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Metaphase spread of a cell line showing a ring chromosome (R) and several sister chromatid exchanges (SCEs), some of which are indicated by arrows.

Sister chromatid exchange (SCE) is the exchange of genetic material between two identical sister chromatids.

It was first discovered by using the giemsa staining method on one chromatid belonging to the sister chromatid complex before anaphase in mitosis. The staining revealed that few segments were passed to the sister chromatid which were not dyed. The giemsa staining was able to stain due to the presence of bromodeoxyuridine analogous base which was introduced to the desired chromatid.

The reason for the (SCE) is not known but it is required and used as a mutagenic testing of many products. Four to five sister chromatid exchange is in the normal distribution, 14-100 exchanges is not normal and presents a danger to the organism. Bloom syndrome is closely related to it, having 100 to 160 s.c.e. SCE. may also be related to tumors.

Sister chromatid exchange has also been observed more frequently in B51(+) Behçet's disease.[1]

External links


  1. ^ Ikbal M, Atasoy M, Pirim I, Aliagaoglu C, Karatay S, Erdem T (February 2006). "The alteration of sister chromatid exchange frequencies in Behçet's disease with and without HLA-B51". J Eur Acad Dermatol Venereol 20 (2): 149–52. doi:10.1111/j.1468-3083.2006.01386.x. PMID 16441621.  


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