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Sp2 transcription factor: Wikis


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Sp2 transcription factor
Symbols SP2;
External IDs OMIM601801 MGI1926162 HomoloGene2340 GeneCards: SP2 Gene
RNA expression pattern
PBB GE SP2 204367 at tn.png
PBB GE SP2 211736 at tn.png
More reference expression data
Species Human Mouse
Entrez 6668 78912
Ensembl ENSG00000167182 ENSMUSG00000018678
UniProt Q02086 Q3U0T7
RefSeq (mRNA) NM_003110 NM_001080964
RefSeq (protein) NP_003101 NP_001074433
Location (UCSC) Chr 17:
43.33 - 43.36 Mb
Chr 11:
96.77 - 96.78 Mb
PubMed search [1] [2]

Transcription factor Sp2 is a protein that in humans is encoded by the SP2 gene.[1][2][3]

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters.[3]



Sp2 transcription factor has been shown to interact with E2F1.[4]


  1. ^ Kingsley C, Winoto A (Oct 1992). "Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression". Mol Cell Biol 12 (10): 4251–61. PMID 1341900.  
  2. ^ Scohy S, Van Vooren P, Szpirer C, Szpirer J (Oct 1998). "Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1), 10q31→q32.1 (Sp2), 3q24→q31 (Sp3) and 6q33 (Sp4) and of the SP2 gene to human chromosome bands 17q21.3→q22 by in situ hybridization". Cytogenet Cell Genet 81 (3-4): 273–4. PMID 9730617.  
  3. ^ a b "Entrez Gene: SP2 Sp2 transcription factor".  
  4. ^ Rotheneder, H; Geymayer S, Haidweger E (Nov. 1999). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". J. Mol. Biol. (ENGLAND) 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. ISSN 0022-2836. PMID 10547281.  

Further reading

  • Philipsen S, Suske G (1999). "A tale of three fingers: the family of mammalian Sp/XKLF transcription factors.". Nucleic Acids Res. 27 (15): 2991–3000. doi:10.1093/nar/27.15.2991. PMID 10454592.  
  • Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.  
  • Rotheneder H, Geymayer S, Haidweger E (2000). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter.". J. Mol. Biol. 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. PMID 10547281.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Moorefield KS, Fry SJ, Horowitz JM (2004). "Sp2 DNA binding activity and trans-activation are negatively regulated in mammalian cells.". J. Biol. Chem. 279 (14): 13911–24. doi:10.1074/jbc.M313589200. PMID 14726517.  
  • Phan D, Cheng CJ, Galfione M, et al. (2004). "Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis.". Cancer Res. 64 (9): 3072–8. doi:10.1158/0008-5472.CAN-03-3730. PMID 15126343.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Phillips RJ, Tyson-Capper Née Pollard AJ, Bailey J, et al. (2005). "Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases.". J. Clin. Endocrinol. Metab. 90 (6): 3479–90. doi:10.1210/jc.2004-1962. PMID 15788387.  
  • Lee YC, Higashi Y, Luu C, et al. (2005). "Sp1 elements in SULT2B1b promoter and 5'-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition.". FEBS Lett. 579 (17): 3639–45. doi:10.1016/j.febslet.2005.05.041. PMID 15953604.  
  • Simmons SO, Horowitz JM (2006). "Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells.". Biochem. J. 393 (Pt 1): 397–409. doi:10.1042/BJ20051030. PMID 16201967.  
  • Moorefield KS, Yin H, Nichols TD, et al. (2006). "Sp2 localizes to subnuclear foci associated with the nuclear matrix.". Mol. Biol. Cell 17 (4): 1711–22. doi:10.1091/mbc.E05-11-1063. PMID 16467376.  
  • Das A, Fernandez-Zapico ME, Cao S, et al. (2007). "Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration.". J. Biol. Chem. 281 (51): 39105–13. doi:10.1074/jbc.M607720200. PMID 17071613.  

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