid">Tetrahydrofolic acid</a>) • <a href="/Vitamin_C" title="Vitamin C">Vitamin C</a> (<a href="/Ascorbic_acid" title="Ascorbic acid">Ascorbic acid</a>) • <a href="/Zinc" title="Zinc">Zinc</a> (Zn<sup>2+</sup>)</div> </td> </tr> <tr style="height:2px"> <td></td> </tr> <tr> <td class="navbox-group" style=";padding-left:0em;padding-right:0em;background-color: LightYellow;"> <div style="padding:0em 0.75em;">Others</div> </td> <td style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;;;" class="navbox-list navbox-odd"> <div style="padding:0em 0.25em"><em>Activity enhancers</em>: <a href="/Benzofuranylpropylaminopentane" title="Benzofuranylpropylaminopentane">Benzofuranylpropylaminopentane</a> (BPAP) • <a href="/Phenylpropylaminopentane" title="Phenylpropylaminopentane">Phenylpropylaminopentane</a> (PPAP); <em>Reuptake enhancers</em>: <a href="/Tianeptine" title="Tianeptine">Tianeptine</a></div> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> <div style="right:10px; display:none;" class="metadata topicon" id="wikipedia_featured_star"><img alt="This is a featured article. Click here for more information." src="http://images-mediawiki-sites.thefullwiki.org/07/1/3/6/85159353311044092.png" width="14" height="14" /></div> <div id='catlinks' class='catlinks'> <div id="wikipedia_mw_normal_catlinks">Categories: <span dir='ltr'><a href="/Category:Selective_serotonin_reuptake_inhibitors" title="Category:Selective serotonin reuptake inhibitors">Selective serotonin reuptake inhibitors</a></span> | <span dir='ltr'><a href="/Category:Amines" title="Category:Amines">Amines</a></span> | <span dir='ltr'><a href="/Category:Drugs" title="Category:Drugs">Drugs</a></span> | <span dir='ltr'><a href="/Category:Naphthalenes" title="Category:Naphthalenes">Naphthalenes</a></span> | <span dir='ltr'><a href="/Category:Organochlorides" title="Category:Organochlorides">Organochlorides</a></span></div> <div id="wikipedia_mw_hidden_catlinks" class="mw-hidden-cats-hidden">Hidden categories: <span dir='ltr'><a href="/Category:All_articles_with_unsourced_statements" title="Category:All articles with unsourced statements">All articles with unsourced statements</a></span> | <span dir='ltr'><a href="/Category:Articles_with_unsourced_statements_from_March_2010" title="Category:Articles with unsourced statements from March 2010">Articles with unsourced statements from March 2010</a></span> | <span dir='ltr'><a href="/Category:Featured_articles" title="Category:Featured articles">Featured articles</a></span></div> </div> </div> </div> </div><br/> </div> <div class="section-delimeter"></div></div> <div id="core_panel_main" > <div class="section" id="citable_sentences"> <h1 class="section-title"> <a name="citable_sentences">Citable sentences</a> </h1> <div style="float:right"> <span class="core-uptodate">Up to date as of December 13, 2010</span> <br> </div> <div class="fragment"> <div id="citable_fragments"> <div id="citableSentencesList"> <p> Here are sentences from other pages on Sertraline, which are similar to those in the above article. <div id="citable__sentence_list"> </div> </p> </div> </div> </div><br/> </div> <div class="section-delimeter"></div> <div id="external_links_revision_history_tooltip"> </div> <script> $(document).ready(function() { $("#external_links_revision_history_fragments a[title]").tooltip({tip: '#external_links_revision_history_tooltip', effect: 'toggle', position: 'bottom right', offset: [-1,2], lazy: true, delay: 100}); $("#external_links_revision_history_fragments img[title]").tooltip({tip: '#external_links_revision_history_tooltip', position: 'bottom right', offset: [-1,0], lazy: true, effect: 'toggle'}); }); </script> <div class="section" id="related_links"> <h1 class="section-title"> <a name="related_links">Related links</a> </h1> <span class="core-uptodate">Up to date as of November 16, 2009</span> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://money.cnn.com/2006/07/17/news/companies/pfizer/index.htm" title="The