The Full Wiki

Squamous cell carcinoma: Wikis

  

Encyclopedia

From Wikipedia, the free encyclopedia

Squamous cell carcinoma, NOS
Classification and external resources

SCC of the skin tends to arise from pre-malignant lesions, actinic keratoses; surface is usually scaly and often ulcerates (as shown here).
ICD-10 C44.
ICD-9 [1]
ICD-O: M8070/3
MedlinePlus 000829
eMedicine derm/401
MeSH D002294
.In medicine, squamous cell carcinoma (SCC) is a form of cancer of the carcinoma type that may occur in many different organs, including the skin, lips, mouth, esophagus, urinary bladder, prostate, lungs, vagina, and cervix.^ Squamous cell carcinoma is second the most common skin in the cancer States,.
  • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

^ Squamous Cell Cancer of the base of tongue The most common type of cancer of the tongue is called Squamous Cell Carcinoma.
  • Tongue Cancer Answers 10 January 2010 9:09 UTC www.tonguecancer.com [Source type: FILTERED WITH BAYES]

^ What are the symptoms of squamous cell carcinoma in cats?
  • Squamous Cell Carcinoma in Cats - Causes, Symptoms & Treatment - Cat-World 10 January 2010 9:09 UTC www.cat-world.com.au [Source type: General]

.It is a malignant tumor of squamous epithelium (epithelium that shows squamous cell differentiation).^ Skin malignancies, squamous cell carcinoma.
  • Or-Live Content: Squamous Cell Carcinoma 10 January 2010 9:09 UTC mediwire.or-live.com [Source type: Academic]

^ The malignancy is characteristic of differentiation of the squamous cell.
  • Treatment for Squamous Cell Carcinoma 10 January 2010 9:09 UTC www.buzzle.com [Source type: Academic]

^ Some of tumor cells showed CD74+.
  • Head & Neck Oncology | Full text | Identification of potential therapeutic targets in human head & neck squamous cell carcinoma 10 January 2010 9:09 UTC www.headandneckoncology.org [Source type: Academic]

Contents

Classification

Squamous cell carcinoma may be classified into the following types:[1]:473

Terminology

A large squamous cell carcinoma of the tongue.
.A carcinoma can be characterized as either in situ (confined to the original site) or invasive, depending on whether the cancer invades underlying tissues; only invasive cancers are able to spread to other organs and cause metastasis.^ On rare occasions this cancer can spread to other organs and even be fatal.
  • Squamous cell cancer, information, photographs, cause, treatment, cure by Orlando Board Certified Dermatologist John L. Meisenheimer, M.D. skin care specialist 10 January 2010 9:09 UTC www.orlandoskindoc.com [Source type: FILTERED WITH BAYES]

^ These lesions can progress to carcinoma in situ and then to invasive cancer.
  • Diagnosis and Treatment of Basal Cell and Squamous Cell Carcinomas - October 15, 2004 - American Family Physician 10 January 2010 9:09 UTC www.aafp.org [Source type: Academic]

^ A carcinoma can be characterized as either ''in situ'' (confined to the original site) or ''invasive'', depending on whether the cancer invades underlying tissues; only invasive cancers are able to spread to other organs and cause metastasis.
  • What is Squamous Cell Carcinoma? 10 January 2010 9:09 UTC www.news-medical.net [Source type: Academic]

.Squamous cell carcinoma in situ are also called Bowen's disease.^ Diseases and conditions, Cancer, Skin cancer, Squamous cell carcinoma .

^ Oral premalignancies and squamous cell carcinoma .
  • Oral premalignancies and squamous cell carcinoma - UQ eSpace 10 January 2010 9:09 UTC espace.library.uq.edu.au [Source type: Academic]

^ What causes basal cell and squamous cell carcinoma?
  • Skin cancer - basal cell and squamous cell carcinoma 10 January 2010 9:09 UTC www.netdoctor.co.uk [Source type: FILTERED WITH BAYES]

Related conditions

.
  • Erythroplasia of Queyrat
  • Keratoacanthoma is a low-grade malignancy of the skin.^ Erythroplasia of Queyrat Keratoacanthoma is a low-grade malignancy of the skin.
    • What is Squamous Cell Carcinoma? 10 January 2010 9:09 UTC www.news-medical.net [Source type: Academic]

    ^ Low grade malignancy called Keratoacanthoma that develops on the skin.
    • Treatment for Squamous Cell Carcinoma 10 January 2010 9:09 UTC www.buzzle.com [Source type: Academic]

    ^ Low-grade SCCs and well-differentiated lesions, such as actinic keratosis, keratoacanthoma, and Bowen disease (SCC in situ), may be managed with medical therapies.
    • Skin Malignancies, Squamous Cell Carcinoma: eMedicine Plastic Surgery 10 January 2010 9:09 UTC emedicine.medscape.com [Source type: Academic]

    .It originates in the pilo-sebaceous glands, and is similar in clinical presentation and microscopic analysis to squamous cell carcinoma, except that it contains a central keratin plug.^ Oral premalignancies and squamous cell carcinoma .
    • Oral premalignancies and squamous cell carcinoma - UQ eSpace 10 January 2010 9:09 UTC espace.library.uq.edu.au [Source type: Academic]

    ^ Squamous cell carcinoma is largely preventable.
    • Squamous Cell Carcinoma of the Skin - a knol by Bryan Cho MD, PhD 10 January 2010 9:09 UTC knol.google.com [Source type: FILTERED WITH BAYES]

    ^ Histopathology Cervix- - Squamous cell carcinoma .
    • "Squamous cell carcinoma" | How To Videos and Guides | Howcast.com 10 January 2010 9:09 UTC www.howcast.com [Source type: FILTERED WITH BAYES]

    Statistically, it is less likely to become invasive than squamous cell carcinoma.
  • Bowen's disease is a sunlight-induced skin disease, and is considered to be an early form of squamous cell carcinoma.
  • Marjolin's ulcer is a type of squamous cell carcinoma that arises from a non-healing ulcer or burn wound.
  • Melanoma
  • Basal Cell Carcinoma

Signs and symptoms

.It begins as a small nodule and as it enlarges the center becomes necrotic and sloughs and the nodule turns into an ulcer.^ Rita had become alarmed when she noticed difficulty in swallowing and a small extraoral nodule inferior to the mandible on the left side.
  • RDH Magazine- - Squamous cell carcinoma of the tonsil 10 January 2010 9:09 UTC www.rdhmag.com [Source type: Academic]

