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Trace amine associated receptor 1
Identifiers
Symbols TAAR1; MGC126874; MGC138399; RP11-295F4.9; TA1; TAR1; TRAR1
External IDs OMIM609333 MGI2148258 HomoloGene24938 IUPHAR: TA1 GeneCards: TAAR1 Gene
RNA expression pattern
PBB GE TAAR1 gnf1h10289 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 134864 111174
Ensembl ENSG00000146399 ENSMUSG00000056379
UniProt Q96RJ0 Q05A85
RefSeq (mRNA) NM_138327 NM_053205
RefSeq (protein) NP_612200 NP_444435
Location (UCSC) Chr 6:
133.01 - 133.01 Mb
Chr 10:
23.61 - 23.61 Mb
PubMed search [1] [2]

Trace amine-associated receptor 1 is a protein that in humans is encoded by the TAAR1 gene.[1][2][3]

TAAR1 is a G protein-coupled receptor activated by trace amines. Trace amines are endogenous amine compounds that account for less than 1% of the biogenic amines in most brain regions (Bunzow et al., 2001).[supplied by OMIM][3]

See also

References

  1. ^ Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C (Aug 2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proc Natl Acad Sci U S A 98 (16): 8966-71. doi:10.1073/pnas.151105198. PMID 11459929.  
  2. ^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (Feb 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics 85 (3): 372-85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.  
  3. ^ a b "Entrez Gene: TAAR1 trace amine associated receptor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=134864.  

Further reading

  • Bunzow JR, Sonders MS, Arttamangkul S, et al. (2001). "Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor.". Mol. Pharmacol. 60 (6): 1181–8. PMID 11723224.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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