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Sleeping kitten
Two men sleeping on a bench in Tehran.

Sleep is a naturally recurring state of relatively suspended sensory and motor activity, characterized by total or partial unconsciousness and the inactivity of nearly all voluntary muscles.[1] It is distinguished from quiet wakefulness by a decreased ability to react to stimuli, and it is more easily reversible than hibernation or coma. Sleep is a heightened anabolic state, accentuating the growth and rejuvenation of the immune, nervous, skeletal and muscular systems. It is observed in all mammals, all birds, and many reptiles, amphibians, and fish. In humans, other mammals, and a substantial majority of other animals that have been studied (such as some species of fish, birds, ants, and fruit flies), regular sleep is essential for survival.[citation needed]

The purposes and mechanisms of sleep are only partially clear and are the subject of intense research.[2]

Contents

Physiology

Stages of sleep

In mammals and birds, sleep is divided into two broad types: Rapid Eye Movement (REM) and Non-Rapid Eye Movement (NREM or non-REM) sleep. Each type has a distinct set of associated physiological, neurological, and psychological features. The American Academy of Sleep Medicine (AASM) further divides NREM into three stages: N1, N2, and N3, the last of which is also called delta, or slow-wave, sleep (SWS).[3]

Sleep cycles through the night, with deep sleep early on and more REM (marked in red) toward morning.
Stage N3 sleep; EEG highlighted by red box. Thirty seconds of deep sleep, here with greater than 50% delta waves.
REM sleep; EEG highlighted by red box; eye movements highlighted by red line. Thirty seconds of sleep.

Sleep proceeds in cycles of REM and NREM, the order normally being N1 → N2 → N3 → N2 → REM. There is a greater amount of deep sleep (stage N3) early in the night, while the proportion of REM sleep increases later in the night and just before natural awakening.

The stages of sleep were first described in 1937 by Alfred Lee Loomis and his coworkers, who separated the different electroencephalography (EEG) features of sleep into five levels (A to E), which represented the spectrum from wakefulness to deep sleep.[4] In 1953, REM sleep was discovered as distinct, and thus William Dement and Nathaniel Kleitman reclassified sleep into four NREM stages and REM.[5] The staging criteria were standardized in 1968 by Allan Rechtschaffen and Anthony Kales in the "R&K sleep scoring manual."[6] In the R&K standard, NREM sleep was divided into four stages, with slow-wave sleep comprising stages 3 and 4. In stage 3, delta waves made up less than 50% of the total wave patterns, while they made up more than 50% in stage 4. Furthermore, REM sleep was sometimes referred to as stage 5.

In 2004, the AASM commissioned the AASM Visual Scoring Task Force to review the R&K scoring system. The review resulted in several changes, the most significant being the combination of stages 3 and 4 into Stage N3. The revised scoring was published in 2007 as The AASM Manual for the Scoring of Sleep and Associated Events.[7] Arousals and respiratory, cardiac, and movement events were also added.[8][9]

Sleep stages and other characteristics of sleep are commonly assessed by polysomnography in a specialized sleep laboratory. Measurements taken include EEG of brain waves, electrooculography (EOG) of eye movements, and electromyography (EMG) of skeletal muscle activity. In humans, each sleep cycle lasts from 90 to 110 minutes on average,[10] and each stage may have a distinct physiological function. This can result in sleep that exhibits loss of consciousness but does not fulfill its physiological functions (i.e., one may still feel tired after apparently sufficient sleep).

NREM sleep

According to the 2007 AASM standards, NREM consists of three stages. There is relatively little dreaming in NREM.

Stage N1 refers to the transition of the brain from alpha waves having a frequency of 8 to 13 Hz (common in the awake state) to theta waves having a frequency of 4 to 7 Hz. This stage is sometimes referred to as somnolence or drowsy sleep. Sudden twitches and hypnic jerks, also known as positive myoclonus, may be associated with the onset of sleep during N1. Some people may also experience hypnagogic hallucinations during this stage, which can be troublesome to them. During N1, the subject loses some muscle tone and most conscious awareness of the external environment.

Stage N2 is characterized by sleep spindles ranging from 11 to 16 Hz (most commonly 12–14 Hz) and K-complexes. During this stage, muscular activity as measured by EMG decreases, and conscious awareness of the external environment disappears. This stage occupies 45% to 55% of total sleep in adults.

Stage N3 (deep or slow-wave sleep) is characterized by the presence of a minimum of 20% delta waves ranging from 0.5 to 2 Hz and having a peak-to-peak amplitude > 75 μV. (EEG standards define delta waves to be from 0 – 4 Hz, but sleep standards in both the original R&K, as well as the new 2007 AASM guidelines have a range of 0.5 to 2 Hz.) This is the stage in which parasomnias such as night terrors, nocturnal enuresis, sleepwalking, and somniloquy occur. Many illustrations and descriptions still show a stage N3 with 20 - 50 % delta waves and a stage N4 with greater than 50 % delta waves; these have been combined as stage N3.

REM sleep

Rapid eye movement sleep, or REM sleep, accounts for 20%–25% of total sleep time in most human adults. The criteria for REM sleep include rapid eye movements as well as a rapid low-voltage EEG. Most memorable dreaming occurs in this stage. At least in mammals, a descending muscular atonia is seen. Such paralysis may be necessary to protect organisms from self-damage through physically acting out scenes from the often-vivid dreams that occur during this stage.

Timing

The human biological clock

Sleep timing is controlled by the circadian clock, sleep-wake homeostasis, and in humans, within certain bounds, willed behaviour. The circadian clock — an inner timekeeping, temperature-fluctuating, enzyme-controlling device — works in tandem with adenosine, a neurotransmitter that inhibits many of the bodily processes associated with wakefulness. Adenosine is created over the course of the day; high levels of adenosine lead to sleepiness. In diurnal animals, sleepiness occurs as the circadian element causes the release of the hormone melatonin and a gradual decrease in core body temperature. The timing is affected by one's chronotype. It is the circadian rhythm that determines the ideal timing of a correctly structured and restorative sleep episode.[11]

Homeostatic sleep propensity (the need for sleep as a function of the amount of time elapsed since the last adequate sleep episode) must be balanced against the circadian element for satisfactory sleep.[12] Along with corresponding messages from the circadian clock, this tells the body it needs to sleep.[13] Sleep offset (awakening) is primarily determined by circadian rhythm. A person who regularly awakens at an early hour will generally not be able to sleep much later than their normal waking time, even if moderately sleep-deprived.

Sleep duration is affected by circadian rhythm which is regulated by a gene named DEC2. Some people have a mutation of this gene; they sleep two hours less than normal. Neurology professor Ying-Hui Fu and her colleagues bred mice that carried the DEC2 mutation and slept less than normal mice. [14]

Optimal amount in humans

Adult

The optimal amount of sleep is not a meaningful concept unless the timing of that sleep is seen in relation to an individual's circadian rhythms. A person's major sleep episode is relatively inefficient and inadequate when it occurs at the "wrong" time of day; one should be asleep at least six hours before the lowest body temperature.[15] The timing is correct when the following two circadian markers occur after the middle of the sleep episode and before awakening:[16]

  • maximum concentration of the hormone melatonin, and
  • minimum core body temperature.

Human sleep need can vary by age and among individuals, and sleep is considered to be adequate when there is no daytime sleepiness or dysfunction.

A University of California, San Diego, psychiatry study of more than one million adults found that people who live the longest self-report sleeping for six to seven hours each night.[17] Another study of sleep duration and mortality risk in women showed similar results.[18] Other studies show that "sleeping more than 7 to 8 hours per day has been consistently associated with increased mortality," though this study suggests the cause is probably other factors such as depression and socioeconomic status, which would correlate statistically.[19] It has been suggested that the correlation between lower sleep hours and reduced morbidity only occurs with those who wake after less sleep naturally, rather than those who use an alarm.

Main health effects of sleep deprivation,[20] indicating impairment of normal maintenance by sleep.

Researchers at the University of Warwick and University College London have found that lack of sleep can more than double the risk of death from cardiovascular disease, but that too much sleep can also be associated with a doubling of the risk of death, though not primarily from cardiovascular disease.[21][22] Professor Francesco Cappuccio said, "Short sleep has been shown to be a risk factor for weight gain, hypertension, and Type 2 diabetes, sometimes leading to mortality; but in contrast to the short sleep-mortality association, it appears that no potential mechanisms by which long sleep could be associated with increased mortality have yet been investigated. Some candidate causes for this include depression, low socioeconomic status, and cancer-related fatigue. …In terms of prevention, our findings indicate that consistently sleeping around seven hours per night is optimal for health, and a sustained reduction may predispose to ill health."

Furthermore, sleep difficulties are closely associated with psychiatric disorders such as depression, alcoholism, and bipolar disorder.[23] Up to 90% of adults with depression are found to have sleep difficulties. Dysregulation found on EEG includes disturbances in sleep continuity, decreased delta sleep and altered REM patterns with regard to latency, distribution across the night and density of eye movements.[24]

Hours by age

A child sleeping.

