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T-type calcium channel: Wikis

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calcium channel, voltage-dependent, T type, alpha 1G subunit
Identifiers
Symbol CACNA1G
IUPHAR Cav3.1
HUGO 1394
OMIM 604065
RefSeq NM_018896
UniProt O43497
Other data
Locus Chr. 17 q22
calcium channel, voltage-dependent, T type, alpha 1H subunit
Identifiers
Symbol CACNA1H
IUPHAR Cav3.2
Entrez 8912
HUGO 1395
OMIM 607904
RefSeq NM_001005407
UniProt O95180
Other data
Locus Chr. 16 p13.3
calcium channel, voltage-dependent, T type, alpha 1I subunit
Identifiers
Symbol CACNA1I
IUPHAR Cav3.3
Entrez 8911
HUGO 1396
OMIM 608230
RefSeq NM_001003406
UniProt Q9P0X4
Other data
Locus Chr. 22 q13.1

The T-type calcium channel is a type of voltage-gated calcium channel. "T" stands for transient referring to the length of activation. As with other sub-types of voltage-gated calcium channel, the α1 subunit is the one that determines most of the channel's properties. T-type calcium channels may contain one of three α1 subunits, α1G (Cav3.1), α1H (Cav3.2) or α1I (Cav3.3)[1][2][3].

Along with sodium "funny current," the T-type calcium channel produces the pacemaker potential in the SA node of the heart.[4]

T-type calcium channel blockers are used primarily as antiepileptics.[5]

See also

References

  1. ^ Nilius B, Talavera K, Verkhratsky A (August 2006). "T-type calcium channels: the never ending story". Cell Calcium 40 (2): 81–8. doi:10.1016/j.ceca.2006.04.011. PMID 16797069.  
  2. ^ Perez-Reyes E, Lory P (December 2006). "Molecular biology of T-type calcium channels". CNS Neurol Disord Drug Targets 5 (6): 605–9. PMID 17168745. http://www.bentham-direct.org/pages/content.php?CNSNDDT/2006/00000005/00000006/0004Z.SGM.  
  3. ^ Talavera K, Nilius B (August 2006). "Biophysics and structure-function relationship of T-type Ca2+ channels". Cell Calcium 40 (2): 97–114. doi:10.1016/j.ceca.2006.04.013. PMID 16777221.  
  4. ^ Mangoni ME, Couette B, Marger L, Bourinet E, Striessnig J, Nargeot J (2006). "Voltage-dependent calcium channels and cardiac pacemaker activity: from ionic currents to genes". Prog. Biophys. Mol. Biol. 90 (1-3): 38–63. doi:10.1016/j.pbiomolbio.2005.05.003. PMID 15979127.  
  5. ^ Lory P, Chemin J (May 2007). "Towards the discovery of novel T-type calcium channel blockers". Expert Opin. Ther. Targets 11 (5): 717–22. doi:10.1517/14728222.11.5.717. PMID 17465728.  

External links

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