drug is now available in generic form in the United States. The generic version of the drug is being produced by Israeli drug maker<br><br><A HREF=http://money.cnn.com/2006/07/17/news/companies/pfizer/index.htm>http://money.cnn.com/2006/07/17/news/companies/pfizer/index.htm</A>">Pfizer needs more drugs</a> - Pfizer's recent sale could help in hunt for new drugs - Jul. 17, 2006</td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.guardian.co.uk/uk_news/story/0,3604,1103563,00.html" title="<A HREF=http://www.guardian.co.uk/uk_news/story/0,3604,1103563,00.html>http://www.guardian.co.uk/uk_news/story/0,3604,1103563,00.html</A>">Drugs for depressed children banned</a> - Drugs for depressed children banned | Science | The Guardian</td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.healyprozac.com/PDAC/PDAC-Zoloft%20Nov%2090.pdf" title="<A HREF=http://www.healyprozac.com/PDAC/PDAC-Zoloft%20Nov%2090.pdf>http://www.healyprozac.com/PDAC/PDAC-Zoloft%20Nov%2090.pdf</A>">Minutes of the 33rd Meeting of Psychopharmacological Drugs Advisory Committee on November 19, 1990</a></td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.mhra.gov.uk/home/idcplg?IdcService=SS_GET_PAGE&useSecondary=true&ssDocName=CON002045&ssTargetNodeId=389" title="<A HREF=http://www.mhra.gov.uk/home/idcplg?IdcService=SS_GET_PAGE&useSecondary=true&ssDocName=CON002045&ssTargetNodeId=389>http://www.mhra.gov.uk/home/idcplg?IdcService=SS_GET_PAGE&useSecondary=true&ssDocName=CON002045&ssTargetNodeId=389</A>">Safety review of antidepressants used by children completed</a> - Press releases : MHRA</td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.mhra.gov.uk/home/idcplg?IdcService=SS_GET_PAGE&useSecondary=true&ssDocName=CON019494&ssTargetNodeId=221" title="<A HREF=http://www.mhra.gov.uk/home/idcplg?IdcService=SS_GET_PAGE&useSecondary=true&ssDocName=CON019494&ssTargetNodeId=221>http://www.mhra.gov.uk/home/idcplg?IdcService=SS_GET_PAGE&useSecondary=true&ssDocName=CON019494&ssTargetNodeId=221</A>">Overview of regulatory status and CSM advice relating to major depressive disorder (MDD) in children and adolescents</a> - Safety warnings and messages for medicines : MHRA</td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://medlibrary.org/research/zoloft.html" title="<TABLE STYLE='font-size: 12;'><TR><TD VALIGN='TOP'>•</TD><TD>Some antidepressants such as Bupropion, mirtazapine, and moclobemide have a sexual tolerability profile significantly better than SSRIs, especially escitalopram, paroxetine, venlafaxine, <B>sertraline</B>, or fluoxetine.</TD></TR><TR><TD VALIGN='TOP'>&bull</TD><TD>The objective of this study was to determine whether low environmentally relevant concentrations of the SSRIs fluoxetine and <B>sertraline</B> could impair growth and development in tadpoles of the African clawed frog (Xenopus laevis), and to evaluate if such effects may be caused by a disruption of the neuroendocrine system.</TD></TR><TR><TD VALIGN='TOP'>&bull</TD><TD>Tadpoles exposed to fluoxetine (1 and 10 microg/L) and <B>sertraline</B> (0.1, 1 and 10 microg/L) exhibited reduced growth at metamorphosis.</TD></TR></TABLE><BR><A HREF=http://medlibrary.org/research/zoloft.html>http://medlibrary.org/research/zoloft.html</A>">Latest medical literature on zoloft</a> - Welcome to zoloft drug research abstracts</td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.fda.gov/ohrms/dockets/ac/06/slides/2006-4272s1-04-FDA.ppt" title="<A HREF=http://www.fda.gov/ohrms/dockets/ac/06/slides/2006-4272s1-04-FDA.ppt>http://www.fda.gov/ohrms/dockets/ac/06/slides/2006-4272s1-04-FDA.ppt</A>">Antidepressants and Suicidality in Adults: Statistical Evaluation. (Presentation at Psychopharmacologic Drugs Advisory Committee; December 13, 2006)</a></td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4272b1-01-FDA.pdf" title="<A HREF=http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4272b1-01-FDA.pdf>http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4272b1-01-FDA.pdf</A>">Statistical Evaluation of Suicidality in Adults Treated with Antidepressants</a></td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.merck.com/mmpe/lexicomp/sertraline.html" title="<TABLE STYLE='font-size: 12;'><TR><TD VALIGN='TOP'>•</TD><TD>Due to adverse effects observed in animal studies, <B>sertraline</B> is classified as pregnancy category C.