Children need more sleep per day in order to develop and function properly: up to 18 hours for newborn babies, with a declining rate as a child ages.[13] A newborn baby spends almost 9 hours a day in REM sleep. By the age of five or so, only slightly over two hours is spent in REM.[25]

Age and condition Average amount of sleep per day
Newborn up to 18 hours
1–12 months 14–18 hours
1–3 years 12–15 hours
3–5 years 11–13 hours
5–12 years 9–11 hours
Adolescents 9–10 hours[26]
Adults, including elderly 7–8 (+) hours
Pregnant women 8 (+) hours

Sleep debt

Sleep debt is the effect of not getting enough rest and sleep; a large debt causes mental, emotional, and physical fatigue. It is unclear why a lack of sleep causes irritability.

Sleep debt results in diminished abilities to perform high-level cognitive functions. Neurophysiological and functional imaging studies have demonstrated that frontal regions of the brain are particularly responsive to homeostatic sleep pressure.[27]

Scientists do not agree on how much sleep debt it is possible to accumulate; whether it is accumulated against an individual's average sleep or some other benchmark; nor on whether the prevalence of sleep debt among adults has changed appreciably in the industrialized world in recent decades. It is likely that children are sleeping less than previously in Western societies.[28]

Genetics

A considerable amount of sleep-related behavior is apparently hard-wired into human biology - humans in all cultures get tired, require sleep for good health, and have similar symptoms when sleep deprived. Scientific research has identified some genetic variations, including:

  • A mutation that moves consolidated sleep earlier, resulting in a sleep cycle from 7:30pm to 3:30am.[29]
  • A mutation in BHLHB3 which apparently reduces the amount of sleep needed for healthy living from 8 hours to only 6.

Functions

The multiple theories proposed to explain the function of sleep reflect the as-yet incomplete understanding of the subject. It is likely that sleep evolved to fulfill some primeval function and took on multiple functions over time. (As an analogy, the larynx in all mammals controls the passage of food and air, but may have descended in humans to take on speech capabilities in addition.)

It has been pointed out that, if sleep were not essential, one would expect to find 1) animal species that do not sleep at all, 2) animals that do not need recovery sleep when they stay awake longer than usual, and 3) animals that suffer no serious consequences as a result of lack of sleep. No animals have been found to date that satisfy any of these criteria.[30]

Some of the many proposed functions of sleep are as follows.

A Kutchi woman sleeping.

Restoration

Wound healing has been shown to be affected by sleep. A study conducted by Gumustekin et al.[31] in 2004 shows sleep deprivation hindering the healing of burns on rats.

It has been shown that sleep deprivation affects the immune system. In a study by Zager et al. in 2007,[32] rats were deprived of sleep for 24 hours. When compared with a control group, the sleep-deprived rats' blood tests indicated a 20% decrease in white blood cell count, a significant change in the immune system. It is now possible to state that "sleep loss impairs immune function and immune challenge alters sleep," and it has been suggested that mammalian species which invest in longer sleep times are investing in the immune system, as species with the longer sleep times have higher white blood cell counts.[33]

It has yet to be proven that sleep duration affects somatic growth. One study by Jenni et al.[34] in 2007 recorded growth, height, and weight, as correlated to parent-reported time in bed in 305 children over a period of nine years (age 1–10). It was found that "the variation of sleep duration among children does not seem to have an effect on growth." It has been shown that sleep—more specifically, slow-wave sleep (SWS)—does affect growth hormone levels in adult men. During eight hours' sleep, Van Cauter, Leproult, and Plat[35] found that the men with a high percentage of SWS (average 24%) also had high growth hormone secretion, while subjects with a low percentage of SWS (average 9%) had low growth hormone secretion.

There are multiple arguments supporting the restorative function of sleep. The metabolic phase during sleep is anabolic; anabolic hormones such as growth hormones (as mentioned above) are secreted preferentially during sleep. The duration of sleep among species is, in general, inversely related to animal size and directly related to basal metabolic rate. Rats with a very high basal metabolic rate sleep for up to 14 hours a day, whereas elephants and giraffes with lower BMRs sleep only 3–4 hours per day.

Energy conservation could as well have been accomplished by resting quiescent without shutting off the organism from the environment, potentially a dangerous situation. A sedentary nonsleeping animal is more likely to survive predators, while still preserving energy. Sleep, therefore, seems to serve another purpose, or other purposes, than simply conserving energy; for example, hibernating animals waking up from hibernation go into rebound sleep because of lack of sleep during the hibernation period. They are definitely well-rested and are conserving energy during hibernation, but need sleep for something else.[36] Rats kept awake indefinitely develop skin lesions, hyperphagia, loss of body mass, hypothermia, and, eventually, fatal septicemia.[37]

Anabolic/catabolic

Non-REM sleep may be an anabolic state marked by physiological processes of growth and rejuvenation of the organism's immune, nervous, muscular, and skeletal systems (with some exceptions). Wakefulness may perhaps be viewed as a cyclical, temporary, hyperactive catabolic state during which the organism acquires nourishment and reproduces.[citation needed]

Ontogenesis

According to the ontogenetic hypothesis of REM sleep, the activity occurring during neonatal REM sleep (or active sleep) seems to be particularly important to the developing organism (Marks et al., 1995). Studies investigating the effects of deprivation of active sleep have shown that deprivation early in life can result in behavioral problems, permanent sleep disruption, decreased brain mass (Mirmiran et al., 1983), and an abnormal amount of neuronal cell death (Morrissey, Duntley & Anch, 2004).

REM sleep appears to be important for development of the brain. REM sleep occupies the majority of time of sleep of infants, who spend most of their time sleeping. Among different species, the more immature the baby is born, the more time it spends in REM sleep. Proponents also suggest that REM-induced muscle inhibition in the presence of brain activation exists to allow for brain development by activating the synapses, yet without any motor consequences that may get the infant in trouble. Additionally, REM deprivation results in developmental abnormalities later in life.

However, this does not explain why older adults still need REM sleep. Aquatic mammal infants do not have REM sleep in infancy;[38] REM sleep in those animals increases as they age.

Memory processing

Scientists have shown numerous ways in which sleep is related to memory. In a study conducted by Turner, Drummond, Salamat, and Brown,[39] working memory was shown to be affected by sleep deprivation. Working memory is important because it keeps information active for further processing and supports higher-level cognitive functions such as decision making, reasoning, and episodic memory. The study allowed 18 women and 22 men to sleep only 26 minutes per night over a four-day period. Subjects were given initial cognitive tests while well-rested, and then were tested again twice a day during the four days of sleep deprivation. On the final test, the average working memory span of the sleep-deprived group had dropped by 38% in comparison to the control group.

Memory seems to be affected differently by certain stages of sleep such as REM and slow-wave sleep (SWS). In one study cited in Born, Rasch, and Gais,[40] multiple groups of human subjects were used: wake control groups and sleep test groups. Sleep and wake groups were taught a task and were then tested on it, both on early and late nights, with the order of nights balanced across participants. When the subjects' brains were scanned during sleep, hypnograms revealed that SWS was the dominant sleep stage during the early night, representing around 23% on average for sleep stage activity. The early-night test group performed 16% better on the declarative memory test than the control group. During late-night sleep, REM became the most active sleep stage at about 24%, and the late-night test group performed 25% better on the procedural memory test than the control group. This indicates that procedural memory benefits from late, REM-rich sleep, whereas declarative memory benefits from early, SWS-rich sleep.

A study conducted by Datta[41] indirectly supports these results. The subjects chosen were 22 male rats. A box was constructed wherein a single rat could move freely from one end to the other. The bottom of the box was made of a steel grate. A light would shine in the box accompanied by a sound. After a five-second delay, an electrical shock would be applied. Once the shock commenced, the rat could move to the other end of the box, ending the shock immediately. The rat could also use the five-second delay to move to the other end of the box and avoid the shock entirely. The length of the shock never exceeded five seconds. This was repeated 30 times for half the rats. The other half, the control group, was placed in the same trial, but the rats were shocked regardless of their reaction. After each of the training sessions, the rat would be placed in a recording cage for six hours of polygraphic recordings. This process was repeated for three consecutive days. This study found that during the posttrial sleep recording session, rats spent 25.47% more time in REM sleep after learning trials than after control trials. These trials support the results of the Born et al. study, indicating an obvious correlation between REM sleep and procedural knowledge.