^ Squamous Cell Carcinoma usually begins as a precancerous growth and slowly develops into a firm small irritated lump.
  • AfraidtoAsk.com » SQUAMOUS CELL CARCINOMA 10 January 2010 9:09 UTC www.afraidtoask.com [Source type: FILTERED WITH BAYES]

^ Actinic keratosis should be removed because in a very small percentage of cases, actinic keratosis can turn into squamous cell carcinoma.
  • Skin Cancer - Squamous Cell Carcinoma - Orlando & Central Florida Urgent Care - Patient Education Library 10 January 2010 9:09 UTC centracare.org [Source type: Academic]
  • Skin Cancer - Squamous Cell Carcinoma - Athens Cancer Center - Athens, OH - Patient Education 10 January 2010 9:09 UTC athenscancercenter.net [Source type: FILTERED WITH BAYES]
  • Skin Cancer - Squamous Cell Carcinoma - Palm Beach Dermatology Group - Delray Beach, FL - Patient Education Library 10 January 2010 9:09 UTC www.palmbeachdermatologygroup.com [Source type: FILTERED WITH BAYES]

.
  • The lesion caused by SCC is often asymptomatic
  • Ulcer or reddish skin plaque that is slow growing
  • Intermittent bleeding from the tumor, especially on the lip
  • The clinical appearance is highly variable
  • Usually the tumor presents as an ulcerated lesion with hard, raised edges
  • The tumor may be in the form of a hard plaque or a papule, often with an opalescent quality, with telangiectasia
  • The tumor can lie below the level of the surrounding skin, and eventually ulcerates and invades the underlying tissue
  • The tumor commonly presents on sun-exposed areas (e.g.^ Ulceration may occur as the lesion enlarges.

    ^ These lesions are usually slow growing and rarely spread to other areas of the body.
    • Basal Cell and Squamous Cell Carcinoma 10 January 2010 9:09 UTC www.umgcc.org [Source type: Academic]

    ^ The appearance may vary from time to time.
    • The National Canine Cancer Foundation - Squamous Cell Carcinoma 10 January 2010 9:09 UTC www.wearethecure.org [Source type: FILTERED WITH BAYES]

    back of the hand, scalp, lip, and superior surface of .pinna)
  • On the lip, the tumor forms a small ulcer, which fails to heal and bleeds intermittently
  • Evidence of chronic skin photodamage, such as multiple actinic keratoses (solar keratoses)
  • The tumor grows relatively slowly
  • Unlike basal cell carcinoma (BCC), squamous cell carcinoma (SCC) has a substantial risk of metastasis
  • Risk of metastasis is higher in SCC arising in scars, on the lower lips or mucosa, and occurring in immunosuppressed patients.^ Diseases and conditions, Cancer, Skin cancer, Squamous cell carcinoma .

    ^ Squamous cell carcinoma may also develop in areas of chronic inflammation or scars, such as ulcers and burns.
    • Basal Cell and Squamous Cell Carcinoma 10 January 2010 9:09 UTC www.umgcc.org [Source type: Academic]

    ^ Squamous cell carcinoma is a form of skin cancer .
    • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

    About *one-third of lingual and mucosal tumors metastasize before diagnosis (these are often related to tobacco and alcohol use)

Cause

HPV

.Human papilloma virus has been associated with SCC of the oropharynx, lung, fingers, anogenital region.^ Their development is associated with the presence of a papilloma virus.
  • Squamous Cell Carcinomas - The Merck Veterinary Manual 10 January 2010 9:09 UTC www.merckvetmanual.com [Source type: Academic]

^ A similar condition microscopically which needs to be differentiated is bowenoid papulosis, which is commonly secondary to an oncogenic human papilloma virus infection.
  • Squamous cell carcinoma in situ 10 January 2010 9:09 UTC www.skincareguide.ca [Source type: Academic]

^ Besides this, oral human papilloma virus (HPV) can also be responsible for causing oral squamous cell carcinoma.
  • Oral Squamous Cell Carcinoma 10 January 2010 9:09 UTC www.buzzle.com [Source type: Academic]

By region

Skin
.Squamous cell carcinoma is the second most common cancer of the skin (after basal cell carcinoma but more common than melanoma).^ Diseases and conditions, Cancer, Skin cancer, Squamous cell carcinoma .

^ Oral premalignancies and squamous cell carcinoma .
  • Oral premalignancies and squamous cell carcinoma - UQ eSpace 10 January 2010 9:09 UTC espace.library.uq.edu.au [Source type: Academic]

^ It is not as common as basal cell carcinoma and is typically found in places exposed.
  • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

.It usually occurs in areas exposed to the sun.^ It usually occurs on sun exposed areas of skin, and the nose is the most frequent site.
  • Re: [MOL] Basil Cell Carcinoma [00243] 10 January 2010 9:09 UTC www.meds.com [Source type: Academic]

^ Like the basal cell carcinoma , squamous cell carcinomas usually occur on the sun-exposed areas.
  • Squamous Cell Carcinoma « VIRGINIA BEACH DERMATOLOGY ASSOCIATES, PLLC. 10 January 2010 9:09 UTC yourskinsite.com [Source type: FILTERED WITH BAYES]

^ Is usually present on sun exposed areas such as the ears, lips, nose, face and tops of the hands.
  • Squamous Cell Carcinoma: Hamilton, Grimsby & Stoney Creek 10 January 2010 9:09 UTC www.doctorv.ca [Source type: FILTERED WITH BAYES]

.Sunlight exposure and immunosuppression are risk factors for SCC of the skin with chronic sun exposure being the strongest environmental risk factor.^ Anyone with a substantial history of being in the sun may develop SCC (environmental factor).
  • Skin Cancer Information - SQUAMOUS-CELL CARCINOMA 10 January 2010 9:09 UTC www.skincancerinfo.com [Source type: Academic]

^ Exposure to sunlight is the main risk factor for skin cancer.
  • Squamous cell carcinoma: The skin cancer you haven’t heard about 10 January 2010 9:09 UTC www.health.harvard.edu [Source type: Academic]

^ Chronic sun exposure.
  • Squamous cell carcinoma 10 January 2010 9:09 UTC www.cnn.com [Source type: General]

