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From Wikipedia, the free encyclopedia

Short bowel syndrome
Classification and external resources
ICD-9 579.3
DiseasesDB 12026
eMedicine med/2746 ped/2088
MeSH D012778

Short bowel syndrome (SBS, also short gut syndrome or simply short gut) is a malabsorption disorder caused by the surgical removal of the small intestine, or rarely due to the complete dysfunction of a large segment of bowel. Most cases are acquired, although some children are born with a congenital short bowel. It usually does not develop unless a person has lost more than two thirds of their small intestine.


Signs and symptoms

The symptoms of short bowel syndrome can include:

Patients with short bowel syndrome may have complications caused by malabsorption of vitamins and minerals, such as deficiencies in vitamins A, D, E, K, and B12, calcium, magnesium, iron, folic acid, and zinc. These may appear as anemia, hyperkeratosis (scaling of the skin), easy bruising, muscle spasms, poor blood clotting, and bone pain.


Short bowel syndrome in adults is usually caused by surgery for:

  • Crohn's disease, an inflammatory disorder of the digestive tract
  • Volvulus, a spontaneous twisting of the small intestine that cuts off the blood supply and leads to tissue death
  • Tumors of the small intestine
  • Injury or trauma to the small intestine
  • Necrotizing enterocolitis (premature newborn)
  • Bypass surgery to treat obesity, a now commonly performed surgical procedure
  • Surgery to remove diseases or damaged portion of the small intestine


In healthy adults, the small intestine has an average length of approximately 6 meters (19.7 feet). Short bowel syndrome usually develops when there is less than 2 meters (6.6 feet) of the small intestine left to absorb sufficient nutrients.

Short bowel syndrome caused by the surgical removal of a portion of the bowel may be a temporary condition, due to the adaptive property of the small intestine.

In a process called intestinal adaptation, physiological changes to the remaining portion of the small intestine occur to increase its absorptive capacity. These changes include:

  • Enlargement and lengthening of the villi found in the lining
  • Increase in the diameter of the small intestine
  • Slow down in peristalsis or movement of food through the small intestine


Symptoms of short bowel syndrome are usually addressed by prescription medicine. These include:

In 2004, the FDA approved a therapy that reduces the frequency and volume of TPN, comprising:

NutreStoreTM [L-glutamine for oral solution] and Zorbtive [somatropin (rDNA origin) for injection] together with a specialized oral diet. Byrne, TA, Wilmore DW, Iyer K, et al. Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome. Ann Surg. 2005;242;655-661


There is no cure for short bowel syndrome. In newborn infants, the 4-year survival rate on parenteral nutrition is approximately 70%. Some studies suggest that much of the mortality is due to a complication of the TPN, especially chronic liver disease.[1] Much hope is vested in Omegaven, a type of lipid TPN feed, in which recent case reports suggest the risk of liver disease is much lower.[2]

Although promising, small intestine transplant has a mixed success rate, with postoperative mortality rate of up to 30%. One-year and 4-year survival rate are 90% and 60%, respectively.

Surgical procedures to lengthen dilated bowel include the Bianchi Procedure (where the bowel is cut in half and one end is sewn to the other) and a newer procedure called serial transverse enteroplasty (STEP—where the bowel is cut and stapled in a zigzag pattern). There is controversy over the efficacy of these procedures. They are usually performed by pediatric surgeons at quaternary hospital who specialize in small bowel surgery.


  1. ^ Vanderhoof JA, Langnas AN (1997). "Short-bowel syndrome in children and adults". Gastroenterology 113 (5): 1767–78. doi:10.1053/gast.1997.v113.pm9352883. PMID 9352883.  
  2. ^ Gura KM, Duggan CP, Collier SB, et al. (2006). "Reversal of parenteral nutrition-associated liver disease in two infants with short bowel syndrome using parenteral fish oil: implications for future management". Pediatrics 118 (1): e197–201. doi:10.1542/peds.2005-2662. PMID 16818533.  

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