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(−)-Stepholidine
(−)-Stepholidine.svg
IUPAC name
Other names l-Stepholidine
Identifiers
CAS number 16562-13-3
PubChem 5290
MeSH Stepholidine
SMILES
Properties
Molecular formula C19H21NO4
Molar mass 327.374 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

(−)-Stepholidine is a naturally-occurring chemical compound found in the herb Stephania intermedia. Stepholidine is a dual D2 receptor antagonist and D1 receptor agonist, and has shown antipsychotic activity in animal studies.[1][2][3][4]

See also

References

  1. ^ Natesan S, Reckless GE, Barlow KB, et al. (August 2008). "The antipsychotic potential of l-stepholidine-a naturally occurring dopamine receptor D(1) agonist and D (2) antagonist". Psychopharmacology (Berl.) 199 (2): 275–89. doi:10.1007/s00213-008-1172-1. PMID 18521575.  
  2. ^ Mo J, Guo Y, Yang YS, Shen JS, Jin GZ, Zhen X (2007). "Recent developments in studies of l-stepholidine and its analogs: chemistry, pharmacology and clinical implications". Curr. Med. Chem. 14 (28): 2996–3002. doi:10.2174/092986707782794050. PMID 18220736. http://www.bentham-direct.org/pages/content.php?CMC/2007/00000014/00000028/0007C.SGM.  
  3. ^ Jin GZ, Zhu ZT, Fu Y (January 2002). "(-)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions". Trends Pharmacol. Sci. 23 (1): 4–7. doi:10.1016/S0165-6147(00)01929-5. PMID 11804640. http://linkinghub.elsevier.com/retrieve/pii/S0165614700019295.  
  4. ^ Fu W, Shen J, Luo X, et al. (September 2007). "Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations". Biophys. J. 93 (5): 1431–41. doi:10.1529/biophysj.106.088500. PMID 17468175.  
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