</TD></TR><TR><TD VALIGN='TOP'>&bull</TD><TD>The long-term effects of in utero SSRI exposure on infant development and behavior are not known.Due to pregnancy-induced physiologic changes, women who are pregnant may require increased doses of <B>sertraline</B> to achieve euthymia.</TD></TR><TR><TD VALIGN='TOP'>&bull</TD><TD><B>Sertraline</B> and desmethyl<B>sertraline</B> are excreted in breast milk.</TD></TR></TABLE><BR><A HREF=http://www.merck.com/mmpe/lexicomp/sertraline.html>http://www.merck.com/mmpe/lexicomp/sertraline.html</A>">List of international brand names for sertraline</a> - Sertraline: Drug Information Provided by Lexi-Comp: Merck Manual Professional</td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.lasuperiorcourt.org/civilCaseSummary/index.asp?CaseType=Civil" title="<A HREF=http://www.lasuperiorcourt.org/civilCaseSummary/index.asp?CaseType=Civil>http://www.lasuperiorcourt.org/civilCaseSummary/index.asp?CaseType=Civil</A>">Los Angeles Superior Court - Civil Case Summary</a> - Los Angeles Superior Court - Civil Case Summary</td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.webmd.com/drugs/mono-8095-SERTRALINE+-+ORAL.aspx?drugid=35&drugname=Zoloft+Oral" title="<TABLE STYLE='font-size: 12;'><TR><TD VALIGN='TOP'>•</TD><TD><B>Sertraline</B> is used to treat depression, panic attacks, obsessive compulsive disorders, post-traumatic stress disorder, social anxiety disorder (social phobia), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder).</TD></TR><TR><TD VALIGN='TOP'>&bull</TD><TD>Read the Medication Guide (US) or Patient Information Leaflet (Canada) available from your pharmacist before you start using <B>sertraline</B> and each time you get a refill.</TD></TR><TR><TD VALIGN='TOP'>&bull</TD><TD>Before taking <B>sertraline</B>, tell your doctor or pharmacist if you are allergic to it;</TD></TR></TABLE><BR><A HREF=http://www.webmd.com/drugs/mono-8095-SERTRALINE+-+ORAL.aspx?drugid=35&drugname=Zoloft+Oral>http://www.webmd.com/drugs/mono-8095-SERTRALINE+-+ORAL.aspx?drugid=35&drugname=Zoloft+Oral</A>">WebMD - Drugs - Sertraline</a> - Zoloft Oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD</td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.depressionblog.com/archives/cat_zoloft.shtml" title="<A HREF=http://www.depressionblog.com/archives/cat_zoloft.shtml>http://www.depressionblog.com/archives/cat_zoloft.shtml</A>">Zoloft feedback</a> - Depression Blog.com: Zoloft Archives</td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.drugtopics.com/drugtopics/Pharmacy+Facts+And+Figures/Top-200-brand-name-drugs-by-units-in-2006/ArticleStandard/Article/detail/407649" title="<A HREF=http://www.drugtopics.com/drugtopics/Pharmacy+Facts+And+Figures/Top-200-brand-name-drugs-by-units-in-2006/ArticleStandard/Article/detail/407649>http://www.drugtopics.com/drugtopics/Pharmacy+Facts+And+Figures/Top-200-brand-name-drugs-by-units-in-2006/ArticleStandard/Article/detail/407649</A>">Top 200 Brand-Name Drugs by Units in 2006</a></td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.drugtopics.com/drugtopics/data/articlestandard/drugtopics/092007/407652/article.pdf" title="<A HREF=http://www.drugtopics.com/drugtopics/data/articlestandard/drugtopics/092007/407652/article.pdf>http://www.drugtopics.com/drugtopics/data/articlestandard/drugtopics/092007/407652/article.pdf</A>">Top 200 Generic Drugs by Units in 2006</a></td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.biopsychiatry.com/sertraline/sertraline-zoloft.pdf" title="Zoloft patient information leaflet<br><br><A