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Stuart A. Aaronson, M.D.
Born February 28, 1942(1942-02-28)
Mount Clemens, Michigan
Alma mater UC Berkeley, UC SF
Occupation biologist
Employer Mount Sinai Medical Center
Known for Cancer research
Title Jane B. and Jack R. Aron Professor of Neoplastic Diseases and Chairman of Oncological Sciences

Stuart A. Aaronson, M.D. , is an American author and internationally recognized cancer biologist.[1][2] He has authored more than 500 publications and holds over 50 patents, and is currently the Jane B. and Jack R. Aron Professor of Neoplastic Diseases and Chairman of Oncological Sciences at Mount Sinai Medical Center in New York City.[3]

Contents

Biography

Aaronson graduated summa cum laude from the University of California, Berkeley, in 1962, with a degree in chemistry. He earned his M.D. from the University of California, San Francisco Medical Center in 1966, and completed a fellowship at the University of Cambridge in England and an internship in medicine at Moffitt Hosptial in San Francisco.[3]

In 1967, Aaronson joined the National Institutes of Health as a Senior Staff Fellow. He headed the Molecular Biology Section of the Viral Carcinogenesis Branch from 1970 until 1977, after which he became Chief of the Laboratory of Cellular and Molecular Biology at the National Cancer Institute, until 1993, when he was named Chairman of Oncological Sciences at Mount Sinai Medical Center.

Research

Aaronson's early research established the transformation-competent but replication-defective nature of mammalian sarcoma viruses and molecularly cloned many of their oncogenes.[3][4] His investigations of the v-sis oncogene established the first normal function of an oncogene and its role in growth factor signaling.[1][2] His discovery of erbB2 as a v-erbB-related gene amplified in a human breast carcinoma and the demonstration of its transforming properties paved the way for targeted therapies directed against its product,[4] and his successful isolation of KGF (FGF7), a growth factor present in the epithelialization-phase of wound healing, led to Amgen's successful phase III clinical trial and FDA approval of KGF for treatment of mucositis.[5][6] Current research includes investigations into the mechanisms by which tumor suppressor genes induce permanent growth arrest/senescence, the signaling pathways involved, and investigations of the autocrine and paracrine acting growth factors PDGF, KGF, HGF, and Wnt ligands.[3]

Awards and honors

  • 1982 Rhoads Memorial Award
  • 1982 PHS Meritorious Service Medal
  • 1989 Paul Ehrlich Award
  • 1989 PHS Distinguished Service Medal
  • 1990 Milken Award
  • 1991 Chirone Prize
  • 1991 Harvey Lecture
  • 1991 Wadsworth Memorial Foundation Award
  • 2005 FLC Mid-Atlantic Regional Excellence in Technology Transfer Award – Kepivance
  • 2006 National FLC Award for Excellence in Technology Transfer – Kepivance: Improving the Quality of Life for Cancer Patients

Patents

Partial list:

Patent Number Title
6479255[7] Polynucleotides encoding human FRP and fragments thereof
6225088[8] DNA encoding plasminogen-like growth factor (PLGF) and related embodiments
6228600[9] Immunoassays for the alpha platelet-derived growth factor receptor
6403769[10] Fusion proteins that include antibody and nonantibody portions
6566098[11] DNA encoding truncated hepatocyte growth factor variants
6639060[12] erbB-3 nucleic acids
6653084[13] Anti-erbB-2 antibodies to human receptor related to but distinct from EGF receptor
6660488[14] Antibodies for the alpha platelet-derived growth factor receptor
6709842[15] DNA encoding a growth factor specific for epithelial cells
6833132[16] Method of stimulating epithelial cells using keratinocyte growth factor (KGF) and method of inhibiting KGF activity

Publications

Partial list:

  • Akiri G, Cherian M, Vijayakumar S, Liu G, Bafico A, Aaronson S. "Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma." Oncogene 2009; 28: 2163-2172. PMID 19377513
  • Liu G, Grumolato L, Arroyave R, Qiao H, Akiri G, Aaronson S. "Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells." Journal of Cell Biology 2009 April; 185(1): 67-75. PMID 19349579
  • Zhao B, Benson E, Qiao R, Wang X, Kim S, Manfredi J, Lee S, Aaronson S. "Cellular senescence and organismal ageing in the absence of p21 CIP1/WAF1 in ku80-/-mice." EMBO 2009;: 71-78. PMID 19079133
  • Ongusaha PP, Qi HH, Raj L, Kim YB, Aaronson SA, Davis R, Shi Y, Liao J, Lee SW. "Identification of ROCK1 as an Upstream Activator of the JIP-3 to JNK Signaling Axis in Response to UVB Damage." Sci Signal 2008 Nov 25; 1(47): ra14. PMID 19036714
  • Munoz-Fontella C, Macip S, Martinez-Sobrido L, Brown L, Ashour J, Garcia-Sastre A, Lee SW, Aaronson SA. "Transcriptional role of p53 in Interferon-mediated antiviral immunity." Journal of Exp. Med 2008 July;: 1-10. PMID 18663127
  • Mahale A, Khan Z, Igarashi M, Nanjangud G, Qiao RF, Yao S, Lee SW, Aaronson SA. "Clonal Selection in Malignant Transformation of Human Fibroblasts Transduces with Defined Cellualr Oncogenes." Cancer Research 2008; 68(5): 1417-1426. PMID 18316605
  • Brown L, Ongusaha P, Kim H, Nuti S, Mandinova A, Lee J, Khosravi-Far R, Aaronson SA, Lee S. "CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner." The EMBO Journal 2007; 26(14): 3410-3422. PMID 17599062
  • Das S, Raj L, Zhao B, Bernstein A, Aaronson SA, Lee SA. "Hzf, a key modulator of p53 mediated transcription, functions as a critical determinant of cell survival and death upon genotoxic stress." Cell 2007; 130: 624-637. PMID 17719541

References

  1. ^ a b "ACGT® - Scientifc Advisory Council - Stuart A. Aaronson, M.D.". http://www.acgtfoundation.org/bio_adv_Aaronson.html+. Retrieved 2010-01-06.  
  2. ^ a b "Breast Cancer Research Foundation: Stuart Aaronson". http://www.bcrfcure.org/action_0809grantees_aaronson.html+. Retrieved 2010-01-06.  
  3. ^ a b c d "Mount Sinai School of Medicine - Faculty profile". http://www.mountsinai.org/Find%20A%20Faculty/profile.do?id=0000072500001497306952&officeDrawer=biz. Retrieved 2010-01-06.  
  4. ^ a b "The Black Family Stem Cell Institute". http://www.blackfamilystemcell.org/BFSCIresearch.html+. Retrieved 2010-01-06.  
  5. ^ "Human Keratinocyte Growth Factor (KGF) from GenWay Biotech, Inc. - Biocompare". http://www.biocompare.com/ProductDetails/990070/Human-Keratinocyte-Growth-Factor-%28KGF%29.html. Retrieved 2010-01-06.  
  6. ^ "Keratinocyte growth factor is a growth factor for mammary epithelium in vivo. The mammary epithelium of lactating rats is resistant to the proliferative action of keratinocyte growth factor.". http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887355/. Retrieved 2010-01-06.  
  7. ^ "United States Patent: 6479255". http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/6479255+.  
  8. ^ "United States Patent: 6225088". http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/6225088+.  
  9. ^ "United States Patent: 6228600". http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/6228600+.  
  10. ^ "United States Patent: 6403769". http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/6403769+.  
  11. ^ "United States Patent: 6566098". http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/6566098+.  
  12. ^ "United States Patent: 6639060". http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/6639060.  
  13. ^ "United States Patent: 6653084". http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/6653084+.  
  14. ^ "United States Patent: 6660488". http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/6660488+.  
  15. ^ "United States Patent: 6709842". http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/6709842+.  
  16. ^ "United States Patent: 6833132". http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/6833132+.  

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