Survival analysis: Wikis

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Survival analysis is a branch of statistics which deals with death in biological organisms and failure in mechanical systems. This topic is called reliability theory or reliability analysis in engineering, and duration analysis or duration modeling in economics or sociology. More generally, survival analysis involves the modeling of time to event data; in this context, death or failure is considered an "event" in the survival analysis literature. Many concepts in Survival analysis have been explained by the Counting Process Theory, which has emerged more recently. The flexibility of a counting process is that it allows modeling multiple (or recurrent) events. This type of modeling fits very well in many situations (e.g. people can go to jail multiple times, alcoholics can start and stop drinking multiple times, people can get married and get a divorce many times).

Survival analysis attempts to answer questions such as: what is the fraction of a population which will survive past a certain time? Of those that survive, at what rate will they die or fail? Can multiple causes of death or failure be taken into account? How do particular circumstances or characteristics increase or decrease the odds of survival?

To answer such questions, it is necessary to define "lifetime". In the case of biological survival, death is unambiguous, but for mechanical reliability, failure may not be well-defined, for there may well be mechanical systems in which failure is partial, a matter of degree, or not otherwise localized in time. Even in biological problems, some events (for example, heart attack or other organ failure) may have the same ambiguity. The theory outlined below assumes well-defined events at specific times; other cases may be better treated by models which explicitly account for ambiguous events.

The theory of survival presented here also assumes that death or failure happens just once for each subject. Recurring event or repeated event models relax that assumption. The study of recurring events is relevant in systems reliability, and in many areas of social sciences and medical research.

This article is phrased primarily in terms of biological survival, but this is just a convenience. An equivalent formulation in terms of mechanical failure can be made by replacing every occurrence of death with failure.

Contents

General formulation

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Survival function

The object of primary interest is the survival function also called survivorship function, conventionally denoted S, which is defined as

S(t) = \Pr(T > t)

where t is some time, T is a random variable denoting the time of death, and "Pr" stands for probability. That is: the survival function is the probability that the time of death is later than some specified time. The survival function is also called the survivor function or survivorship function in problems of biological survival, and the reliability function in mechanical survival problems. In the latter case, the reliability function is denoted R(t).

Usually one assumes S(0) = 1, although it could be less than 1 if there is the possibility of immediate death or failure.

The survival function must be non-increasing: S(u) ≤ S(t) if u > t. This property follows directly from F(t) = 1 - S (t) being the integral of a non-negative function. This reflects the notion that survival at a later age is only possible if surviving all younger ages. Given this property, the lifetime distribution function and event density (F and f below) are well-defined.

The survival function is usually assumed to approach zero as age increases without bound, i.e., S(t) → 0 as t → ∞, although the limit could be greater than zero if eternal life is possible. For instance, we could apply survival analysis to a mixture of stable and unstable carbon isotopes; unstable isotopes would decay sooner or later, but the stable isotopes would last indefinitely.

Lifetime distribution function and event density

Related quantities are defined in terms of the survival function. The lifetime distribution function, conventionally denoted F, is defined as the complement of the survival function,

F(t) = \Pr(T \le t) = 1 - S(t)

and the derivative of F (i.e., the density function of the lifetime distribution) is conventionally denoted f,

f(t) = F'(t) = \frac{d}{dt} F(t)

f is sometimes called the event density; it is the rate of death or failure events per unit time.

The survival function is often defined in terms of distribution and density functions

S(t) = \Pr(T > t) = \int_t^{\infty} f(u)\,du = 1-F(t).

Similarly, a survival event density function can be defined as

s(t) = S'(t) = \frac{d}{dt} S(t) = \frac{d}{dt} \int_t^{\infty} f(u)\,du = \frac{d}{dt} [1-F(t)] = -f(t)

Hazard function and cumulative hazard function

The hazard function, conventionally denoted λ, is defined as the event rate at time t conditional on survival until time t or later (that is, Tt),

\lambda(t)\,dt = \Pr(t \leq T < t+dt\,|\,T \geq t) = \frac{f(t)\,dt}{S(t)} = -\frac{S'(t)\,dt}{S(t)}

Force of mortality is a synonym of hazard function which is used particularly in demography and actuarial science. The term hazard rate is another synonym.

The hazard function must be non negative, λ(t) ≥ 0, and its integral over [0, \infty] must be infinite, but is not otherwise constrained; the hazard function may be increasing or decreasing, nonmonotonic, or discontinuous. An example is the bathtub curve hazard function, which is large for small values of t, decreasing to some minimum, and thereafter increasing again; this can model the property of some mechanical systems to either failure soon after operation, or much later, as the system ages.

The hazard function can alternatively be represented in terms of the cumulative hazard function, conventionally denoted Λ:

\Lambda(t) = -\log S(t)\,

so

\frac{d}{dt} \Lambda(t) = -\frac{S'(t)}{S(t)} = \lambda(t)

Λ is called the cumulative hazard function because the preceding definitions together imply

 \Lambda(t) = \int_0^{t} \lambda(u) \, du ,

which is the "accumulation" of the hazard over time.

From Λ(t) = − logS(t) we see that Λ(t) increases without bound as t tends to infinity (assuming S(t) tends to zero). This implies that λ(t) must not decrease too quickly, since, by definition, the cumulative hazard has to diverge. For example, exp( − t) is not the hazard function of any survival distribution, because its integral converges (to 1).

