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Steroid sulfatase: Wikis


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Steroid sulfatase (microsomal), arylsulfatase C, isozyme S

PDB rendering based on 1p49.
Available structures
External IDs OMIM308100 HomoloGene47918 GeneCards: STS Gene
EC number
RNA expression pattern
PBB GE STS 203767 s at tn.png
PBB GE STS 203768 s at tn.png
PBB GE STS 203769 s at tn.png
More reference expression data
Species Human Mouse
Entrez 412 n/a
Ensembl ENSG00000101846 n/a
UniProt P08842 n/a
RefSeq (mRNA) NM_000351 n/a
RefSeq (protein) NP_000342 n/a
Location (UCSC) Chr X:
7.15 - 7.28 Mb
PubMed search [1] n/a

Steroid sulfatase (or steryl-sulfatase) is an sulfatase enzyme involved in the metabolism of steroids. It is encoded by the STS gene.[1]



The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to estrogens during pregnancy. The encoded protein is found in the endoplasmic reticulum, where it acts as a homodimer.[1]

Clinical significance

A deficiency is associated with X-linked ichthyosis, a scaly-skin disease affecting roughly 1 in every 2,000-6,000 males.[2][3]

See also


Further reading

  • Elias PM, Crumrine D, Rassner U, et al. (2004). "Basis for abnormal desquamation and permeability barrier dysfunction in RXLI.". J. Invest. Dermatol. 122 (2): 314–9. doi:10.1046/j.1523-1747.2003.22258.x. PMID 15009711.  
  • Basler E, Grompe M, Parenti G, et al. (1992). "Identification of point mutations in the steroid sulfatase gene of three patients with X-linked ichthyosis.". Am. J. Hum. Genet. 50 (3): 483–91. PMID 1539590.  
  • Shankaran R, Ameen M, Daniel WL, et al. (1991). "Characterization of arylsulfatase C isozymes from human liver and placenta.". Biochim. Biophys. Acta 1078 (2): 251–7. PMID 2065092.  
  • Stein C, Hille A, Seidel J, et al. (1989). "Cloning and expression of human steroid-sulfatase. Membrane topology, glycosylation, and subcellular distribution in BHK-21 cells.". J. Biol. Chem. 264 (23): 13865–72. PMID 2668275.  
  • Kawano J, Kotani T, Ohtaki S, et al. (1989). "Characterization of rat and human steroid sulfatases.". Biochim. Biophys. Acta 997 (3): 199–205. PMID 2765556.  
  • Yen PH, Allen E, Marsh B, et al. (1987). "Cloning and expression of steroid sulfatase cDNA and the frequent occurrence of deletions in STS deficiency: implications for X-Y interchange.". Cell 49 (4): 443–54. PMID 3032454.  
  • Conary JT, Lorkowski G, Schmidt B, et al. (1987). "Genetic heterogeneity of steroid sulfatase deficiency revealed with cDNA for human steroid sulfatase.". Biochem. Biophys. Res. Commun. 144 (2): 1010–7. PMID 3034252.  
  • Ballabio A, Parenti G, Carrozzo R, et al. (1988). "X/Y translocation in a family with X-linked ichthyosis, chondrodysplasia punctata, and mental retardation: DNA analysis reveals deletion of the steroid sulphatase gene and translocation of its Y pseudogene.". Clin. Genet. 34 (1): 31–7. PMID 3165728.  
  • Yen PH, Marsh B, Allen E, et al. (1989). "The human X-linked steroid sulfatase gene and a Y-encoded pseudogene: evidence for an inversion of the Y chromosome during primate evolution.". Cell 55 (6): 1123–35. PMID 3203382.  
  • Chang PL, Varey PA, Rosa NE, et al. (1986). "Association of steroid sulfatase with one of the arylsulfatase C isozymes in human fibroblasts.". J. Biol. Chem. 261 (31): 14443–7. PMID 3464600.  
  • Munroe DG, Chang PL (1987). "Tissue-specific expression of human arylsulfatase-C isozymes and steroid sulfatase.". Am. J. Hum. Genet. 40 (2): 102–14. PMID 3471087.  
  • Müller CR, Wahlström J, Ropers HH (1982). "Further evidence for the assignment of the steroid sulfatase X-linked ichthyosis locus to the telomer of Xp.". Hum. Genet. 58 (4): 446. PMID 6948769.  
  • Migeon BR, Shapiro LJ, Norum RA, et al. (1982). "Differential expression of steroid sulphatase locus on active and inactive human X chromosome.". Nature 299 (5886): 838–40. PMID 6957717.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.  
  • Alperin ES, Shapiro LJ (1997). "Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein.". J. Biol. Chem. 272 (33): 20756–63. PMID 9252398.  
  • Sugawara T, Shimizu H, Hoshi N, et al. (2000). "PCR diagnosis of X-linked ichthyosis: identification of a novel mutation (E560P) of the steroid sulfatase gene.". Hum. Mutat. 15 (3): 296. doi:10.1002/(SICI)1098-1004(200003)15:3<296::AID-HUMU17>3.0.CO;2-#. PMID 10679952.  
  • Oyama N, Satoh M, Iwatsuki K, Kaneko F (2000). "Novel point mutations in the steroid sulfatase gene in patients with X-linked ichthyosis: transfection analysis using the mutated genes.". J. Invest. Dermatol. 114 (6): 1195–9. doi:10.1046/j.1523-1747.2000.00004.x. PMID 10844566.  
  • Jimenez Vaca AL, Valdes-Flores Mdel R, Rivera-Vega MR, et al. (2002). "Deletion pattern of the STS gene in X-linked ichthyosis in a Mexican population.". Mol. Med. 7 (12): 845–9. PMID 11844872.  
  • Hoffmann R, Rot A, Niiyama S, Billich A (2002). "Steroid sulfatase in the human hair follicle concentrates in the dermal papilla.". J. Invest. Dermatol. 117 (6): 1342–8. doi:10.1046/j.0022-202x.2001.01547.x. PMID 11886493.  
  • Matsuoka R, Yanaihara A, Saito H, et al. (2002). "Regulation of estrogen activity in human endometrium: effect of IL-1beta on steroid sulfatase activity in human endometrial stromal cells.". Steroids 67 (7): 655–9. PMID 11996939.  

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