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Sp3 transcription factor

PDB rendering based on 1va1.
Available structures
Symbols SP3; DKFZp686O1631; SPR-2
External IDs OMIM601804 MGI1277166 HomoloGene7952 GeneCards: SP3 Gene
RNA expression pattern
PBB GE SP3 213168 at tn.png
More reference expression data
Species Human Mouse
Entrez 6670 20687
Ensembl ENSG00000172845 ENSMUSG00000027109
UniProt Q02447 Q2M4I5
RefSeq (mRNA) NM_001017371 NM_011450
RefSeq (protein) NP_001017371 NP_035580
Location (UCSC) Chr 2:
174.48 - 174.54 Mb
Chr 2:
72.74 - 72.78 Mb
PubMed search [1] [2]

Sp3 transcription factor, also known as SP3, refers to both a protein and the gene it is encoded by.

This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted.[1]


Sp3 transcription factor has been shown to interact with Histone deacetylase 2,[2][3] PIAS1,[4] E2F1[5] and GABPA.[6]


  1. ^ "Entrez Gene: SP3 Sp3 transcription factor".  
  2. ^ Won, Jaejoon; Yim Jeongbin, Kim Tae Kook (Oct. 2002). "Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells". J. Biol. Chem. (United States) 277 (41): 38230–8. doi:10.1074/jbc.M206064200. ISSN 0021-9258. PMID 12151407.  
  3. ^ Sun, Jian-Min; Chen Hou Yu, Moniwa Mariko, Litchfield David W, Seto Edward, Davie James R (Sep. 2002). "The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2". J. Biol. Chem. (United States) 277 (39): 35783–6. doi:10.1074/jbc.C200378200. ISSN 0021-9258. PMID 12176973.  
  4. ^ Sapetschnig, Alexandra; Rischitor Grigore, Braun Harald, Doll Andreas, Schergaut Marion, Melchior Frauke, Suske Guntram (Oct. 2002). "Transcription factor Sp3 is silenced through SUMO modification by PIAS1". EMBO J. (England) 21 (19): 5206–15. ISSN 0261-4189. PMID 12356736.  
  5. ^ Rotheneder, H; Geymayer S, Haidweger E (Nov. 1999). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". J. Mol. Biol. (ENGLAND) 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. ISSN 0022-2836. PMID 10547281.  
  6. ^ Galvagni, F; Capo S, Oliviero S (Mar. 2001). "Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter". J. Mol. Biol. (England) 306 (5): 985–96. doi:10.1006/jmbi.2000.4335. ISSN 0022-2836. PMID 11237613.  

Further reading

  • Tseng L, Gao J, Mazella J, et al. (1997). "Differentiation-dependent and cell-specific regulation of the hIGFBP-1 gene in human endometrium.". Ann. N. Y. Acad. Sci. 828: 27–37. doi:10.1111/j.1749-6632.1997.tb48521.x. PMID 9329821.  
  • Zhang Y, Dufau ML (2003). "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes.". J. Steroid Biochem. Mol. Biol. 85 (2-5): 401–14. doi:10.1016/S0960-0760(03)00230-9. PMID 12943729.  


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