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Sulfinpyrazone: Wikis

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Sulfinpyrazone
Systematic (IUPAC) name
1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]pyrazolidine-3,5-dione
Identifiers
CAS number 57-96-5
ATC code M04AB02
PubChem 5342
DrugBank APRD00620
Chemical data
Formula C 23H20N2O3S 
Mol. mass 404.48 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 98–99%
Metabolism hepatic
Half life  ?
Excretion renal
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes oral intravenous
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Sulfinpyrazone is a uricosuric medication used to treat gout. It also sometimes is used to reduce platelet aggregation by inhibiting degranulation of platelets which reduces the release of ADP and thromboxane.

Like other uricosurics, sulfinpyrazone works by competitively inhibiting uric acid reabsorption in the proximal tubule of the kidney.

Contraindications

Sulfinpyrazone must not be used in persons with renal impairment or a high rate of excretion of uric acid (hyperuricosuria).[1]

References

  1. ^ Underwood M (June 2006). "Diagnosis and management of gout". BMJ 332 (7553): 1315–9. doi:10.1136/bmj.332.7553.1315. PMID 16740561.  
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