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Stephen V. Faraone
Born July 27, 1956
Babylon, NY, USA
Nationality United States
Fields Child Psychology and Psychiatry
Institutions Harvard Medical School

Massachusetts General Hospital

State University of New York Upstate Medical University
Alma mater State University of New York at Stony Brook (B.A.)
University of Iowa (Ph.D.)
Brown Medical School (Internship & Post Doctoral Programs)
Doctoral advisor Richard Hurtig, Ph.D.
Known for Studies of the genetics of ADHD
Notable awards CHADD Hall of Fame, SUNY Upstate President’s Award for Excellence and Leadership in Research.

Stephen V. Faraone is an American psychiatric geneticist. He has worked mainly on attention-deficit hyperactivity disorder and related disorders.

Contents

Education and career

Faraone graduated in 1978 from the State University of New York at Stony Brook with a BA in Psychology with highest honors. He then went to the University of Iowa where he obtained his master’s and Ph.D. degrees. Faraone completed a postdoctoral clinical psychology internship and a research fellowship at the Brown University Program in Medicine.

After completing his post-doctoral fellowship at Brown, Faraone came to the Harvard Department of Psychiatry where he began a career in psychiatric genetics. He first served as an instructor in 1985, and as an Assistant Professor in 1989. He was promoted to Associate Professor in 1993 and Full Professor in 2002. In 2004 he moved to SUNY Upstate Medical University where he is now Professor of Psychiatry and of Neuroscience and Physiology.[1] He is also Senior Scientific Advisor to the Research Program Pediatric Psychopharmacology at the Massachusetts General Hospital[2] and a lecturer at Harvard Medical School. Faraone is principal investigator on several National Institutes of Health funded grants studying the nature and causes of mental disorders in childhood. He is one of the world’s leading authorities on the genetics of psychiatric disorders and has also made substantial contributions to research in psychopharmacology and research methodology.

Research

Faraone’s studies of the genetic epidemiology of attention-deficit hyperactivity disorder (ADHD) focused on the establishing patterns of familial transmission in families ascertained through ADHD boys and girls with colleagues at the Massachusetts General Hospital and Harvard Medical School.[3][4][5][6] His subsequent studies clarified the genetic heterogeneity of that disorder. He has shown that 1) ADHD with conduct or bipolar disorders is a genetically homogeneous subtype of ADHD[7][8][9][10][11][12]; and 2) major depression is a nonspecific expression of ADHD genotypes.[13][14] He has also shown that the form of ADHD that persists into adolescence is highly heritable, making a suitable candidate for linkage analyses.[15][16] He used genetic paradigms to provide evidence for the validity of diagnosing ADHD in adults and has used adult samples to confirm the putative association between ADHD and the DRD4 receptor gene[17] and completed a meta-analysis to confirm the validity of the association across many studies.[18]

Faraone obtained funding from the National Institute of Mental Health to chair yearly international meetings of researchers studying the molecular genetics of ADHD. The main goal of these meetings is to foster collaboration (and reduce unproductive competition) among researchers studying the genetics of ADHD.[19][20][21][22]

One line of his research has focused on assessing the validity of the diagnosis of ADHD in adults, which has been a source of much controversy in the scientific and clinical literature about ADHD.[23] His review of the literature supported idea that adult ADHD is a valid disorder[24] and his meta-analysis of ADHD follow-up studies showed that about two-thirds of ADHD youth continue to have impairing symptoms of ADHD in adulthood.[25] He has also addressed psychometric issues from several perspectives. In one paper he presented theoretical issues that suggest ADHD is not a developmentally sensitive diagnosis.[26] In another he showed that having an ADHD child does not bias adults with ADHD to over-report ADHD symptoms.[27] He has also shown that, from a genetic perspective, symptom reporting in adults with ADHD may be more valid than symptom reporting in children.[28] He has also shown using patterns of inheritance,[29] neuropsychological studies,[30] studies of substance use disorders,[31] and studies of personality traits,[32] that the DSM-IV age at onset criterion is too strict and that ADHD may validly onset in adolescence.

Additional published work includes animal model studies of ADHD,[33][34] family studies of ADHD,[35][36][37][38][39][40][41][42][43][44][45] candidate gene studies of ADHD,[46][47][48][49][50][51][52] meta-analyses of candidate gene studies,[53][54][55] linkage analyses of ADHD,[56][57][58] a genome-wide association study (GWAS) of ADHD[59][60] and a pharmacogenetic GWAS of methylphenidate response in ADHD.[61] He has also published methodological papers,[62][63][64][65] and systematic reviews of the genetics of ADHD,[66][67][68] the neurobiology of ADHD[69][70] and environmental risk factors for ADHD.[71]

Awards and honors

Faraone has authored over 550 journal articles,[72] editorials, chapters, and books and was the eighth highest producer of High Impact Papers in Psychiatry from 1990 to 1999 as determined by the Institute for Scientific Information (ISI).[73] In 2005, ISI determined him to be the second highest cited author in the area of ADHD[74] and in 2007 he was the third most highly cited researcher in psychiatry[75] for the preceding decade.