[2] .The risk of metastasis is low, but is much higher than basal cell carcinoma.^ What causes basal cell and squamous cell carcinoma?
  • Skin cancer - basal cell and squamous cell carcinoma 10 January 2010 9:09 UTC www.netdoctor.co.uk [Source type: FILTERED WITH BAYES]

^ Basal Cell Carcinoma at 40x Magnification .
  • Nikon MicroscopyU | Human Pathology Digital Image Gallery 10 January 2010 9:09 UTC www.microscopyu.com [Source type: Academic]

^ It also rarely spreads, but does so much more often than basal cell carcinoma.
  • Skin Cancer—Overview (Basal Cell Carcinoma, Squamous Cell Carcinoma) | ThirdAge Articles 10 January 2010 9:09 UTC www.thirdage.com [Source type: FILTERED WITH BAYES]

.Squamous cell cancers of the lip and ears have high metastatic and recurrence rate (20 to 50%)[3].^ Recurrent squamous cell carcinoma of the skin.
  • Re: [MOL] Basil Cell Carcinoma [00243] 10 January 2010 9:09 UTC www.meds.com [Source type: Academic]

^ Skin cancer, squamous cell on the hands.
  • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

^ Squamous cell skin cancer .
  • Squamous cell skin cancer: MedlinePlus Medical Encyclopedia 10 January 2010 9:09 UTC www.nlm.nih.gov [Source type: Academic]
  • Squamous cell skin cancer 10 January 2010 9:09 UTC nortonhealthcare.adam.com [Source type: Academic]
  • Basal Cell Carcinoma | LIVESTRONG.COM 10 January 2010 9:09 UTC www.livestrong.com [Source type: FILTERED WITH BAYES]
  • Squamous cell skin cancer - Baptist Hospital Northeast 10 January 2010 9:09 UTC baptistnortheast.adam.com [Source type: Academic]
  • Squamous cell skin cancer - Edward Hospital, Naperville IL Area 10 January 2010 9:09 UTC www.edward.org [Source type: Academic]

.Squamous cell cancers of the skin in individuals on immunotherapy or having lymphoproliferative disorders (leukemias) are much more aggressive, regardless of their location.^ Diseases and conditions, Cancer, Skin cancer, Squamous cell carcinoma .

^ Squamous cell carcinoma is a form of skin cancer .
  • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

^ It doesn’t get as much attention as other skin cancers, but squamous cell cancer is common and serious.
  • Squamous cell carcinoma: The skin cancer you haven’t heard about 10 January 2010 9:09 UTC www.health.harvard.edu [Source type: Academic]

[4]
.Squamous cell carcinoma can generally be treated by excision or mohs surgery.^ What are the symptoms of squamous cell carcinoma in cats?
  • Squamous Cell Carcinoma in Cats - Causes, Symptoms & Treatment - Cat-World 10 January 2010 9:09 UTC www.cat-world.com.au [Source type: General]

^ How is squamous cell carcinoma in cats treated?
  • Squamous Cell Carcinoma in Cats - Causes, Symptoms & Treatment - Cat-World 10 January 2010 9:09 UTC www.cat-world.com.au [Source type: General]

^ Squamous cell carcinoma is largely preventable.
  • Squamous Cell Carcinoma of the Skin - a knol by Bryan Cho MD, PhD 10 January 2010 9:09 UTC knol.google.com [Source type: FILTERED WITH BAYES]

.Nonsurgical options for the treatment of cutaneous SCC include topical chemotherapy, topical immune response modifiers, photodynamic therapy (PDT), radiotherapy, and systemic chemotherapy.^ One squamous cell carcinoma treatment option is photodynamic therapy (PDT).
  • Squamous Cell Carcinoma Treatment from Cancer Treatment Centers of America 10 January 2010 9:09 UTC www.cancercenter.com [Source type: Academic]

^ PDT, photodynamic therapy, has been shown to be comparable with response from the use of cryotherapy.
  • Squamous cell carcinoma in situ 10 January 2010 9:09 UTC www.skincareguide.ca [Source type: Academic]

^ These include cryosurgery or specialized adjunct treatments such as photodynamic therapy or radiotherapy.
  • Skin Origin Squamous Cell Carcinoma in Dogs | Dog Oncology Index | Articles & Resources about Cancer in Dogs | FetchDog 10 January 2010 9:09 UTC www.fetchdog.com [Source type: Academic]

.The use of topical therapy and PDT is generally limited to premalignant (ie, AKs) and in situ lesions.^ Topical therapy with imiquimod26 or 5-fluorouracil27 can be used on superficial lesions.
  • Squamous Cell Carcinoma in Organ Transplant Recipients: Approach to Management 10 January 2010 9:09 UTC www.skintherapyletter.com [Source type: Academic]

^ You can also use radiation therapy, it generally for older or debilitated patients and for those areas where surgery is difficult, such as the eyes, ears, nose, and throat.

^ Two studies have shown that renal transplant patients using topical tretinoin have significantly less keratotic skin lesions.
  • Squamous Cell Carcinoma in Solid-Organ Transplantation 10 January 2010 9:09 UTC dermatology.cdlib.org [Source type: Academic]

.Radiation therapy is a primary treatment option for patients in whom surgery is not feasible and is an adjuvant therapy for those with metastatic or high-risk cutaneous SCC. At this time, systemic chemotherapy is used exclusively for patients with metastatic disease.^ Treatment involves either surgery or a combination of chemotherapy with radiation treatment.

^ Radiotherapy is a rational choice as adjuvant therapy for the treatment of high-risk cutaneous SCC after excision.

^ Radiation therapy and chemotherapy are often used as adjuvants to surgery, but are occasionally the primary means of treatment, especially in individuals that are unable to undergo surgery for health reasons.
  • Nikon MicroscopyU | Human Pathology Digital Image Gallery 10 January 2010 9:09 UTC www.microscopyu.com [Source type: Academic]

.Australian scientist Ian Frazer who developed the cervical cancer vaccine, says that animal tests have been effective in preventing squamous cell carcinoma in animals, and there may be a human vaccine against this kind of skin cancer within the decade.^ What are the symptoms of squamous cell carcinoma in cats?
  • Squamous Cell Carcinoma in Cats - Causes, Symptoms & Treatment - Cat-World 10 January 2010 9:09 UTC www.cat-world.com.au [Source type: General]

^ If it is a precursor condition, early treatment will prevent it from developing into a squamous cell carcinoma.

^ Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin.
  • WikiGenes - Carcinoma, Squamous Cell 10 January 2010 9:09 UTC www.wikigenes.org [Source type: Academic]

[5]
Head and neck cancer
.
Biopsy of a highly differentiated squamous cell carcinoma of the mouth.
^ What are the symptoms of squamous cell carcinoma in cats?
  • Squamous Cell Carcinoma in Cats - Causes, Symptoms & Treatment - Cat-World 10 January 2010 9:09 UTC www.cat-world.com.au [Source type: General]

^ Squamous cell carcinoma is largely preventable.
  • Squamous Cell Carcinoma of the Skin - a knol by Bryan Cho MD, PhD 10 January 2010 9:09 UTC knol.google.com [Source type: FILTERED WITH BAYES]

^ Squamous cell carcinoma - invasive.
  • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

Haematoxylin & eosin stain.
.Most cases of head and neck cancer (cancer of the mouth, nasal cavity, nasopharynx, throat and associated structures) are due to squamous cell carcinoma.^ Diseases and conditions, Cancer, Skin cancer, Squamous cell carcinoma .

^ Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck .
  • Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck -- Li et al. 25 (10): 1911 -- Carcinogenesis 10 January 2010 9:09 UTC carcin.oxfordjournals.org [Source type: Academic]

^ Thyroid neoplasm, carcinoma, squamous cell carcinoma, cancer .
  • Primary Squamous Cell Carcinoma of the Thyroid - A Case Report - Malaysian Abstracting and Indexing System 10 January 2010 9:09 UTC myais.fsktm.um.edu.my [Source type: Academic]

.Symptoms may include a poorly healing mouth ulcer, a hoarse voice or other persistent problems in the area.^ Microscopic shaving (Mohs surgery) may be used to remove tumors in visible areas, such as the nose, ears, and other areas of the face.
  • Squamous cell skin cancer: MedlinePlus Medical Encyclopedia 10 January 2010 9:09 UTC www.nlm.nih.gov [Source type: Academic]

^ Symptoms include: A raised red patch that is scaly or rough A raised patch of skin that may appear to have horn-like rough edges In color, the patch may be reddish, pink, flesh-colored, or reddish-brown Poorly defined outline, with some satellite growths A long-standing sore that will not heal with simple at-home treatment .
  • Kent Hospital Warwick, RI 10 January 2010 9:09 UTC www.kenthospital.org [Source type: Academic]
  • St. David's HealthCare - Health Information - Squamous Cell Carcinoma 10 January 2010 9:09 UTC stdavids.com [Source type: Academic]
  • Squamous Cell Carcinoma ; Seattle Washington WA 10 January 2010 9:09 UTC www.swedish.org [Source type: Academic]
  • Your Health - Squamous Cell Carcinoma 10 January 2010 9:09 UTC www.aurorahealthcare.org [Source type: FILTERED WITH BAYES]
  • Squamous Cell Carcinoma (Nonmelanoma Skin Cancer) | ThirdAge Articles 10 January 2010 9:09 UTC www.thirdage.com [Source type: General]
  • Tufts Medical Center - Squamous Cell Carcinoma 10 January 2010 9:09 UTC www.tufts-nemc.org [Source type: Academic]
  • St. Joseph and Redwood Memorial Hospitals - Squamous Cell Carcinoma 10 January 2010 9:09 UTC stjosepheureka.myhospitalwebsite.com [Source type: Academic]
  • Northern Arizona Healthcare - Squamous Cell Carcinoma 10 January 2010 9:09 UTC www.nahealth.com [Source type: Academic]

^ However, depending on the severity of the specific symptoms and the reproductive intentions of the patient, other treatments may be recommended.
  • Nikon MicroscopyU | Human Pathology Digital Image Gallery 10 January 2010 9:09 UTC www.microscopyu.com [Source type: Academic]

.Treatment is usually with surgery (which may be extensive) and radiotherapy.^ Rabuzzi DD, Mickler AS, Clutter DJ, et al: Treatment results of combined high-dose preoperative radiotherapy and surgery for oropharyngeal cancer.
  • Radiation Therapy for Squamous Cell Carcinoma of the Tonsillar Region: A Preferred Alternative to Surgery? -- Mendenhall et al. 18 (11): 2219 -- Journal of Clinical Oncology 10 January 2010 9:09 UTC jco.ascopubs.org [Source type: Academic]

^ If they are not treated, some of them may become skin cancer, requiring more extensive treatment.
  • Skin Cancer Detection - Precancerous Growths - Melanoma - Basal Cell Carcinoma - Squamous Cell Carcinoma - Fullerton Renee Cobos 10 January 2010 9:09 UTC fullertondermatology.com [Source type: FILTERED WITH BAYES]

^ Treatment may involve surgery, radiation therapy, and/or chemotherapy.
  • The National Canine Cancer Foundation - Squamous Cell Carcinoma 10 January 2010 9:09 UTC www.wearethecure.org [Source type: FILTERED WITH BAYES]

Risk factors include smoking and alcohol consumption
Causation: Cancers of the head and neck are usually caused by tobacco and alcohol, but according to the CDC, recent studies show that about 25% of mouth and 35% of throat cancers are caused by HPV. The 5 year disease free survival rate for HPV positive cancer is significantly higher when appropriately treated with surgery, radiation and chemotherapy as compared to non-HPV positive cancer, substantiated by multiple studies including research conducted by Dr. Maureen Gillison et al. of .Johns Hopkins Sidney Kimmel Cancer Center.^ Health Alert links to John's Hopkins, a highly respected medical institution, advocates cancer prevention.
  • Can someone explain squamous cell carcinoma? - Yahoo! Answers 10 January 2010 9:09 UTC answers.yahoo.com [Source type: General]

^ Second off, the John Hopkins's Cancer Alert referred to in the answer above is a hoax and was not released by John Hopkins.
  • Can someone explain squamous cell carcinoma? - Yahoo! Answers 10 January 2010 9:09 UTC answers.yahoo.com [Source type: General]

^ I simply went to the web site for John's Hopkins and clicked on health alerts and how they do confirm prevention of cancer or disease through nutrition.
  • Can someone explain squamous cell carcinoma? - Yahoo! Answers 10 January 2010 9:09 UTC answers.yahoo.com [Source type: General]

Esophagus
.Esophageal cancer may be due to either squamous cell carcinoma (ESCC) or adenocarcinoma (EAC).^ What are the symptoms of squamous cell carcinoma in cats?
  • Squamous Cell Carcinoma in Cats - Causes, Symptoms & Treatment - Cat-World 10 January 2010 9:09 UTC www.cat-world.com.au [Source type: General]

^ Diseases and conditions, Cancer, Skin cancer, Squamous cell carcinoma .