An observation of the Datta study is that the learning group spent 180% more time in SWS than did the control group during the post-trial sleep-recording session. This phenomenon is supported by a study performed by Kudrimoti, Barnes, and McNaughton.[42] This study shows that after spatial exploration activity, patterns of hippocampal place cells are reactivated during SWS following the experiment. In a study by Kudrimoti et al., seven rats were run through a linear track using rewards on either end. The rats would then be placed in the track for 30 minutes to allow them to adjust (PRE), then they ran the track with reward-based training for 30 minutes (RUN), and then they were allowed to rest for 30 minutes. During each of these three periods, EEG data were collected for information on the rats' sleep stages. Kudrimoti et al. computed the mean firing rates of hippocampal place cells during prebehavior SWS (PRE) and three ten-minute intervals in postbehavior SWS (POST) by averaging across 22 track-running sessions from seven rats. The results showed that ten minutes after the trial RUN session, there was a 12% increase in the mean firing rate of hippocampal place cells from the PRE level; however, after 20 minutes, the mean firing rate returned rapidly toward the PRE level. The elevated firing of hippocampal place cells during SWS after spatial exploration could explain why there were elevated levels of SWS sleep in Datta's study, as it also dealt with a form of spatial exploration.

A study has also been done involving direct current stimulation to the prefrontal cortex to increase the amount of slow oscillations during SWS (Marshall et al., 2006, as cited in Walker, 2009). The direct current stimulation greatly enhanced word-pair retention the following day, giving evidence that SWS plays a large role in the consolidation of episodic memories.[43]

The different studies all suggest that there is a correlation between sleep and the complex functions of memory. Harvard sleep researchers Saper and Stickgold[44] point out that an essential part of memory and learning consists of nerve cell dendrites' sending of information to the cell body to be organized into new neuronal connections. This process demands that no external information is presented to these dendrites, and it is suggested that this may be why it is during sleep that memories and knowledge are solidified and organized.

Preservation

The "Preservation and Protection" theory holds that sleep serves an adaptive function. It protects the animal during that portion of the 24-hour day in which being awake, and hence roaming around, would place the individual at greatest risk.[45] Organisms do not require 24 hours to feed themselves and meet other necessities. From this perspective of adaptation, organisms are safer by staying out of harm's way, where potentially they could be prey to other, stronger organisms. They sleep at times that maximize their safety, given their physical capacities and their habitats. (Allison & Cicchetti, 1976; Webb, 1982).

However, this theory fails to explain why the brain disengages from the external environment during normal sleep. Another argument against the theory is that sleep is not simply a passive consequence of removing the animal from the environment, but is a "drive"; animals alter their behaviors in order to obtain sleep. Therefore, circadian regulation is more than sufficient to explain periods of activity and quiescence that are adaptive to an organism, but the more peculiar specializations of sleep probably serve different and unknown functions. Moreover, the preservation theory needs to explain why carnivores like lions, which are on top of the food chain and thus have little to fear, sleep the most. It has been suggested that they need to minimize energy expenditure when not hunting.

Preservation also does not explain why aquatic mammals sleep while moving. Quiescence during these vulnerable hours would do the same and would be more advantageous, because the animal would still be able to respond to environmental challenges like predators, etc. Sleep rebound that occurs after a sleepless night will be maladaptive, but obviously must occur for a reason. A zebra falling asleep the day after it spent the sleeping time running from a lion is more, not less, vulnerable to predation.

Dreaming

Dreaming is the perception of sensory images and sounds during sleep, in a sequence which the dreamer usually perceives more as an apparent participant than an observer. Dreaming is stimulated by the pons and mostly occurs during the REM phase of sleep.

People have proposed many hypotheses about the functions of dreaming. Sigmund Freud postulated that dreams are the symbolic expression of frustrated desires that had been relegated to the unconscious mind, and he used dream interpretation in the form of psychoanalysis to uncover these desires. See Freud: The Interpretation of Dreams.

Freud's work concerns the psychological role of dreams, which clearly does not exclude any physiological role they may have. It is not ruled out therefore by the increased modern interest in the organization and consolidation of recent memory and experience. Recent research claims that sleep has this overall role of consolidation and organization of synaptic connections formed during learning and experience.

John Allan Hobson and Robert McCarley's activation synthesis theory proposes that dreams are caused by the random firing of neurons in the cerebral cortex during the REM period. According to this theory, the forebrain then creates a story in an attempt to reconcile and make sense of the nonsensical sensory information presented to it; hence, the odd nature of many dreams.[46]

Effect of food and drink on sleep

Hypnotics

Often, people start drinking alcohol in order to get to sleep (alcohol is initially a sedative and will cause somnolence, encouraging sleep).[48] However, being addicted to alcohol can lead to disrupted sleep, because alcohol has a rebound effect later in the night. As a result, there is strong evidence linking alcoholism and forms of insomnia.[49] Alcohol also reduces REM sleep.[47]

Barbiturates cause drowsiness and have actions similar to alcohol in that it has a rebound effect and inhibits REM sleep, so it is not used as a long term sleep aid.[50]

Melatonin is a naturally occurring hormone that regulates sleepiness. It is made in the brain, where tryptophan is converted into serotonin and then into melatonin, which is released at night by the pineal gland to induce and maintain sleep. Melatonin supplementation may be used as a sleep aid, both as a hypnotic and as a chronobiotic (see phase response curve, PRC).

  • Siesta and the "post-lunch dip"

Many people have a temporary drop in alertness in the early afternoon, commonly known as the "post-lunch dip." While a large meal can make a person feel sleepy, the post-lunch dip is mostly an effect of the biological clock. People naturally feel most sleepy (have the greatest "drive for sleep") at two times of the day about 12 hours apart—for example, at 2:00 a.m. and 2:00 p.m. At those two times, the body clock "kicks in." At about 2 p.m. (14:00), it overrides the homeostatic buildup of sleep debt, allowing several more hours of wakefulness. At about 2 a.m. (02:00), with the daily sleep debt paid off, it "kicks in" again to ensure a few more hours of sleep.

The amino acid tryptophan is a building block of proteins. It has been claimed to contribute to sleepiness, since it is a precursor of the neurotransmitter serotonin, involved in sleep regulation. However, no solid data have ever linked modest dietary changes in tryptophan to changes in sleep.

Stimulants

Amphetamines (amphetamine, dextroamphetamine, methamphetamine, etc.) are often used to treat narcolepsy and ADHD disorders and when used recreationally may be referred to as "speed." Their most common effects are anxiety, insomnia, stimulation, increased alertness, and decreased hunger.

Caffeine is a stimulant that works by slowing the action of the hormones in the brain that cause somnolence, particularly by acting as an antagonist at adenosine receptors. Effective dosage is individual, in part dependent on prior usage. It can cause a rapid reduction in alertness as it wears off.

Studies on cocaine have shown its effects to be mediated through the circadian rhythm system.[51] This may be related to the onset of hypersomnia (oversleeping) in regard to "Cocaine-Induced Sleep Disorder."[52]

The stimulating effects of energy drinks come from stimulants such as caffeine, and sugars, and they will eventually create a rapid reduction in alertness similar to that of caffeine.

The class of drugs called empathogen-entactogens keep users awake with intense euphoria. Commonly known as "ecstasy."

Commonly known by the brand names Ritalin and Concerta, methylphenidate is similar in action to amphetamines and cocaine.

Causes of difficulty in sleeping

There are many reasons for poor sleep. Following sleep hygienic principles may solve problems of physical or emotional discomfort.[53] When the culprit is pain, illness, drugs, or stress, the cause must be treated. Back pain and neck pain particularly effect the sleep cycle and the quality of sleep.[54] Sleep disorders (including the sleep apneas, narcolepsy, primary insomnia, periodic limb movement disorder (PLMD), restless leg syndrome (RLS), and the circadian rhythm sleep disorders) are treatable.

Older people are more easily awoken by disturbances in the environment[55] and may to some degree lose the ability to consolidate sleep.

Various patents, products and sleep techniques exist as sleep aids, allowing a more natural position during sleep for better circulation and less body pain. These methods range from returning to sleep on the floor since beds are a relatively recent invention in human history,[56] to products which lift blankets off one's feet[57] to many kinds of "memory foam" which create a surface customized to an individual's body position.[58]

Anthropology of sleep

Research suggests that sleep patterns vary significantly across cultures.[59][60] The most striking differences are between societies that have plentiful sources of artificial light and ones that do not.[59] The primary difference appears to be that prelight cultures have more broken-up sleep patterns.[59] For example, people might go to sleep far sooner after the sun sets, but then wake up several times throughout the night, punctuating their sleep with periods of wakefulness, perhaps lasting several hours.[59] The boundaries between sleeping and waking are blurred in these societies.[59] Some observers believe that nighttime sleep in these societies is most often split into two main periods, the first characterised primarily by deep sleep and the second by REM sleep.[59]

Some societies display a fragmented sleep pattern in which people sleep at all times of the day and night for shorter periods. In many nomadic or hunter-gatherer societies, people will sleep on and off throughout the day or night depending on what is happening.[59] Plentiful artificial light has been available in the industrialised West since at least the mid-19th century, and sleep patterns have changed significantly everywhere that lighting has been introduced[59] In general, people sleep in a more concentrated burst through the night, going to sleep much later, although this is not always true.[59]

In some societies, people generally sleep with at least one other person (sometimes many) or with animals. In other cultures, people rarely sleep with anyone but a most intimate relation, such as a spouse. In almost all societies, sleeping partners are strongly regulated by social standards. For example, people might only sleep with their immediate family, extended family, spouses, their children, children of a certain age, children of specific gender, peers of a certain gender, friends, peers of equal social rank, or with no one at all. Sleep may be an actively social time, depending on the sleep groupings, with no constraints on noise or activity.[59]

People sleep in a variety of locations. Some sleep directly on the ground; others on a skin or blanket; others sleep on platforms or beds. Some sleep with blankets, some with pillows, some with simple headrests, some with no head support. These choices are shaped by a variety of factors, such as climate, protection from predators, housing type, technology, and the incidence of pests.[59]

Sleep in nonhumans

Many animals sleep, but neurological sleep states are difficult to define in lower-order animals. In these animals, sleep is defined using behavioral characteristics such as minimal movement, postures typical for the species, and reduced responsiveness to external stimulation. Sleep is quickly reversible, as opposed to hibernation or coma, and sleep deprivation is followed by longer or deeper sleep. Herbivores, who require a long waking period to gather and consume their diet, typically sleep less each day than similarly sized carnivores, who might well consume several days' supply of meat in a sitting.