In 2002, Faraone was inducted into the CHADD Hall of Fame in recognition of outstanding achievement in medicine and education research on attention disorders.[76] In 2004 and 2008 he was elected to the Vice Presidency of the International Society of Psychiatric Genetics[77] . In 2008, he received the SUNY Upstate President’s Award for Excellence and Leadership in Research.

References

  1. ^ "Faculty:Psychiatry:SUNY Upstate Medical University". http://www.upstate.edu/psych/faculty.php?EmpID=MWTZIUAFGl. Retrieved 2009-05-10.  
  2. ^ "About Our Department: Steve Faraone, PhD". http://www2.massgeneral.org/pediatricpsych/staff/faraone.html. Retrieved 2009-05-10.  
  3. ^ Faraone, Biederman, Chen, Krifcher, Keenan, Moore, Sprich and Tsuang (1992) Segregation analysis of attention deficit hyperactivity disorder: Evidence for single gene transmission. Psychiatric Genetics. 2 257-275
  4. ^ Faraone, Biederman, Keenan and Tsuang (1991) A family-genetic study of girls with DSM-III attention deficit disorder. American Journal of Psychiatry. 148 112-117
  5. ^ Faraone, Biederman, Mick, Doyle, Wilens, Spencer, Frazier and Mullen (2001) A family study of psychiatric comorbidity in girls and boys with attention deficit hyperactivity disorder. Biological Psychiatry. 50 586-592
  6. ^ Faraone, Biederman, Mick, Williamson, Wilens, Spencer, Weber, Jetton, Kraus, Pert and Zallen (2000) Family study of girls with attention deficit hyperactivity disorder. American Journal of Psychiatry. 157 1077-83
  7. ^ Faraone, Biederman, Garcia Jetton and Tsuang (1997) Attention deficit disorder and conduct disorder: Longitudinal evidence for a familial subtype. Psychological Medicine. 27 291-300
  8. ^ Faraone, Biederman, Keenan and Tsuang (1991) Separation of DSM-III attention deficit disorder and conduct disorder: Evidence from a family-genetic study of American child psychiatric patients. Psychological Medicine. 21 109-121
  9. ^ Faraone, Biederman, Mennin and Russell (1998) Bipolar and antisocial disorders among relatives of ADHD children: Parsing familial subtypes of illness. Am J Med Genet. 81 108-116
  10. ^ Faraone, Biederman, Mennin, Wozniak and Spencer (1997) Attention-deficit hyperactivity disorder with bipolar disorder: a familial subtype? Journal of the American Academy of Child and Adolescent Psychiatry. 36 1378-87; discussion 1387-90
  11. ^ Faraone, Biederman and Monuteaux (2000) Attention-deficit disorder and conduct disorder in girls: evidence for a familial subtype. Biological Psychiatry. 48 21-29
  12. ^ Faraone, Biederman and Monuteaux (2001) Attention deficit hyperactivity disorder with bipolar disorder in girls: further evidence for a familial subtype? Journal of Affective Disorders. 64 19-26.
  13. ^ Faraone and Biederman (1998) Depression: a family affair. Lancet. 351 158
  14. ^ Faraone and Biederman (1997) Do attention deficit hyperactivity disorder and major depression share familial risk factors? Journal of Nervous and Mental Disease. 185 533-541
  15. ^ Faraone, Biederman, Feighner and Monuteaux (2000) Assessing symptoms of attention deficit hyperactivity disorder in children and adults: which is more valid? Journal of Consulting and Clinical Psychology. 68 830-42
  16. ^ Faraone, Biederman and Monuteaux (2000) Toward guidelines for pedigree selection in genetic studies of attention deficit hyperactivity disorder. Genetic Epidemiology. 18 1-16
  17. ^ Faraone (1999) A family based association study of the DAT and DRD4 genes in ADHD. World Congress of Psychiatric Genetics.
  18. ^ Faraone, Doyle, Mick and Biederman (2001) Meta-analysis of the association between the 7-repeat allele of the dopamine d(4) receptor gene and attention deficit hyperactivity disorder. American Journal of Psychiatry. 158 1052-7.
  19. ^ ADHD Molecular Genetics Network (2000) Collaborative possibilities for molecular genetic studies of attention deficit hyperactivity disorder: Report from an International Conference. American Journal of Medical Genetics. 96 251-257