^ Related Searches: esophageal adenocarcinoma , esophageal cancer , neoadjuvant therapy , radiochemotherapy , squamous cell carcinoma, esophageal .
  • Search results: squamous cell carcinoma: Current Medical Articles and Commentary 10 January 2010 9:09 UTC www.jwatch.org [Source type: Academic]

.SCCs tend to occur closer to the mouth, while adenocarcinomas occur closer to the stomach.^ Regardless of the etiology, SCCs in OTRs tend to occur more frequently and be more severe.
  • Squamous Cell Carcinoma in Organ Transplant Recipients: Approach to Management 10 January 2010 9:09 UTC www.skintherapyletter.com [Source type: Academic]

^ Four patients (8%) were diagnosed with SCC at the surgical site after MMS. Recurrent lesions tended to be superficial and occurred in the setting of severe actinic cheilitis.

^ SCCs can occur in the mouth (common in smokers), genital region, within areas of chronic inflammation and scarring, and on the lower lip.

.Dysphagia (difficulty swallowing, solids worse than liquids) and odynophagia are common initial symptoms.^ This was also seen in our case as the patient developed neck nodes first and only later developed other local symptoms like difficulty in swallowing.
  • Cylindric cell carcinoma of the base of the tongue: A rare variant of squamous cell carcinoma Kumar M, Bahl A, Sharma DN, Sharma R, Gupta R, Ahmed S, Julka PK, Rath GK - J Can Res Ther 10 January 2010 9:09 UTC www.cancerjournal.net [Source type: Academic]

.If the disease is localized, esophagectomy may offer the possibility of a cure.^ It may be possible to prevent or arrest the course of the preneoplastic disease by limiting exposure to the sun or tattooing to add pigment protection.
  • Squamous Cell Carcinoma 10 January 2010 9:09 UTC maxshouse.com [Source type: FILTERED WITH BAYES]

^ If the cancer is localized, a partial gastrectomy, which involves the surgical removal of portions of the stomach, is generally the treatment of choice and may result in a permanent cure.
  • Nikon MicroscopyU | Human Pathology Digital Image Gallery 10 January 2010 9:09 UTC www.microscopyu.com [Source type: Academic]

^ They are also sometimes utilized to shrink or slow the growth of tumors and relieve symptoms in individuals whose disease is so advanced at the time of diagnosis that a cure is not possible, though their lives may be prolonged with medical care.
  • Nikon MicroscopyU | Human Pathology Digital Image Gallery 10 January 2010 9:09 UTC www.microscopyu.com [Source type: Academic]

.If the disease has spread, chemotherapy and radiotherapy are commonly used.^ The sole use for chemotherapy is for widespread disease.
  • Modern Pathology - Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Precursors and Problematic Variants 10 January 2010 9:09 UTC www.nature.com [Source type: Academic]

^ The term is most frequently used to describe a diseased state of the liver, the organ that most commonly is affected by cirrhosis.
  • Nikon MicroscopyU | Human Pathology Digital Image Gallery 10 January 2010 9:09 UTC www.microscopyu.com [Source type: Academic]

^ Chemotherapy in an adjuvant setting for microscopic disease following surgery or in conjunction with radiotherapy should be investigated for high-grade lesions.
  • Squamous Cell Carcinoma 10 January 2010 9:09 UTC maxshouse.com [Source type: FILTERED WITH BAYES]

Lung
.
Photograph of a squamous cell carcinoma.
^ Squamous cell carcinoma is largely preventable.
  • Squamous Cell Carcinoma of the Skin - a knol by Bryan Cho MD, PhD 10 January 2010 9:09 UTC knol.google.com [Source type: FILTERED WITH BAYES]

^ Squamous cell carcinoma - invasive.
  • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

^ What causes basal cell and squamous cell carcinoma?
  • Skin cancer - basal cell and squamous cell carcinoma 10 January 2010 9:09 UTC www.netdoctor.co.uk [Source type: FILTERED WITH BAYES]

Tumour is on the left, obstructing the bronchus (lung). Beyond the tumour, the bronchus is inflammed and contains mucus.
.When associated with the lung, it often causes ectopic production of parathyroid hormone-related protein (PTHrP), resulting in hypercalcemia.^ For instance, intravenous drug users can transmit the microorganism via the blood, which often results in multiple abscesses in various parts of the lungs.
  • Nikon MicroscopyU | Human Pathology Digital Image Gallery 10 January 2010 9:09 UTC www.microscopyu.com [Source type: Academic]

^ When photons of UVB light are absorbed by the DNA, damage is caused to the DNA helix, often resulting in C-T single mutations or CC-TT tandem mutations.

^ Tobacco-related carcinogenesis is not limited to the smoking of tobacco products, but there is also a strong association between the use of smokeless tobacco and the development of oral squamous carcinoma.
  • Modern Pathology - Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Precursors and Problematic Variants 10 January 2010 9:09 UTC www.nature.com [Source type: Academic]

Penis
.When squamous cell carcinoma in situ (Bowen's disease) is found on the penis, it is called erythroplasia of Queyrat[6].^ Diseases and conditions, Cancer, Skin cancer, Squamous cell carcinoma .

^ Squamous cell carcinoma - invasive.
  • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

^ What causes basal cell and squamous cell carcinoma?
  • Skin cancer - basal cell and squamous cell carcinoma 10 January 2010 9:09 UTC www.netdoctor.co.uk [Source type: FILTERED WITH BAYES]

.This type of cancer responds very well to imiquimod.^ Chemotherapy, which is a popular form of treatment for many cancer types, has not proven very effective at battling kidney cancer.
  • Nikon MicroscopyU | Human Pathology Digital Image Gallery 10 January 2010 9:09 UTC www.microscopyu.com [Source type: Academic]

^ The different forms of squamous cell carcinoma, a potentially lethal yet usually very treatable skin cancer, will be discussed as well as various types of skin cancer surgery and other therapies currently in use to treat squamous cell carcinoma.
  • Skin Cancer Information - SQUAMOUS-CELL CARCINOMA 10 January 2010 9:09 UTC www.skincancerinfo.com [Source type: Academic]

