The Full Wiki

More info on Sulfapyridine

Sulfapyridine: Wikis

Advertisements
  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Sulfapyridine
Systematic (IUPAC) name
4-amino-N-pyridin-2-ylbenzenesulfonamide
Identifiers
CAS number 000144-83-2
ATC code J01EB04 QJ01EQ04
PubChem 5336
Chemical data
Formula C 11H11N3O2S 
Mol. mass 249.29 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Original laboratory code and Brand Name: M&B 693. Sulfapyridine, original UK spelling Sulphapyridine, is a sulfonamide antibacterial.

Sulfapyridine is not prescribed for treatment in humans any more. However, it may be used to treat Linear IgA Disease. It is a good antibacterial drug, but its water solubility is very pH dependent. Thus there is a risk of crystallization within the bladder or urethra, which could lead to pain or blockage.

Discovered by May & Baker Ltd and logged in their Test Book on 2 November 1937 under Code No M&B693[1]. Successfully used to treat Winston Churchill's bacterial pneumonia in 1942. In a subsequent radio broadcast he said "This admirable M&B from which I did not suffer any inconvenience, was used at the earliest moment and, after a week's fever, the intruders were repulsed." In 1944 M&B693 also saved Nero, the Royal Circus lion, from pneumonia.[Glasgow Evening News January 1944.]

The drug sulfasalazine is structurally one molecule of mesalamine linked to one molecule of Sulfapyridine with an azo bond.

References

  1. ^ Lesch, John (2007). "Chapter 7". The First Miracle Drugs (illustrated ed.). Oxford University Press. ISBN 019518775X.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message