Horses and other herbivorous ungulates can sleep while standing, but must necessarily lie down for REM sleep (which causes muscular atony) for short periods. Giraffes, for example, only need to lie down for REM sleep for a few minutes at a time. Bats sleep while hanging upside down. Some aquatic mammals and some birds can sleep with one half of the brain while the other half is awake, so-called unihemispheric slow-wave sleep.[61] Birds and mammals have cycles of non-REM and REM sleep (as described above for humans), though birds’ cycles are much shorter and they do not lose muscle tone (go limp) to the extent that most mammals do.

Many mammals sleep for a large proportion of each 24-hour period when they are very young.[62] However, killer whales and some dolphins do not sleep during the first month of life.[63] Such differences may be explained by the ability of land-mammal newborns to be easily protected by parents while sleeping, while marine animals must, even while very young, be more continuously vigilant for predators.

See also

Positions, practices, and rituals

Notes

  1. ^ Macmillan Dictionary for Students Macmillan, Pan Ltd. (1981), page 936. Retrieved 2009-10-1.
  2. ^ Bingham, Roger; Terrence Sejnowski, Jerry Siegel, Mark Eric Dyken, Charles Czeisler, Paul Shaw, Ralph Greenspan, Satchin Panda, Philip Low, Robert Stickgold, Sara Mednick, Allan Pack, Luis de Lecea, David Dinges, Dan Kripke, Giulio Tononi (February 2007). "Waking Up To Sleep" (Several conference videos). The Science Network. http://thesciencenetwork.org/programs/waking-up-to-sleep. Retrieved 2008-01-25. 
  3. ^ Silber MH, Ancoli-Israel S, Bonnet MH, et al. (March 2007). "The visual scoring of sleep in adults". Journal of Clinical Sleep Medicine 3 (2): 121–31. PMID 17557422. http://www.aasmnet.org/jcsm/Articles/030203.pdf. 
  4. ^ Loomis, Alfred L; Harvey EN, Hobart GA (1937). "III Cerebral states during sleep, as studied by human brain potentials". J Exp Psychol. 21: 127–44. doi:10.1037/h0057431. 
  5. ^ Dement, William; Nathaniel Kleitman (1957). "Cyclic variations in EEG during sleep and their relation to eye movements, body motility and dreaming". Electroencephalogr Clin Neurophysiol 9 (4): 673–90. doi:10.1016/0013-4694(57)90088-3. PMID 13480240. 
  6. ^ Rechtschaffen A, Kales A, editors. A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Washington: Public Health Service, US Government Printing Office; 1968.
  7. ^ Iber, C; Ancoli-Israel, S; Chesson, A; Quan, SF for the American Academy of Sleep Medicine (2007). The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications.. Westchester: American Academy of Sleep Medicine. 
  8. ^ Psychology World (1998). "Stages of Sleep" (PDF). http://web.mst.edu/~psyworld/general/sleepstages/sleepstages.pdf. Retrieved 2008-06-15. "(includes illustrations of "sleep spindles" and "K-complexes")" 
  9. ^ Schulz H (April 2008). "Rethinking sleep analysis". Journal of Clinical Sleep Medicine 4 (2): 99–103. PMID 18468306. 
  10. ^ Swierzewski, Stanley J., M.D. (01 December 2000, reviewed 04 December 2007). "Sleep Stages. Overview, Waking, Non-REM, REM, Sleep Cycle, Factors, Age". Sleep Channel, Healthcommunities.com. http://www.sleepdisorderchannel.com/stages/. Retrieved 2008-02-10. 
  11. ^ Wyatt, James K.; Ritz-De Cecco, Angela; Czeisler, Charles A.; Dijk, Derk-Jan (1 October 1999). "Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day". Am J Physiol 277 (4): R1152–R1163. Fulltext. PMID 10516257. http://ajpregu.physiology.org/cgi/content/full/277/4/R1152. Retrieved 2007-11-25. 
  12. ^ Zisapel, N. (2007). "Sleep and sleep disturbances: biological basis and clinical implications." (Abstract). Cell Mol Life Sci 64 (10): 1174–86. doi:10.1007/s00018-007-6529-9. PMID 17364142. http://www.websciences.org/cftemplate/NAPS/archives/indiv.cfm?ID=20066335. Retrieved 2009-01-05. 
  13. ^ a b de Benedictis, Tina, Ph.D.; Heather Larson, Gina Kemp, M.A., Suzanne Barston, Robert Segal, M.A. (2007). "Understanding Sleep: Sleep Needs, Cycles, and Stages". Helpguide.org. http://www.helpguide.org/life/sleeping.htm. Retrieved 2008-01-25. 
  14. ^ News.Yahoo.com, Scientists find rare gene behind short sleepers.
  15. ^ Dijk, Derk-Jan; Steven W. Lockley (February 2002). "Functional Genomics of Sleep and Circadian Rhythm Invited Review: Integration of human sleep-wake regulation and circadian rhythmicity". J Appl Physiol 92 (2): 852–62. doi:10.1152/japplphysiol.00924.2001. PMID 11796701. http://jap.physiology.org/cgi/content/full/92/2/852. Retrieved 2009-04-04. "Consolidation of sleep for 8 h or more is only observed when sleep is initiated ~6-8 h before the temperature nadir.". 
  16. ^ Wyatt, James K.; Ritz-De Cecco, Angela; Czeisler, Charles A.; Dijk, Derk-Jan (1 October 1999). "Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day". Am J Physiol 277 (4): R1152–R1163. PMID 10516257. http://ajpregu.physiology.org/cgi/content/full/277/4/R1152. Retrieved 2007-11-25. "... significant homeostatic and circadian modulation of sleep structure, with the highest sleep efficiency occurring in sleep episodes bracketing the melatonin maximum and core body temperature minimum". 
  17. ^ Rhonda Rowland (2002-02-15). "Experts challenge study linking sleep, life span". http://archives.cnn.com/2002/HEALTH/02/14/sleep.study/index.html. Retrieved 2007-04-22. 
  18. ^ Patel SR, Ayas NT, Malhotra MR, et al. (May 2004). "A prospective study of sleep duration and mortality risk in women". Sleep 27 (3): 440–4. PMID 15164896. 
  19. ^ Patel SR, Malhotra A, Gottlieb DJ, White DP, Hu FB (July 2006). "Correlates of long sleep duration". Sleep 29 (7): 881–9. PMID 16895254. ; cf. Irwin MR, Ziegler M (February 2005). "Sleep deprivation potentiates activation of cardiovascular and catecholamine responses in abstinent alcoholics". Hypertension 45 (2): 252–7. doi:10.1161/01.HYP.0000153517.44295.07. PMID 15642774. 
  20. ^ Reference list is found on image page in Commons: Commons:File:Effects of sleep deprivation.svg#References
  21. ^ ""Researchers say lack of sleep doubles risk of death… but so can too much sleep"". http://www2.warwick.ac.uk/newsandevents/pressreleases/researchers_say_lack/. 
  22. ^ Ferrie JE, Shipley MJ, Cappuccio FP, et al. (December 2007). "A prospective study of change in sleep duration: associations with mortality in the Whitehall II cohort". Sleep 30 (12): 1659–66. PMID 18246975. 
  23. ^ Thase, Me (2006). "Depression and sleep: pathophysiology and treatment" (Free full text). Dialogues in clinical neuroscience 8 (2): 217–26. ISSN 1294-8322. PMID 16889107. http://www.nlm.nih.gov/medlineplus/depression.html.  edit
  24. ^ Mann, Joseph John; David J. Kupfer (1993) (Google books). Biology of Depressive Disorders: Subtypes of depression and comorbid disorders, Part 2. Springer. p. 49. ISBN 0306442965. http://books.google.no/books?id=qbbTmje6oskC&printsec=frontcover&hl=en&source=gbs_v2_summary_r&cad=0. Retrieved 2009-07-24. 
  25. ^ Siegel, Jerome M. (1999). "Sleep". Encarta Encyclopedia. Microsoft. http://www.npi.ucla.edu/sleepresearch/encarta/Article.htm. Retrieved 2008-01-25. 
  26. ^ "Backgrounder: Later School Start Times". National Sleep Foundation. Undated. http://www.sleepfoundation.org/article/hot-topics/backgrounder-later-school-start-times. Retrieved 2009-10-02. "Teens are among those least likely to get enough sleep; while they need on average 9 1/4 hours of sleep per night..." 