  20. ^ Faraone (2003) Report from the fourth international meeting of the attention deficit hyperactivity disorder molecular genetics network. American Journal of Medical Genetics (Neuropsychiatric Genetics). 121B 55-59
  21. ^ Faraone (2001) Report from the second international meeting of the attention deficit hyperactivity disorder molecular genetics network. American Journal of Medical Genetics. 105 255-8.
  22. ^ Faraone (2002) Report from the third international meeting of the Attention-Deficit Hyperactivity Disorder Molecular Genetics Network. Am J Med Genet. 114 272-6.
  23. ^ Faraone, Biederman, Spencer, Wilens, Seidman, Mick and Doyle (2000) Attention deficit hyperactivity disorder in adults: an overview. Biological Psychiatry. 48 9-20
  24. ^ Faraone, Biederman, Spencer, Wilens, Seidman, Mick and Doyle (2000) Attention deficit hyperactivity disorder in adults: an overview. Biological Psychiatry. 48 9-20
  25. ^ Faraone, Biederman and Mick (2006) The Age Dependent Decline Of Attention-Deficit/Hyperactivity Disorder: A Meta-Analysis Of Follow-Up Studies. Psychological Medicine. 36 159-165
  26. ^ Faraone (2000) Attention deficit hyperactivity disorder in adults: Implications for theories of diagnosis. Current Directions in Psychological Science. 9 33-36
  27. ^ Faraone, Biederman and Mick (1997) Symptom reports by adults with attention deficit hyperactivity disorder: are they influenced by attention deficit hyperactivity disorder in their children? Journal of Nervous and Mental Diseases. 185 583-584
  28. ^ Faraone, Biederman, Feighner and Monuteaux (2000) Assessing symptoms of attention deficit hyperactivity disorder in children and adults: which is more valid? Journal of Consulting and Clinical Psychology. 68 830-42
  29. ^ Faraone, Biederman, Spencer, Mick, Murray, Petty, Adamson and Monuteaux (2006) Diagnosing Adult attention deficit hyperactivity disorder: Are Late Onset and Subthreshold Diagnoses Valid? American Journal of Psychiatry. 163 1720-9
  30. ^ Faraone, Biederman, Doyle, Murray, Petty, Adamson and Seidman (2006) Neuropsychological Studies of Late Onset and Subthreshold Diagnoses of Adult ADHD. Biological Psychiatry. 60 1081-1087
  31. ^ Faraone, Wilens, Petty, Antshel, Spencer and Biederman (2007) Substance use among ADHD adults: Implications of late onset and subthreshold diagnoses. American Journal on Addictions. 16 24-34
  32. ^ Faraone, Adamson and Biederman (in press) Personality Traits among ADHD Adults: Implications of Late Onset and Subthreshold Diagnoses. Psychological Medicine.
  33. ^ Dasbanerjee, Middleton, Berger, Lombardo, Sagvolden and Faraone (2008) A comparison of molecular alterations in environmental and genetic rat models of ADHD: A pilot study. Am J Med Genet B Neuropsychiatr Genet. 147B 1554-1563
  34. ^ Sagvolden, Dasbanerjee, Zhang-James, Middleton and Faraone (2008) Behavioral and genetic evidence for a novel animal model of Attention-Deficit/Hyperactivity Disorder Predominantly Inattentive Subtype. Behav Brain Funct. 4 56
  35. ^ Faraone, Biederman and Friedman (2000) Validity of DSM-IV subtypes of attention-deficit/hyperactivity disorder: A family study perspective. Journal of the American Academy of Child and Adolescent Psychiatry. 39 300-307
  36. ^ Faraone, Biederman, Garcia Jetton and Tsuang (1997) Attention deficit disorder and conduct disorder: Longitudinal evidence for a familial subtype. Psychological Medicine. 27 291-300
  37. ^ Faraone, Biederman, Mennin, Russell and Tsuang (1998) Familial subtypes of attention deficit hyperactivity disorder: A 4-year follow-up study of children from antisocial-ADHD families. Journal of Child Psychology and Psychiatry. 39 1045-1053
  38. ^ Faraone, Biederman, Keenan and Tsuang (1991) A family-genetic study of girls with DSM-III attention deficit disorder. American Journal of Psychiatry. 148 112-117
