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Setastine
Systematic (IUPAC) name
1-[2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]ethyl]azepane
Identifiers
CAS number 59767-13-4
ATC code  ?
PubChem 43082
ChemSpider 39258
Chemical data
Formula C22H28ClNO
Mol. mass 357.92 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Setastine (Loderix) is an antihistamine used to treat allergies and rhinitis.[1][2]

Contents

Pharmacology

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Pharmacodynamics

Setastine acts as a highly selective H1 receptor antagonist.[3] It posses no anticholinergic, antiadrenergic, or antiserotonergic effects.

Pharmacokinetics

Setastine penetrates the blood-brain-barrier only weakly, hence, it is not sedating or is only mildly so.[3]

See also

References

  1. ^ Lantos A, Tóth A, Zsiray M (1991). "Loderix (setastine) tablets in the treatment of allergic rhinoconjunctivitis". Therapia Hungarica (English Edition) 39 (1): 22–4. PMID 1677500.  
  2. ^ Hirschberg A, Ribári O, Krasznai M (1989). "Results obtained with Loderix tablet in chronic rhinitis patients". Therapia Hungarica (English Edition) 37 (4): 202–4. PMID 2576575.  
  3. ^ a b Porszász J, Varga F, Porszász KG, et al. (December 1990). "Pharmacology of the new H1-receptor antagonist setastine hydrochloride". Arzneimittel-Forschung 40 (12): 1340–5. PMID 1982751.  

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