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Somatostatin receptor 1
Symbols SSTR1; SRIF-2
External IDs OMIM182451 MGI98327 HomoloGene820 IUPHAR: sst1 GeneCards: SSTR1 Gene
RNA expression pattern
PBB GE SSTR1 208482 at tn.png
More reference expression data
Species Human Mouse
Entrez 6751 20605
Ensembl ENSG00000139874 ENSMUSG00000035431
UniProt P30872 Q543T0
RefSeq (mRNA) NM_001049 XM_984503
RefSeq (protein) NP_001040 XP_989597
Location (UCSC) Chr 14:
37.75 - 37.75 Mb
Chr 12:
59.13 - 59.13 Mb
PubMed search [1] [2]

Somatostatin receptor type 1 is a protein that in humans is encoded by the SSTR1 gene.[1][2]

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. The encoded protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments, and is expressed in highest levels in jejunum and stomach.[2]


See also


  1. ^ Yamada Y, Stoffel M, Espinosa R 3rd, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (Apr 1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics 15 (2): 449-52. doi:10.1006/geno.1993.1088. PMID 8449518.  
  2. ^ a b "Entrez Gene: SSTR1 somatostatin receptor 1".  

Further reading

  • Yamada Y, Post SR, Wang K, et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. doi:10.1073/pnas.89.1.251. PMID 1346068.  
  • Fujita T, Yamaji Y, Sato M, et al. (1994). "Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines.". Life Sci. 55 (23): 1797–806. doi:10.1016/0024-3205(94)90090-6. PMID 7968260.  
  • Kaupmann K, Bruns C, Hoyer D, et al. (1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain.". FEBS Lett. 331 (1-2): 53–9. doi:10.1016/0014-5793(93)80296-7. PMID 8405411.  
  • Le Romancer M, Cherifi Y, Levasseur S, et al. (1996). "Messenger RNA expression of somatostatin receptor subtypes in human and rat gastric mucosae.". Life Sci. 58 (13): 1091–8. doi:10.1016/0024-3205(96)00063-X. PMID 8622562.  
  • Fukusumi S, Kitada C, Takekawa S, et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide.". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.  
  • de Lecea L, Ruiz-Lozano P, Danielson PE, et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.". Genomics 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.  
  • Jaïs P, Terris B, Ruszniewski P, et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.". Eur. J. Clin. Invest. 27 (8): 639–44. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525.  
  • Ferone D, van Hagen PM, van Koetsveld PM, et al. (1999). "In vitro characterization of somatostatin receptors in the human thymus and effects of somatostatin and octreotide on cultured thymic epithelial cells.". Endocrinology 140 (1): 373–80. doi:10.1210/en.140.1.373. PMID 9886848.  
  • Kumar U, Sasi R, Suresh S, et al. (1999). "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.". Diabetes 48 (1): 77–85. doi:10.2337/diabetes.48.1.77. PMID 9892225.  
  • Rocheville M, Lange DC, Kumar U, et al. (2000). "Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers.". J. Biol. Chem. 275 (11): 7862–9. doi:10.1074/jbc.275.11.7862. PMID 10713101.  
  • Schwärzler A, Kreienkamp HJ, Richter D (2000). "Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast.". J. Biol. Chem. 275 (13): 9557–62. doi:10.1074/jbc.275.13.9557. PMID 10734105.  
  • Zatelli MC, Tagliati F, Taylor JE, et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.". J. Clin. Endocrinol. Metab. 86 (5): 2161–9. doi:10.1210/jc.86.5.2161. PMID 11344221.  
  • Klisovic DD, O'Dorisio MS, Katz SE, et al. (2001). "Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study.". Invest. Ophthalmol. Vis. Sci. 42 (10): 2193–201. PMID 11527930.  
  • Pasquali D, Notaro A, Esposito D, et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID 11753241.  
  • Papotti M, Bongiovanni M, Volante M, et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis.". Virchows Arch. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID 12021920.  
  • Zatelli MC, Tagliati F, Piccin D, et al. (2002). "Somatostatin receptor subtype 1-selective activation reduces cell growth and calcitonin secretion in a human medullary thyroid carcinoma cell line.". Biochem. Biophys. Res. Commun. 297 (4): 828–34. doi:10.1016/S0006-291X(02)02307-0. PMID 12359227.  
  • Ferone D, Pivonello R, Van Hagen PM, et al. (2002). "Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes.". Am. J. Physiol. Endocrinol. Metab. 283 (5): E1056–66. doi:10.1152/ajpendo.00205.2001. PMID 12376335.  
  • Pasquali D, Notaro A, Bonavolonta' G, et al. (2002). "Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease.". J. Clin. Endocrinol. Metab. 87 (11): 5125–9. doi:10.1210/jc.2002-020790. PMID 12414882.  
  • Dizeyi N, Konrad L, Bjartell A, et al. (2002). "Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines.". Urol. Oncol. 7 (3): 91–8. doi:10.1016/S1078-1439(01)00173-9. PMID 12474541.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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