  39. ^ Faraone, Biederman, Keenan and Tsuang (1991) Separation of DSM-III attention deficit disorder and conduct disorder: Evidence from a family-genetic study of American child psychiatric patients. Psychological Medicine. 21 109-121
  40. ^ Faraone, Biederman, Mennin and Russell (1998) Bipolar and antisocial disorders among relatives of ADHD children: Parsing familial subtypes of illness. Am J Med Genet. 81 108-116
  41. ^ Faraone, Biederman, Mennin, Wozniak and Spencer (1997) Attention-deficit hyperactivity disorder with bipolar disorder: a familial subtype? Journal of the American Academy of Child and Adolescent Psychiatry. 36 1378-87; discussion 1387-90
  42. ^ Faraone, Biederman, Mick, Wozniak, Kiely, Guite, Ablon, Warburton and Reed (1996) Attention deficit hyperactivity disorder in a multigenerational pedigree. Biological Psychiatry. 39 906-908
  43. ^ Faraone, Biederman and Monuteaux (2000) Attention-deficit disorder and conduct disorder in girls: evidence for a familial subtype. Biological Psychiatry. 48 21-29
  44. ^ Faraone, Biederman and Monuteaux (2001) Attention deficit hyperactivity disorder with bipolar disorder in girls: further evidence for a familial subtype? Journal of Affective Disorders. 64 19-26.
  45. ^ Faraone, Biederman and Monuteaux (2000) Toward guidelines for pedigree selection in genetic studies of attention deficit hyperactivity disorder. Genetic Epidemiology. 18 1-16
  46. ^ Brookes, Xu, Chen, Zhou, Neale, Lowe, Aneey, Franke, Gill, Ebstein, Buitelaar, Sham, Campbell, Knight, Andreou, Altink, Arnold, Boer, Buschgens, Butler, Christiansen, Feldman, Fleischman, Fliers, Howe-Forbes, Goldfarb, Heise, Gabriels, Korn-Lubetzki, Marco, Medad, Minderaa, Mulas, Muller, Mulligan, Rabin, Rommelse, Sethna, Sorohan, Uebel, Psychogiou, Weeks, Barrett, Craig, Banaschewski, Sonuga-Barke, Eisenberg, Kuntsi, Manor, McGuffin, Miranda, Oades, Plomin, Roeyers, Rothenberger, Sergeant, Steinhausen, Taylor, Thompson, Faraone, Asherson and Johansson (2006) The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry
  47. ^ Li, Kang, Wang, Zhou, Wang, Guan, Yang and Faraone (2006) Contribution of 5-HT2A receptor gene -1438A>G polymorphism to outcome of attention-deficit/hyperactivity disorder in adolescents. Am J Med Genet B Neuropsychiatr Genet
  48. ^ Li, Wang, Zhou, Wang, Zhang, Yang and Faraone (2006) Association of attention-deficit/hyperactivity disorder with serotonin 4 receptor gene polymorphisms in Han Chinese subjects. Neurosci Lett
  49. ^ Li, Wang, Zhou, Wang, Zhang, Yang and Faraone (2006) No association of attention-deficit/hyperactivity disorder with genes of the serotonergic pathway in Han Chinese subjects. Neurosci Lett
  50. ^ Li, Wang, Zhou, Zhang, Yang, Wang and Faraone (2007) Association between polymorphisms in serotonin transporter gene and attention deficit hyperactivity disorder in Chinese Han subjects. Am J Med Genet B Neuropsychiatr Genet. 144 14-9
  51. ^ Li, Zhang, Wang, Zhou, Zhang, Yang, Wang and Faraone (2006) The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects. Am J Med Genet B Neuropsychiatr Genet. 141B 874-876
  52. ^ Qian, Wang, Li, Yang, Wang, Zhou, Glatt and Faraone (2006) Evaluation of potential gene-gene interactions for attention deficit hyperactivity disorder in the Han Chinese population. Am J Med Genet B Neuropsychiatr Genet.
  53. ^ Faraone, Doyle, Mick and Biederman (2001) Meta-analysis of the association between the 7-repeat allele of the dopamine d(4) receptor gene and attention deficit hyperactivity disorder. American Journal of Psychiatry. 158 1052-7.
  54. ^ Faraone, Perlis, Doyle, Smoller, Goralnick, Holmgren and Sklar (2005) Molecular genetics of attention deficit hyperactivity disorder. Biological Psychiatry. 57 1313-1323
  55. ^ Glatt, Faraone and Tsuang (2003) Association between a functional catechol o-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies. Am J Psychiatry. 160 469-76.
