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Syndecan 1: Wikis


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Syndecan 1
Symbols SDC1; CD138; SDC; SYND1; syndecan
External IDs OMIM186355 MGI1349162 HomoloGene2252 GeneCards: SDC1 Gene
RNA expression pattern
PBB GE SDC1 201286 at tn.png
PBB GE SDC1 201287 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6382 20969
Ensembl ENSG00000115884 ENSMUSG00000020592
UniProt P18827 Q3THY2
RefSeq (mRNA) NM_001006946 NM_011519
RefSeq (protein) NP_001006947 NP_035649
Location (UCSC) Chr 2:
20.26 - 20.29 Mb
Chr 12:
8.8 - 8.82 Mb
PubMed search [1] [2]

Syndecan 1 is a protein which in humans is encoded by the SDC1 gene.[1][2]



The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.[3]


It is a useful marker for plasma cells,[4] but only if the cells tested are already known to be derived from blood.[5]


  1. ^ Mali M, Jaakkola P, Arvilommi AM, Jalkanen M (April 1990). "Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans". J. Biol. Chem. 265 (12): 6884–9. ISSN  . PMID 2324102.  
  2. ^ Ala-Kapee M, Nevanlinna H, Mali M, Jalkanen M, Schröder J (September 1990). "Localization of gene for human syndecan, an integral membrane proteoglycan and a matrix receptor, to chromosome 2". Somat. Cell Mol. Genet. 16 (5): 501–5. doi:10.1007/BF01233200. PMID 2173154.  
  3. ^ "Entrez Gene: SDC1 syndecan 1".  
  4. ^ Rawstron AC (May 2006). "Immunophenotyping of plasma cells". Curr Protoc Cytom Chapter 6: Unit6.23. doi:10.1002/0471142956.cy0623s36. PMID 18770841.  
  5. ^ O'Connell FP, Pinkus JL, Pinkus GS (February 2004). "CD138 (syndecan-1), a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms". Am. J. Clin. Pathol. 121 (2): 254–63. doi:10.1309/617D-WB5G-NFWX-HW4L. PMID 14983940.  

Further reading

  • David G (1992). "Structural and functional diversity of the heparan sulfate proteoglycans". Adv. Exp. Med. Biol. 313: 69–78. PMID 1442271.  
  • Jaakkola P, Jalkanen M (1999). "Transcriptional regulation of Syndecan-1 expression by growth factors". Prog. Nucleic Acid Res. Mol. Biol. 63: 109–38. doi:10.1016/S0079-6603(08)60721-7. PMID 10506830.  
  • Wijdenes J, Dore JM, Clement C, Vermot-Desroches C (2003). "CD138". J. Biol. Regul. Homeost. Agents 16 (2): 152–5. PMID 12144130.  
  • Lories V, Cassiman JJ, Van den Berghe H, David G (1992). "Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cells and lung fibroblasts". J. Biol. Chem. 267 (2): 1116–22. PMID 1339431.  
  • Vainio S, Jalkanen M, Bernfield M, Saxén L (1992). "Transient expression of syndecan in mesenchymal cell aggregates of the embryonic kidney". Dev. Biol. 152 (2): 221–32. doi:10.1016/0012-1606(92)90130-9. PMID 1644217.  
  • Kiefer MC, Ishihara M, Swiedler SJ, et al. (1992). "The molecular biology of heparan sulfate fibroblast growth factor receptors". Ann. N. Y. Acad. Sci. 638: 167–76. doi:10.1111/j.1749-6632.1991.tb49027.x. PMID 1664683.  
  • Ala-Kapee M, Nevanlinna H, Mali M, et al. (1990). "Localization of gene for human syndecan, an integral membrane proteoglycan and a matrix receptor, to chromosome 2". Somat. Cell Mol. Genet. 16 (5): 501–5. doi:10.1007/BF01233200. PMID 2173154.  
  • Mali M, Jaakkola P, Arvilommi AM, Jalkanen M (1990). "Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans". J. Biol. Chem. 265 (12): 6884–9. PMID 2324102.  
  • Sanderson RD, Lalor P, Bernfield M (1992). "B lymphocytes express and lose syndecan at specific stages of differentiation". Cell Regul. 1 (1): 27–35. PMID 2519615.  
  • Asundi VK, Carey DJ (1995). "Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region". J. Biol. Chem. 270 (44): 26404–10. doi:10.1074/jbc.270.44.26404. PMID 7592855.  
  • Zhang L, David G, Esko JD (1995). "Repetitive Ser-Gly sequences enhance heparan sulfate assembly in proteoglycans". J. Biol. Chem. 270 (45): 27127–35. doi:10.1074/jbc.270.45.27127. PMID 7592967.  
  • Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence". Proc. Natl. Acad. Sci. U.S.A. 90 (17): 7941–5. doi:10.1073/pnas.90.17.7941. PMID 7690138.  
  • Spring J, Goldberger OA, Jenkins NA, et al. (1994). "Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family". Genomics 21 (3): 597–601. doi:10.1006/geno.1994.1319. PMID 7959737.  
  • Sneed TB, Stanley DJ, Young LA, Sanderson RD (1994). "Interleukin-6 regulates expression of the syndecan-1 proteoglycan on B lymphoid cells". Cell. Immunol. 153 (2): 456–67. doi:10.1006/cimm.1994.1042. PMID 8118875.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Kokenyesi R, Bernfield M (1994). "Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1". J. Biol. Chem. 269 (16): 12304–9. PMID 8163535.  
  • Albini A, Benelli R, Presta M, et al. (1996). "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene 12 (2): 289–97. PMID 8570206.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Kaukonen J, Alanen-Kurki L, Jalkanen M, Palotie A (1997). "The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p". Hum. Genet. 99 (3): 295–7. doi:10.1007/s004390050360. PMID 9050911.  

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