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Spermidine: Wikis

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Spermidine
Spermidine-2D-skeletal.png
Spermidine-3D-balls.png
IUPAC name
Other names 1,5,10-triazadecane
Identifiers
CAS number 124-20-9 Yes check.svgY
PubChem 1102
MeSH Spermidine
SMILES
Properties
Molecular formula C7H19N3
Molar mass 145.246
Density 0.925 g/mL at 25 °C
Melting point

22-25.0 °C

 Yes check.svgY (what is this?)  (verify)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Spermidine is a polyamine involved in cellular metabolism that can be used to stimulate the enzyme, T7 RNA polymerase, a type of RNA polymerase. Spermidine has also been found to reduce the amount of ageing in yeast, flies, worms and human immune cells by inducing autophagy[1].

Contents

Biochemical actions

  • Inhibits neuronal nitric oxide synthase (nNOS).
  • Binds and precipitates DNA.
  • May be used for purification of DNA binding proteins.
  • Stimulates T4 polynucleotide kinase activity.

Some of the uses

  • Can be used in electroporation while transferring the DNA into the cell under the electrical impulse.

See also

References

  1. ^ Eisenberg et al. (2009). Induction of autophagy by spermidine promotes longevity. Nature Cell Biology

External links


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