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Setiptiline
Systematic (IUPAC) name
2-methyl-2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2- c]pyridine
Identifiers
CAS number  ?
ATC code none
PubChem 5205
Chemical data
Formula C 19H19N 
Mol. mass 261.36 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Prescription only
Routes Oral

Setiptiline (Tecipul), also known as teciptiline, is a tetracyclic antidepressant which acts as a noradrenergic and specific serotonergic antidepressant. It was launched in 1989 for the treatment of depression in Japan by Mochida. [1] [2] Setiptiline is closely related to mianserin and mirtazapine.

Contents

Chemistry

Setiptiline has a tetracyclic structure and is a close analogue of mianserin and mirtazapine, with setiptiline being delta(13b,4a),4a-carba-mianserin, and mirtazapine being 6-aza-mianserin.

Pharmacology

Setiptiline acts as a norepinephrine reuptake inhibitor,[3] α2-adrenergic receptor receptor_antagonist,[4] and serotonin receptor antagonist,[5] likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor antagonist or antihistamine.[3]

See also

References

  1. ^ "Antidepressants, antipsychotics ... - Google Books". http://books.google.com/books?id=yXD4QA-Y_Z0C&lpg=PA248&dq=setiptiline&as_brr=3&pg=PA248#v=onepage&q=&f=false.  
  2. ^ "Index nominum, international drug ... - Google Books". http://books.google.com/books?id=5GpcTQD_L2oC&lpg=PA1638&dq=setiptiline&lr=&as_brr=3&pg=PA942#v=onepage&q=setiptiline&f=false.  
  3. ^ a b Niho T, Ito C, Shibutani Y, Hashizume H, Yamaguchi K (October 1986). "[Pharmacological properties of MO-8282, a novel antidepressant]" (in Japanese). Nippon Yakurigaku Zasshi. Folia Pharmacologica Japonica 88 (4): 309–20. PMID 3792961.  
  4. ^ Mizota M, Oikawa Y, Nakayama K, et al. (December 1986). "[Pharmacological studies of MO-8282, a new antidepressant]" (in Japanese). Nippon Yakurigaku Zasshi. Folia Pharmacologica Japonica 88 (6): 457–66. PMID 2881854.  
  5. ^ Przegaliński E, Baran L, Siwanowicz J, Rawłów A (1986). "The lack of antidepressant properties and a potent central antiserotonin activity of Org 8282". Polish Journal of Pharmacology and Pharmacy 38 (4): 377–84. PMID 3774630.  







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