  27. ^ Gottselig JM, Adam M, Rétey JV, Khatami R, Achermann P, Landolt HP (March 2006). "Random number generation during sleep deprivation: effects of caffeine on response maintenance and stereotypy". Journal of Sleep Research 15 (1): 31–40. doi:10.1111/j.1365-2869.2006.00497.x. PMID 16490000. 
  28. ^ Iglowstein I, Jenni OG, Molinari L, Largo RH (February 2003). "Sleep duration from infancy to adolescence: reference values and generational trends". Pediatrics 111 (2): 302–7. doi:10.1542/peds.111.2.302. PMID 12563055. http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=12563055. "Thus, the shift in the evening bedtime across cohorts accounted for the substantial decrease in sleep duration in younger children between the 1970s and the 1990s. …[A] more liberal parental attitude toward evening bedtime in the past decades is most likely responsible for the bedtime shift and for the decline of sleep duration…". 
  29. ^ Don’t need much sleep? Rare gene may play role by Lauran Neergaard. Associated Press. 14 Aug 2009.
  30. ^ Cirelli, Chiara; Giulio Tononi (August 26, 2008). "Is Sleep Essential?" (Essay). PLoS Biol (Public Library of Science) 6 (8): e216. doi:10.1371/journal.pbio.0060216. PMID 18752355. PMC 2525690. http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0060216&ct=1. Retrieved 2009-04-21. "... it would seem that searching for a core function of sleep, particularly at the cellular level, remains a worthwhile exercise". 
  31. ^ Gumustekin, K.; Seven, B., Karabulut, N., Aktas, O., Gursan, N., Aslan, S., Keles, M., Varoglu, E., Dane S. (2004). "Effects of sleep deprivation, nicotine, and selenium on wound healing in rats" (Abstract). Int J Neurosci 2004;114(11): 1433-42. http://websciences.org/cftemplate/NAPS/archives/indiv.cfm?ID=20044648. 
  32. ^ Zager, A., Andersen, M.L., Ruiz, F.S., Antunes, I.B., & Tufik, S. (2007). Effects of acute and chronic sleep loss on immune modulation of rats [Electronic version]. Regulatory, Integrative and Comparative Physiology, 293, R504-R509.
  33. ^ Opp, Mark R. (January 2009). "Sleeping to fuel the immune system: mammalian sleep and resistance to parasites" (Full text, Creative Commons Attribution License). BMC Evolutionary Biology (BioMed Central Ltd.) 9 (8): 1471–2148. doi:10.1186/1471-2148-9-8. http://www.biomedcentral.com/1471-2148/9/8. Retrieved 2009-06-28. 
  34. ^ Jenni, O. G., Molinari, L., Caflisch, J. A., & Largo, R. H. (2007). Sleep duration from ages 1 to 10 years: Variability and stability in comparison with growth [Electronic version]. Pediatrics, 120, e769-e776.
  35. ^ Van Cauter, E., Leproult, R., & Plat, L. (2000). Age-related changes in slow-wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men [Electronic version]. Journal of the American Medical Association, 284, 861-868.
  36. ^ Daan S, Barnes BM, Strijkstra AM (1991). "Warming up for sleep? Ground squirrels sleep during arousals from hibernation". Neurosci. Lett. 128 (2): 581. doi:10.1016/0304-3940(91)90276-Y. PMID 1945046. http://linkinghub.elsevier.com/retrieve/pii/0304-3940(91)90276-Y. 
  37. ^ Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research. Institute for Laboratory Animal Research (ILAR), National Research Council. The National Academies Press. 2003. p. 121. ISBN 978-0-309-08903-6. http://books.nap.edu/openbook.php?record_id=10732&page=121. "Sleep deprivation of over 7 days with the disk-over-water system results in the development of ulcerative skin lesions, hyperphagia, loss of body mass, hypothermia, and eventually septicemia and death in rats (Everson, 1995; Rechtschaffen et al., 1983)." 
  38. ^ Amanda Schaffer (Mai 27, 2007). "Why do we Sleep?". Slate.com. http://www.slate.com/id/2162475/entry/2162477/. Retrieved 2008-08-23. 
  39. ^ Turner, T.H., Drummond, S.P.A., Salamat, J.S., & Brown, G.G. (2007). Effects of 42 hr sleep deprivation on component processes of verbal working memory [Electronic version]. Neuropsychology, 21, 787-795.
  40. ^ Born, J., Rasch, J., & Gais, S. (2006). Sleep to remember [Electronic version]. Neuroscientist, 12, 410.
  41. ^ Datta, S. (2000). Avoidance task training potentiates phasic pontine-wave density in the rat: A mechanism for sleep-dependent plasticity [Electronic version]. The Journal of Neuroscience, 20, 8607-8613.
  42. ^ Kudrimoti, H.S., Barnes, C.A., & McNaughton, B.L. (1999). Reactivation of hippocampal cell assemblies: Effects of behavioral state, experience, and EEG dynamics [Electronic version]. The Journal of Neuroscience, 19, 4090-4101.
  43. ^ Walker, M.P. "The Role of Sleep in Cognition and Emotion." Annals of the New York Academy of Sciences. 1156. (2009): 174.
  44. ^ "Nature, 10/05
  45. ^ New Theory Questions Why We Sleep by Charles Q. Choi, LiveScience.com, Aug 25, 2009.
  46. ^ Hobson, J.A., & McCarley, R. (1977). The brain as a dream state generator: An activation-synthesis hypothesis of the dream process. American Journal of Psychiatry, 134, 1335–1348.
  47. ^ a b Lee-chiong, Teofilo (24 April 2008). Sleep Medicine: Essentials and Review. Oxford University Press, USA. p. 52. ISBN 0-19-530659-7. http://books.google.co.uk/books?id=s1F_DEbRNMcC&pg=PT52. 
  48. ^ Sleepdex.org
  49. ^ Alcoholism.about.com
  50. ^ Sleepdex.org
  51. ^ Abarca C, Albrecht U, Spanagel R (June 2002). "Cocaine sensitization and reward are under the influence of circadian genes and rhythm". Proceedings of the National Academy of Sciences of the United States of America 99 (13): 9026–30. doi:10.1073/pnas.142039099. PMID 12084940. 
  52. ^ Primary hypersomnia: Diagnostic Features
  53. ^ Little, Nan (2007-01-01). "What Causes Sleep Difficulty?". Insight Journal. http://www.anxiety-and-depression-solutions.com/wellness_concerns/sleep/sleep_problem_causes.php. Retrieved 2008-01-25. 
  54. ^ Sleep FAQ | Natural Form - Understanding the sleep cycle and disruptions
  55. ^ How Aging Changes Sleep Patterns by Allison Aubrey. Morning Edition, 3 Aug 2009.
  56. ^ BetterSleep.org
  57. ^ FootSleepguard.com
  58. ^ SleepAidFactory.com
  59. ^ a b c d e f g h i j k Carol M. Worthman and Melissa K. Melby. "6. Toward a comparative developmental ecology of human sleep" (PDF). A comparative developmental ecology. Emory University. http://webdrive.service.emory.edu/groups/research/lchb/PUBLICATIONS%20Worthman/PUBLICATIONS%20CMW%202002/Ecology%20of%20Human%20sleep.pdf. 
  60. ^ Slumber's Unexplored Landscape, Science News Online (9/25/99)
  61. ^ Mukhametova LM; Supina AY, Polyakovaa IG (1977-10-14). "Interhemispheric asymmetry of the electroencephalographic sleep patterns in dolphins". Brain Research 134 (3): 581–584. doi:10.1016/0006-8993(77)90835-6. PMID 902119. 
  62. ^ Faraco, Juliette (2000-08-01). "Re: Are there animals who don't sleep or that sleep very little?". MadSci Network: Zoology. http://www.madsci.org/posts/archives/2000-08/965504574.Zo.r.html. Retrieved 2008-01-25. 
  63. ^ LiveScience.com, Insomnia Mania: Newborn Mammals Don't Sleep for a Month.

References

External links


Quotes

Up to date as of January 14, 2010

From Wikiquote

Sleep is the natural state of bodily rest observed in animals.