^ Prostate carcinoma is generally a very slow-growing type of cancer and most typically develops late in life.
  • Nikon MicroscopyU | Human Pathology Digital Image Gallery 10 January 2010 9:09 UTC www.microscopyu.com [Source type: Academic]

Prostate
.When associated with the prostate, squamous cell carcinoma is very aggressive in nature.^ Squamous cell carcinoma is largely preventable.
  • Squamous Cell Carcinoma of the Skin - a knol by Bryan Cho MD, PhD 10 January 2010 9:09 UTC knol.google.com [Source type: FILTERED WITH BAYES]

^ Squamous cell carcinoma - invasive.
  • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

^ It was a squamous cell carcinoma.
  • The Straight Dope: How serious is squamous cell carcinoma? 10 January 2010 9:09 UTC www.straightdope.com [Source type: General]

.It is difficult to detect as there is no increase in prostate specific antigen levels seen; meaning that the cancer is often diagnosed at an advanced stage.^ In addition to age, however, there are a number of other risk factors that increase the likelihood that a woman will develop an adenocarcinoma or other cancer of the endometrium.
  • Nikon MicroscopyU | Human Pathology Digital Image Gallery 10 January 2010 9:09 UTC www.microscopyu.com [Source type: Academic]

^ Uterine sarcomas have often already reached an advanced stage by the time signs or symptoms of the disease become noticeable.
  • Nikon MicroscopyU | Human Pathology Digital Image Gallery 10 January 2010 9:09 UTC www.microscopyu.com [Source type: Academic]

^ There are no specific and efficient antibodies to perform immuno histochemistry, based on the protein backbone of the mucins.
  • Molecular Cancer | Full text | Expression of peanut agglutinin-binding mucin-type glycoprotein in human esophageal squamous cell carcinoma as a marker 10 January 2010 9:09 UTC www.molecular-cancer.com [Source type: Academic]

Vagina and cervix
.Vaginal squamous cell carcinoma spreads slowly and usually stays near the vagina, but may spread to the lungs and liver.^ Squamous cell carcinoma is largely preventable.
  • Squamous Cell Carcinoma of the Skin - a knol by Bryan Cho MD, PhD 10 January 2010 9:09 UTC knol.google.com [Source type: FILTERED WITH BAYES]

^ Squamous cell carcinoma - invasive.
  • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

^ What causes basal cell and squamous cell carcinoma?
  • Skin cancer - basal cell and squamous cell carcinoma 10 January 2010 9:09 UTC www.netdoctor.co.uk [Source type: FILTERED WITH BAYES]

.This is the most common type of vaginal cancer.^ If so, then SCC could be considered the most common type of skin cancer.
  • Histologic Variants of Squamous Cell Carcinoma of the Skin: Introduction 10 January 2010 9:09 UTC www.medscape.com [Source type: Academic]

^ Basal cell carcinoma is the most common type of cancer in humans.
  • Nikon MicroscopyU | Human Pathology Digital Image Gallery 10 January 2010 9:09 UTC www.microscopyu.com [Source type: Academic]

^ Exposure to ultraviolet radiation is the most common cause of this type of cancer.
  • NEJM -- Cutaneous Squamous-Cell Carcinoma 10 January 2010 9:09 UTC content.nejm.org [Source type: Academic]

Diagnosis

Diagnosis is via a biopsy. .For the skin, look under skin biopsy.^ Surgery, including Mohs surgery, in which skin is cut out and immediately looked at under a microscope to check for cancer.
  • Basal Cell Carcinoma | LIVESTRONG.COM 10 January 2010 9:09 UTC www.livestrong.com [Source type: FILTERED WITH BAYES]

^ The dermatologist will look at the skin growth and take a sample, called a biopsy , to test for cancerous cells.
  • Squamous Cell Carcinoma (Nonmelanoma Skin Cancer) | ThirdAge Articles 10 January 2010 9:09 UTC www.thirdage.com [Source type: General]
  • St. Joseph and Redwood Memorial Hospitals - Squamous Cell Carcinoma 10 January 2010 9:09 UTC stjosepheureka.myhospitalwebsite.com [Source type: Academic]

^ Mohs surgery involves cutting out a layer of the skin cancer and immediately looking at it under a microscope to check if any cancer has been left behind.

.The pathological appearance of a squamous cell cancer varies with the depth of the biopsy.^ Skin cancer, squamous cell on the hands.
  • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

^ The appearance of squamous cell carcinoma is more varied than basal cell carcinoma .
  • Squamous Cell Carcinoma of the Skin - Symptoms, Treatment and Prevention 10 January 2010 9:09 UTC www.healthscout.com [Source type: Academic]

^ Squamous cell carcinoma has a variety of appearances.
  • Skin Cancer - Squamous Cell Carcinoma - Orlando & Central Florida Urgent Care - Patient Education Library 10 January 2010 9:09 UTC centracare.org [Source type: Academic]
  • Skin Cancer - Squamous Cell Carcinoma - Athens Cancer Center - Athens, OH - Patient Education 10 January 2010 9:09 UTC athenscancercenter.net [Source type: FILTERED WITH BAYES]
  • Skin Cancer - Squamous Cell Carcinoma - Palm Beach Dermatology Group - Delray Beach, FL - Patient Education Library 10 January 2010 9:09 UTC www.palmbeachdermatologygroup.com [Source type: FILTERED WITH BAYES]

.For that reason, a biopsy including the subcutanous tissue and basalar epithelium, to the surface is necessary for correct diagnosis.^ Diagnosis is often made by medical history and physical examination and confirmed by a skin biopsy (sampling a small portion of tissue for microscopic analysis).
  • Squamous Cell Carcinoma of the Skin - Symptoms, Treatment and Prevention 10 January 2010 9:09 UTC www.healthscout.com [Source type: Academic]

^ A, infiltrating tumor arising in continuity with the surface epithelium arranged in a variety of growth patterns, including lobular (solid) and cord-like patterns.
  • Modern Pathology - Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Precursors and Problematic Variants 10 January 2010 9:09 UTC www.nature.com [Source type: Academic]

.The performance of a shave biopsy (see skin biopsy) might not acquire enough information for a diagnosis.^ If you or your doctor finds a bump or spot that is suspicious for skin cancer, a biopsy may be performed.
  • Squamous Cell Carcinoma of the Skin - a knol by Bryan Cho MD, PhD 10 January 2010 9:09 UTC knol.google.com [Source type: FILTERED WITH BAYES]

