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Squalene epoxidase
Cholesterol-Synthesis-Reaction11.png
Chemical reaction catalyzed by squalene epoxidase.
Identifiers
EC number 1.14.99.7
CAS number 9029-62-3
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures
Gene Ontology AmiGO / EGO
squalene epoxidase
Identifiers
Symbol SQLE
Entrez 6713
HUGO 11279
OMIM 602019
RefSeq NM_003129
UniProt Q14534
Other data
EC number 1.14.99.7
Locus Chr. 8 q24.1

Squalene monooxygenase (or squalene epoxidase) is an enzyme that uses NADPH and molecular oxygen to oxidize squalene to 2,3-oxidosqualene (squalene epoxide). Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway.[1] In humans, squalene epoxidase is encoded by the SQLE gene.[2]

Contents

Inhibitors

Inhibitors of squalene epoxidase have found application mainly as antifungal drugs:[3]

Since squalene epoxidase is on the biosynthetic pathway leading to cholesterol, inhibitors of this enzyme may also find application in treatment of hypercholesterolemia.[5]

Localization

squalene epoxidase is localized to both the endoplasmic reticulum and lipid droplets. Only the ER localized protein is active.

Additional products

Squalene epoxidase also catalyzes the formation of 2,3;22,23-diepoxysqualene (DOS). DOS is converted to 24(S),25-epoxylanosterol by lanosterol synthase.

See also

References

  1. ^ "Entrez Gene: SQLE squalene epoxidase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6713.  
  2. ^ Nagai M, Sakakibara J, Wakui K, Fukushima Y, Igarashi S, Tsuji S, Arakawa M, Ono T (August 1997). "Localization of the squalene epoxidase gene (SQLE) to human chromosome region 8q24.1". Genomics 44 (1): 141–3. doi:10.1006/geno.1997.4825. PMID 9286711.  
  3. ^ Favre B, Ryder NS (February 1996). "Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents". Antimicrob. Agents Chemother. 40 (2): 443–7. PMID 8834895. PMC 163131. http://aac.asm.org/cgi/pmidlookup?view=long&pmid=8834895.  
  4. ^ Ryder NS (February 1992). "Terbinafine: mode of action and properties of the squalene epoxidase inhibition". Br. J. Dermatol. 126 Suppl 39: 2–7. PMID 1543672.  
  5. ^ Chugh A, Ray A, Gupta JB (January 2003). "Squalene epoxidase as hypocholesterolemic drug target revisited". Prog. Lipid Res. 42 (1): 37–50. PMID 12467639. http://linkinghub.elsevier.com/retrieve/pii/S0163782702000292.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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