HREF=http://www.biopsychiatry.com/sertraline/sertraline-zoloft.pdf>http://www.biopsychiatry.com/sertraline/sertraline-zoloft.pdf</A>">Zoloft patient information leaflet</a></td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.baumhedlundlaw.com/media/zoloft/Australian%20Zoloft%20Ruling.htm" title="<A HREF=http://www.baumhedlundlaw.com/media/zoloft/Australian%20Zoloft%20Ruling.htm>http://www.baumhedlundlaw.com/media/zoloft/Australian%20Zoloft%20Ruling.htm</A>">Australian Supreme Court Justice Rules Zoloft Caused Man to Murder his wife</a> - Court Rules Zoloft Caused Man to Murder His Wife</td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://drugs.com/zoloft.html" title="<TABLE STYLE='font-size: 12;'><TR><TD VALIGN='TOP'>•</TD><TD>You must wait at least 14 days after stopping an MAO inhibitor before you can take <B>sertraline</B>.</TD></TR><TR><TD VALIGN='TOP'>&bull</TD><TD>It is not known whether <B>sertraline</B> passes into breast milk or if it could harm a nursing baby.</TD></TR><TR><TD VALIGN='TOP'>&bull</TD><TD><B>Sertraline</B> is available with a prescription under the brand name Zoloft.</TD></TR></TABLE><BR><A HREF=http://drugs.com/zoloft.html>http://drugs.com/zoloft.html</A>">Zoloft Information</a> - Zoloft Information from Drugs.com</td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.tevapharm.com/pr/2006/pr_626.asp" title="Teva's AB-rated <B>Sertraline</B> Tablets are indicated for treatment of major depressive disorder.<br><br><A HREF=http://www.tevapharm.com/pr/2006/pr_626.asp>http://www.tevapharm.com/pr/2006/pr_626.asp</A>">Teva Announces Launch of Generic Zoloft®</a> - Teva > News & PR</td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.epa.gov/greenchemistry/pubs/pgcc/winners/gspa02.html" title="<TABLE STYLE='font-size: 12;'><TR><TD VALIGN='TOP'>•</TD><TD>Innovation and Benefits: Pfizer dramatically improved its manufacturing process for <B>sertraline</B>, the active ingredient in its popular drug, Zoloft®.</TD></TR><TR><TD VALIGN='TOP'>&bull</TD><TD><B>Sertraline</B> is the active ingredient in the important pharmaceutical, Zoloft®.</TD></TR><TR><TD VALIGN='TOP'>&bull</TD><TD>Applying the principles of green chemistry, Pfizer has dramatically improved the commercial manufacturing process of <B>sertraline</B>.</TD></TR></TABLE><BR><A HREF=http://www.epa.gov/greenchemistry/pubs/pgcc/winners/gspa02.html>http://www.epa.gov/greenchemistry/pubs/pgcc/winners/gspa02.html</A>">2002 Greener Synthetic Pathways Award</a> - 2002 Greener Synthetic Pathways Award | Green Chemistry | US EPA</td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.duchs.com/information/zoloft" title="Frequently Asked Questions<br><br><A HREF=http://www.duchs.com/information/zoloft>http://www.duchs.com/information/zoloft</A>">Zoloft Education</a></td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.drugtopics.com/drugtopics/article/articleDetail.jsp?id=407652" title="<A HREF=http://www.drugtopics.com/drugtopics/article/articleDetail.jsp?id=407652>http://www.drugtopics.com/drugtopics/article/articleDetail.jsp?id=407652</A>">Top 200 generic drugs by units in 2006. Top 200 brand-name drugs by units.</a></td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://money.cnn.com/2007/01/22/news/companies/pfizer/index.htm?postversion=2007012207" title="<A HREF=http://money.cnn.com/2007/01/22/news/companies/pfizer/index.htm?postversion=2007012207>http://money.cnn.com/2007/01/22/news/companies/pfizer/index.htm?postversion=2007012207</A>">Pfizer to cut 10,000 jobs, shut 5 plants</a> - Pfizer to cut 10,000 jobs, close five plants; profit grows - Jan. 22, 2007</td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://medicine.plosjournals.org/archive/1549-1676/2/12/pdf/10.1371_journal.pmed.0020392-L.pdf" title="". ''PLos Medicine'', 2(12), e392.