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Sialic acid binding Ig-like lectin 1, sialoadhesin
Identifiers
Symbol SIGLEC1
Alt. symbols SN, CD169
Entrez 6614
HUGO 11127
OMIM 600751
RefSeq NM_023068
UniProt Q9BZZ2
Other data
Locus Chr. 20 p13

Sialoadhesin is a cell adhesion molecule found on the surface of certain cells of the immune system called macrophages. It is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin superfamily (IgSF). Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. Alternate names for sialoadhesin include siglec-1 and CD169 (cluster of differentiation 169). [1]

Sialoadhesin predominately binds neutrophils, but can also bind monocytes, natural killer cells, B cells and a subset of cytotoxic T cells by interacting with sialic acid molecules in the ligands on their surfaces.[2]

References

  1. ^ Ajit Varki. "PROW Guide: Sialoadhesin, Siglec-1 (CD169)". http://mpr.nci.nih.gov/PROW/guide/985165905_g.htm. Retrieved 2008-02-23.  
  2. ^ Kelm S, Pelz A, Schauer R, Filbin M, Tang S, de Bellard M, Schnaar R, Mahoney J, Hartnell A, Bradfield P (1994). "Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily". Curr Biol 4 (11): 965–72. doi:10.1016/S0960-9822(00)00220-7. PMID 7533044.  
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