^ A shave biopsy removes the top layers of the skin.
  • Skin Cancer - Squamous Cell Carcinoma - Orlando & Central Florida Urgent Care - Patient Education Library 10 January 2010 9:09 UTC centracare.org [Source type: Academic]
  • Skin Cancer - Squamous Cell Carcinoma - Athens Cancer Center - Athens, OH - Patient Education 10 January 2010 9:09 UTC athenscancercenter.net [Source type: FILTERED WITH BAYES]
  • Skin Cancer - Squamous Cell Carcinoma - Palm Beach Dermatology Group - Delray Beach, FL - Patient Education Library 10 January 2010 9:09 UTC www.palmbeachdermatologygroup.com [Source type: FILTERED WITH BAYES]

^ If they suspect that the lesion may be cancerous, they might perform a skin biopsy to confirm their clinical diagnosis.
  • Squamous Cell Carcinoma of the Skin - a knol by Bryan Cho MD, PhD 10 January 2010 9:09 UTC knol.google.com [Source type: FILTERED WITH BAYES]

.An excision biopsy is ideal, but not practical in most cases.^ An excisional biopsy would give you the diagnosis, but if it is cancer, ideally the initial definitive procedure in the neck is a formal neck dissection.
  • Squamous Cell Carcinoma of the Tonsil 10 January 2010 9:09 UTC www.bcm.edu [Source type: Academic]

.An incisional or punch biopsy is preferred.^ In the case of large lesions, incisional biopsies, a small punch biopsy (2 to 3 mm), or a shave biopsy is easy to perform.
  • Diagnosis and Treatment of Basal Cell and Squamous Cell Carcinomas - October 15, 2004 - American Family Physician 10 January 2010 9:09 UTC www.aafp.org [Source type: Academic]

^ After numbing your skin, your doctor may perform a shave, punch, incisional, or excisional biopsy.
  • Skin Cancer - Squamous Cell Carcinoma - Orlando & Central Florida Urgent Care - Patient Education Library 10 January 2010 9:09 UTC centracare.org [Source type: Academic]
  • Skin Cancer - Squamous Cell Carcinoma - Athens Cancer Center - Athens, OH - Patient Education 10 January 2010 9:09 UTC athenscancercenter.net [Source type: FILTERED WITH BAYES]
  • Skin Cancer - Squamous Cell Carcinoma - Palm Beach Dermatology Group - Delray Beach, FL - Patient Education Library 10 January 2010 9:09 UTC www.palmbeachdermatologygroup.com [Source type: FILTERED WITH BAYES]

^ Punch, shave, incisional, or excisional biopsies may be performed and must extend to the level of the mid dermis in order to establish the level of invasion.
  • Skin Malignancies, Squamous Cell Carcinoma: eMedicine Plastic Surgery 10 January 2010 9:09 UTC emedicine.medscape.com [Source type: Academic]

.A shave biopsy is least ideal, especially if only the superficial portion is acquired.^ Raised lesions (i.e., most basal cell and squamous cell carcinomas) can be sampled easily with a simple superficial shave biopsy.
  • Diagnosis and Treatment of Basal Cell and Squamous Cell Carcinomas - October 15, 2004 - American Family Physician 10 January 2010 9:09 UTC www.aafp.org [Source type: Academic]

^ Whenever possible, "superficial" portions from the mucosa overlying the tumor and nontumorous control specimens from at least 5 cm away from the primary tumor site were also obtained.
  • Viable Bacteria Present within Oral Squamous Cell Carcinoma Tissue -- Hooper et al. 44 (5): 1719 -- Journal of Clinical Microbiology 10 January 2010 9:09 UTC jcm.asm.org [Source type: Academic]

Management

.Most squamous cell carcinomas are removed with surgery or topical medication.^ Treatment of Squamous cell carcinoma .

^ Basaloid-squamous cell carcinoma of the bronchus.

^ Squamous cell carcinoma is largely preventable.
  • Squamous Cell Carcinoma of the Skin - a knol by Bryan Cho MD, PhD 10 January 2010 9:09 UTC knol.google.com [Source type: FILTERED WITH BAYES]

.Surgical excision with a margin of healthy tissue is a frequent treatment modality.^ The treatment of PVL is by surgical excision.
  • Modern Pathology - Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Precursors and Problematic Variants 10 January 2010 9:09 UTC www.nature.com [Source type: Academic]

^ Surgical excision with a margin of normal skin .
  • Squamous Cell Carcinoma Treatment Chicago 10 January 2010 9:09 UTC www.lakeviewderm.com [Source type: Academic]

^ If local excision is the chosen method of treatment, a 6-mm margin of surrounding normal tissue should be removed to allow a 95 percent chance of cure.
  • NEJM -- Cutaneous Squamous-Cell Carcinoma 10 January 2010 9:09 UTC content.nejm.org [Source type: Academic]

.Radiotherapy, given as external beam radiotherapy or as brachytherapy (internal radiotherapy), can also be used to treat squamous cell carcinomas.^ Squamous cell carcinoma is largely preventable.
  • Squamous Cell Carcinoma of the Skin - a knol by Bryan Cho MD, PhD 10 January 2010 9:09 UTC knol.google.com [Source type: FILTERED WITH BAYES]

^ Squamous cell carcinoma - invasive.
  • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

^ Invasive squamous cell carcinoma.
  • Modern Pathology - Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Precursors and Problematic Variants 10 January 2010 9:09 UTC www.nature.com [Source type: Academic]

.Mohs surgery is frequently utilized; considered the treatment of choice for squamous cell carcinoma of the skin, physicians have also utilized the method for the treatment of squamous cell carcinoma of the mouth, throat, and neck.^ Diseases and conditions, Cancer, Skin cancer, Squamous cell carcinoma .

^ Squamous cell carcinoma is a form of skin cancer .
  • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

^ Squamous cell carcinoma - invasive.
  • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

[7]
.Imiquimod (Aldara) has been used with success for squamous cell carcinoma in situ of the skin and the penis, but the morbidity and discomfort of the treatment is severe.^ Diseases and conditions, Cancer, Skin cancer, Squamous cell carcinoma .