  56. ^ Faraone, Doyle, Lasky-Su, Sklar, D'Angelo, Gonzalez-Heydrich, Kratochvil, Mick, Klein, Rezac and Biederman (2007) Linkage analysis of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 147B 1387-1391
  57. ^ Zhou, Asherson, Sham, Franke, Anney, Buitelaar, Ebstein, Gill, Brookes, Buschgens, Campbell, Chen, Christiansen, Fliers, Gabriels, Johansson, Marco, Mulas, Muller, Mulligan, Neale, Rijsdijk, Rommelse, Uebel, Psychogiou, Xu, Banaschewski, Sonuga-Barke, Eisenberg, Manor, Miranda, Oades, Roeyers, Rothenberger, Sergeant, Steinhausen, Taylor, Thompson and Faraone (2008) Linkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings. Biol Psychiatry
  58. ^ Zhou, Dempfle, Arcos-Burgos, Bakker, Banaschewski, Biederman, Buitelaar, Castellanos, Doyle, Ebstein, Ekholm, Forabosco, Franke, Freitag, Friedel, Gill, Hebebrand, Hinney, Jacob, Lesch, Loo, Lopera, McCracken, McGough, Meyer, Mick, Miranda, Muenke, Mulas, Nelson, Nguyen, Oades, Ogdie, Palacio, Pineda, Reif, Renner, Roeyers, Romanos, Rothenberger, Schafer, Sergeant, Sinke, Smalley, Sonuga-Barke, Steinhausen, van der Meulen, Walitza, Warnke, Lewis, Faraone and Asherson (2008) Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 147B 1392-1398
  59. ^ Lasky-Su, Neale, Franke, Anney, Zhou, Maller, Vasquez, Chen, Asherson, Buitelaar, Banaschewski, Ebstein, Gill, Miranda, Mulas, Oades, Roeyers, Rothenberger, Sergeant, Sonuga-Barke, Steinhausen, Taylor, Daly, Laird, Lange and Faraone (2008) Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Am J Med Genet B Neuropsychiatr Genet. 147B 1345-1354
  60. ^ Neale, Lasky-Su, Anney, Franke, Zhou, Maller, Vasquez, Asherson, Chen, Banaschewski, Buitelaar, Ebstein, Gill, Miranda, Oades, Roeyers, Rothenberger, Sergeant, Steinhausen, Sonuga-Barke, Mulas, Taylor, Laird, Lange, Daly and Faraone (2008) Genome-wide association scan of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 147B 1337-1344
  61. ^ Mick, Neale, Middleton, McGough and Faraone (2008) Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 147B 1412-1418
  62. ^ Faraone and Tsuang (1994) Measuring diagnostic accuracy in the absence of a "gold standard". American Journal of Psychiatry. 151 650-657
  63. ^ Faraone, Biederman, Spencer and Wilens (2000) The drug-placebo response curve: a new method for assessing drug effects in clinical trials. Journal of Clinical Psychopharmacology. 20 673-9
  64. ^ Faraone, Biederman, Sprich, Buckminster, Chen and Tsuang (1993) Efficiency of diagnostic criteria for attention deficit disorder: Toward an empirical approach to designing and validating diagnostic algorithms. Journal of the American Academy of Child and Adolescent Psychiatry. 32 166-174
  65. ^ Lunetta, Faraone, Biederman and Laird (2000) Family-based tests of association and linkage that use unaffected sibs, covariates, and interactions. American Journal of Human Genetics. 66 605-14
  66. ^ Faraone (2004) Genetics of adult attention-deficit/hyperactivity disorder. Psychiatr Clin North Am. 27 303-21
  67. ^ Faraone, Perlis, Doyle, Smoller, Goralnick, Holmgren and Sklar (2005) Molecular genetics of attention deficit hyperactivity disorder. Biological Psychiatry. 57 1313-1323
  68. ^ Mick and Faraone (2008) Genetics of attention deficit hyperactivity disorder. Child Adolesc Psychiatr Clin N Am. 17 261-84, vii-viii
  69. ^ Faraone and Biederman (1998) Neurobiology of attention-deficit hyperactivity disorder. Biological Psychiatry. 44 951-958
  70. ^ Faraone and Biederman (2004) Neurobiology of Attention Deficit Hyperactivity Disorder. Neurobiology of Mental Illness, Second Edition.
  71. ^ Banerjee, Middleton and Faraone (2007) Environmental risk factors for attention-deficit hyperactivity disorder. Acta Pediatrica. 96 1269-74
  72. ^ Publications - link to PubMed
  73. ^ Science, 2000, Vol 288, pg 959
  74. ^ An Interview with Dr. Stephen Faraone
  75. ^ "The Most-Cited Researchers in Psychiatry/Psychology
  76. ^ Children and adults with Attention Deficit Hyperactivity Disorder
  77. ^ [1]
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