<br><br><A HREF=http://medicine.plosjournals.org/archive/1549-1676/2/12/pdf/10.1371_journal.pmed.0020392-L.pdf>http://medicine.plosjournals.org/archive/1549-1676/2/12/pdf/10.1371_journal.pmed.0020392-L.pdf</A>">Serotonin and Depression: A Disconnect Between the Advertisements and Scientific Literature</a></td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://dailystrength.org/treatments/Zoloft" title="Patient experiences with zoloft<br><br><A HREF=http://dailystrength.org/treatments/Zoloft>http://dailystrength.org/treatments/Zoloft</A>">Patient Feedack</a> - Zoloft: 11872 user reviews - DailyStrength</td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.sciencemag.org/cgi/content/full/sci;309/5735/728" title="<A HREF=http://www.sciencemag.org/cgi/content/full/sci;309/5735/728>http://www.sciencemag.org/cgi/content/full/sci;309/5735/728</A>">Science/AAAS | Science Magazine: Sign In</a></td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.answers.com/topic/pfizer" title="<A HREF=http://www.answers.com/topic/pfizer>http://www.answers.com/topic/pfizer</A>">Pfizer: Information from Answers.com</a></td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://www.drugs.com/zoloft.html" title="<TABLE STYLE='font-size: 12;'><TR><TD VALIGN='TOP'>•</TD><TD>You must wait at least 14 days after stopping an MAO inhibitor before you can take <B>sertraline</B>.</TD></TR><TR><TD VALIGN='TOP'>&bull</TD><TD>It is not known whether <B>sertraline</B> passes into breast milk or if it could harm a nursing baby.</TD></TR><TR><TD VALIGN='TOP'>&bull</TD><TD><B>Sertraline</B> is available with a prescription under the brand name Zoloft.</TD></TR></TABLE><BR><A HREF=http://www.drugs.com/zoloft.html>http://www.drugs.com/zoloft.html</A>">drugs.com</a> - Zoloft Information from Drugs.com</td></tr></table> </div> </span><br/> <span class="fragment"> <div id="external_links_revision_history_fragments"> <table border="0" cellpadding="0" cellspacing="0" hspace="0" vspace="0"><tr><td valign="top" nowrap bgcolor="white"><nobr><img src="images/external_links_revision_history/spacer.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"><img src="images/external_links_revision_history/square2-8x11.gif" align="bottom" width="8" height="11"> </nobr></td><td><a href="http://medicine.plosjournals.org/perlserv/?request=get-pdf&file=10.1371_journal.pmed.0020392-S.pdf" title="<A HREF=http://medicine.plosjournals.org/perlserv/?request=get-pdf&file=10.1371_journal.pmed.0020392-S.pdf>http://medicine.plosjournals.org/perlserv/?request=get-pdf&file=10.1371_journal.pmed.0020392-S.pdf</A>">Serotonin and depression: a disconnect between the advertisements and the scientific literature</a></td></tr></table> </div> </span><br/> </div> <div class="section-delimeter"></div> <div class="section" id="related_topics"> <h1 class="section-title"> <a name="related_topics">Related topics</a> </h1> <span class="core-uptodate">Up to date as of August 19, 2010</span> <ul> <span class="fragment"> <li> <a href="/Fluoxetine">Fluoxetine</a> </li> </span> <span class="fragment"> <li> <a href="/Mirtazapine">Mirtazapine</a> </li> </span> <span class="fragment"> <li> <a href="/Tranylcypromine">Tranylcypromine</a> </li> </span> <span class="fragment"> <li> <a href="/Trazodone">Trazodone</a> </li> </span> <span class="fragment"> <li> <a href="/Tramadol">Tramadol</a> </li> </span> <span class="fragment"> <li> <a href="/Buspirone">Buspirone</a> </li> </span> <span class="fragment"> <li> <a href="/Clomipramine">Clomipramine</a> </li> </span> <span class="fragment"> <li> <a href="/Amitriptyline">Amitriptyline</a> </li> </span> <span class="fragment"> <li> <a href="/Nefazodone">Nefazodone</a> </li> </span> <span class="fragment"> <li> <a href="/Citalopram">Citalopram</a> </li> </span> </ul> </div> <div class="section-delimeter"></div></div> </div> <br/><br/><br/> <script type="text/javascript" language="javascript"><!-- function checkEmail(myForm) { if (/^\w+([\.-]?\w+)*@\w+([\.-]?\w+)*(\.\w{2,3})+$/.test(myForm.str_email.value)){ return (true); } alert("Invalid E-mail Address! 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