Quotes

  • There is a time for many words, and there is also a time for sleep.
  • Even where sleep is concerned, too much is a bad thing.'
  • I have never taken any exercise except sleeping and resting.
  • All men, whilst they are awake, are in one common world: but each of them, when he is asleep, is in a world of his own.
  • Laugh and the world laughs with you, snore and you sleep alone.
  • Most people are walking in their sleep; turn them around, start them in the opposite direction, and they wouldn’t even know the difference.
    • Al Hubbard
  • There are two types of people in this world, good and bad. The good sleep better, but the bad seem to enjoy the waking hours much more.
  • Death, so called, is a thing which makes men weep: And yet a third of Life is passed in sleep.
  • "I love sleep. My life has the tendency to fall apart when I'm awake, you know?"
  • To achieve the impossible dream, try going to sleep
    • Joan Klempner
  • Sleep that knits up the ravelled sleeve of care
    The death of each day's life, sore labour's bath
    Balm of hurt minds, great nature's second course,
    Chief nourisher in life's feast.
  • In Sleep we lie all naked and alone, in Sleep we are united at the heart of night and darkness, and we are strange and beautiful asleep; for we are dying the darkness and we know no death.
  • No day is so bad it can't be fixed with a nap.
  • It's at night, when perhaps we should be dreaming, that the mind is most clear, that we are most able to hold all our life in the palm of our skull. I don't know if anyone has ever pointed out that great attraction of insomnia before, but it is so; the night seems to release a little more of our vast backward inheritance of instincts and feelings; as with the dawn, a little honey is allowed to ooze between the lips of the sandwich, a little of the stuff of dreams to drip into the waking mind. I wish I believed, as J. B. Priestley did, that consciousness continues after disembodiment or death, not forever, but for a long while. Three score years and ten is such a stingy ration of time, when there is so much time around. Perhaps that's why some of us are insomniacs; night is so precious that it would be pusillanimous to sleep all through it! A "bad night" is not always a bad thing.
    • Brian W. Aldiss
  • Life is something that happens when you can't get to sleep
    • Fran Lebowitz
  • Consciousness: that annoying time between naps.
  • A good laugh and a long sleep are the best cures in the doctor's book.
  • Sleep is a symptom of caffeine deprivation.
  • A ruffled mind makes a restless pillow
    • Charlotte Brontë
  • The best bridge between despair and hope is a good night's sleep
    • E. Joseph Cossman
  • When you say to a child 'Bedtime, it's bedtime now' that's not what the child hears. What the child hears is 'Go and lie down in the dark. For hours. And don't move. I'm locking the door now'
  • There is no sleep, it has never existed
    • John Bowman
  • "Welcome is sleep, more welcome the sleep of stone
    Whilst crime and shame continue in the land;
    My happy fortune, not to see or hear;
    Waken me not - in mercy, whisper low."
  • "Now I lay me down to sleep / I pray the funk will make me freak / If I should die before I waked / Allow me Lord to rock out naked."
    • Red Hot Chili Peppers

External links

Wikipedia
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Look up sleep in Wiktionary, the free dictionary

Source material

Up to date as of January 22, 2010

From Wikisource

Sleep
disambiguation
This is a disambiguation page, which lists works which share the same title. If an article link referred you here, please consider editing it to point directly to the intended page.


Sleep may refer to:


1911 encyclopedia

Up to date as of January 14, 2010

From LoveToKnow 1911

SLEEP (0. Eng. sloepan; Ger. schlafen; cf. Lat. labi, to glide, and "slip"), a normal condition of the body, occurring periodically, in which there is a greater or less degree of unconsciousness due to inactivity of the nervous system and more especially of the brain and spinal cord. It may be regarded as the condition of rest of the nervous system during which there is a renewal of the energy that has been expended in the hours of wakefulness; for in the nervous system the general law holds good that periods of physiological rest must alternate with periods of physiological activity, and, as the nervous system is the dominating mechanism in the body, when it reposes all the other systems enjoy the same condition to a greater or less extent. Rest alternates with work in all vital phenomena. After a muscle has contracted frequently at short intervals, a period of relaxation is necessary for the removal of waste products and the restitution of energy; the pulsating heart, apparently working without intermission, is in reality not doing so, as there are short intervals of relaxation between individual beats in which there is no expenditure of energy; the cells in a secreting gland do not always elaborate, but have periods when the protoplasm is comparatively at rest. Nervous action also involves physico-chemical changes of matter and the expenditure of energy. This is true even of the activity of the brain associated with sensation, perception, emotion, volition and other psychical phenomena, and therefore the higher nervous centres require rest, during which they are protected from the stream of impressions flowing in from the sense-organs, and in which waste matters are removed and the cerebral material is recuperated for another time of wakeful activity. (See also Hypnotism, and the physiological sections of the articles Brain, and Muscle And Nerve.) The coincidence of the time of sleep with the occurrence of the great terrestrial phenomena that cause night is more apparent than real. The oscillations of vital activity are not correlated to the terrestrial revolutions as effect and cause, but the occurrence of sleep, in the majority of cases, on the advent of night is largely the result of habit. Whilst the darkness and stillness of night are favourable to sleep, the state of physiological repose is determined more by the condition of the body itself. Fatigue will normally cause sleep at any time of the twenty-four hours. Thus many of the lower animals habitually sleep during the day and prowl in search of food in the night; some hibernate during the winter season, passing into long periods of sleep during both day and night; and men whose avocations require them to work during the night find that they can maintain health and activity by sleeping the requisite time during the day.

The approach of sleep is usually marked by a desire for sleep, or sleepiness, embracing an obscure and complicated group of sensations, resembling such bodily states of feeling as hunger, thirst, the necessity of breathing, &c. All of these bodily states, although on the whole ill-defined, are referred with some precision to special organs. Thus hunger, although due to a general bodily want, is referred to the stomach, thirst to the fauces, and breathing to the chest; and in like manner the desire for sleep is referred chiefly to the region of the head and neck. There is a sensation of weight in the upper eyelids, intermittent spasm of the sub-hyoid muscles causing yawning, and drooping of the head. Along with these signs there is obscuration of the intelligence, depression both of general sensibility and of the special senses, and relaxation of the muscular system. The halfclosed eyelids tend more and more to close; the inspirations become slower and deeper; the muscles supporting the lower jaw become relaxed, so that the mouth opens; the muscles of the back of the neck that tend to support the head also relax and the chin droops on the breast; and the limbs relax and tend to fall into a line with the body. At the same time the hesitating utterances of the sleepy man indicate vagueness of thought, and external objects gradually cease to make an impression on the senses. These are the chief phenomena of the advent of sleep. After it has supervened there are many gradations in its depth and character. In some cases the sleep may be so light that the individual is partially conscious of external impressions and of the disordered trains of thought and feeling that pass through his mind, constituting dreams, and these may be more or less vivid, according to the degree of consciousness remaining. On th&other hand, the sleep may be so profound as to abolish all psychical phenomena: there are no dreams, and when the sleeper awakes the time passed in this unconscious state is a blank. The first period of sleep is the most profound. After a variable period, usually from five to six hours of deep sleep, the faculties awaken, not simultaneously but often fitfully, so that there are transient periods of consciousness. This is the time of dreaming. As the period of waking approaches the sensibility becomes more acute, so that external impressions are faintly perceived. These impressions may influence and mould the flow of images in the mind of the sleeper, frequently altering the nature of his dreams or making them more vivid. The moment of waking is usually not instantaneous, but is preceded by an intermediate state of partial consciousness, and a strange play of the mental faculties that has more of the character of an "intellectual mirage" than of consecutive thought.

The intensity of sleep has been measured by Kohlschi tter by the intensity of the sound necessary to awaken the sleeper. This intensity increases rapidly during the first hour, then decreases, sometimes rapidly, sometimes slowly, during the next two or three hours, and then very slowly until the time of waking. This statement agrees generally with experience. As a rule the deeper the sleep the longer it lasts.