Quantities derived from the survival distribution

Future lifetime at a given time t0 is denoted by the time remaining until death, thus future lifetime is Tt0 in the present notation. The expected future lifetime is the expected value of future lifetime. The probability of death at or before t + t0, given survival until t0, is just

P(T \le t_0 + t | T > t_0) = \frac{P(t_0 < T \le t_0 + t)}{P(T > t_0)} = \frac{F(t_0 + t) - F(t_0)}{S(t_0)}

Therefore the probability density of future lifetime is

\frac{d}{dt}\frac{F(t_0 + t) - F(t_0)}{S(t_0)} = \frac{f(t_0 + t)}{S(t_0)}

and the expected future lifetime is

\frac{1}{S(t_0)} \int_0^{\infty} t\,f(t+t_0)\,dt

For t0 = 0, i.e., at birth, this reduces to the expected lifetime.

In reliability problems, the expected lifetime is called the mean time to failure, and the expected future lifetime is called the mean residual lifetime.

The probability of individual survival until t or later is S(t), by definition. The expected number of survivors, in a population of n individuals, is n × S(t), assuming the same survival function for all. Thus the expected proportion of survivors is S(t), and the variance of the proportion of survivors is S(t) × (1-S(t))/n.

The age at which a specified proportion of survivors remain can be found by solving the equation S(t) = q for t, where q is the quantile in question. Typically one is interested in the median lifetime, for which q = 1/2, or other quantiles such as q = 0.90 or q = 0.99.

One can also make more complex inferences from the survival distribution. In mechanical reliability problems, one can bring cost (or utility, more generally) into consideration and solve problems concerning repair or replacement. See age-replacement problem and durability and renewal theory and reliability theory of aging and longevity for further discussion of this topic.

Censoring

Censoring is a form of missing data problem which is common in survival analysis. Ideally, both the birth and death dates of a subject are known, in which case the lifetime is known. If it is known only that the date of death is after some date, this is called right censoring. Right censoring will occur for those subjects whose birth date is known but who are still alive when they are lost to follow-up or when the study ends. If a subject's lifetime is known to be less than a certain duration, the lifetime is said to be left-censored. It may also happen that subjects with a lifetime less than some threshold may not be observed at all: this is called truncation. Note that truncation is different from left censoring, since for a left censored datum, we know the subject exists, but for a truncated datum, we may be completely unaware of the subject. Truncation is also common. In a so-called delayed entry study, subjects are not observed at all until they have reached a certain age. For example, people may not be observed until they have reached the age to enter school. Any deceased subjects in the pre-school age group would be unknown.

Fitting parameters to data

Survival models can be usefully viewed as ordinary regression models in which the response variable is time. However, computing the likelihood function (needed for fitting parameters or making other kinds of inferences) is complicated by the censoring. The likelihood function for a survival model, in the presence of censored data, is formulated as follows. By definition the likelihood function is the joint probability of the data given the parameters of the model. It is customary to assume that the data are independent given the parameters. Then the likelihood function is the product of the likelihood of each datum. It is convenient to partition the data into four categories: uncensored, left censored, right censored, and interval censored. These are denoted "unc.", "l.c.", "r.c.", and "i.c." in the equation below.

 L(\theta) = \prod_{T_i\in unc.} \Pr(T = T_i|\theta) \prod_{i\in l.c.} \Pr(T < T_i|\theta) \prod_{i\in r.c.} \Pr(T > T_i|\theta) \prod_{i\in i.c.} \Pr(T_{i,l} < T < T_{i,r}|\theta) .

For an uncensored datum, with Ti equal to the age at death, we have

 \Pr(T = T_i|\theta) = f(T_i|\theta) .

For a left censored datum, such that the age at death is known to be less than Ti, we have

 \Pr(T < T_i|\theta) = F(T_i|\theta) = 1 - S(T_i|\theta) .

For a right censored datum, such that the age at death is known to be greater than Ti, we have

 \Pr(T > T_i|\theta) = 1 - F(T_i|\theta) = S(T_i|\theta) .

For an interval censored datum, such that the age at death is known to be less than Ti,r and greater than Ti,l, we have

 \Pr(T_{i,l} < T < T_{i,r}|\theta) = S(T_{i,l}|\theta) - S(T_{i,r}|\theta) .

An important application where interval censored data arises is current status data, where the actual occurrence of an event Ti is only known to the extent that it known not to occurred before observation time and to have occurred before the next.

Distributions used in survival analysis

See also

External links

References

  • David Collett. Modelling Survival Data in Medical Research, Second Edition. Boca Raton: Chapman & Hall/CRC. 2003. ISBN 978-1584883258
  • Regina Elandt-Johnson and Norman Johnson. Survival Models and Data Analysis. New York: John Wiley & Sons. 1980/1999.
  • Jerald F. Lawless. Statistical Models and Methods for Lifetime Data, 2nd edition. John Wiley and Sons, Hoboken. 2003.
  • Terry Therneau. "A Package for Survival Analysis in S". http://www.mayo.edu/hsr/people/therneau/survival.ps, at: http://mayoresearch.mayo.edu/mayo/research/biostat/therneau.cfm
  • "Engineering Statistics Handbook", NIST/SEMATEK, [1]
  • Rausand, M. and Hoyland, A. System Reliability Theory: Models, Statistical Methods, and Applications, John Wiley & Sons, Hoboken, 2004. See web site.

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