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Somatostatin receptor 4
Symbols SSTR4;
External IDs OMIM182454 MGI105372 HomoloGene20286 IUPHAR: sst4 GeneCards: SSTR4 Gene
RNA expression pattern
PBB GE SSTR4 214556 at tn.png
More reference expression data
Species Human Mouse
Entrez 6754 20608
Ensembl ENSG00000132671 ENSMUSG00000037014
UniProt P31391 Q8BQ97
RefSeq (mRNA) NM_001052 NM_009219
RefSeq (protein) NP_001043 NP_033245
Location (UCSC) Chr 20:
22.96 - 22.97 Mb
Chr 2:
148.09 - 148.09 Mb
PubMed search [1] [2]

Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene.[1][2]

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.[2]


See also


Further reading

  • Patel YC (1999). "Somatostatin and its receptor family.". Frontiers in neuroendocrinology 20 (3): 157–98. doi:10.1006/frne.1999.0183. PMID 10433861.  
  • Yamada Y, Post SR, Wang K, et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. doi:10.1073/pnas.89.1.251. PMID 1346068.  
  • Demchyshyn LL, Srikant CB, Sunahara RK, et al. (1993). "Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20.". Mol. Pharmacol. 43 (6): 894–901. PMID 8100352.  
  • Yasuda K, Espinosa R, Davis EM, et al. (1993). "Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2.". Genomics 17 (3): 785–6. doi:10.1006/geno.1993.1410. PMID 8244401.  
  • Yamada Y, Kagimoto S, Kubota A, et al. (1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.". Biochem. Biophys. Res. Commun. 195 (2): 844–52. doi:10.1006/bbrc.1993.2122. PMID 8373420.  
  • Kaupmann K, Bruns C, Hoyer D, et al. (1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain.". FEBS Lett. 331 (1-2): 53–9. doi:10.1016/0014-5793(93)80296-7. PMID 8405411.  
  • Yamada Y, Stoffel M, Espinosa R, et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms.". Genomics 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518.  
  • Xu Y, Song J, Bruno JF, Berelowitz M (1993). "Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4.". Biochem. Biophys. Res. Commun. 193 (2): 648–52. doi:10.1006/bbrc.1993.1673. PMID 8512564.  
  • Fukusumi S, Kitada C, Takekawa S, et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide.". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.  
  • de Lecea L, Ruiz-Lozano P, Danielson PE, et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.". Genomics 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.  
  • Jaïs P, Terris B, Ruszniewski P, et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.". Eur. J. Clin. Invest. 27 (8): 639–44. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525.  
  • Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.". Mol. Endocrinol. 13 (1): 82–90. doi:10.1210/me.13.1.82. PMID 9892014.  
  • Forssell-Aronsson EB, Nilsson O, Bejegård SA, et al. (2000). "111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors.". J. Nucl. Med. 41 (4): 636–42. PMID 10768564.  
  • Zatelli MC, Tagliati F, Taylor JE, et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.". J. Clin. Endocrinol. Metab. 86 (5): 2161–9. doi:10.1210/jc.86.5.2161. PMID 11344221.  
  • Talme T, Ivanoff J, Hägglund M, et al. (2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3.". Clin. Exp. Immunol. 125 (1): 71–9. doi:10.1046/j.1365-2249.2001.01577.x. PMID 11472428.  
  • Pasquali D, Notaro A, Esposito D, et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID 11753241.  
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  
  • Papotti M, Bongiovanni M, Volante M, et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis.". Virchows Arch. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID 12021920.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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