Various physiological changes have been observed during sleep, but much remains to be done in this direction. The pulse becomes less frequent; the respiratory movements are fewer in number and are almost wholly thoracic, not abdominal; all the secretions are reduced in quantity; the gastric and intestinal peristaltic movements are less rapid; the pupils of the eye are contracted and during profound sleep are not affected by light; and the eyeballs are rotated upwards. The pupils dilate slightly when strong sensory or auditory stimuli are applied, and they dilate the more the lighter the sleep; at the moment of waking they become widely dilated. Whilst muscular relaxation is general, there seems to be increased contraction of certain sphincter muscles, as the circular fibres of the iris and the fibres concerned in closing the eyelids. The state of the circulation of the brain has been frequently investigated. The older view was that there was a degree of plethora or congestion of the vessels of the brain, as is the state of matters in coma, to which the state of sleep has a superficial resemblance. Coma, however, is not sleep, but a condition of inactivity of the cerebral matter owing to the accumulation of dark venous blood in its vessels. This has been actually observed in cases where it was possible to see the brain. During sleep the surface of the exposed brain has been observed to become pale and to shrink somewhat from the sides of the opening (Johann Blumenbach, 1752-1840). A careful experimental research was conducted by Arthur E. Durham in 1860, in which he trephined a portion of bone as large as a shilling from the parietal region of a dog, and, to obviate the effects of atmospheric pressure, inserted a watch glass into the aperture so that the surface of the brain could be seen. His results are summarized thus: "(1) Pressure of distended veins on the brain is not the cause of sleep, for during sleep the veins are not distended; and, when they are, symptoms and appearances arise which differ from those which characterize sleep. (2) During sleep the brain is in a comparatively bloodless condition, and the blood in the encephalic vessels is not only diminished in quantity, but moves with diminished rapidity. (3) The condition of the cerebral circulation during sleep is, from physical causes, that which is most favourable to the nutrition of the brain tissue; and, on the other, hand, the condition which prevails during waking is associated with mental activity, because it is that which is most favourable to oxidation of the brain substance, and to various changes in its chemical constitution. (4) The blood which is derived from the brain during sleep is distributed to the alimentary and excretory organs. (5) Whatever increases the activity of the cerebral circulation tends to preserve wakefulness; and whatever decreases the activity of the cerebral circulation, and, at the same time, is not inconsistent with the general health of the body, tends to induce and favour sleep. Such circumstances may act primarily through the nervous or through the vascular system. Among those which act through the nervous system may be instanced the presence or absence of impressions upon the senses, and the presence or absence of exciting ideas. Among those which act through the vascular system may be mentioned unnaturally or naturally increased or decreased force or frequency of the heart's action." Dr William A. Hammond and Dr Silas Weir Mitchell (b. 1830) repeated and extended Durham's observations, with the same general results (1866), and Ehrmann, Salathe (1877), Francois Franck (1877) and Mosso (1881), by more refined methods of observation arrived at the same general conclusions. Angelo Mosso (b. 1846) in particular applied with great success the graphic method of registration to the study of the movements of the brain and of the circulation during sleep. He made observations on three persons who had lost a portion of the cranial vault and in whom there was a soft pulsating cicatrix. They were a woman of thirty-seven years of age, a man of thirty-seven years and a child of about twelve years. By special arrangements, Mosso took simultaneous tracings of the pulse at the wrist, of the beat of the heart, of the movements of the wall of the chest in respiration, and of the movements of the denuded brain. Further, by means of the plethysmograph - an instrument of Mosso's own invention - he obtained tracings showing changes in the volume of the hand and forearm; and he succeeded in showing that during sleep there is a diminished amount of blood in the brain, and at the same time an increased amount in the extremities. He showed further that there are frequent adjustments in the distribution of the blood, even during sleep. Thus a strong stimulus to the skin or to a sense organ - but not strong enough to awaken the sleeper - caused a contraction of the vessels of the forearm, an increase of blood pressure, and a determination of blood towards the brain; and, on the other hand, on suddenly awakening the sleeper, there was a contraction of the vessels of the brain, a general rise of pressure, and an accelerated flow of blood through the hemispheres of the brain. So sensitive is the whole organism in this respect, even during sleep, that a loudly spoken word, a sound, a touch, the action of light or any moderate sensory impression modified the rhythm of respiration, determined a contraction of the vessels of the forearm, increased the general pressure of the blood, caused an increased flow to the brain, and quickened the frequency of the beats of the heart. These observations show how a physiological explanation can be suggested of the influence of external impressions in modifying the dreams of a sleeper. Further, Mosso found that during very profound sleep these oscillations disappear: the pulsatory movements are uniform and are not affected by sensory impressions, and probably this condition exists when there is the absolute unconsciousness of a "dead" sleep. By such methods as have been employed by Mosso, three movements of the brain have been observed - (r) pulsations, corresponding to the beats of the heart; (2) oscillations, or longer waves, sometimes coinciding with the heart beats, or more generally consisting of longer festoons, carrying each a number of smaller waves, and believed to correspond generally to the respiratory movements; and (3) undulations, still longer and less marked elevations and depressions, first clearly observed by Mosso, and believed by him to indicate rhythmic contractions of the vessels of the pia mater and of the brain. This view is in keeping with the observations of Franz Cornelius Donders (b. 1818), Adolf Kussmaul (b. 1822), Tenner and others on changes of calibre observed in the cerebral vessels, and with the experiments of many physiologists, showing that the vessels of the pia mater, like other vessels, are controlled by the vaso-motor system of nerves. It may therefore be considered certain that during sleep there is an anaemia, or partially bloodless condition, of the brain, and that the blood is drawn off to other organs, whilst at the same time this anaemic condition may be modified by changes in the circulation or in the respiratory mechanism caused by position, by sensory impressions or by sudden changes in the state of repose of the muscles. The examination of the retina (which may be regarded as a cerebral outwork) by the ophthalmoscope during sleep also shows a comparatively bloodless condition. Such are the facts; the deficiency in the way of a theoretical explanation is that physiologists cannot satisfactorily account for the anaemic condition causing unconsciousness. Sudden haemorrhage from the brain and nerve-centres, or a sudden cessation of the supply of blood to the brain, as occurs in syncope (failure of the heart's action - a faint), no doubt causes unconsciousness, but in these circumstances there is a tendency to convulsive spasm. Such spasm is usually absent in sleep, but sudden jerks of the limbs may sometimes be observed during the time when there is the confusion of ideas preceding the passage into sleep.

During sleep the amount of carbonic acid eliminated is very much reduced, indicating that molecular changes in the tissues do not occur to the same extent as in the waking state. This is also shown by the fact that less heat is produced. Hermann von Helmholtz (b. 1821) states that the amount of heat produced by a man weighing 67 kilogrammes (147 41b) is about 40 calories per hour during sleep, as against 112 calories per hour while awake. This diminished production of heat may be largely accounted for by the quiet condition of the muscles of locomotion, but it also indicates diminished tissue changes throughout the body. In profound sleep the bodily temperature may fall from 6° to 2° Fahr. In consequence of diminished oxidation changes during sleep, it is not improbable that excess of nutrient matter may then be stored up in the form of fat, and that thus the proverb "He who sleeps dines" is based on a correct appreciation of the fact that sleep tends to produce plethora or obesity.

Whilst it is easy to state that sleep is caused by fatigue of the nervous system, it is more difficult to explain what the precise changes are that produce the state of unconsciousness. Various hypotheses have been advanced, but it cannot be said that any one is wholly satisfactory. Aware that the fatigue of muscle is associated with the accumulation of sarcolactic acid, Thierry William Preyer (b. 1841) surmised that the activity of nervous matter might be interfered with by the accumulation in the nervecentres of some such acid, or of its soda salt (lactate of soda), but this view has not been supported by the results of experiment, as the injection into the blood of a dose of lactate of soda has not produced sleep. Pfliiger has observed that frogs deprived for a considerable time of oxygen passed gradually into a state resembling profound sleep, and he has advanced the theory that there is no organ of the body so quickly affected by deprivation of oxygen as the brain. According to Eduard F. W. Pfliiger (b. 182 9), the phenomena of life depend on a dissociation of living matter, and in particular the activity of the cerebral substance connected with psychical states depends on dissociation changes in the grey matter. To excite the dissociation, however, oxygen is necessary. The oxygen unites with certain of the compounds set free by the dissociation, forming, amongst other substances, carbonic acid. If such matters as these that unite with oxygen are in sufficient amount to use up all the oxygen, the grey matter of the brain suffers from a deficiency of oxygen (or from its absence), and also from the accumulation of carbonic acid. According to such a theory, cerebral activity depends on cerebral respiration, and sleep is a kind of cerebral asphyxia. Some such condition is not improbable, but it must be stated that the evidence at present in support of it is meagre. Possibly, in attempting to account for the phenomenon of sleep, too much importance has been attributed to the changes occurring in the brain, forgetting that not merely brain matter but every tissue of the body becomes exhausted by work, and that sleep may be partly due to phenomena occurring throughout the body and not in the brain alone.

All the phenomena of sleep point to a diminished excitability of the cerebral nerve-centres and of the spinal cord. Contrary to what is often stated, there can be no doubt that reflex action is in partial abeyance and that the spinal cord is in a state of partial inactivity as well as the brain. The only nerve-centres that do not sleep are those absolutely essential to life, such as those connected with the heart, with respiratory movements, and with the distribution of blood by the vaso-motor arrangements; and Mosso's experiments indicate that even these have a certain amount of repose in profound sleep.

There is little doubt that all living beings require periods of repose alternating with periods of activity. Many plants close their flowers and bend their petioles at certain times of the day. These phenomena, called "the sleep of plants," depend apparently on changes in solar radiation, and there is no reason to believe that during the time of quiescence any reparative processes go on, as during the sleeping period of animals. Naturalists have observed many of the lower animals apparently in a state of sleep. Insects, crustaceans, fishes, reptiles, may all be observed occasionally to be almost motionless for considerable periods of time. The sleeping of birds is familiar to all, and in these there are anatomical arrangements by which the bird may, like the crane, sleep perched on one leg, or grasping a branch with both feet, like perching birds generally, without any muscular effort and consequently without fatigue.

