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Somatostatin receptor 2
Identifiers
Symbols SSTR2;
External IDs OMIM182452 MGI98328 HomoloGene37427 IUPHAR: sst2 GeneCards: SSTR2 Gene
RNA expression pattern
PBB GE SSTR2 214597 at tn.png
PBB GE SSTR2 217455 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6752 20606
Ensembl ENSG00000180616 ENSMUSG00000047904
UniProt P30874 P30875
RefSeq (mRNA) NM_001050 XM_990740
RefSeq (protein) NP_001041 XP_995834
Location (UCSC) Chr 17:
68.67 - 68.68 Mb
Chr 11:
113.44 - 113.44 Mb
PubMed search [1] [2]

Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene.[1]

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.[2]

Contents

Interactions

Somatostatin receptor 2 has been shown to interact with SHANK1.[3]

See also

References

  1. ^ Yamada Y, Stoffel M, Espinosa R 3rd, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (Apr 1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518.  
  2. ^ "Entrez Gene: SSTR2 somatostatin receptor 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6752.  
  3. ^ Zitzer, H; Hönck H H, Bächner D, Richter D, Kreienkamp H J (Nov. 1999). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain". J. Biol. Chem. (UNITED STATES) 274 (46): 32997–3001. ISSN 0021-9258. PMID 10551867.  

Further reading

  • Yamada Y, Post SR, Wang K, et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. doi:10.1073/pnas.89.1.251. PMID 1346068.  
  • Reubi JC, Waser B, Schaer JC, Markwalder R (1995). "Somatostatin receptors in human prostate and prostate cancer.". J. Clin. Endocrinol. Metab. 80 (9): 2806–14. doi:10.1210/jc.80.9.2806. PMID 7673428.  
  • Kagimoto S, Yamada Y, Kubota A, et al. (1994). "Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein.". Biochem. Biophys. Res. Commun. 202 (2): 1188–95. doi:10.1006/bbrc.1994.2054. PMID 7914078.  
  • Fujita T, Yamaji Y, Sato M, et al. (1994). "Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines.". Life Sci. 55 (23): 1797–806. doi:10.1016/0024-3205(94)90090-6. PMID 7968260.  
  • Patel YC, Greenwood M, Kent G, et al. (1993). "Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation.". Biochem. Biophys. Res. Commun. 192 (1): 288–94. doi:10.1006/bbrc.1993.1412. PMID 8386508.  
  • Fukusumi S, Kitada C, Takekawa S, et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide.". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.  
  • Jaïs P, Terris B, Ruszniewski P, et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.". Eur. J. Clin. Invest. 27 (8): 639–44. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525.  
  • Lopez F, Estève JP, Buscail L, et al. (1997). "The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling.". J. Biol. Chem. 272 (39): 24448–54. doi:10.1074/jbc.272.39.24448. PMID 9305905.  
  • Tsutsumi A, Takano H, Ichikawa K, et al. (1997). "Expression of somatostatin receptor subtype 2 mRNA in human lymphoid cells.". Cell. Immunol. 181 (1): 44–9. doi:10.1006/cimm.1997.1193. PMID 9344495.  
  • Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.". Mol. Endocrinol. 13 (1): 82–90. doi:10.1210/me.13.1.82. PMID 9892014.  
  • Kumar U, Sasi R, Suresh S, et al. (1999). "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.". Diabetes 48 (1): 77–85. doi:10.2337/diabetes.48.1.77. PMID 9892225.  
  • Zitzer H, Richter D, Kreienkamp HJ (1999). "Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1.". J. Biol. Chem. 274 (26): 18153–6. doi:10.1074/jbc.274.26.18153. PMID 10373412.  
  • Zitzer H, Hönck HH, Bächner D, et al. (2000). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain.". J. Biol. Chem. 274 (46): 32997–3001. PMID 10551867.  
  • Petersenn S, Rasch AC, Presch S, et al. (2000). "Genomic structure and transcriptional regulation of the human somatostatin receptor type 2.". Mol. Cell. Endocrinol. 157 (1-2): 75–85. PMID 10619399.  
  • Kreienkamp HJ, Zitzer H, Richter D (2001). "Identification of proteins interacting with the rat somatostatin receptor subtype 2.". J. Physiol. Paris 94 (3-4): 193–8. doi:10.1016/S0928-4257(00)00204-7. PMID 11087996.  
  • Ho MK, Yung LY, Chan JS, et al. (2001). "Galpha(14) links a variety of G(i)- and G(s)-coupled receptors to the stimulation of phospholipase C.". Br. J. Pharmacol. 132 (7): 1431–40. doi:10.1038/sj.bjp.0703933. PMID 11264236.  
  • Zatelli MC, Tagliati F, Taylor JE, et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.". J. Clin. Endocrinol. Metab. 86 (5): 2161–9. doi:10.1210/jc.86.5.2161. PMID 11344221.  
  • Talme T, Ivanoff J, Hägglund M, et al. (2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3.". Clin. Exp. Immunol. 125 (1): 71–9. doi:10.1046/j.1365-2249.2001.01577.x. PMID 11472428.  
  • Klisovic DD, O'Dorisio MS, Katz SE, et al. (2001). "Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study.". Invest. Ophthalmol. Vis. Sci. 42 (10): 2193–201. PMID 11527930.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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