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Spiramide: Wikis


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Systematic (IUPAC) name
CAS number 510-74-7
ATC code none
PubChem 68186
Chemical data
Formula C22H27FN3O2 
Mol. mass 384.466 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status

Spiramide (AMI-193) is a a selective 5-HT2A, 5-HT1A, and D2 receptor antagonist. It has negligible affinity for the 5-HT2C receptor.[1][2][3]


  1. ^ Czoty PW, Howell LL (October 2000). "Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist, in the squirrel monkey". Pharmacology, Biochemistry, and Behavior 67 (2): 257–64. PMID 11124389. 
  2. ^ Luparini MR, Garrone B, Pazzagli M, Pinza M, Pepeu G (November 2004). "A cortical GABA-5HT interaction in the mechanism of action of the antidepressant trazodone". Progress in Neuro-psychopharmacology & Biological Psychiatry 28 (7): 1117–27. doi:10.1016/j.pnpbp.2004.05.046. PMID 15610924. 
  3. ^ Hamada K, Yoshida M, Isayama H, Yagi Y, Kanazashi S, Kashihara Y, Takeuchi K, Yamaguchi I (November 2007). "Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice". Journal of Pharmacological Sciences 105 (3): 240–50. PMID 17965538. 


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