The amount of sleep required by man varies according to age, sex and habit. The popular notion that a child sleeps half its time, an adult one-third, whilst an old person may do little except eat and sleep is not far wrong. In early life the cerebral faculties appear to be easily exhausted and during the frequent and prolonged sleeps of infancy the brain rests and the vegetative changes connected with nutrition and growth go on actively. As life advances, less sleep is required, until in adult life a period of seven or eight hours is sufficient. As a rule, women require more sleep than men; but much depends on habit. Thus most women bear the loss of sleep in the first instance better than men, because they have been accustomed more to loss or irregularity of sleep. The effect of habit is well seen in nurses, both male and female, who will often be able to work for weeks continuously with snatches of sleep, not amounting to more than two or three hours daily. Sooner or later, however, even in these cases nature asserts her demands, and prolonged sleep is necessary to maintain health and vigour. Wakefulness during the time when one ought to be asleep is frequently a distressing condition, undermining the strength and incapacitating for active and efficient work (see Insomnia).

It is a matter of common observation not only that certain persons require more sleep than others but that they have less power of resisting its onset and of awaking. This condition may become morbid, constituting a veritable nervous disease, to which the name "maladie du sommeil" or hypnosia may be given. It may be described as invincible sleep, and it may continue for weeks and for months, terminating in convulsive seizures, and even death. A persistent drooping of the upper eyelid has been observed even during waking hours. Dr W. Ogle has observed in such cases an engorgement of the cervical ganglia of the sympathetic; but this may have nothing to do with the condition. Cases of very prolonged sleep are not uncommon, especially amongst hysterical persons, lasting four, seven or ten days. On awaking the patient is exhausted and pale, with cold extremities, and not infrequently, after a brief interval of waking, passes off into another lethargic sleep. Something similar to this may be seen in very aged persons towards the close of life. (See also DREAMS, SOMNAMBULISM and HYPNOTISM.) Among older works, see article "Sommeil" in the Dictionnaire encyclopedique des sciences medicales, where a bibliography is given and where also there is an account of the medico-legal questions connected with sleep and somnambulism; Macnish, Physiology of Sleep; Durham, "On the Physiology of Sleep," in Guy's Hospital Reports (1860); Kohlschiitter, "Die Mechanik des Schlafes," in Z. f. ration. Med., vol. xxxiii. (1869); Pfliiger, "Theorie des Schlafes," in Pfliiger's Archiv, vol. x. (1875); Mosso, Ober den Kreislauf des Blutes im menschlichen Gehirn (Leipzig, 1881). Also Manacelne, Sleep, its Physiology, Pathology, Hygiene and Psychology (Eng. trans. 1897), with bibliography. (J. G. M.)


<< Sir William Henry Sleeman

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Simple English

File:A child
A child sleeping
Simple English Wiktionary has the word meaning for:

Sleep is a state of rest, which happens in animals, including humans. Animals that sleep are in an unconscious state, or mostly so. Most of the muscles that animals can control on purpose are inactive.[1] Animals that are asleep do not react to stimuli as fast as those that are awake. They can wake up from sleep more easily than from hibernation or coma. All mammals and birds, and many reptiles, amphibians, and fish, sleep. In humans, other mammals, and most other animals that were studied, sleeping regularly is essential for survival.

The purpose of sleep is not fully known, and it is still studied today.[2] We do know for sure, though, that sleep is necessary to most animals for survival.[3] Not having enough sleep can even be used for torture.

A person sleeps when he or she is not awake. Usually, this is during the night. During the day, most people are awake. They work, go to school or university, or do other things. Many people sleep for a short time in the early afternoon for a quick rest. This is called a nap.

Contents

Word

The word "sleep" comes from the old Old Germanic verbs for sleep.[4] In Old and Middle High German it was called "SLAF". The original meaning of the word was "to slap", which was related to the word for "flabby" (not hard or firm).[5]

Many words related to "sleep" have very different meanings, though. For example, "sleep" was also used to mean death, so that "putting an animal to sleep" meant to kill the animal without pain.[4] "Sleep with someone" can also have a sexual meaning.[4]

What sleep is for

Generally, the reason for sleep is that the brain has work to do during sleep. The details are not fully understood, but it is important to get enough sleep for the body and the brain to be healthy and work properly. Usually animals (and people) sleep at periodic intervals, such as once a day. Certain animals send out signals to the others that they will soon go to sleep. Yawning is such a signal.

Both humans and many animals sleep about once a day. Some animals, such as cats, sleep many times a day for short periods.

When people sleep they often have dreams. Probably some animals do, too.

Not only people sleep, all mammals and birds, and most fish, reptiles and other animals do, too.

Different categories of sleep

In mammals and birds, sleep can be divided into two categories. In one of them, the eyes move rapidly. It is called REM-sleep (from rapid eye movement). Most dreams take place in this phase. REM-sleep occurs normally at intervals throughout the night, and the periods of REM-sleep increase in length in the second half of the night. REM-sleep was first discovered in 1952-53.

The other category, where this movement of the eyes does not happen, is called NREM-sleep (Non-REM sleep). Usually, dreams do not occur during this time. There are three or four stages of NREM-sleep. Stage I is just barely sleeping, or dozing. Stage II is also light sleep. Normally, in adult humans, about half of the time spent asleep is spent in light sleep. Stages III and IV are called deep sleep. Deep sleep is necessary for growth and healing. It can be quite difficult to awaken someone who is in stage III or stage IV sleep. Sometimes stages III and IV are combined and called stage III.

Adult humans normally sleep in cycles of 90 to 110 minutes each. The night's sleep can be 4 or 5 of these cycles. Each cycle includes, in this order: stage I, stage II, stage III (IV), stage II and REM.

Getting enough sleep

The timing of sleep and the amount of it are both important. Both are different for different people. Some adults sleep best from 22:00 to 05:00 or 06:00 or 07:00. Some sleep best from midnight to seven or eight. These variations are normal.

How much sleep is enough also depends on age. Children need more sleep than adults. Newborn babies sleep about 18 hours per day. Small babies sleep many times a day; human babies do not develop circadian rhythms before they are 3 - 4 months old. At the age of 1 year, they sleep for about 14 hours.

A nine-year-old should sleep about 9-10 hours per day and teenagers, too, need that much sleep. Adults who sleep less than about 8 hours a day perform worse than those who sleep that long. [6][7]

Sleeping problems

People may have trouble going to sleep, staying asleep or getting enough sleep. This usually means that they are too sleepy in the daytime.

There are many things that influence sleep. Also some substances, called stimulants - coffee is such an example - can cause poor sleep. When people have just eaten something, the body is busy digesting. This can cause poor sleep, too. Worrying and stress can cause poor sleep.

There are many diseases that cause poor sleep. Fever can lead to bad dreams. Poor sleep can be a side effect of some medications.

Sleep disorders directly influence how a person sleeps. Examples of sleep disorders are narcolepsy, sleep apnea and circadian rhythm sleep disorders.

Sleep specialists - doctors specialised in sleeping problems - often suggest better sleep hygiene to people with sleeping problems. Sleep hygiene means things people can try, such as

  • avoid extreme emotion in the hours before sleep
  • trying to get up at the same time every day,
  • sleeping in a cool, quiet and very dark place,
  • avoiding bright light the last hour before bedtime,
  • avoiding a big meal just before bedtime, and
  • getting enough exercise every day.

References

  1. Macmillan Dictionary for Students Macmillan, Pan Ltd. (1981), page 936. Retrieved 2009-10-1.
  2. Bingham, Roger; Terrence Sejnowski, Jerry Siegel, Mark Eric Dyken, Charles Czeisler, Paul Shaw, Ralph Greenspan, Satchin Panda, Philip Low, Robert Stickgold, Sara Mednick, Allan Pack, Luis de Lecea, David Dinges, Dan Kripke, Giulio Tononi (February 2007). "Waking Up To Sleep" (Several conference videos). The Science Network. http://thesciencenetwork.org/programs/waking-up-to-sleep. Retrieved 2008-01-25. 
  3. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research, Institute for Laboratory Animal Research (ILAR), National Research Council, S. pg 121, The National Academies Press 2003, ISBN 978-0-309-08903-6
  4. 4.0 4.1 4.2 "Online Etymology Dictionary". etymonline.com. http://www.etymonline.com/index.php?search=sleep&searchmode=none. Retrieved 29 September 2010. 
  5. Alexander Borbély: Das Geheimnis des Schlafs. Deutsche Verlags-Anstalt, Stuttgart 1984. ISBN 3-421-02734-X
  6. ""Let Sleep Work for You" provided by the National Sleep Foundation". http://www.sleepfoundation.org/site/c.huIXKjM0IxF/b.2421185/k.7198/Let_Sleep_Work_for_You.htm. 
  7. Rhonda Rowland (2002-02-15). "Experts challenge study linking sleep, life span". http://archives.cnn.com/2002/HEALTH/02/14/sleep.study/index.html. Retrieved 2007-04-22. 

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