^ Squamous cell carcinoma is a form of skin cancer .
  • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

^ Squamous cell carcinoma is largely preventable.
  • Squamous Cell Carcinoma of the Skin - a knol by Bryan Cho MD, PhD 10 January 2010 9:09 UTC knol.google.com [Source type: FILTERED WITH BAYES]

.An advantage is the cosmetic result: after treatment, the skin resembles normal skin without the usual scarring and morbidity associated with standard excision.^ It is usually associated with a superior cosmetic result.
  • Re: [MOL] Basil Cell Carcinoma [00243] 10 January 2010 9:09 UTC www.meds.com [Source type: Academic]

^ Advantages of the treatment It usually is an effective treatment.

^ These tumors usually occur in areas of sun-damaged skin and at sites of previous actinic keratoses, burns, scars, or chronic ulcers.
  • Squamous Cell Carcinoma of the Skin - Symptoms, Treatment and Prevention 10 January 2010 9:09 UTC www.healthscout.com [Source type: Academic]

.Imiquimod is not FDA-approved for any squamous cell carcinoma.^ Squamous cell carcinoma is largely preventable.
  • Squamous Cell Carcinoma of the Skin - a knol by Bryan Cho MD, PhD 10 January 2010 9:09 UTC knol.google.com [Source type: FILTERED WITH BAYES]

^ Invasive squamous cell carcinoma.
  • Modern Pathology - Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Precursors and Problematic Variants 10 January 2010 9:09 UTC www.nature.com [Source type: Academic]

^ Squamous Cell Carcinoma at 10x Magnification .
  • Nikon MicroscopyU | Human Pathology Digital Image Gallery 10 January 2010 9:09 UTC www.microscopyu.com [Source type: Academic]

.In 2007, Australian biopharmaceutical company Clinuvel Pharmaceuticals Limited began clinical trials with an experimental treatment, a melanocyte-stimulating hormone called afamelanotide (formerly CUV1647)[8] to provide photoprotection for organ transplant patients against squamous cell carcinoma of the skin and actinic keratosis.^ Diseases and conditions, Cancer, Skin cancer, Squamous cell carcinoma .

^ Squamous cell carcinoma is largely preventable.
  • Squamous Cell Carcinoma of the Skin - a knol by Bryan Cho MD, PhD 10 January 2010 9:09 UTC knol.google.com [Source type: FILTERED WITH BAYES]

^ Squamous cell carcinoma (SCC) usually arises in skin damaged by actinic rays.
  • Squamous cell carcinoma of the scalp arising from chronic cutaneous lupus erythematosus: Report of two Indian patients Bikash Ranjan Kar, Vinod Nair, Gigi Ebenezer, CK Job - Indian J Dermatol Venereol Leprol 10 January 2010 9:09 UTC www.ijdvl.com [Source type: Academic]

[9][10]

Epidemiology

Age-standardized death from melanoma and other skin cancers per 100,000 inhabitants in 2004.[11]
     no data      less than 0.7      0.7-1.4      1.4-2.1      2.1-2.8      2.8-3.5      3.5-4.2      4.2-4.9      4.9-5.6      5.6-6.3      6.3-7      7-7.7      more than 7.7
.Incidence of squamous cell carcinoma varies with age, gender, race, geography, and genetics.^ What is the incidence of sqamous cell carcinoma in albinism?

^ Squamous cell carcinoma is largely preventable.
  • Squamous Cell Carcinoma of the Skin - a knol by Bryan Cho MD, PhD 10 January 2010 9:09 UTC knol.google.com [Source type: FILTERED WITH BAYES]

^ Squamous cell carcinoma - invasive.
  • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

.The incidence of SCC increases with age and the peak incidence is usually around 66 years old.^ Incidence of the tumors increases with age.
  • Nikon MicroscopyU | Human Pathology Digital Image Gallery 10 January 2010 9:09 UTC www.microscopyu.com [Source type: Academic]

^ Incidence of SCC varies around the world.

^ In incidence of NMSC in Caucasians increases proportionally with proximity to the equator, with the incidence of SCC doubling for each 8-10 degree decline in latitude.

.Males are affected with SCC at a ratio of 2:1 in comparison to females.^ Tonsillar cancer is more common in men with a male to female ratio of four to one.
  • Squamous Cell Carcinoma of the Tonsil 10 January 2010 9:09 UTC www.bcm.edu [Source type: Academic]

^ The male to female ratio is approximately 6:1 and the average age is 60 years with a significant history of alcohol and tobacco use typically.
  • Squamous Cell Carcinoma: Management of Cervical Lymph Node Metastasis with an Unknown Primary 10 January 2010 9:09 UTC www.bcm.edu [Source type: Academic]

^ It was found that the SCC-like material is present in human female urine at a level much higher than that found in human serum and in human male urine.
  • Squamous cell carcinoma-like immunoreactive antigen from human female urine - Patent 5306811 10 January 2010 9:09 UTC www.freepatentsonline.com [Source type: Academic]

.Caucasians are more likely to be affected, especially those with fair Celtic skin, if chronically exposed to UV radiation.^ Caucasians and is usually found on fair-skinned .
  • Squamous Carcinoma Cell Lung Cancer Epidermoid 10 January 2010 9:09 UTC martovskiy.ifrance.com [Source type: Academic]

^ Squamous cell carcinoma is the second most common skin cancer found in Caucasians, and is usually found on fair-skinned persons.
  • Squamous Cell Carcinoma, Robert Wood Johnson University Hospital, New Brunswick, NJ, 08903 10 January 2010 9:09 UTC www.rwjuh.edu [Source type: Academic]
  • Squamous Cell Carcinoma 10 January 2010 9:09 UTC www.sharp.com [Source type: Academic]
  • Cancer Types - Squamous Cell Carcinoma, Robert Wood Johnson University Hospital, New Brunswick, NJ, 08903 10 January 2010 9:09 UTC www.rwjuh.edu [Source type: Academic]

^ Other risks include genetic predisposition (skin cancers are more common in those who have light colored skin, blue or green eyes, and blond or red hair), chemical pollution, and overexposure to X-rays or other forms of radiation.
  • AllRefer Health - Squamous Cell Cancer (Cancer - Skin - Squamous Cell, Skin Cancer - Squamous Cell) 10 January 2010 9:09 UTC health.allrefer.com [Source type: Academic]

There are also a few rare congenital diseases predispose to cutaneous malignancy.In certain geographic locations, exposure to arsenic in well water or from industrial sources may significantly increase the risk of SCC. [2]

See also

External links

References


Citable sentences

Up to date as of December 30, 2010

Here are sentences from other pages on Squamous cell carcinoma, which are similar to those in the above article.








Got something to say? Make a comment.
Your name
Your email address
Message