Steatorrhea: Wikis

  
  

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Steatorrhea
Classification and external resources
ICD-10 K90.
ICD-9 579.8
MeSH D045602

Steatorrhea is the presence of excess fat in feces. Stools may also float due to excess lipid, have an oily appearance and be especially foul smelling. An oily anal leakage or some level of fecal incontinence may occur. There is increased fat excretion, which can be measured by determining the fecal fat level. While definitions have not been standardised, fat excretion in feces in excess of 0.3 (g/kg)/day is considered indicative of steatorrhea.

Contents

Possible biological causes

Possible biological causes can be lack of bile acids (due to liver damage, hypolipidemic drugs, or having had the gallbladder removed in a cholecystectomy), defects in pancreatic juices (enzymes), and defective mucosal cells. The absence of bile acids will cause the feces to turn gray or pale. Another cause of steatorrhea is due to the adverse effect of octreotide or lanreotide which are analogs of somatostatin, used clinically to treat acromegaly.

Seen in

As a side effect of weight-loss drugs or 'functional foods'

Steatorrhea can also be due to eating non-digestible oils or fats such as Olestra, and a side-effect of medicines that prevent the absorption of dietary fats such as Orlistat.[1][2][3][4]

Artificial fats

The fat substitute Olestra, used in some reduced-fat foods, was reported to cause leakage in some consumers during the test-marketing phase. As a result, the product was reformulated before general release to a hydrogenated form that is not liquid at physiologic temperature. The United States Food and Drug Administration warning indicated that excessive consumption of Olestra could result in "loose stools"; this warning has not been required since 2003.[2][4]

Medications

Orlistat (Xenical) is a diet pill that works by blocking the enzymes that digest fat. As a result fat cannot be absorbed from the gut and some fat is excreted in the feces instead of being metabolically digested, sometimes causing oily anal leakage.[1][3]

Natural fats

Consuming jojoba oil has been documented to cause steatorrhea and anal leakage because it is indigestible.[5]

Consuming escolar and oilfish (sometimes called butterfish) will often cause steatorrhea. The fish is commonly used in party catering due to its delicate flavor and the fact that it is cheap and readily available.

Treatment

Treatments are mainly correction of the underlying cause, as well as digestive enzyme supplements.[6]

References

  1. ^ a b "Weighing a Pill For Weight Loss". Washington Post. http://www.washingtonpost.com/wp-dyn/content/article/2006/01/23/AR2006012301270.html. Retrieved 2007-07-06. "While the Food and Drug Administration (FDA) still must approve the switch, the agency often follows the advice of its experts. If it does, Orlistat (xenical) -- currently sold only by prescription -- could be available over-the-counter (OTC) later this year. But it's important to know that the weight loss that's typical for users of the drug -- 5 to 10 percent of total weight -- will be less than many dieters expect. And many consumers may be put off by the drug's significant gastrointestinal side effects, including flatulence, diarrhea and anal leakage."  
  2. ^ a b "Frito-Lay Study: Olestra Causes "Anal Oil Leakage"". Center for Science in the Public Interest. February 13, 1997. http://www.cspinet.org/new/flaynal.html. Retrieved 2007-07-07. "The Frito-Lay report states: "The anal oil leakage symptoms were observed in this study (3 to 9% incidence range above background), as well as other changes in elimination. ... Underwear spotting was statistically significant in one of two low level consumer groups at a 5% incidence above background." Despite those problems, the authors of the report concluded that olestra-containing snacks "should have a high potential for acceptance in the marketplace.""  
  3. ^ a b "The Word Is 'Leakage'. Accidents may happen with a new OTC diet drug.". Newsweek. June 25, 2007. http://www.msnbc.msn.com/id/19263093/site/newsweek/. Retrieved 2007-06-21. "GlaxoSmithKline has a tip for people who decide to try Alli, the over-the-counter weight-loss drug it is launching with a multimillion-dollar advertising blitz—keep an extra pair of pants handy. That's because Alli, a lower-dose version of the prescription drug Xenical, could (cue the late-night talk-show hosts) make you soil your pants. But while Alli's most troublesome side effect, anal leakage, is sure to be good for a few laughs, millions of people who are desperate to take off weight may still decide the threat of an accident is worth it."  
  4. ^ a b "Reported medical side-effects of Olestra according to Procter and Gamble studies". Center for Science in the Public Interest. http://www.cspinet.org/olestra/11cons.html. Retrieved 2007-06-21. "Olestra sometimes causes underwear staining associated with "anal leakage." Olestra sometimes causes underwear staining. That phenomenon may be caused most commonly by greasy, hard-to-wipe-off fecal matter, but occasionally also from anal leakage (leakage of liquid olestra through the anal sphincter)."  
  5. ^ Comparative aspects of lipid digestion and absorption: physiological correlates of wax ester digestion
  6. ^ WrongDiagnosis >Treatments for Steatorrhea Retrieved on 20 Mars, 2009







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